Clinical trials: Endocrine System Disorder
Hypoglycemia Unawareness
Restoration of Hypoglycemia Awareness With Metoclopramide
Metoclopramide is a drug approved by the FDA for gastroesophageal reflux and to relieve symptoms in adults with acute and recurrent diabetic gastroparesis.
- Trial name
- NCT03970720
- Testing
- Metoclopramide
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Simon Fisher
Type 2 Diabetes
Roflumilast Plus Alogliptin Proof-of-Mechanism Study in Type2 Diabetes
The purpose of this study is to assess the effect of roflumilast plus alogliptin on glucagon-like peptide-1 (GLP-1) and glucose levels in patients with type 2 diabetes.
- Trial name
- NCT01664624
- Testing
- Roflumilast, Alogliptin, Exenatide
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- AstraZeneca
Hyperparathyroidism, Kidney Disease
Safety and Efficacy Study of Paricalcitol Versus Calcitriol in the Treatment of Secondary Hyperparathyroidism
The purpose of this study is to determine whether oral paricalcitol is safer and more efficacious compared to oral calcitriol in the treatment of hyperparathyroidism in chronic kidney disease patients undergoing dialysis.
- Trial name
- NCT00800358
- Testing
- Paricalitol, Calcitriol
- Where
- 11 sites in Malaysia
- Volunteers
- 69 people
- Sponsor
- Penang Hospital, Malaysia
Adrenal Cortex Neoplasms
Surgery Plus Chemotherapy (Doxorubicin, Vincristine and Etoposide), Mitotane, and Tariquidar to Treat Adrenocortical Cancer
This study will examine the safety and effectiveness of treating adrenocortical cancer with combination chemotherapy using doxorubicin, vincristine, and etoposide in addition to the drugs mitotane and tariquidar and, when…
- Trial name
- NCT00071058
- Testing
- XR9576 (Tariquidar)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Cancer Institute (NCI)
Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor
Amifostine to Protect From Side Effects of PSCT in Treating Patients With Solid Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of…
- Conditions
- Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor, Chordoma, Kidney Cancer
- Trial name
- NCT00003926
- Testing
- amifostine trihydrate, busulfan, filgrastim
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Diabetes Mellitus, Type 2, Hemodialysis
Efficacy and Tolerance of Liraglutide for Weight Loss in Obese Type 2 Diabetic Hemodialysis Patients
Diabetes is the second leading cause of end stage renal disease in France (22% in the 2016 REIN register). In hemodialysis, its prevalence is higher, between 30-40% depending on the study.
- Conditions
- Diabetes Mellitus, Type 2, Hemodialysis, Obese
- Trial name
- LIRADIAL (NCT04529278)
- Testing
- Liraglutide
- Where
- 4 sites in France
- Volunteers
- 18 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Efficacy and Safety
Evaluation of PLD Combined With Carboplatin Versus Paclitaxel Plus Carboplatin in the First-line Treatment of Epithelial Ovarian Cancer
This is a randomized, multicenter, open, controlled Post-Marketing Study. 396 patients who were histopathology or exfoliated cell pathology of pleural and ascites confirmed with epithelial ovarian cancer/fallopian tube/peritoneal…
- Trial name
- NCT03794778
- Testing
- pegylated liposomal doxorubicin, paclitaxel, Carboplatin
- Where
- China
- Volunteers
- 396 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Diabetes, Healthy
Bioequivalence of Two Formulations of Biphasic Insulin Aspart 50 in Healthy Subjects
This trial is conducted in Europe. The aim of this trial is to investigate the bioequivalence of two formulations of biphasic insulin aspart 50 in healthy male subjects.
- Trial name
- NCT01527643
- Testing
- biphasic insulin aspart 50
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Type 2 Diabetes
Evaluating the Effect of a Diabetes Health Coach in Individuals With Type 2 Diabetes
Background: Health coaching is defined as health education, promotion and support by a professional to enhance the well-being of individuals and facilitate the achievement of their health-related goals.
- Trial name
- DiabCoach (NCT02128815)
- Testing
- Coaching
- Where
- 2 sites in Canada
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- McMaster University
Type 2 Diabetes Mellitus
Cholesterol Metabolism and Lipid Transfer in Diabetes
The diabetic dyslipidemia is one of the most important risk factor in the development of coronary artery disease. The low density lipoprotein (LDL)-like nanoemulsions is being used to study the clearance of cholesteryl ester and…
- Trial name
- NCT01010035
- Testing
- Plasma kinetic study
- Where
- Brazil
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Type 2 Diabetes
Degludec Glargine U300 Hospital Study
Limited data exist about the use of insulin degludec and insulin glargine U300 in the hospitalized patients. A previous study compared the safety and efficacy of insulin degludec versus insulin glargine U100 for the management of…
- Trial name
- NCT05036876
- Testing
- Degludec, Glargine U300
- Where
- India
- Volunteers
- 220 people
- Sponsor
- Medanta, The Medicity, India
Diabetes Mellitus Type 2
ENhancing Outcomes Through Goal Assessment and Generating Engagement in Diabetes Mellitus
The purpose of this study is to evaluate whether a combination of pharmacist-delivered patient engagement techniques improves disease control and medication adherence among patients with poorly-controlled diabetes compared with…
- Trial name
- ENGAGE-DM (NCT02910089)
- Testing
- Shared Decision Making
- Where
- United States
- Volunteers
- 1,400 people
- Sponsor
- AstraZeneca
Hyponatremia, Hyponatremic
Hyponatremia Study (Delayed Hyponatremia After Pituitary Surgery)
Hyponatremia is defined as sodium below the normal range of 135-145. Symptomatically, it can cause patients to experience a wide range of symptoms including lethargy, headache, nausea, vomiting and in severe cases coma and even…
- Conditions
- Hyponatremia, Hyponatremic, Pituitary Tumor, Pituitary
- Trial name
- DHAPS (NCT03636568)
- Testing
- Fluid Restricted Group
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Washington University School of Medicine
Diabetes
Effect of Artıfıcıal Intellıgence Based Mobıle Vırtual Assıstant
Aim: This study was conducted experimentally to examine the effect of artificial intelligence-based mobile virtual assistant developed for individuals with diabetes on cost, hospitalization rate, self-care and hypoglycemia.
- Trial name
- AI (NCT06079450)
- Testing
- artificial intelligence based mobile application
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people
- Sponsor
- Izmir Tinaztepe University
Amenorrhea, Dysmenorrhea
Ethinyl Estradiol and Cyproterone Acetate in Irregular Menstruation
This is a Phase IV, randomized, double-blind, comparative study of the use of two preparations of ethinyl estradiol and cyproterone acetate in the treatment of menstrual irregularities of hyper-androgenic origin.
- Conditions
- Amenorrhea, Dysmenorrhea, Menstruation Disturbances, Hyperandrogenism
- Trial name
- NCT01103518
- Testing
- Ethinyl Estradiol + Cyproterone acetate
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Fundação Educacional Serra dos Órgãos
Diabetes, Type 1 Diabetes
Telemedicine-Delivered Unified Protocol for Cognitive Behavioral Therapy for Anxiety and Depression
This project will evaluate a telemedicine-delivered, Unified Protocol for Cognitive-Behavioral Therapy (UP-CBT) enhanced with continuous glucose monitor (CGM) review to target anxiety and depressive symptoms and glycemic control…
- Trial name
- UP-CBT (NCT05734313)
- Testing
- Unified protocol for cognitive behavioral therapy (UP-CBT), Continuous Glucose Monitoring (CGM)
- Where
- 2 sites in United States
- Volunteers
- 94 people
- Sponsor
- Albert Einstein College of Medicine
COVID - 19, Diabetes Mellitus
DIFFERENT SARS-COV-2 VARIANTS' EFFECT ON THE COURSE OF COVID-19 IN ESTONIAN CHILDREN
The study focuses on Estonian children under 18 who had COVID-19 from 27.02.2020 to 01.03.2023. The main aim is to find out the risk factors for severe COVID-19 in children.
- Conditions
- COVID - 19, Diabetes Mellitus, Post-COVID Conditions, MIS-C Associated With COVID-19
- Trial name
- NCT06784713
- Where
- Estonia
- Volunteers
- 127,277 people
- Sponsor
- University of Tartu
Type 1 Diabetes
Evaluation of Glycemic Control and Quality of Life in Adults With Type 1 Diabetes During Continuous Glucose Monitoring When Switching to Insulin Glargine 300 U/mL
Retrospective multicenter study analyzing data gathered during the FUTURE study (S59342) to assess the effect of using Insulin Glargine 300 U/mL (Gla-300) on measures of diabetes control and quality of life.
- Trial name
- FUTURE-GLARE (NCT05109520)
- Testing
- Insulin Glargine 300 UNT/ML [Toujeo]
- Where
- 3 sites in Belgium
- Volunteers
- 867 people
- Sponsor
- prof dr Pieter Gillard
Type II Diabetes Mellitus
A Study of CX11 Tablets in Patients With Type 2 Diabetes Mellitus
This study is testing whether a new medication called CX11 works and is safe for participants with type 2 diabetes who have not reached good blood sugar control while taking a steady dose of metformin, with or without a steady…
- Trial name
- NCT07340320
- Testing
- CX11
- Where
- 48 sites in United States, Poland
- Volunteers
- 240 people
- Sponsor
- Corxel Pharmaceuticals
Diabetic Neuropathies, Pain
The Effects of the Magnetic Molecular Energizer (MME) on Diabetic Peripheral Neuropathy
This study is intended to demonstrate that exposure to a high intensity, DC electromagnetic field, as supplied by the investigational device known as the Molecular Magnetic Energizer (MME), will create a clinically meaningful…
- Conditions
- Diabetic Neuropathies, Pain, Neuralgia
- Trial name
- NCT00134524
- Testing
- MME procedure
- Where
- 5 sites in United States
- Volunteers
- 100 people
- Sponsor
- Advanced Magnetic Research Institute International
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