Clinical trials: Endocrine System Disorder
Diabetes Mellitus Type 2, Hypercholesterolemia
Effect of Ezetimibe or Simvastatin or Both on Low Densitiy Lipoprotein -Subfractions in Patients With Type 2 Diabetes
It is of interest how ezetimibe alone or in combination with statin may influence atherogenic dense Low Density Lipoprotein (dLDL) in patients with type 2 diabetes mellitus.
- Trial name
- EZE (NCT01384058)
- Testing
- ezetimibe, simvastatin, Ezetimibe 10/Simvastatin 20
- Where
- 2 sites in Germany
- Volunteers
- 41 people
- Sponsor
- University Hospital Freiburg
Pancreas Cancer
Multidom Remote Monitoring of Patient With Advanced Pancreatic Cancer Treated With Florinox Using the PiCaDo Plateform
Pancreatic cancer is a rapidly developing cancer with a poor prognosis. The mFOLFIRINOX protocol has become the standard medical treatment for this pathology.
- Trial name
- MULTIDOM (NCT04263948)
- Testing
- Picado system internet platform and connected objects
- Where
- France
- Volunteers
- 58 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Diabetes Mellitus, Type 2
C-Reactive Protein (CRP) in Obese Diabetic Women
The purpose of this study is to determine whether treatment with rosuvastatin for 6 months in obese type 2 diabetic women will improve their lipid profiles and thus prevent the progression to cardiovascular disease.
- Trial name
- NCT00262548
- Testing
- Rosuvastatin; improvement of lipid profile
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- AstraZeneca
Liver Malignant Tumors, Cholangiocarcinoma Metastatic
High Dose-Rate Brachytherapy for the Treatment of Both Primary and Secondary Unresectable Liver Malignancies
Over the past three decades, the treatment of both primary and secondary liver malignancies has been improved by the development and optimization of multiple minimally invasive thermal ablative therapies.
- Conditions
- Liver Malignant Tumors, Cholangiocarcinoma Metastatic, Pancreatic Cancer, Melanoma
- Trial name
- NCT05053555
- Testing
- high dose rate brachytherapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- M.D. Anderson Cancer Center
Pancreatic Cancer
Feasibility of the Loop Brush EUS-FNA for Characterization of Pancreatic Cysts: Pilot Clinical Investigation
This investigation aims to demonstrate the feasibility of the lbFNA device for the first time in pancreatic cysts in humans. This study will be used as a base for further investigations on the safety and diagnostic accuracy of…
- Trial name
- PCLoop-Pilot (NCT07814326)
- Testing
- Loop Brush Fine Needle Aspiration
- Where
- Sweden
- Volunteers
- 8 people
- Sponsor
- Urban Arnelo
Tuberculosis, Diabetes Mellitus
Tuberculosis Drug Levels and Continuous Glucose Monitoring in Diabetic Patients
Diabetes significantly increases the risk of developing active tuberculosis (TB). Diabetic patients who do develop TB have worse treatment outcomes and overall mortality.
- Trial name
- NCT05329415
- Testing
- TB Drug Levels
- Where
- United Kingdom
- Volunteers
- 48 people
- Sponsor
- London North West Healthcare NHS Trust
Diabetes Mellitus, Physical Activity
Community-Clinic Partnership to Promote Physical Activity in South Asian Women
The goal of this study is to pilot-test a culturally-salient physical activity intervention, using a randomized design, among under served, overweight/obese South Asian women at high risk for developing Diabetes.
- Trial name
- NCT02342535
- Testing
- Physical Activity
- Where
- 2 sites in United States
- Volunteers
- 68 people
- Sponsor
- Northwestern University
Type 2 Diabetes, Type 2 Diabetes Mellitus
Regular Insulin vs Rapid Insulin Delivered by V-Go
The purpose of the study is to collect data about how well U-100 Regular Human Insulin can be used in the V-Go Insulin Delivery Device compared to U-100 Rapid Acting Insulin in the V-Go Insulin Delivery Device.
- Trial name
- NCT03495908
- Testing
- VGo
- Where
- 2 sites in United States
- Volunteers
- 136 people
- Sponsor
- East Coast Institute for Research
Clear Cell Renal Cell Cancer (ccRCC), Urothelial Carcinoma (UC)
18F-T2 PET/CT Imaging for CAIX Positive Solid Tumors
The goal of this clinical trial is to evaluate the diagnostic value of CAIX protein specific probe 18F-T2 in PET/CT imaging in participants with solid tumors.
- Conditions
- Clear Cell Renal Cell Cancer (ccRCC), Urothelial Carcinoma (UC), Colorectal Cancer, Cervical Cancer
- Trial name
- NCT07557225
- Testing
- 18F-T2 PET/CT
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
Bladder Cancer, Low Testosterone Levels
Perioperative Hypogonadism in Men Undergoing Radical Cystoprostatectomy for Bladder Cancer
The purpose of this study is to examine the relationship between testosterone level changes around the time of radical cystectomy.
- Trial name
- NCT03063125
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Kansas Medical Center
Central Precocious Puberty
Analysis of Genetic and Environmental Parameters Influencing Growth Rate of Precocious Puberty Children
The goal of CPP-EDG 01 study is to assess possible genetic and/or environmental parameters which may influence the growth rate of children affected by precocious puberty.
- Trial name
- CPP-EDG 01 (NCT00438217)
- Testing
- Triptorelin (GnRH agonists), Leuprolide (GnRH agonists)
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pisa
Vitamin D Supplementation, PreDiabetes
Vitamin D Supplementation on Surrogate Markers of Ageing, Ageing Genes, Glycemic and Metabolic Markers in North India
Prediabetes is a substantial problem in India not only because it itself can be associated with morbidities such as coronary artery disease but also because it is a point of important for prevention of diabetes.
- Conditions
- Vitamin D Supplementation, PreDiabetes, Aging
- Trial name
- NCT04025489
- Testing
- Randomized control trial of vitamin D supplementation
- Where
- India
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Diabetes Foundation, India
Diabetes Mellitus, Type 1
Tandem Freedom - Feasibility Trial 2
This feasibility study is a prospective, single arm study evaluating the Tandem Freedom system in adults with type 1 diabetes. Existing Control-IQ technology users will use Control-IQ technology at home for a one week run-in…
- Trial name
- NCT06834568
- Testing
- t:slim X2 insulin pump with Tandem Freedom Algorithm
- Where
- New Zealand
- Volunteers
- 10 people
- Sponsor
- Tandem Diabetes Care, Inc.
Type 2 Diabetes, Obesity, Abdominal
Long-term Effect of Moderate and Vigorous Exercise on Incident Diabetes in Obese Subjects
Our previous randomized controlled trial has recruited 220 subjects with central obesity and allocated the subjects to the non-exercise control, moderate exercise and vigorous exercise groups.
- Trial name
- NCT05346250
- Testing
- Non-exercise control, Moderate intensity exercise, Vigorous intensity exercise
- Volunteers
- 220 people
- Sponsor
- Shanghai Zhongshan Hospital
Type 1 Diabetes
A Trial Investigating the Accuracy of Continuous Glucose Monitor Systems ("Supersapiens" Abbott Libre Sense and Dexcom G6) During Exercise in People With Normal Glucose Tolerance
A two-phase, observational trial in an exercise laboratory and a prospective real-world setting to test the hypothesis that The Libre Sense Glucose Sport device has acceptable accuracy in people with normal glucose tolerance and…
- Trial name
- SuperComEx (NCT06034574)
- Testing
- Continuous glucose monitoring
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Diabetes
Improving Diabetes Efforts Across Language and Literacy (IDEALL)
The IDEALL Project (Improving Diabetes Efforts Across Language and Literacy) is a 3-arm randomized controlled trial to explore contextual factors at the patient, clinician, and organizational level of two patient self-management…
- Trial name
- NCT00214474
- Testing
- ATSM Intervention, GMV Intervention
- Where
- United States
- Volunteers
- 339 people
- Sponsor
- Agency for Healthcare Research and Quality (AHRQ)
Type 1 Diabetes
EMERALD: Effects of Metformin on Cardiovascular Function in Adolescents With Type 1 Diabetes
Diabetes is increasingly common among youth, forecasting early complications. Type 1 (T1D) cause early heart disease, shortening lifespan despite modern improvements in control of blood sugars and other risk factors for heart…
- Trial name
- EMERALD (NCT01808690)
- Testing
- Metformin
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Colorado, Denver
Pediatric Obesity, Overnutrition, Child
IMplementation of the Family Support PRogramme A Healthy School Start to Prevent OVErweight and Obesity (IMPROVE)
IMPROVE is an implementation study aiming to explore the effects of two bundled implementation strategies on the intervention fidelity of the Healthy School Start program (primary outcome) while simultaneously monitoring effects…
- Conditions
- Pediatric Obesity, Overnutrition, Child, Prediabetic State, Diabetes Mellitus, Type 2
- Trial name
- IMPROVE (NCT04984421)
- Testing
- Healthy School Start
- Where
- 3 sites in Sweden
- Volunteers
- 1,634 people
- Sponsor
- Karolinska Institutet
Adult Growth Hormone Deficiency
Safety, Pharmacokinetic (PK) Profile and Efficacy of Inpegsomatropin Injection in Adults With Growth Hormone Deficiency
This is a multiple-dose, dose-escalation, randomized, double-blind, placebo-controlled phase Ⅱa clinical trial. A total of 36 adult participants with growth hormone deficiency will be enrolled sequentially in ascending dose…
- Trial name
- NCT07551804
- Testing
- Inpegsomatropin Injection
- Where
- 6 sites in China
- Volunteers
- 36 people
- Sponsor
- Xiamen Amoytop Biotech Co., Ltd.
Diabetes Mellitus, Type 2, Coronary Disease
A Study Comparing Standard Care for Diabetes to Case-managed Care for Diabetes in Patients With Coronary Artery Disease
The purpose of this study is to compare two ways to treat patients with Type 2 Diabetes, Standard Care or Case-Managed Care. In-Patient Standard Care is guided by the assigned cardiologist and Out-Patient Standard Care by the…
- Trial name
- NCT00248352
- Testing
- Consultation with Endocrinologist, Counseling from Dietician, Counseling from Diabetes Educator
- Where
- Canada
- Volunteers
- 169 people
- Sponsor
- Ottawa Heart Institute Research Corporation
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