Clinical trials: Endocrine System Disorder
Previously AG Chemotherapy Treated Pancreatic Cancer
Second-line Zimberelimab and SIRIOX Chemotherapy for Patient With Previously AG Chemotherapy Treated Pancreatic Cancer
This is a prospective, single arm, phase II clinical study investigating second-line Zimberelimab and SIROX chemotherapy for patient with previously AG chemotherapy treated pancreatic cancer.
- Trial name
- NCT06166589
- Testing
- Zimberelimab, Oxaliplatin, S-1
- Where
- China
- Volunteers
- 19 people
- Sponsor
- Shanghai Zhongshan Hospital
Prediabetes, Hypertension
Intervention With a GABA Supplement in Prediabetics
In this double-blind parallel placebo controlled intervention study the effects of 3 times daily 500 mg gamma-aminobutyric acid (GABA) supplementation on glucose tolerance and cardiovascular health will be assessed in…
- Trial name
- NCT04303468
- Testing
- GABA
- Where
- Netherlands
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Male Hypogonadism, Androgen Deficiency
Registry of Hypogonadism in Men
The primary objective of the Registry of HYpogonadism in MEn (RHYME) is to establish and maintain a large, multi-national prospective registry of male patients who have been diagnosed with male hypogonadism (HG), also known as…
- Conditions
- Male Hypogonadism, Androgen Deficiency, Testosterone Deficiency
- Trial name
- RHyMe (NCT00858650)
- Testing
- Standard of Care
- Where
- 25 sites in Germany, Italy and 4 more
- Volunteers
- 999 people
- Sponsor
- Carelon Research
Asthma, Atopy
The JOIN Project: The Air in Diagnosis and Prevention of Asthma and Allergy
The JOIN project combines the health and indoor environment research areas to contribute in the development and validation of a new asthma diagnosis method through exhaled VOC analysis.
- Trial name
- JOIN (NCT02802891)
- Where
- Portugal
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
Epilepsy, Diabetic Nephropathy
Study on the Population Pharmacokinetics of Levetiracetam in Epileptic Patients With Diabetic Kidney Disease
The individualized drug delivery system of levetiracetam based on population pharmacokinetics and quantitative pharmacology model in patients with epilepsy complicated by diabetic kidney disease was established.
- Trial name
- NCT05330390
- Testing
- Levetiracetam
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The Second Hospital of Shandong University
Pancreatic Carcinoma, Pancreatic Intraductal Papillary Mucinous Neoplasm, Pancreatobiliary-Type
Ultra-High Resolution Optical Coherence Tomography in Detecting Micrometer Sized Early Stage Pancreatic Cancer in Participants With Pancreatic Cancer
This trial studies how well ultra-high resolution optical coherence tomography works in detecting micrometer sized early stage pancreatic cancer in participants with pancreatic cancer.
- Trial name
- NCT03711890
- Testing
- Optical Coherence Tomography, Therapeutic Conventional Surgery, Laboratory Evaluation
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Prediabetic State, Metabolic Syndrome
Effects of Sweetener Consumption on Risk Factors for Heart Disease in Prediabetic Subjects
The aim of this prospective interventional study is to investigate the metabolic effects of consuming artificial and natural sweeteners in persons with prediabetes.
- Conditions
- Prediabetic State, Metabolic Syndrome, Insulin Resistance, Thrombosis
- Trial name
- Sweetheart (NCT07377097)
- Testing
- Saccharin, Sucralose, Erythritol
- Volunteers
- 80 people
- Sponsor
- Charite University, Berlin, Germany
Diabetes Mellitus, Type 1
REducing With MetfOrmin Vascular Adverse Lesions in Type 1 Diabetes (REMOVAL)
The trial is conducted in the United Kingdom (UK), Australia, Canada, Denmark and the Netherlands. The aim is to test whether 3 years treatment with metformin added to titrated insulin therapy (towards target HbA1c 7.0%/53…
- Trial name
- REMOVAL (NCT01483560)
- Testing
- Metformin
- Where
- 24 sites in Australia, Canada and 3 more
- Volunteers
- 493 people
- Sponsor
- University of Glasgow
Neuroendocrine Tumor of Pancreas, Pancreatic Neuroendocrine Tumors
Patients With High-grade Pancreatic Neuroendocrine Tumors
Pancreatic neuroendocrine tumor (pNET) is a rare form of cancer. Treatment options such as hormonal therapy (octreotide) and targeted therapy (everolimus and sunitinib) may be considered for grade 1 or 2 pNETs; however, cytotoxic…
- Trial name
- NCT07121478
- Testing
- Lurbinectedin 4 MG Injection [Zepzelca]
- Where
- South Korea
- Volunteers
- 46 people
- Sponsor
- National Cancer Center, Korea
Polycystic Ovary Syndrome
Polycystic Ovary Syndrome Genetics and Treatment Response
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive age women. Women with PCOS have a high risk of prediabetes, type 2 diabetes and heart disease.
- Trial name
- NCT01389778
- Testing
- Metformin ER, Metformin
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Massachusetts General Hospital
Type 2 Diabetes Mellitus
Evaluation of Low Blood Sugar Events in Participants With Diabetes (MK-0431-402)
This is a multicenter, observational, retrospective and cross-sectional study to be conducted in a cohort of consecutively selected participants with type 2 diabetes mellitus (T2DM) who have been treated with sulphonylurea (SU)…
- Trial name
- NEEDS (NCT01278485)
- Testing
- Sulphonylurea, Metformn
- Volunteers
- 726 people
- Sponsor
- Merck Sharp & Dohme LLC
Type 2 Diabetes
Empowerment and Support for the Diabetic Patient
CHANGE-D objectives are to evaluate to what extent personal coaching for healthy lifestyle and treatment adherence improves clinical outcomes among uncontrolled diabetic patients.
- Trial name
- CHANGE-D (NCT02179385)
- Testing
- Health Coaching
- Volunteers
- 300 people
- Sponsor
- Clalit Health Services
Hyperthyroidism/Thyrotoxicosis
LIthium as Bridging thErapy Prior to Radioactiveiodine in hyperThYroidism
A prospective randomised controlled open label, single centre study. subjects will be randomised into lithium or carbimazole arms in a 1:1 ratio.
- Trial name
- LIBERTY (NCT05512715)
- Testing
- radioactive iodine
- Where
- Malaysia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Painful Diabetic Neuropathy (PDN), Diabetic Neuropathies
Efficacy of Topical Lidocaine Gel vs. Oral Duloxetine for Painful Diabetic Peripheral Neuropathy
The goal of this clinical trial is to learn if topical lidocaine gel can effectively reduce pain intensity compared to oral duloxetine in adult patients (aged 30-70 years) with type 2 diabetes suffering from painful diabetic…
- Conditions
- Painful Diabetic Neuropathy (PDN), Diabetic Neuropathies, Type 2 Diabetes
- Trial name
- NCT07800468
- Testing
- Topical Lidocaine 2% Gel, Duloxetine (60 MG)
- Volunteers
- 80 people
- Sponsor
- Wah Medical college , POF hospital
Thyroid Cancer, Thyroid Nodule
Da-vinci sp Versus xi Thyroid Surgery
One year comparative analysis between SPRA* versus BABA** thyroid surgery. * SPRA: da-Vinci SP Robotic Areolar approach thyroid surgery ** BABA: da-Vinci Xi robotic Bilateral. Axillary Breast Approach thyroid surgery
- Trial name
- NCT06573268
- Testing
- robot surgery device
- Where
- South Korea
- Volunteers
- 270 people
- Sponsor
- Inha University Hospital
Mild Autonomous Cortisol Secretion (MACS), Autonomous Cortisol Secretion (ACS)
IMPACT-MACS: Adrenalectomy vs Semaglutide for Metabolic Outcomes in Mild Autonomous Cortisol Secretion
The goal of this study is to learn how two treatments-adrenalectomy (surgical removal of an adrenal gland) and semaglutide (a medication used for weight management)-affect insulin resistance and cortisol regulation in adults with…
- Conditions
- Mild Autonomous Cortisol Secretion (MACS), Autonomous Cortisol Secretion (ACS), Subclinical Cushing's, Mild Autonomous Cortisol Excess
- Trial name
- IMPACT-MACS (NCT07361874)
- Testing
- Intervention 1: Adrenalectomy, Intervention 2: Semaglutide
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Texas Southwestern Medical Center
Type 1 Diabetes Mellitus
Single Hormone Closed Loop Study With PDT Sensor
The study described within this protocol is designed to test a single hormone closed-loop algorithm for managing blood glucose in type 1 diabetes using insulin only and a new device for measuring glucose continuously in the…
- Trial name
- NCT03528174
- Testing
- Artificial Pancreas Control system (APC), Pacific Diabetes Technologies CGM Insulin Infusion system
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Oregon Health and Science University
Diabetes Mellitus, Type 2, Prediabetic State
PREDICT-DM: Community Pharmacy-Based Point-of-Care Testing for Undiagnosed T2DM
The goal of this observational study is to learn whether community pharmacy-based risk assessment and point-of-care HbA1c testing can help detect undiagnosed type 2 diabetes and prediabetes among adults in Irbid Governorate…
- Conditions
- Diabetes Mellitus, Type 2, Prediabetic State, Prediabetes / Type 2 Diabetes, T2DM
- Trial name
- PREDICT-DM (NCT07795918)
- Where
- Jordan
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Kidney Transplant, Type 2 Diabetes
Sitagliptin Treatment in Patients With Type 2 DM After Kidney Transplant
This study is designed to look at the effect sitagliptin has on tacrolimus and sirolimus drug levels in kidney transplant patients. It is also designed to look at the side effects experienced in the transplant population.
- Trial name
- NCT00466518
- Testing
- Administration of sitagliptin
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Oklahoma
Ischemia Limb, Diabete Mellitus
Comparative Study of Negative-Pressure Wound Therapy Integrated With Silver Nanoparticle Spray Versus Negative-Pressure Wound Therapy in Post-Revascularization Diabetic Foot Wound Management
This was a prospective, parallel-group, randomized controlled trial conducted at the Vascular Surgery Department of Kafrelsheikh University Hospital, Egypt.
- Trial name
- SNIPS-FOOT (NCT07147790)
- Testing
- After successful revacularization, We will categorize patients into two groups : groups A (The patient's wound will be cleaned and irrigated with silver nanoparticle spray, then we will cover the woun, Silver Nanoparticles Irrigant
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Kafrelsheikh University
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