Clinical trials: Endocrine System Disorder
Polycystic Ovary Syndrome
Study of the Safety and Efficacy of Elagolix in Women With Polycystic Ovary Syndrome
This study will assess the potential impact of elagolix on disordered pituitary and ovarian hormones in women with polycystic ovary syndrome (PCOS).
- Trial name
- NCT03951077
- Testing
- Elagolix
- Where
- 54 sites in United States, Puerto Rico
- Volunteers
- 118 people
- Sponsor
- AbbVie
Diabetes Mellitus
Ease of Use of New Blood Glucose Meter With In-built Insulin Calculator at Home Study
The aim of this study is to evaluate user preference and ease of use of the FreeStyle InsuLinx system, compared to current methodology, when used at home by subjects with diabetes.
- Trial name
- IHUT (NCT01432275)
- Testing
- ADC blood glucose meter, Comparator blood glucose meter, ADC blood glucose meter with insulin calculator active
- Where
- 7 sites in United Kingdom
- Volunteers
- 179 people
- Sponsor
- Abbott Diabetes Care
Diabetes Mellitus, Type 2, Obesity
Association of Diabetes and Metabolic Syndrome With Severe Malaria in Cameroon
The aim of this study is to investigate if diabetes, obesity and metabolic syndrome affects disease presentation and severity of malaria in adults in a hospital setting in Cameroon.
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Metabolic Syndrome, Severe Malaria
- Trial name
- NCT05685875
- Testing
- diabetes
- Where
- 2 sites in Cameroon
- Volunteers
- 300 people
- Sponsor
- Karolinska Institutet
Hypothyroidism, Trisomy 21
Use of Liquid Stable Levothyroxine in Trisomy 21 Pediatric Patients
Children with levothyroxine (T21) have developmental delay and other functional gastrointestinal (GI) issues that may negatively affect L-T4 tolerability and absorption.
- Trial name
- NCT04747275
- Testing
- Liquid stable levothyroxine (L-T4) Tirosint-SOL, Oral tablet levothyroxine (L-T4)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Children's Mercy Hospital Kansas City
Type 2 Diabetes
A Study to Demonstrate the Bioequivalence of Sitagliptin/Metformin Combination Tablets and Concomitant Administration of Sitagliptin and Metformin as Individual Tablets (0431A-048)
A two-part study to demonstrate the bioequivalence of a single dose of the Final Market Image (FMI) of sitagliptin /metformin (50/500 and 50/1000 mg) Fixed-Dose Combination (FDC) tablet and co-administration of a single dose of…
- Trial name
- NCT00961857
- Testing
- sitagliptin phosphate (+) metformin hydrochloride, Comparator: metformin 500 mg, Comparator: sitagliptin
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Type 2 Diabetes Mellitus
Development of Diabetes Mobile Application
this study is to measure the effectiveness of a diabetes mobile application for improving patient's knowledge, compliance and diabetes control among uncontrolled Type 2 Diabetes Mellitus mellitus patients in Kedah
- Trial name
- NCT04686201
- Testing
- Diabetes Mobile Application
- Where
- Malaysia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Cholangiocarcinoma, Pancreatic Cancer
Registry for Advanced Endoscopy
Observational registry including endoscopic diagnostic and therapeutic interventions in the gastrointestinal tract
- Conditions
- Cholangiocarcinoma, Pancreatic Cancer, Sclerosing Cholangitis
- Trial name
- ERDB (NCT05187312)
- Testing
- Endoscopic retrograde Cholangio- pancreatography, Endoscopic ultrasound
- Where
- Sweden
- Volunteers
- 1,000 people
- Sponsor
- Region Stockholm
Type 1 Diabetes
Resilience Promotion in Teens With Type 1 Diabetes: Preventing Negative Outcomes
Adolescents with type 1 diabetes are at increased risk for depressive symptoms, poor coping and problem-solving skills, poor regimen adherence, and negative diabetes-specific health outcomes.
- Trial name
- NCT01490619
- Testing
- Healthy Thinking In Teens, Advanced Diabetes Education.
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Diabetes Mellitus, Type 1, Endothelial Dysfunction
Therapeutic Strategies for Microvascular Dysfunction in Type 1 Diabetes
The investigators will test the hypothesis that, in adults with type 1 diabetes (T1D), glucagon-like peptide-1 receptor agonism (GLP-1RA, i.e.
- Trial name
- MCD-1 (NCT05478707)
- Testing
- Dulaglutide
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- AdventHealth Translational Research Institute
Diabetic Retinopathy (DR), Retinal Vein Occlusion (RVO)
High-throughput Large-model-based AI-assisted Diagnosis Using OCT
This observational study aims to establish key technologies for high-throughput, large-model-based AI-assisted diagnosis using optical coherence tomography (OCT) and OCT angiography (OCTA).
- Conditions
- Diabetic Retinopathy (DR), Retinal Vein Occlusion (RVO), Age-Related Macular Degeneration (AMD), Pathologic Myopia
- Trial name
- NCT07249307
- Testing
- No intervention
- Volunteers
- 2,000 people
- Sponsor
- Peking Union Medical College Hospital
Pancreatic Cancer
Exploratory Platform Research on Precision Therapy of Advanced Pancreatic Cancer
The study is being conducted to evaluate the safety, tolerability and efficacy of ADC drugs monotherapy or combination therapy with HRS-4642 or immunotherapy in subjects with locally advanced or metastatic pancreatic cancer.
- Trial name
- NCT06547736
- Testing
- SHR-A2102 or/and HRS-4642, SHR-A1904 or/and HRS-4642, SHR-A1811 or/and HRS-4642
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Fudan University
Type 2 Diabetes Mellitus
Efficacy and Safety of Sotagliflozin Versus Glimepiride and Placebo in Participants With Type 2 Diabetes Mellitus That Are Taking Metformin Monotherapy
Primary Objective: To demonstrate the non-inferiority of Sotagliflozin 400 milligrams (mg) compared to Glimepiride on hemoglobin A1c (HbA1c) reduction at Week 52 in participants with Type 2 Diabetes (T2D) who have inadequate…
- Trial name
- SOTA-GLIM (NCT03332771)
- Testing
- Sotagliflozin (SAR439954), Glimepiride, Metformin
- Where
- 142 sites in United States, Bulgaria and 2 more
- Volunteers
- 954 people
- Sponsor
- Lexicon Pharmaceuticals
Vein Occlusion, Macular Degeneration Choroidal Neovascularization
Comparing Post-intravitreal Injection Pain Scores Using Loteprednol, Bromfenac Sodium, and Artificial Tears Over a 24-hour Period
The goal of this clinical trial is to learn how various topical drops (bromfenac, loteprednol, and artificial tears) fare in alleviating post-intravitreal injection pain.
- Conditions
- Vein Occlusion, Macular Degeneration Choroidal Neovascularization, Macular Edema, Diabetic Retinopathy
- Trial name
- NCT07090044
- Testing
- Bromfenac Sodium 0.07%, Loteprednol Etabonate 0.38% Ophthalmic Gel/Jelly, Propylene Glycol Preservative-free Artificial Tears
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Retina Research Institute, LLC
Psychosomatic Disorder
Superficial Supportive Psychotherapy Model and Its Effect on Acute Coronary Syndrome Psycho-Neuro-Endocrine Studies
Hypothesis 1. The supportive psychotherapy model can be structured and developed for the non-pharmacologic therapy of acute coroner syndrome patients in intensive cardiac care unit 2.
- Trial name
- NCT04868734
- Testing
- Supportive Psychotherapy
- Where
- Indonesia
- Volunteers
- 80 people
- Sponsor
- Universitas Indonesia
Type 2 Diabetes, Cardiovascular Risk
Different Insulin Regimens and Postprandial Coagulation Activation
The purpose of this study in patients with type 2 diabetes was to investigate the acute effect of postprandial blood glucose levels modified by two different insulin treatment regimens on coagulation activation, inflammation and…
- Conditions
- Type 2 Diabetes, Cardiovascular Risk, Hemostasis, Inflammation
- Trial name
- NCT01053234
- Testing
- Standardised meals
- Where
- Denmark
- Volunteers
- 78 people
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Advanced Fallopian Tube Carcinoma, Advanced Malignant Solid Neoplasm
Testing the Addition of an Anti-cancer Drug, Elimusertib (BAY 1895344) ATR Inhibitor, to the Chemotherapy Treatment (Gemcitabine) for Advanced Pancreatic and Ovarian Cancer, and Advanced Solid Tumors
This phase I trial identifies the best dose, possible benefits and/or side effects of gemcitabine in combination with elimusertib (BAY 1895344) in treating patients with pancreatic, ovarian, and other solid tumors that have…
- Conditions
- Advanced Fallopian Tube Carcinoma, Advanced Malignant Solid Neoplasm, Advanced Ovarian Carcinoma, Advanced Pancreatic Adenocarcinoma
- Trial name
- NCT04616534
- Testing
- Biopsy Procedure, Biospecimen Collection, Diagnostic Imaging Testing
- Where
- 3 sites in United States
- Volunteers
- 14 people
- Sponsor
- National Cancer Institute (NCI)
Hypogonadism
A Preliminary Clinical Study to Evaluate Fispemifene in the Treatment of Hypogonadism
The purpose of this study is to determine whether one or more fispemifene dose regimens are more effective than placebo in the treatment of hypogonadism in older men.
- Trial name
- NCT00290134
- Testing
- Fispemifene once daily for 4 weeks
- Where
- 16 sites in United States
- Volunteers
- 100 people
- Sponsor
- QuatRx Pharmaceuticals Company
Type 1 Diabetes Mellitus
To Evaluate if Wide Blood Sugar Fluctuations Lead to Injury of Heart Function and Heart Nerves
This proposal will test if, in patients with type 1 diabetes, wide blood glucose fluctuations lead to the injury to heart nerves , called cardiac autonomic neuropathy (CAN), and to impaired heart contractile (pumping) function…
- Trial name
- NCT01170832
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Bladder Cancer, Breast Cancer
OGX-011 and Docetaxel in Treating Patients With Metastatic or Locally Recurrent Solid Tumors
RATIONALE: OGX-011 may kill tumor cells by blocking some of the proteins that may cause tumor cells to grow. Drugs used in chemotherapy, such as docetaxel, work in different ways to stop the growth of tumor cells, either by…
- Conditions
- Bladder Cancer, Breast Cancer, Kidney Cancer, Lung Cancer
- Trial name
- NCT00471432
- Testing
- custirsen sodium, docetaxel, pharmacological study
- Volunteers
- 40 people
- Sponsor
- NCIC Clinical Trials Group
Painful Diabetic Neuropathy
A Phase 2, Multicenter, Randomized, Double-blind, Placebo Controlled Study for the Pain of Diabetic Peripheral Neuropathy
Primary Objective: To evaluate the efficacy of SKL11197 for the treatment of diabetic peripheral neuropathy pain (DPN). Secondary Objective: To evaluate the safety and tolerability of SKL11197 in subjects with painful diabetic…
- Trial name
- NCT01521598
- Testing
- SKL11197
- Where
- 13 sites in United States
- Volunteers
- 128 people
- Sponsor
- SK Life Science, Inc.
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