Clinical trials: Endocrine System Disorder
Ovarian Neoplasms, Endometrial Neoplasms
A Study of Sofe-M in Participants With Selected Advanced Solid Tumors
The purpose of this study is to find out whether the study drug, Sofetabart Mipitecan (LY4170156), is safe, tolerable and effective in participants with advanced solid tumors.
- Conditions
- Ovarian Neoplasms, Endometrial Neoplasms, Uterine Cervical Neoplasms, Carcinoma, Non-Small-Cell Lung
- Trial name
- NCT06400472
- Testing
- Sofe-M, bevacizumab, carboplatin
- Where
- 25 sites in United States, Australia and 5 more
- Volunteers
- 575 people
- Sponsor
- Eli Lilly and Company
Type 2 Diabetes Mellitus
Omnipod® 5 Automated Insulin Delivery System in Patients With Type 2 Diabetes
The study subjects will be separated into 2 groups, depending on their previous insulin therapy with approximately 50% of subjects from each group, continuous glucose monitoring (CGM) naive.
- Trial name
- NCT04617795
- Testing
- Omnipod 5 Automated Insulin Delivery System
- Where
- 4 sites in United States
- Volunteers
- 25 people
- Sponsor
- Insulet Corporation
Pituitary Tumor
Postoperative Cognitive Dysfunction in Patients Undergoing Pituitary Removal Surgery
As postoperative cognitive dysfunction rates are high especially in elder patients, cognitive dysfunction is not diagnosed and treated effectively.
- Trial name
- NCT03719781
- Testing
- standardized minimental testing
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Kocaeli University
Resistant Hypertension, NIDDM
Resistant Hypertension in Patients With Type-II-Diabetes Mellitus
The risk of cardiovascular disease (CVD) in patients with type-II-diabetes mellitus (type-II-DM)is more than doubled and CVD accounts for 70% of deaths in this group of patients.
- Trial name
- RESIST (NCT01056367)
- Where
- Denmark
- Volunteers
- 180 people
- Sponsor
- Svendborg Hospital
Ovarian Carcinoma
MLN8237 for Treatment of Participants With Ovarian, Fallopian Tube, or Peritoneal Carcinoma
The purpose of this study is to evaluate the anti-tumour activity of alisertib (MLN8237) in the treatment of participants with platinum-refractory or platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal…
- Trial name
- NCT00853307
- Testing
- Alisertib
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Millennium Pharmaceuticals, Inc.
Type 2 Diabetes Mellitus
A Study of an Investigational Drug Sitagliptin for Type 2 Diabetes Mellitus (0431-044)
The purpose of this trial is to determine the efficacy and safety of an investigational drug in patients with type 2 diabetes mellitus.
- Trial name
- NCT00127192
- Testing
- sitagliptin phosphate
- Volunteers
- 363 people
- Sponsor
- Merck Sharp & Dohme LLC
Diabetes Type 1
Insul-In This Together: Leveraging Family Support and Diabetes Technology for Adolescents Living With Type 1 Diabetes
The goal of this clinical trial is to learn if the "Insul-In This Together" family program works to improve outcomes for adolescents living with type 1 diabetes.
- Trial name
- IITT (NCT07856836)
- Testing
- Insul-In This Together
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Stanford University
Diabetic Foot
Study of Subjects With Diabetic Foot Ulcer (DFU)
Foot ulceration is a common and costly complication of diabetes. GSK1278863 is a topical drug, which is being developed to treat wounds associated with DFU.
- Trial name
- NCT03153007
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- GlaxoSmithKline
Solid Tumor, Microsatellite Instability-High (MSI-H) Solid Tumors
A Study of Anti-PD-L1 Checkpoint Antibody (LY3300054) Alone and in Combination in Participants With Advanced Refractory Solid Tumors
The main purpose of this study is to evaluate the safety and tolerability of anti-programmed cell death ligand 1 (PD-L1) checkpoint antibody LY3300054 in participants with advanced refractory solid tumors.
- Conditions
- Solid Tumor, Microsatellite Instability-High (MSI-H) Solid Tumors, Cutaneous Melanoma, Pancreatic Cancer
- Trial name
- PACT (NCT02791334)
- Testing
- LY3300054, Ramucirumab, Abemaciclib
- Where
- 14 sites in United States, Belgium and 5 more
- Volunteers
- 164 people
- Sponsor
- Eli Lilly and Company
Diabetes Mellitus
Assessment of Tissue Oxygenation Using Multispectral Imaging
In Canada, the age-standardized prevalence of diabetes is on the rise (increasing from 3.3% in 1998/99 to 5.6% in 2008/2009 Public Health Agency of Canada (July 2011)) and is almost 1 in 10 globally.
- Trial name
- NCT03516864
- Testing
- MIMOSA Imager, Kent Camera
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Diabetes Mellitus, Steroid Diabetes
Effect of Corticosteroid Injections on Blood Glucose
The purpose of this study is to measure the effect of various corticosteroids administered to the shoulder, knee and hip joints in diabetic patients on resultant blood glucose readings.
- Conditions
- Diabetes Mellitus, Steroid Diabetes, Shoulder Osteoarthritis, Knee Osteoarthritis
- Trial name
- CSI (NCT05048264)
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Duke University
Cushing Disease, Pituitary Adenoma
FET PET/CT Imaging To Localize Pituitary Adenomas In Cushing Disease
The purpose of this research is to evaluate the performance [sensitivity, specificity, accuracy] of FET PET/CT imaging to detect ACTH-secreting pituitary adenoma, using operative findings and histopathology as truth standard.
- Trial name
- NCT07460232
- Testing
- Fluoro-O-(2) fluoroethyl-L-tyrosine (FET) PET
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Head and Neck Cancer
The Incidence and Risk Factors of Radiotherapy Induced Hypothyroidism in Head and Neck Cancer With Long Term Follow up
This is a retrospective study with long term follow up to evaluate the incidence, timing and risk factors of radiotherapy induced hypothyroidism in non-thyroid head and neck cancer patients who were treated with RT alone or in…
- Trial name
- NCT03699098
- Testing
- TSH, T3, T4 and thyroid gland DVH
- Where
- Egypt
- Volunteers
- 101 people
- Sponsor
- Cairo University
Hyperglycemia Steroid-induced, Insulin Resistance, Diabetes
Use of NPH Versus Basal Bolus Insulin for Steroid Induced Hyperglycemia
Glucocorticoids are known to cause an increase in insulin resistance, leading to hyperglycemia, in both diabetic and non-diabetic patients.
- Trial name
- NCT03511521
- Testing
- NPH Insulin, glargine, Insulin Aspart
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Northwestern University
Hypogonadism
Efficacy and Tolerability of Testogel/Nebido in Combination With Exercise and Diet in Hypogonadal Male Patients
With advancing age testosterone levels decline in men. Low testosterone levels plus certain symptoms are called "Late Onset Hypogonadism (LOH)". Adipose tissue may contribute to testosterone deficiency.
- Trial name
- NCT00847314
- Testing
- Testosterone Undeconate (Nebido-R, BAY86-5037)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Bayer
Bladder Cancer, Diabetes
BLADDER CANCER SCREENING AMONG DIABETIC PATIENTS
patients om metformin from diabetic clinic were checked for bladder cancer
- Trial name
- NCT02505516
- Testing
- metformin
- Where
- Ghana
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- UFUOMA MILLER FAKPOR
Obesity, Diabetes Mellitus, Type 2
Postprandial Profiles of Metabolites and Appetite-regulating Hormones in Plasma and Cerebrospinal Fluid
Overweight and obesity are rising in prevalence and becoming a growing threat to public health. Obesity is associated with an increased all-cause mortality, impaired quality of life, and numerous of disorders.
- Trial name
- NCT06115304
- Testing
- Large liquid meal, spinal catheter and venous line
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mikkel Bring Christensen
Type 2 Diabetes Mellitus
Phase II Dose-Finding Study of SK-0403 With Type 2 Diabetes Mellitus
The purpose of this study is to evaluate the clinical efficacy and safety of SK-0403 in patients with Type2 Diabetes Mellitus
- Trial name
- NCT00532506
- Testing
- SK-0403
- Where
- 10 sites in Japan
- Sponsor
- Sanwa Kagaku Kenkyusho Co., Ltd.
Type 1 Diabetes Mellitus
A Study of LY2605541 in Participants With Type 1 Diabetes Mellitus
The primary purpose of participation in this study is to compare the safety and efficacy of different dosing schedules of LY2605541 and how different dosing schedules of LY2605541 affect Hemoglobin A1c (HbA1c).
- Trial name
- IMAGINE 7 (NCT01792284)
- Testing
- LY2605541, Insulin Lispro
- Where
- 18 sites in United States, Puerto Rico
- Volunteers
- 212 people
- Sponsor
- Eli Lilly and Company
Ovarian Cancer
Maintenance Treatment With BGB-290 Versus Placebo in Participants With Platinum-sensitive Recurrent Ovarian Cancer
To evaluate the efficacy, safety and tolerability of maintenance therapy with BGB-290(Pamiparib) versus placebo in Chinese participants with recurrent ovarian cancer who achieved a complete response (CR) or partial response (PR)…
- Trial name
- NCT03519230
- Testing
- Pamiparib capsule
- Where
- 28 sites in China
- Volunteers
- 224 people
- Sponsor
- BeiGene
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