Clinical trials: Endodontic Treatment
Necrotic Mandibular Molars, Apical Periodontitis
Impact of Minimally Invasive Endodontic Treatment on the Prognosis of Mandibular Permanent Molars With Necrotic Pulp and Apical Periodontitis
Statement of the problem: The effectiveness of minimally invasive endodontic treatments in managing necrotic pulp with apical periodontitis remains understudied.
- Trial name
- NCT07762248
- Testing
- Root canal treatment
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mohamed Ashraf Abdeen
Root Canal Treatment
Retrospective Database Study: Influence of Post-endodontic Restoration Placement on Survival of Root Canal-treated Teeth
The aim of this study is to assess the influence (i.e. type and timing) of post-endodontic restorations on the survival of root canal-treated teeth and to determine the influence of patient-, tooth-, treatment-, and…
- Trial name
- NCT06441058
- Testing
- No patient treatment is associated with the study
- Where
- Germany
- Volunteers
- 541 people
- Sponsor
- University of Göttingen
Pulp Necroses, Apical Periodontitis
"Postoperative Pain Following Laser-Assisted Root Canal Treatment: A Randomized Clinical Trial"
The aim of this study is to evaluate in vivo the post operative pain after laser root canal treatment in necrotic teeth in an evidence-based clinical trial.
- Conditions
- Pulp Necroses, Apical Periodontitis, Pulp Disease, Dental
- Trial name
- NCT06129643
- Testing
- Conventional group, Dual laser group, Combined group
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Dental Caries in Children
Can Zirconia Crown be the First Choice for Primary Teeth?
Objective: Early loss of primary teeth due to caries, can cause occlusion disorders, aesthetic problems, nutritional problems, abnormal language habits, speech disorders and psychological problems temporary or permanent.
- Trial name
- NCT04574180
- Testing
- Dental Crown
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Root Canal Treatment
Post-Endodontic Pain According to Menstrual Cycle Phases
This study aimed to evaluate whether the phase of the menstrual cycle affects pain after root canal treatment. A total of 99 patients (72 females and 27 males) who needed root canal treatment in lower molar teeth were included.
- Trial name
- PEP-MC (NCT07291518)
- Testing
- root canal treathment
- Where
- Turkey (Türkiye)
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Ahter Sanal Cikman
Necrotic Pulp, Regenerative Endodontic Procedures
Maximum Occlusal Bite Force of Necrotic Permanent Teeth Treated by Regenerative Technique: Randomized Clinical Trial
Further investigation is warranted to ascertain whether the regaining of sensibility and nerve function in regenerated teeth leads to the re-establishment of the proprioceptive protective mechanism inherent in vital teeth.
- Conditions
- Necrotic Pulp, Regenerative Endodontic Procedures, Bite Force
- Trial name
- NCT06934317
- Testing
- measurement of maximum bite force using bite fork, conventional root canal treatment, pulp revascularization by induced bleeding
- Where
- Jordan
- Volunteers
- 40 people
- Sponsor
- Lama Awawdeh
Pulpitis - Irreversible
Single Gene Polymorphism and the Success Rate of Inferior Alveolar Nerve Block
The inferior alveolar nerve block (IANB) is one of the most commonly used techniques in dentistry to achieve mandibular anesthesia during endodontic treatment.
- Trial name
- SNP&IANB (NCT07012382)
- Testing
- Inferior Alveolar Nerve Block, Inferior-Alveolar-Nerve-Block
- Where
- India
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Jamia Millia Islamia
Diagnoses Disease
Effect of Cone Beam Computed Tomography on Diagnostic and Therapeutic Decision Making
this study will determine the effect of CBCT examinations on diagnostic and therapeutic decision making in endodontics.
- Trial name
- NCT04689126
- Testing
- surgical or nonsurgical endodontic treatment
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Pain, Acute, Necrotic Pulp
The Frequency Of Sodium Hypochlorite Extrusion During Endodontic Treatments
Sodium hypochlorite is a commonly used irrigation agent. However, the solution may extrude beyond the apex of tooth and cause pain during the treatment.The aim of this prospective observational investigation is to determinate the…
- Trial name
- NCT04262362
- Testing
- Root canal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 1,000 people
- Sponsor
- Bulent Ecevit University
Post Operative Pain After Root Canal Therapy
Postoperative Pain Comparison of Two Root Canal Sealers in Irreversible Pulpitis
This study, approved by the Institutional Ethics Review Committee, AFID (Annex "A"), will involve 62 eligible patients from the Operative Dentistry Department, Armed Forces Institute of Dentistry.
- Trial name
- NCT06975761
- Testing
- Resin Based sealer, ZnO eugenol based sealers
- Where
- Pakistan
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Armed Forces Institute of Dentistry, Pakistan
Pulp Disorder
Endodontic Treatment of Primary Teeth With Guedes-Pinto Paste Without Antibiotic
The pulp therapy in primary teeth is still necessary even with all odontopediatrics evolution in prevention and minimal intervention, aiming to keep the tooth free of inflammation or infection and in a functional state until its…
- Trial name
- NCT03839485
- Testing
- Endodontic treatment using Guedes-Pinto Paste, Endodontic using Guedes-Pinto Paste without antibiotic
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Periapical Periodontitis, Treatment Outcome
2-year Treatment Outcomes of Teeth Estimated by Means of Periapical and Endodontic Status Scale
Objectives: Evaluation of endodontic treatment success is largely based on radiographical assessment of anatomical and treatment-related parameters of teeth with apical periodontitis (AP).
- Trial name
- NCT04495270
- Testing
- Analysis of treatment outcomes of teeth with apical periodontitis based on cone-beam computed tomography and estimated by means of Periapical and Endodontic Status Scale"
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Postoperative Pain After Endodontic Treatment, Dental Anxiety
Effect of Intracanal Cryotherapy on Pain, Anxiety, and Salivary Irisin After Root Canal Treatment
Some people feel pain after a root canal treatment. This study will test whether intracanal cryotherapy, a final rinse of the tooth with cold sterile saline, can reduce this pain compared with a room-temperature rinse.
- Conditions
- Postoperative Pain After Endodontic Treatment, Dental Anxiety, Root Canal Treatment
- Trial name
- CRYO-IRISIN (NCT07889050)
- Testing
- Intracanal cryotherapy, Standard room-temperature irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Alanya Alaaddin Keykubat University
Apical Periodontitis, Insulin Resistance
Serum Pro-Diabetes Inflammation Biomarkers in Patients With Apical Periodontitis.
Inflammation is a common factor of chronic periodontitis and diabetes. However, to date, there is no scientific evidence supporting a causal effect of the inflammation created by apical periodontitis on the onset of insulin…
- Conditions
- Apical Periodontitis, Insulin Resistance, PreDiabetes, Diabetes; Stable
- Trial name
- NCT04824209
- Where
- 2 sites in Italy
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Endodontically Treated Teeth, Endodontic Underfill
No Code Artificial Intelligence to Detect Radiographic Features Associated With Unsatisfactory Endodontic Treatment
Developing neural network-based models for image analysis can be time-consuming, requiring dataset design and model training. No-code AI platforms allow users to annotate object features without coding.
- Conditions
- Endodontically Treated Teeth, Endodontic Underfill, Endodontic Overfill, Apical Periodontitis
- Trial name
- NCT06450938
- Testing
- AI guidance for finding radiographic features
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Root Canal Infection, Endodontic Disease
Occurrence of Post-op Pain Following Gentlewave
This is a clinical study that will investigate the occurrence of post-operative discomfort following the use of the Gentlewave System for root canal disinfection and irrigation.
- Conditions
- Root Canal Infection, Endodontic Disease, Endodontic Inflammation, Post-Operative Pain
- Trial name
- NCT03635515
- Testing
- Gentlewave, Standard Endodontic Protocol
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Symptomatic Irreversible Pulpitis
Comparison of Postoperative Pain After Root Canal Irrigation in Symptomatic Irreversible Pulpitis
This randomized controlled trial will compare postoperative pain following root canal treatment in patients with symptomatic irreversible pulpitis.
- Trial name
- NCT07821359
- Testing
- Dexamethasone, Sodium Chloride 0.9%
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- CMH Lahore Medical College and Institute of Dentistry
Apical Periodontitis, Postoperative Pain
Sealers in Chronic Apical Lesions
This clinical study evaluated whether different root canal sealers influence postoperative pain and early periapical healing in patients with apical periodontitis.
- Conditions
- Apical Periodontitis, Postoperative Pain, Periapical Healing
- Trial name
- NCT07339579
- Testing
- Root Canal Treatment With Sealapex, Root Canal Treatment With MTA Fillapex, Root Canal Treatment With AH Plus
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Postoperative Pain After Endodontic Treatment
EFFECT OF NITI SYSTEMS AND XP-ENDO FINISHER ON POSTOPERATIVE PAIN
Title Evaluation of the Effect of Reciprocal and Rotational NiTi File Systems and XP-Endo Finisher Combination on Postoperative Pain Clinical Research Protocol Summary Objective The aim of this study is to compare the effects of…
- Trial name
- NCT07642596
- Testing
- Rotary NiTi file system, Rotary NiTi file system with irrigation activation device, Reciprocating NiTi file system
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- BUSRA OZTURK
Dental Pulp Necroses
Efficacy of Regenerative Endodontic Treatment With PRF as a Secondary Treatment of Mature Necrotic Incisors in Adolescents
Evalaution of clinical success of secondary treatment for total 40 permanent incisors with failed root canal treatment with apical radiolucency.
- Trial name
- PRF (NCT05517187)
- Testing
- no intervention, Platelet rich fibrin
- Where
- 2 sites in Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Nahda University