Clinical trials: Endometrial Biopsy
Endometrial Neoplasms
Sentinel Lymph Node Mapping In Endometrial Cancer
Lymph node assessment provides the crucial information about the prognosis of endometrial cancer. Sentinel lymph node stands in the first station on the lymph node metastasis pathways.
- Trial name
- SLNMIEC (NCT03778255)
- Testing
- Sentinel Lymph Node Biopsy
- Where
- China
- Volunteers
- 635 people
- Sponsor
- Peking University People's Hospital
Endometrial Cancer, Endometrial Neoplasms
Pilot Study: Can Ultrasound Guided Biopsy be Used as an Alternative to Hysteroscopy?
Aim: Assess accuracy of histological diagnosis using ultrasound guided biopsy for women with suspected endometrial cancer (as an alternative to hysteroscopy guided biopsy).
- Conditions
- Endometrial Cancer, Endometrial Neoplasms, Endometrial Hyperplasia, Endometrial Polyp
- Trial name
- NCT03207126
- Testing
- Ultrasound guided biopsy
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Imperial College London
Endometrial Cancer, Sentinel Lymph Node
Tracers for Endometrial Cancer Sentinel Node Labeling
Sentinel lymph node (SLN) biopsy is currently used in the management of vulvar and breast cancers as well as in malignant melanoma, and is being intensively studied in patients with cervical and endometrial cancers.
- Trial name
- TESLA-1 (NCT04665544)
- Testing
- SLN side-specific detection rate using radioactive tracer with/without blue dye and ICG tracer.
- Where
- 6 sites in Czechia, Poland and 1 more
- Volunteers
- 83 people
- Sponsor
- University Medical Centre Maribor
Cancer Screening
Endometrial Cancer Screening in High-risk Populations
Endometrial cancer is one of the most common malignancies of the reproductive system. The incidence of endometrial cancer has increased in recent years. No effective, low-cost screening method for populations at high risk exists.
- Trial name
- NCT06125886
- Testing
- transvaginal ultrasound and microscale endometrial sampling biopsy
- Volunteers
- 22,000 people
- Sponsor
- Peking University People's Hospital
Endometrial Cancer Stage, Gynecologic Cancer
The Compatibility of Preoperative Endometrial Biopsies With Postoperative Final Pathology in Endometrial Cancer
Although there are many studies comparing preoperative and postoperative histological diagnoses in the literature, there are no studies evaluating the compatibility of preoperative histological diagnoses obtained from different…
- Trial name
- NCT04917341
- Testing
- re-evaluation of endometrial biopsy samples by a gynecopathologist working at a university hospital
- Volunteers
- 960 people
- Sponsor
- Batman Training and Research Hospital
Infertility, Endometritis
Chronic Endometritis in Patients With Recurrent Miscarriages or Repeated Implantation Failures in In-vitro Fertilization
Chronic endometritis is a persistent inflammation of the endometrium. Chronic endometritis is asymptomatic or little symptomatic.
- Conditions
- Infertility, Endometritis, Abortion, Spontaneous
- Trial name
- NCT01762098
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Clinique Ovo
Endometrial Cancer
Detection of Tumor DNA Through Cervical Smear and Liquid Biopsy in Endometrial Cancer Patients and Evaluation of Prognostic and Predictive Values of Tumor DNA Assay
Circulating tumor DNA (ctDNA) may help detect and prognosis-stratify patients with endometrial cancer. Both cervical swab-based genomic DNA (gDNA) and whole blood-based ctDNA can be utilized for this goal.
- Trial name
- NCT05504161
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Yonsei University
Office-based Endometrial Sampling Procedures
Effectiveness of Paracervical Block in Endometrial Sampling Procedures for Pain Control
Office-based endometrial procedures are preferred over diagnostic dilation and curettage, nowadays. Paracervical block is single-shot nerve block that involve a one-time injection of local anesthetic adjacent to the utero-vaginal…
- Trial name
- NCT04572828
- Testing
- Paracervical Block, 550 mg Naproxen Sodium 60 minutes before the procedure, The capped needle
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ege University
Infertility, Female
Clinical Efficacy of Virtual Reality During Office Hysteroscopy and Endometrial Biopsy in Subfertility
This study is a comparison between the current standard practice of performing a diagnostic hysteroscopy and a relatively recently developed technology that is added to the standard diagnostic hysteroscopy.
- Trial name
- HYSVIR (NCT04438759)
- Testing
- Oncomfort, commercially available Virtual Reality headset
- Where
- Belgium
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Solid Tumor, Advanced Solid Tumor
A Study on the Prevalence of Clinically Useful Mutations in Solid Tumor Characterized by Next Generation Sequencing Methods on Liquid Biopsy Analysis (POPCORN)
The implementation of liquid biopsy in clinical practice has been favored by the rapid development of genome sequencing techniques designed to analyze mutations in ctDNA.
- Conditions
- Solid Tumor, Advanced Solid Tumor, Locally Advanced Solid Tumor, Colon Rectal Cancer
- Trial name
- POPCORN (NCT06028724)
- Where
- Italy
- Volunteers
- 782 people
- Sponsor
- Centro di Riferimento Oncologico - Aviano
Infertility, Implantation Failure
Does Local Injury of the Endometrium Improve Controlled Ovarian Hyperstimulation (COH) + Intrauterine Insemination (IUI) Outcome?
It was previously demonstrated in in vitro fertilization (IVF) patients that local injury of the endometrium during a spontaneous menstrual cycle that precedes IVF treatment doubled the rates of implantation and pregnancy.
- Trial name
- NCT01111799
- Testing
- endometrial biopsy, natural cycle + IUI + endometrial biopsy
- Where
- Israel
- Volunteers
- 600 people
- Sponsor
- Meir Medical Center
Endometrial Cancer
Hormone Therapy in Preventing Endometrial Cancer in Patients With a Genetic Risk For Hereditary Nonpolyposis Colon Cancer
Randomized phase II trial to compare two different hormone therapy regimens in preventing endometrial cancer in women who have a genetic risk for hereditary nonpolyposis colon cancer.
- Trial name
- NCT00033358
- Testing
- medroxyprogesterone, ethinyl estradiol, norgestrel
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- National Cancer Institute (NCI)
Uterine Fibroids, Vaginal Bleeding
Optimal Order of Concurrent Office Hysteroscopy and Endometrial Biopsy
This study will look at the optimal order in which to perform concurrent office hysteroscopy and endometrial biopsy in female patients who present for evaluation of abnormal uterine bleeding at a fibroid and endometriosis…
- Trial name
- NCT02472184
- Testing
- Office hysteroscopy, Endometrial biopsy
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Endometrium, Biopsy
Tenaculum in Endometrial Sampling Procedure
Most of gynecological office procedure such as endometrial sampling procedure, hysterosalpingography, hysteroscopy, insertion of contraceptive intrauterine device, difficult intrauterine insemination or embryo transfer procedures…
- Trial name
- Tenaculum (NCT01506778)
- Testing
- Tenaculum
- Where
- Turkey (Türkiye)
- Volunteers
- 115 people
- Sponsor
- Cukurova University
Cancer Screening, Endometrial Cancer
Host DNA Methylation for Endometrial Cancer Screening
Based on the previous study of NCT04651738, we performed this trial to further confirm the accuracy of host DNA CDO1 and CELF4 methylation for endometrial cancer screening in a multi-center cohort.
- Conditions
- Cancer Screening, Endometrial Cancer, DNA Methylation, Cervical Cytology
- Trial name
- NCT05290415
- Testing
- DNA methylation testing
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Lei Li
Endometrial Biopsy, Abnormal Uterine Bleeding
Effectiveness of Paracervical Block Versus Lidocaine Spray During Endometrial Biopsy
The purpose of this study to determine effectiveness of paracervical block, lidocaine spray and only oral analgesic drugs for pain relief during endometrial biopsy.
- Trial name
- NCT01908738
- Testing
- paracervical block with 1%lidocaine, 10%lidocaine spray
- Where
- Thailand
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Abnormal Uterine Bleeding, Postmenopausal Bleeding
Pipelle Versus Karman Endometrial Biopsy Under Standardized Paracervical Block
Endometrial biopsy is a commonly used outpatient procedure to evaluate abnormal uterine bleeding and postmenopausal bleeding. Different sampling methods are available, but their diagnostic adequacy and patient experience may…
- Trial name
- PB-EMB (NCT07366814)
- Testing
- Pipelle Endometrial Biopsy, Karman Cannula Endometrial Biopsy
- Where
- Turkey (Türkiye)
- Volunteers
- 480 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital