Clinical trials: Endometrial Cancer, open to volunteers
Endometrial Neoplasms, Atypical Endometrial Hyperplasia
GnRHa + Letrozole in Non-obese Progestin-insensitive Endometrial Cancer and Atypical Hyperplasia Patients
To investigate the efficacy of GnRHa plus letrozole vs Diane-35 plus metformin in non-obese progestin-insensitive early-stage endometrial cancer (EEC) and atypical hyperplasia(EAH) patients asking for conservative treatment.
- Conditions
- Endometrial Neoplasms, Atypical Endometrial Hyperplasia, Progesterone Resistance
- Trial name
- NCT05316935
- Testing
- GnRHa, Letrozole 2.5mg, Diane-35
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- Xiaojun Chen
Neoplasms, Endometrial
A Study to Investigate Mocertatug Rezetecan Compared With Chemotherapy in Participants With Endometrial Cancer After Platinum-based Chemotherapy and Immunotherapy (BEHOLD-Endometrial01)
This study specifically aims to evaluate how well mocertatug rezetecan (Mo-Rez) works in treating Endometrial Cancer (EC) compared to standard of care.
- Trial name
- NCT07286331
- Testing
- Mocertatug rezetecan, Paclitaxel, Doxorubicin
- Where
- 56 sites in United States, Argentina and 8 more
- Volunteers
- 600 people
- Sponsor
- GlaxoSmithKline
Endometrial Cancer, Endometrial Hyperplasia
Cohort Study of Intrauterine Diseases
"This study employs a prospective cohort design by establishing a uterine cavity diseases research platform. The investigators will collect participants' current medical history, menstrual and obstetric history, past medical…
- Conditions
- Endometrial Cancer, Endometrial Hyperplasia, Endometrial Polyps
- Trial name
- TJ Intrauterin (NCT07048327)
- Testing
- No intervention (observational study)
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Wenwen Wang
Ovarian Cancer, Fallopian Tube Cancer
HS-20089 in Patients With Ovarian Cancer and Endometrial Cancer
HS-20089 is an investigational antibody-drug conjugate (ADC) composed of a humanized IgG1 anti-B7-H4 monoclonal antibody conjugated to the topoisomerase I inhibitor payload via a protease-cleavable linker, with an average…
- Conditions
- Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Cancer, Endometrial Cancer
- Trial name
- NCT06014190
- Testing
- HS-20089
- Where
- 28 sites in China
- Volunteers
- 460 people
- Sponsor
- Hansoh BioMedical R&D Company
Colorectal Cancer, Endometrial Cancer
Discovering New Targets for Colorectal and Endometrial Cancer Risk Reduction
The primary aim of this study is to collect and store data, tissue, and personal and family histories from patients being screened for colorectal cancer and/or endometrial cancer at NYPH and WCM for routine clinical care and to…
- Conditions
- Colorectal Cancer, Endometrial Cancer, Hereditary Cancer Syndromes
- Trial name
- NCT06096688
- Where
- United States
- Volunteers
- 1,120 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Gynaecological Oncology, Gynaecological Malignancies
Laparotomy vs Laparoscopy in Endometrial Cancer Staging
Endometrial cancer is one of the most common gynecological malignancies worldwide. Surgical staging is the cornerstone of management and traditionally performed via laparotomy.
- Conditions
- Gynaecological Oncology, Gynaecological Malignancies, Laparoscopic
- Trial name
- NCT07546825
- Testing
- laparoscopic surgical staging, open surgical staging
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Assiut University
Endometrial Cancer
A Study of Multiparametric Ultrasound Imaging (mpUS) for People With Endometrial Cancer
The researchers are doing this study to see how well multiparametric ultrasound (mpUS) imaging can evaluate vaginal tissue before and after IVRT.
- Trial name
- NCT07318415
- Testing
- Multiparametric Ultrasound Imaging, The vaginal assessment score (VAS)
- Where
- 7 sites in United States
- Volunteers
- 10 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Endometrial Atypical Hyperplasia, Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia
Semaglutide, Weight Loss, and LNG-IUD for Conservative Treatment of Endometrial Atypical Hyperplasia and Grade 1 Endometrial Cancer
The goal of this clinical trial is to learn if a combination treatment of a hormonal intrauterine device (LNG-IUD), semaglutide, and a structured weight loss program can treat endometrial atypical hyperplasia or grade 1…
- Conditions
- Endometrial Atypical Hyperplasia, Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia, Endometrial Cancer Stage I, Endometrial Cancer
- Trial name
- SWIFT (NCT07820358)
- Testing
- Semaglutide (Wegovy) weekly injection, LNG-IUD (Progestin), Structured Weight Loss Program
- Where
- 4 sites in United States
- Volunteers
- 48 people
- Sponsor
- The Methodist Hospital Research Institute
Endometrial Cancer, Lynch Syndrome
Menstrual Cup for Early Endometrial Cancer Detection in Lynch Syndrome
Study Goal: This pilot study wants to find out if using a menstrual cup can be a good, non-invasive way to collect samples from the lining of the uterus (called the endometrium) to help screen for endometrial cancer.
- Conditions
- Endometrial Cancer, Lynch Syndrome, Screening, Early Detection of Cancer
- Trial name
- SCREEN-CUP (NCT07220239)
- Testing
- Menstrual cup use
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Jessica D. St. Laurent, MD
Advanced Solid Tumor, Advanced Cancer
A Study of MGC026 in Participants With Advanced Solid Tumors
The study is designed to understand the safety, tolerability, pharmacokinetics, immunogenicity, and preliminary antitumor activity of vobramitamab tavatecan (MGC026) in participants with relapsed or refractory, unresectable…
- Conditions
- Advanced Solid Tumor, Advanced Cancer, Metastatic Cancer, Squamous Cell Carcinoma of Head and Neck
- Trial name
- NCT06242470
- Testing
- MGC026 Dose Escalation, MGC026 Dose for Expansion, Pembrollizumab
- Where
- 12 sites in United States, Australia and 1 more
- Volunteers
- 394 people
- Sponsor
- MacroGenics
Cancer Screening, Transgender
Cervical and Endometrial Cancer Screening in Patients Seeking Gender-Affirming Hysterectomy
This study aims to quantify the rates of cervical cancer screening and endometrial sampling prior to gender-affirming hysterectomy, assess the need for these tests in TGD individuals, and explore patient-centered options for…
- Conditions
- Cancer Screening, Transgender, Gender Diverse Populations
- Trial name
- NCT07075731
- Testing
- No intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Minnesota
Endometrial Cancer Stage I, Mmr Deficiency
SATELLITE Study (feaSibility sAfeTy Efficacy dostarLimab earLy-stage defIcient endomeTrial cancEr)
The main goal of this clinical trial is to evaluate dostarlimab, an immunotherapy drug, as a potential alternative to surgery for early-stage endometrial cancer with Mismatch Repair deficiency, a genetic cause for 20-30% of…
- Conditions
- Endometrial Cancer Stage I, Mmr Deficiency, Endometrioid Endometrial Adenocarcinoma, Immune-related Adverse Event
- Trial name
- SATELLITE (NCT06278857)
- Testing
- Dostarlimab-Gxly 50 MG/1 ML Intravenous Solution [JEMPERLI]
- Where
- 3 sites in Australia
- Volunteers
- 10 people
- Sponsor
- Queensland Centre for Gynaecological Cancer
Non-small Cell Lung Cancer, Colorectal Carcinoma
Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors
Phase I Study, a master protocol to investigate TCR-Engineered T cells recognizing KRAS mutations in adult subjects with Unresectable, Advanced, and/or Metastatic Solid Tumors.
- Conditions
- Non-small Cell Lung Cancer, Colorectal Carcinoma, Pancreatic Ductal Adenocarcinoma, Endometrial Cancer
- Trial name
- NCT06218914
- Testing
- NT-112: Autologous, engineered T Cells targeting KRAS G12D, AZD0240: Autologous, engineered T Cells targeting KRAS G12D
- Where
- 18 sites in United States
- Volunteers
- 108 people
- Sponsor
- AstraZeneca
Endometrial Cancer
Fasting InTervention for Endometrial Cancer
The goal of this study is to find out if it is safe for women with endometrial cancer who are going to have surgery to fast (not eat) overnight.
- Trial name
- FIT-ENDO (NCT07622901)
- Testing
- Prolonged Overnight Fasting (POF), Blood Specimen Collection, Blood Sugar Monitor
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Miami
Endometrial Cancer
Oral Topotecan With Toripalimab for Patients With Endometrial Cancer
This study aims to explore the safety and efficacy of oral topotecan combined with toripalimab in treating advanced/recurrent endometrial cancer through a single-center, prospective, single-arm, phase II clinical trial.
- Trial name
- NCT06548763
- Testing
- Topotecan, Toripalimab
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Fudan University
Endometrial Cancer
Chemotherapy vs Chemoradiotherapy for Post-operative Endometrial Cancer Patients With P53-mutation
Aim to compare chemotherapy alone or chemoradiotherapy for post-operative endometrial cancer (stage I-IVA) with p53 mutation.
- Trial name
- NCT05489848
- Testing
- Paclitaxel, Carboplatin, Cisplatin
- Volunteers
- 294 people
- Sponsor
- Fudan University
Endometrial Cancer, Endometrial Adenocarcinoma
Prognosis of METTL-14 in Endometrial Carcinoma
1. To evaluate immunohistochemical expression of METTL14 in type1 endometrial carcinoma. 2. To evaluate the correlation between METTL14 expression and clinicopathological parameters of patients with type 1endometrial carcinoma…
- Trial name
- NCT06861855
- Testing
- Observation, IHC
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Endometrial Cancer
Improving Endometrial Cancer Assessment by Combining Genomic Profiling and Surgical Assessment
EUGENIE is a prospective multicentre interventional study, focused on improving endometrial cancer (EC) assessment by combining the new technique of genomic profiling with surgical extra uterine disease assessment.
- Trial name
- EUGENIE (NCT06354738)
- Testing
- total hysterectomy with bilateral salpingo-oophorectomy, lymph node staging and comprehensive peritoneal staging
- Where
- Belgium
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Gasthuisberg
Endometrial Cancer
A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy in Patients With Recurring Uterine Cancer
The study is divided into two cohorts (Cohort 1 and Cohort 2), to which participants will be enrolled based on the amount of human epidermal growth factor receptor 2 (HER2) in their tumor sample.
- Trial name
- Fern-EC-01 (NCT06340568)
- Testing
- BNT323/DB-1303, Doxorubicin, Paclitaxel
- Where
- 206 sites in United States, Argentina and 25 more
- Volunteers
- 480 people
- Sponsor
- BioNTech SE
Endometrial Cancer
27-Inch Versus 55-Inch Monitors in Women Undergoing Endometrial Cancer Surgery
This study will compare the use of 27-inch and 55-inch endoscopic imaging monitors during minimally invasive surgery for women with endometrial cancer. Participants will be randomly assigned to one of the two monitor groups.
- Trial name
- NCT07882277
- Testing
- 27-Inch Endoscopic Imaging Monitor, 55-Inch Endoscopic Imaging Monitor
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Metehan Uzundal