Clinical trials: Endometrial Carcinoma
Estrogen Receptor-positive, Early Stage Endometrial Cancer
Phase II Study of CAmizestrant in Resectable Endometrial Adenocarcinoma
This is a window of opportunity study designed to provide short duration exposure to camizestrant prior to planned curative intent surgery, with the anticipated benefit of demonstrating target engagement and suppression of ER…
- Trial name
- CARA (NCT07840443)
- Testing
- Camizestrant
- Where
- 6 sites in Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Cervical Cancer, Endometrial Cancer
Capecitabine and Radiation Therapy in Treating Patients With Locally Advanced Cervical Cancer or Other Pelvic Cancer
RATIONALE: Drugs used in chemotherapy, such as capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Cervical Cancer, Endometrial Cancer, Ovarian Cancer, Vaginal Cancer
- Trial name
- NCT00118300
- Testing
- capecitabine, brachytherapy, radiation therapy
- Where
- 2 sites in United States
- Sponsor
- Case Comprehensive Cancer Center
Prostate Cancer, Salivary Gland Cancer
A Clinical Trial to Determine the Most Suitable Dose of OPB-111001 in Patients With Advanced Cancer
The purpose of this study is to determine the tolerability profile of OPB-111001 and to determine the most suitable dose of OPB-111001 in patients with advanced cancer
- Conditions
- Prostate Cancer, Salivary Gland Cancer, Endometrial Cancer, Squamous Cell Carcinoma of the Cervix
- Trial name
- NCT02042885
- Testing
- OPB-111001
- Where
- 2 sites in United Kingdom
- Volunteers
- 79 people
- Sponsor
- Otsuka Novel Products GmbH
Endometrium Cancer
Weight Management in Overweight Endometrial Cancer Patients Undergoing Fertility-sparing Treatment
In this study, overweight and obese patients with endometrial cancer treated with fertility- sparing therapy were randomly divided into two groups.
- Trial name
- NCT06169449
- Testing
- Weight management--diet, Weight management--exercise, Weight management--accompany
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Peking University People's Hospital
Endometrial Cancer, Cervical Cancer
Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors
The objective of this study is to evaluate the safety, tolerability, and efficacy of BL-M07D1 in patients with HER2 expressing advanced tumors.
- Conditions
- Endometrial Cancer, Cervical Cancer, Ovarian Cancer, Urothelial Carcinoma
- Trial name
- NCT06293898
- Testing
- BL-M07D1
- Where
- 26 sites in United States
- Volunteers
- 280 people
- Sponsor
- SystImmune Inc.
Endometrial Carcinoma, Recurrent Fallopian Tube Carcinoma
An Automated Personalized Physical Activity Intervention to Improve Immune Function and Clinical Outcomes in Stage II-IV Ovarian, Primary Peritoneal or Fallopian Tube Cancer and Newly Diagnosed Endometrial Cancer, Life on the Go 3 Study
This clinical trial compares the effect of an automated personalized physical activity intervention supported by wearable technology to standard of care on physical activity levels and quality of life in patients with stage II…
- Conditions
- Endometrial Carcinoma, Recurrent Fallopian Tube Carcinoma, Recurrent Ovarian Carcinoma, Recurrent Primary Peritoneal Carcinoma
- Trial name
- NCT06855706
- Testing
- Behavioral Intervention, Best Practice, Biospecimen Collection
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Roswell Park Cancer Institute
Endometriosis, Pelvic Prolapse
Suspension of the Pelvic and Abdominal Organs During Minimally Invasive Surgery
The goal of this retrospective observational study is to evaluate the efficacy, safety, and practicality of an organ suspension technique with adjustable tension suture in facilitating minimally invasive gynecologic surgeries at…
- Conditions
- Endometriosis, Pelvic Prolapse, Endometrium Cancer
- Trial name
- NCT06187558
- Testing
- Pelvic and abdominal organ suspension technique
- Where
- Italy
- Volunteers
- 330 people
- Sponsor
- University of Cagliari
Endometrial Cancer
Retrospective Case Study Examining Patient Outcomes Compared to the ChemoFx Assay in Endometrial Cancer Patients
The purpose of this study is to assess the relationship of assay sensitive patients versus assay resistant patients with progression free survival.
- Trial name
- NCT01049126
- Testing
- ChemoFx
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Precision Therapeutics
Endometrial Cancer, Ovarian Cancer
Phase 1/2a Evaluation of AL3818 in Subjects With Recurrent or Metastatic Endometrial, Ovarian or Cervical Cancer (AL3818-US-001)
The purpose of Part 1 (Phase 1b) is to evaluate the general safety and tolerability of repeated 21-day cycles of AL3818 therapy, and to reevaluate the maximum tolerated dose (MTD).
- Conditions
- Endometrial Cancer, Ovarian Cancer, Cervical Cancer
- Trial name
- AL3818 (NCT02558348)
- Testing
- AL3818
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Advenchen Laboratories, LLC
Endometrial Cancer
From Fetal-maternal Interface Immune Tolerance to Endometrial Cancer Immune Escape: Potential Targets for Immunotherapy
Non-interventional retro-prospective study on Endometrial tissue samples taken from surgically treated patients.
- Trial name
- NCT06273878
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- Regina Elena Cancer Institute
Gastric Cancer, Bladder Cancer
Safety, Tolerability and Pharmacokinetics of Oral CPL304110, in Adult Subjects With Advanced Solid Malignancies
The purpose of the study is to determine to evaluate safety and tolerability of CPL304110 when administered once daily to adults with advanced solid malignancies.
- Conditions
- Gastric Cancer, Bladder Cancer, Squamous Non-small Cell Lung Cancer, Cholangiocarcinoma
- Trial name
- NCT04149691
- Testing
- CPL304110
- Where
- 7 sites in Poland
- Volunteers
- 37 people
- Sponsor
- Celon Pharma SA
Neoplasms, Endometrial, Endometrial Cancer
Intravenous Weekly Topotecan In Subjects With Recurrent Or Persistent Endometrial Cancer
The purpose of this study is to find out if Hycamtin given weekly is safe and effective for treating your endometrial cancer.
- Trial name
- NCT00267488
- Testing
- topotecan
- Where
- 24 sites in United States, Canada and 1 more
- Volunteers
- 70 people
- Sponsor
- GlaxoSmithKline
Neoplasms
Phase I Dose Escalation Study for VIP152 in Patients With Advanced Cancer
Determine the safety, tolerability, pharmacokinetics, maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D) of VIP152 (BAY 1251152) as monotherapy or in combination in patients with solid tumors and aggressive…
- Trial name
- NCT02635672
- Testing
- VIP152 (BAY 1251152), VIP152 (BAY 1251152) 30 mg, Keytruda
- Where
- 16 sites in United States, Chile and 1 more
- Volunteers
- 110 people
- Sponsor
- Vincerx Pharma, Inc.
Cervix Cancer, Uterine Cancer
Prolonged Grief and Perception of Femininity in Gynecological Cancer Patients
The aim of this study is to determine the effect of the 'Feminine Identity Improvement Program', based on cognitive behavioral and expressive techniques applied to gynecological cancer patients, on prolonged grief reactions and…
- Conditions
- Cervix Cancer, Uterine Cancer, Ovarian Cancer, Endometrial Cancer
- Trial name
- NCT05529303
- Testing
- Such as art therapy, play therapy, breathing techniques
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kevser Pamuk
Androgen Receptor Abnormal, Endometrial Disorder
The Effect of Androgen Receptor Polymorphism on Endometrial Cancer
Endometrial tissue is a hormonal-dependent tissue in both pre- and postmenopausal period. The endometrial cells are expressing receptors for all sex hormones, mainly for estrogen, progesterone and androgens.
- Trial name
- AREC (NCT05157373)
- Testing
- Endometrial sampling and Peripheral blood collection, FSFI Scale
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Nicosia
Endometrial Cancer, Fertility
Refining Fertility-sparing Treatment in Endometrial Carcinoma Based on Molecular Classification
Endometrial cancer (EC) stands among the most common gynecological malignancies in developed countries and regions, with a notable trend toward younger age at onset.
- Trial name
- FEMUS (NCT07319429)
- Testing
- PD1 antibody, Medroxyprogesterone Acetate 500 MG, Megestrol Acetate 160 MG
- Where
- 2 sites in China
- Volunteers
- 260 people
- Sponsor
- Fudan University
Telemedicine, Counseling
Telemedicine Use in Preoperative Counseling for Endometrial Cancer Survivors
To determine whether telemedicine is an acceptable addition to pre-operative counseling, compared to face-to-face communication alone for patients with endometrial cancer.
- Trial name
- NCT05712668
- Testing
- Preoperative counseling, Asynchronous telemedicine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Carilion Clinic
Endometrial Cancer
Liposomal Doxorubicin in Treating Patients With Advanced or Recurrent Endometrial Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of liposomal doxorubicin in treating women who have…
- Trial name
- NCT00005861
- Testing
- pegylated liposomal doxorubicin hydrochloride
- Where
- 10 sites in United States
- Sponsor
- Gynecologic Oncology Group
Pelvic Cancer, Cervical Cancer
Sexual Quality of Life of Patients With Gynecologic Cancer Treated With Brachytherapy.
Gynecologic cancer treatments (chemoradiotherapy, brachytherapy and surgery) greatly impact patients' sexual quality of life (QoL). Use of the vaginal dilators may reduce vaginal stenosis.
- Trial name
- Gyn&Co (NCT04184154)
- Testing
- Questionnaires
- Where
- France
- Volunteers
- 167 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Endometriosis, Endometrial Cancer
Serum Trace Element Levels in Some Gynecological Diseases
The aim of this clinical study is to measure the levels of various trace elements in the blood serum of women with various gynecological diseases and to compare them with healthy controls.
- Conditions
- Endometriosis, Endometrial Cancer, Over Cancer, Healthy Control
- Trial name
- NCT07210918
- Testing
- Blood Product
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cumhuriyet University
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