Clinical trials: Endometrial Carcinoma
Endometrial Cancer, Chemotherapy Effect
Impact of Adjuvant Chemotherapy on the Quality of Life of Patients Treated for Stage II / III Endometrial Cancer
Through this study, The investigator believe to evaluate the impact in terms of overall quality of life of adjuvant chemotherapy in patients with locally advanced endometrial cancer at a distance from their care
- Conditions
- Endometrial Cancer, Chemotherapy Effect, Quality of Life
- Trial name
- EndoQOL (NCT03466788)
- Testing
- Self questionnaires of quality of life and living conditions
- Where
- 5 sites in France
- Volunteers
- 51 people
- Sponsor
- Centre Francois Baclesse
Advanced Lymphoma, Advanced Malignant Solid Neoplasm
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)
This phase II MATCH screening and multi-sub-trial studies how well treatment that is directed by genetic testing works in patients with solid tumors, lymphomas, or multiple myelomas that may have spread from where it first…
- Conditions
- Advanced Lymphoma, Advanced Malignant Solid Neoplasm, Bladder Carcinoma, Breast Carcinoma
- Trial name
- NCT02465060
- Testing
- Adavosertib, Afatinib, Afatinib Dimaleate
- Where
- 1,410 sites in United States, Guam and 1 more
- Volunteers
- 6,452 people
- Sponsor
- National Cancer Institute (NCI)
Endometrial Cancer
Surgery Plus Medroxyprogesterone in Preventing Endometrial Cancer
RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. The use of surgery with or without medroxyprogesterone may be an effective way to prevent the development…
- Trial name
- NCT00003179
- Testing
- medroxyprogesterone
- Where
- 31 sites in United States, Norway
- Volunteers
- 360 people
- Sponsor
- Gynecologic Oncology Group
Endometrial Adenocarcinoma, Endometrial Adenosquamous Cell Carcinoma
Temsirolimus in Treating Patients With Metastatic or Locally Advanced Recurrent Endometrial Cancer
This phase II trial studies how well temsirolimus works in treating patients with endometrial cancer that has spread to other parts of the body or has spread from where it started to nearby tissue or lymph nodes and has come back…
- Conditions
- Endometrial Adenocarcinoma, Endometrial Adenosquamous Cell Carcinoma, Endometrial Clear Cell Carcinoma, Endometrial Papillary Serous Carcinoma
- Trial name
- NCT00072176
- Testing
- temsirolimus, laboratory biomarker analysis
- Where
- Canada
- Volunteers
- 62 people
- Sponsor
- National Cancer Institute (NCI)
Endometrial Cancer
Liposome-Encapsulated Doxorubicin Citrate and Carboplatin in Treating Patients With Advanced or Metastatic Recurrent Endometrial Cancer
RATIONALE: Drugs used in chemotherapy, such as liposome-encapsulated doxorubicin citrate and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT01100359
- Testing
- carboplatin, liposome-encapsulated doxorubicin citrate, laboratory biomarker analysis
- Where
- Austria
- Volunteers
- 39 people
- Sponsor
- Medical University Innsbruck
Gynecological Malignancies, Cervical Cancer
Immunotherapy-related CRP Kinetics in Metastatic Gynecological Malignancies
ICK-Gyn is a prospective, multicentric, non-interventional investigator-initiated trial (IIT) that aims to investigate the prognostic value of CRP kinetics in advanced or metastatic gynecological malignancies under immune…
- Conditions
- Gynecological Malignancies, Cervical Cancer, Endometrial Cancer, Ovarian Cancer
- Trial name
- NCT05914974
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- University Hospital Tuebingen
Advanced Endometrial Cancer
Study of Envafolimab Alone or With Lenvatinib in Patients With Advanced Endometrial Cancer
This is an open-label, multi-center, multi-corhort Phase II study of Envafolimab alone or with Lenvatinib in patients with advanced endometrial cancer.The primary objective is to evaluate objective response rate of envafolimab…
- Trial name
- NCT05112991
- Testing
- Envafolimab+Lenvatinib, Envafolimab
- Where
- 19 sites in China
- Volunteers
- 108 people
- Sponsor
- 3D Medicines (Sichuan) Co., Ltd.
Endometrial Cancer Stage I, Endometrial Cancer Stage II
PORTEC-4a: Molecular Profile-based Versus Standard Adjuvant Radiotherapy in Endometrial Cancer
This is prospective, multicenter, randomised phase III trial among women with endometrial cancer with high-intermediate risk features to investigate the role of an integrated clinicopathological and molecular risk profile to…
- Trial name
- PORTEC-4a (NCT03469674)
- Testing
- Vaginal brachytherapy, External beam radiotherapy, Observation
- Where
- 31 sites in Austria, Belgium and 6 more
- Volunteers
- 550 people
- Sponsor
- Leiden University Medical Center
Endometrial Cancer
Activity and Cancer Survivorship Exercise Pilot
This early phase I clinical trial measures the changes in functional fitness following home-based comprehensive exercise program in patients who have endometrial cancer who have completed treatment.
- Trial name
- NCT07283029
- Testing
- Functional fitness following home-based comprehensive exercise program
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Iowa
Solid Tumor, Ovarian Cancer
A Phase I Study of XS-02 Capsules in Patients With Advanced Solid Tumors
A study to evaluate the safety, tolerability, pk, and efficacy of XS-02 capsules in patients with advanced solid tumors.
- Conditions
- Solid Tumor, Ovarian Cancer, Breast Cancer, Endometrial Cancer
- Trial name
- NCT06531486
- Testing
- XS-02 capsules
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd.
Advanced Solid Tumors, Breast Cancer
A Phase 1 Study of ATV-1601 in Patients With Advanced Cancer That Have AKT1 E17K Mutations
This is a Phase 1, open-label study to evaluate the safety and tolerability of ATV-1601 administered orally in adults with AKT1 E17K-mutant, advanced solid tumors and also in HR+/HER2- advanced and metastatic breast cancer, with…
- Conditions
- Advanced Solid Tumors, Breast Cancer, Breast Carcinoma, Breast Neoplasms
- Trial name
- NCT07038369
- Testing
- ATV-1601, ATV-1601 + Fulvestrant
- Where
- 8 sites in United States, France and 2 more
- Volunteers
- 134 people
- Sponsor
- Atavistik Bio, Inc
Endometrial Cancer, DNA Methylation
Cervical Cytology DNA Methylation for Endometrial Cancer Screening
This study intends to conduct the "Real-world Study on Cervical Cytology Methylation Testing for Endometrial Cancer Screening" project through a multi-center real-world research approach.
- Conditions
- Endometrial Cancer, DNA Methylation, Cytology, Cancer Screening
- Trial name
- NCT07874529
- Testing
- CDO1 and CELF4 gene methylation
- Where
- China
- Volunteers
- 30,000 people
- Sponsor
- Lei Li
Gynecologic Cancer, Gynecologic Neoplasm
Patient-Reported Outcomes Among Women Wtih Gynecological Cancer (The CONNECT Study)
Systematic nurse-led consultations based on electronic patient-reported outcomes (ePRO) will be tested among women with ovarian - and endometrial cancer receiving first-line chemotherapy.
- Conditions
- Gynecologic Cancer, Gynecologic Neoplasm, Ovarian Cancer, Endometrial Cancer
- Trial name
- NCT04945187
- Testing
- Nurse-led consultations based on electronic patient-reported outcomes
- Where
- Denmark
- Volunteers
- 94 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Neoplasms, Endometrial
A Study to Investigate Mocertatug Rezetecan as Maintenance Treatment for Participants With MMRp Endometrial Cancer (BEHOLD-Endometrial02)
The purpose of this study is to see how well mocertatug rezetecan (Mo-Rez) in combination with physician's choice of immunotherapy (dostarlimab or pembrolizumab) works as maintenance therapy in participants with advanced or…
- Trial name
- NCT07684599
- Testing
- Mocertatug rezetecan, Dostarlimab, Pembrolizumab
- Where
- 8 sites in Japan
- Volunteers
- 610 people
- Sponsor
- GlaxoSmithKline
Endometrial Cancer
Phase 2 Study Evaluating the Efficacy of the Combination of DKN-01 (DKK1 Inhibitor, Leap Therapeutics) and Pembrolizumab in the Treatment of Advanced or Recurrent Endometrial Cancer
To learn if the combination of DKN-01 and pembrolizumab can help to control advanced or recurrent endometrial cancer.
- Trial name
- NCT05761951
- Testing
- DKN-01, Pembrolizumab
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- M.D. Anderson Cancer Center
Endometrial Cancer, Sarcoma
Perifosine in Treating Patients With Metastatic or Locally Advanced Soft Tissue Sarcoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of perifosine in treating patients who have metastatic or…
- Trial name
- NCT00053794
- Testing
- perifosine
- Where
- 6 sites in Canada
- Volunteers
- 17 people
- Sponsor
- NCIC Clinical Trials Group
Metastatic Breast Carcinoma, Locally Advanced Breast Cancer
Repeatability of 68-GaNOTA-Anti-HER2 VHH1 PET/CT in Breast Carcinoma Patients
Study objective: Cohort 1: To quantify the uptake of 68GaNOTA-Anti-HER2 VHH1 in local or distant metastases from breast carcinoma patients and to assess repeatability of the image-based HER2 quantification.
- Conditions
- Metastatic Breast Carcinoma, Locally Advanced Breast Cancer, Cancer of Pancreas, Solid Tumor With Intermediate or High HER2 Expression
- Trial name
- VUBAR (NCT03924466)
- Testing
- 68GaNOTA-Anti-HER2 VHH1
- Where
- Belgium
- Volunteers
- 55 people
- Sponsor
- Universitair Ziekenhuis Brussel
Cervical Cancer, Ovarian Cancer
Clinical Database and Biobank of Patients With Gynecologic Neoplasms
The database and biobank establishment started in 1997 in our institute. However, the sample size was too small with respect to our clinical and fundamental scientific research's requirement.
- Conditions
- Cervical Cancer, Ovarian Cancer, Endometrial Cancer, Choriocarcinoma
- Trial name
- NCT01267851
- Where
- China
- Volunteers
- 1,600,000 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology
Endometrial Cancer, Endometrial Carcinoma
MK-3475 Immunotherapy in Endometrial Carcinoma
Due to the high expression of PD-L1 in endometrial cancers as well as in ovarian cancers which are molecularly similar to uterine serous cancers, using pembrolizumab should be beneficial in this patient population.
- Conditions
- Endometrial Cancer, Endometrial Carcinoma, Neoplasms, Endometrial
- Trial name
- NCT02630823
- Testing
- MK-3475, Surgical resection (standard of care), Paclitaxel (standard of care)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Washington University School of Medicine
Lung Cancer, Gastric Cancer
INSPIRE: a Multi-Cancer Early Detection Study
This research constitutes a multi-centric, case-control designed investigation aimed at developing and implementing a blinded validation of a machine learning-powered, multi-cancer early detection model.
- Conditions
- Lung Cancer, Gastric Cancer, Liver Cancer, Colorectal Cancer
- Trial name
- INSPIRE (NCT06440018)
- Where
- China
- Volunteers
- 5,350 people
- Sponsor
- Singlera Genomics Inc.
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