Clinical trials: Endometrial Carcinoma
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
Web-based Lifestyle Program, mHealth and EMA Intervention, to Improve Weight Loss in Rural Stage I-III Postmenopausal Breast and Endometrial Cancer Survivors, HERO-C Trial
This clinical trial identifies the needs and preferences of rural stage I-III postmenopausal breast and endometrial cancer survivors and evaluates the impact of an adaptive, online program, mobile (m)Health + ecological momentary…
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, Endometrial Carcinoma
- Trial name
- NCT07723235
- Testing
- Aerobic Exercise, Biospecimen Collection, Dietary Intervention
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Endometrial Cancer, p53abn
Randomized Phase III Trial Testing Maintenance Olaparib Versus Observation After Adjuvant Chemoradiation for p53abn Endometrial Cancer
The RAINBO program is a studies group which proposes personalized treatment of patients suffering from endometrial cancer according to their molecular profile.
- Trial name
- RAINBO-RED (NCT06712472)
- Testing
- Olaparib (300 mg BID)
- Where
- 15 sites in France
- Volunteers
- 554 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Recurrent/ Metastatic Endometrial Carcinoma
A Study of Pembrolizumab in Combination With Epacadostat in Women With Recurrent/Metastatic Endometrial Carcinoma
Expression of IDO and PD-1/L1 has been found to be increased in endometrial cancer. Expression of these markers on the tumor cells leads to immunosuppression in the micro-environment of tumors that prevents immune system from…
- Trial name
- NCT03310567
- Testing
- Epacadostat + pembrolizumab
- Where
- United States
- Sponsor
- Fox Chase Cancer Center
Granulosa Cell Ovarian Cancer, Low Grade Serous Ovarian/ Primary Peritoneal Cancer
A Study of Onapristone ER Alone Or In Combination With Anastrozole in Gynecologic Cancers That Respond to Progesterone
The purpose of this study is to test any good and bad effect of the study drug, onapristone extended-release (ER) alone and in combination with anastrozole.
- Conditions
- Granulosa Cell Ovarian Cancer, Low Grade Serous Ovarian/ Primary Peritoneal Cancer, Endometrioid Endometrial Cancer
- Trial name
- NCT03909152
- Testing
- Onapristone ER, Onapristone ER + Anastrozole
- Where
- 8 sites in United States
- Volunteers
- 34 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Endometrial Neoplasms
An Observational Study Based on Endometrial Cancer Risk Screening Model
The goal of this observational study is to test the efficiency of our endometrial cancer risk screening calculator, and improve the endometrial cancer risk screening model to form a stable and reliable non-invasive auxiliary…
- Trial name
- NCT05634798
- Testing
- no intervention
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Endometrial Cancer
Durvalumab and Lenvatinib in Participants With Advanced and Recurrent Endometrial Carcinoma
This study will evaluate the safety and efficacy of durvalumab in combination with lenvatinib in participants with advanced and recurrent endometrial carcinoma.The primary hypothesis of this study are that patients with advanced…
- Trial name
- Dulect2020-2 (NCT04444193)
- Testing
- Durvalumab, Lenvatinib Oral Product
- Volunteers
- 20 people
- Sponsor
- Shanghai First Maternity and Infant Hospital
Corpus Uteri, Endometrial Cancer
Pharmacology Study of Aerosolized Liposomal 9-Nitro-20 (S)-Camptothecin (L9NC)
The purpose of this study is to determine the amount of Aerosolized Liposomal-Nitro-20 (S)-Camptothecin (L9NC) in a patients blood and tumor.
- Trial name
- NCT00250016
- Where
- United States
- Sponsor
- University of New Mexico
PDL1 Gene Mutation, Non Small Cell Lung Cancer
177Lu-anti-PD-L1 sdAb in Metastatic Solid Tumors
This is a Phase 0/1, First-in-Human (FIH), study to evaluate safety, tolerability of 177Lu-RAD204 in participants with selected solid tumors, and to determine the MTD and/or recommended dose for future exploration.
- Conditions
- PDL1 Gene Mutation, Non Small Cell Lung Cancer, Small Cell Lung Cancer ( SCLC ), TNBC, Triple Negative Breast Cancer
- Trial name
- NCT06305962
- Testing
- 177Lu-RAD204
- Where
- 6 sites in Australia
- Volunteers
- 30 people
- Sponsor
- Radiopharm Theranostics, Ltd
Endometrial Carcinoma
UTOLA: UTerin OLAparib
This is a phase IIB, national, randomized, double-blinded, comparative, multi-center study, to assess the efficacy of Olaparib as maintenance after a platinum based chemotherapy in patients with Advanced or metastatic endometrial…
- Trial name
- UTOLA (NCT03745950)
- Testing
- Olaparib Oral Capsule
- Where
- 36 sites in France
- Volunteers
- 147 people
- Sponsor
- ARCAGY/ GINECO GROUP
Low Grade Ovarian Serous Adenocarcinoma, Endometrial Cancer
Imlunestrant/Abemaciclib/Selinexor in Ovarian and Endometrial
This is a phase 2, interventional treatment trial evaluating imlunestrant, abemaciclib, and selinexor in two separate patient cohorts: low grade serous ovarian cancer and endometrioid endometrial cancer.
- Trial name
- SIERRA (NCT07832227)
- Testing
- Imlunestrant, Abemaciclib, Selinexor
- Volunteers
- 60 people
- Sponsor
- Dana-Farber Cancer Institute
Endometrial Carcinoma
Trial of Vascular Endothelial Growth Factor (VEGF), Bevacizumab, in Combination With Cytotoxic Chemotherapy for Endometrial Cancer
The purpose of this study is to find out whether the addition of a drug called Avastin (avastin) to the two-drug combination of carboplatin and paclitaxel shrinks tumors better than the two-drug combination alone in the treatment…
- Trial name
- NCT00879359
- Testing
- carboplatin, paclitaxel, and bevacizumab
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Endometrium Cancer, Gynecologic Cancer
The Surveillance, Epidemiology, and End Results Database Program on Endometrial Cancer in the Italian Population
The aim of this study is to lay the bases for an ambitious project that reports and records all the epidemiological-clinical information of the cases of endometrial carcinoma diagnosed and treated in the reference oncology…
- Trial name
- ENDOCancerDATA (NCT07558889)
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Triple Negative Breast Cancer, Non-small Cell Lung Cancer
A Biomarker Screening Protocol for Participants With Solid Tumors
Biomarker Screening Protocol for Preliminary Eligibility Determination for Adoptive T-cell Therapy Trials:This is a decentralized, multi-site, US-based biomarker screening study to identify participants who have specific disease…
- Conditions
- Triple Negative Breast Cancer, Non-small Cell Lung Cancer, Non Small Cell Lung Cancer, Non Small Cell Lung Cancer Metastatic
- Trial name
- START (NCT05891197)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Lyell Immunopharma, Inc.
Endometrial Cancer
Prognostic Impact of Programmed Death Ligand-1 Expression in Advanced Endometrial Cancer
The aim of this study was to assess the frequency of PD-L1 expression in stage III-IV ECs and to investigate its correlation impact with progression-free survival (PFS), and clinicopathological features including microsatellite…
- Trial name
- NCT02987777
- Volunteers
- 80 people
- Sponsor
- Institut de Cancérologie de Lorraine
Endometrial Cancer
Pilot Study Using a PET Gamma Probe to Evaluate Lymph Nodes in Endometrial Cancer
The surgical management of high-risk endometrial cancer often involves an extensive operation to remove lymph nodes as sites of possible cancer spread.
- Trial name
- NCT01467219
- Testing
- lymphadenectomy, therapeutic conventional therapy, Positron Emission Tomography/ Computed Tomography
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University Health Network, Toronto
Triple Negative Breast Cancer, Pancreatic Carcinoma
Phase Ib/II Study of MCS110 in Combination With PDR001 in Patients With Advanced Malignancies
The purpose of this study of MCS110 with PDR001 was to characterize the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and antitumor activity of the combination of MCS110 with PDR001 in adult patients with…
- Conditions
- Triple Negative Breast Cancer, Pancreatic Carcinoma, Melanoma, Endometrial Carcinoma
- Trial name
- NCT02807844
- Testing
- MCS110, PDR001
- Where
- 20 sites in United States, Belgium and 9 more
- Volunteers
- 141 people
- Sponsor
- Novartis Pharmaceuticals
Endometrial Adenocarcinoma, Endometrial Adenosquamous Carcinoma
Paclitaxel, Carboplatin, and Bevacizumab or Paclitaxel, Carboplatin, and Temsirolimus or Ixabepilone, Carboplatin, and Bevacizumab in Treating Patients With Stage III, Stage IV, or Recurrent Endometrial Cancer
This randomized phase II trial studies paclitaxel, carboplatin, and bevacizumab or paclitaxel, carboplatin, and temsirolimus or ixabepilone, carboplatin, and bevacizumab to see how well they work in treating patients with stage…
- Conditions
- Endometrial Adenocarcinoma, Endometrial Adenosquamous Carcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Serous Adenocarcinoma
- Trial name
- NCT00977574
- Testing
- Bevacizumab, Carboplatin, Ixabepilone
- Where
- 230 sites in United States
- Volunteers
- 349 people
- Sponsor
- National Cancer Institute (NCI)
Endometrial Cancer, Endometrial Neoplasms
Study of XL147 (SAR245408) in Advanced or Recurrent Endometrial Carcinoma
There has not been any systemic therapy approved in the United States or in Europe for treating advanced or recurrent endometrial cancer (EC).
- Trial name
- NCT01013324
- Testing
- XL147 (SAR245408)
- Where
- 13 sites in United States, Belgium
- Volunteers
- 67 people
- Sponsor
- Sanofi
Endometrial Hyperplasia, Endometrial Cancer
Fertility Sparing Management of EndomeTrial Cancer and Hyperplasia
This study protocol evaluates the use of hysteroscopic endomyometrial resection in women diagnosed with atypical endometrial hyperplasia or grade I endometrial cancer who have not responded to anti-hormone therapy.
- Conditions
- Endometrial Hyperplasia, Endometrial Cancer, Gynecologic Cancer
- Trial name
- FETCH (NCT04362046)
- Testing
- Hysteroscopic uterine resection
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Vancouver Coastal Health Research Institute
Endometrial Cancer
Role of Uterine Manipulator in Hysterectomy - Ro.Man.HY
Prospective multicentric randomized trial to evaluate the role of uterine manipulator on laparoscopic/robotic total hysterectomy for the treatment of early stage G1 - G2 endometrial cancer (International Federation of Gynecology…
- Trial name
- RoManHy (NCT02762214)
- Testing
- Clermont-Ferrand Uterine Manipulator, No uterine Manipulator
- Where
- Italy
- Volunteers
- 154 people
- Sponsor
- Catholic University of the Sacred Heart
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