Clinical trials: Endometrial Disease
Corpus Uteri, Lung Cancer
Aerosolized Liposomal Camptothecin in Patients With Metastatic or Recurrent Cancer of the Endometrium or the Lung
To determine the concentration of 9-nitrocamptothecin (9NC) in the alveolar fluid over time. 1.2. To determine the arterial concentration of 9NC administered by inhalation in comparison to venous and urine concentrations. 1.3.
- Trial name
- NCT00277082
- Testing
- 9-NC in aerosol reservoir
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of New Mexico
Endometrial Cancer, Papillary Serous
Vaginal Cuff Brachytherapy Followed by Chemotherapy in Endometrial Cancer
The purpose of this study is to determine the feasibility of treatment in patients with high risk endometrial cancer treated by vaginal cuff brachytherapy followed by 3 cycles of dose dense paclitaxel and carboplatin chemotherapy.
- Conditions
- Endometrial Cancer, Papillary Serous, Clear Cell Endometrial Cancer
- Trial name
- NCT03189446
- Testing
- Vaginal Cuff Brachytherapy, Carboplatin, Paclitaxel
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Oklahoma
Endometrial Cancer, Cervical Cancer (Early Detection)
Remote Robotic Surgery for Gynecologic Cancer: A Safety and Effectiveness Study
This investigator-initiated, multicenter, single-blind, randomized controlled clinical study is designed to evaluate the safety and effectiveness of the MP2000 thoracoabdominal endoscopic surgical system (Shenzhen Jingfeng…
- Trial name
- RRS-GYN-RCT (NCT07896720)
- Testing
- MP2000 Thoracoabdominal Endoscopic Surgical System
- Volunteers
- 92 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Advanced Solid Tumor, Lymphoma
A Open-Label, Multiple Ascending Dose Study of DS-3078a, an Oral TORC1/2 Kinase Inhibitor, in Subjects With Advanced Solid Tumors or Lymphomas
DS-3078a will be evaluated as a single agent in subjects with advanced solid tumor malignancies or lymphomas refractory to standard treatment or for which no standard treatment is available.
- Trial name
- NCT01588678
- Testing
- DS-3078a
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Daiichi Sankyo
Uterine Cervical Neoplasms, Endometrial Neoplasms
[F-18] Fluorothymidine PET/CT Imaging for Pelvic Cancers
[F-18] Fluorothymidine PET imaging will be used to create a radiation therapy treatment plan to avoid active bone marrow in the pelvis. This will be done to evaluate if sparing bone marrow will help maintain blood counts.
- Conditions
- Uterine Cervical Neoplasms, Endometrial Neoplasms, Anus Neoplasms, Rectal Neoplasms
- Trial name
- NCT01717391
- Testing
- fluorothymidine F 18
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- John M. Buatti
Infertility
Clinical Performance and Safety Investigation of ENDOmetrial Washing MEdical DEvice Forielle
This is a multicenter, prospective randomized controlled, interventional investigation to assess the safety and clinical performance of Forielle, a medical device for endometrial washing, in restoring favorable endometrial…
- Trial name
- ENDOMEDE (NCT03387059)
- Testing
- Forielle
- Where
- 7 sites in Italy
- Volunteers
- 9 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Cancer
Laboratory Assay in Determining Cancer Resistance in Patients With Metastatic Cancer and in Healthy Participants
RATIONALE: Studying samples of blood and tissue in the laboratory from patients with cancer and from healthy participants may help doctors learn more about cancer.
- Trial name
- NCT00899496
- Testing
- immunological diagnostic method, physiologic testing
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Female Infertility, Anovulatory Infertility
Vaginal Estradiol and Oral Guaifenesin in Clomiphene Ovulation Induction
Clomiphene citrate is commonly used for ovulation induction; however, it may negatively affect endometrial development and cervical mucus quality, which can reduce pregnancy rates.
- Conditions
- Female Infertility, Anovulatory Infertility, Unexplained Infertility
- Trial name
- CC-OVI (NCT07398924)
- Testing
- Clomiphene Citrate., Guaifenesin, Estradiol (E2)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Yuzuncu Yil University
Genital Diseases, Female, Ovarian Diseases
Efficacy,Tolerability,Safety of Temsirolimus in Women With Platinum-refractory Ovarian Carcinoma or Advanced Endometrial Carcinoma
The purpose of this study is to determine the activity, tolerability and safety of Temsirolimus in women with ovarian cancer who progressed during the previous platinum chemotherapy alternatively within 6 months from completion…
- Conditions
- Genital Diseases, Female, Ovarian Diseases, Ovarian Neoplasms, Endometrial Neoplasms
- Trial name
- NCT01460979
- Testing
- Temsirolimus
- Where
- 18 sites in Germany
- Volunteers
- 47 people
- Sponsor
- AGO Study Group
Lynch Syndrome, Endometrial Neoplasms
Universal Screening for Lynch Syndrome in Women With Endometrial and Non-Serous Ovarian Cancer
This study will maximize identification of women with Lynch Syndrome using an enhanced screening strategy to identify those at risk.
- Conditions
- Lynch Syndrome, Endometrial Neoplasms, Ovarian Neoplasms, Colorectal Neoplasms
- Trial name
- LS2 (NCT02494791)
- Testing
- Questionnaire, Educational Material
- Where
- Canada
- Volunteers
- 886 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Endometrial Cancer, Cervical Stromal Invasion
Radiomics Based Multimodal Transvaginal Ultrasound Imaging in Endometrial Cancer
Retrospectively collect preoperative transvaginal B-mode ultrasound (BMUS), color Doppler flow imaging (CDFI) and three-dimensional ultrasound (3D-US) images and clinical data in patients with non-endometrial cancer diseases and…
- Conditions
- Endometrial Cancer, Cervical Stromal Invasion, Transvaginal Ultrasound
- Trial name
- NCT05387460
- Testing
- radiomics
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Tongji Hospital
Endometrial Cancer
Biomarker Guided Treatment in Gynaecological Cancer
MoMaTEC2 aims to test, in clinically oriented studies, the applicability of already identified and promising molecular biomarkers, to promote individualisation of treatment for patients with endometrial cancer.
- Trial name
- Momatec2 (NCT02543710)
- Testing
- Biomarker (ER/PR) guided lymphadenectomy, Biomarker guided weekly taxane treatment in endometrial/ ovarian cancer
- Where
- 9 sites in Netherlands, Norway and 1 more
- Volunteers
- 1,300 people
- Sponsor
- Haukeland University Hospital
Endometrial Carcinoma, Ovarian Carcinoma
Phase 1/2a/3 Evaluation of Adding AL3818 to Standard Platinum-Based Chemotherapy in Subjects With Recurrent or Metastatic Endometrial, Ovarian, Fallopian, Primary Peritoneal or Cervical Carcinoma (AL3818-US-002)
This trial is a Phase 1b/2a/3 trial designed to evaluate the safety and efficacy of adding oral AL3818 (Anlotinib, INN: Catequentinib), a Dual Receptor Tyrosine Kinase Inhibitor, to standard platinum-based chemotherapy…
- Conditions
- Endometrial Carcinoma, Ovarian Carcinoma, Fallopian Tube Carcinoma, Primary Peritoneal Carcinoma
- Trial name
- AL3818 (NCT02584478)
- Testing
- AL3818, Paclitaxel, Pegylated Liposomal Doxorubicin (PLD)
- Where
- 41 sites in United States, China and 4 more
- Volunteers
- 294 people
- Sponsor
- Advenchen Laboratories, LLC
Endometrial Cancer, Brachytherapy
A Novel Tapered Applicator for Vaginal Vault Brachytherapy
This study will assess the comfort and fit of a novel applicator for endometrial cancer patients who are candidates for vaginal brachytherapy. This study is only assessing the applicator fitting.
- Conditions
- Endometrial Cancer, Brachytherapy, Quality of Life
- Trial name
- NCT04318340
- Testing
- Tapered applicator, Standard applicator
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Yale University
Polycystic Ovarian Syndrome
Endometrial Effects of Metformin Action in Women With Polycystic Ovarian Syndrome (PCOS)
The investigators aim is to conduct a prospective un-blinded pilot study of premenopausal women diagnosed with Polycystic Ovarian Syndrome (PCOS), defined using criteria developed at the 1990 NICHD conference on PCOS, undergoing…
- Trial name
- NCT01070160
- Testing
- Endometrin (progesterone 100mg vaginal inserts), Metformin
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Yale University
Endometrial Neoplasms
Tislelizumab in Combination With Chemotherapy as a Neoadjuvant Treatment for Advanced Endometrial Cancer
The goal of this clinical trial is to evaluate the efficacy and safety of tislelizumab in combination with chemotherapy as a neoadjuvant treatment for advanced endometrial cancer.
- Trial name
- NCT06363708
- Testing
- Tislelizumab, Paclitaxel, Carboplatin
- Where
- 3 sites in China
- Volunteers
- 20 people
- Sponsor
- Zhongnan Hospital
Endometrial Carcinoma
Elemene Liposomes in Endometrial Cancer
The goal of this clinical trial is to learn if Elemene Liposomes, combined with carboplatin and paclitaxel (TC) chemotherapy can improve prognosis in patients with advanced or recurrent endometrial cancer.
- Trial name
- NCT07738315
- Testing
- Elemene Injection/Elemene Oral Emulsion, Carboplatin-Paclitaxel chemotherapy
- Where
- China
- Volunteers
- 212 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Endometrial Cancer, Postmenopausal Bleeding
Patient's Experience and Choice Between Investigations for Endometrial Cancer in Postmenopausal Bleeding
Endometrial cancer is the most common malignancy of the female genital tract in Hong Kong. The aim in the evaluation of PMB is to exclude underlying malignancy.
- Trial name
- NCT03330015
- Where
- Hong Kong
- Volunteers
- 206 people
- Sponsor
- Chinese University of Hong Kong
Cervical Cancer, Endometrial Cancer
Phone or Email Reminder in Increasing Vaginal Dilator Use in Patients With Gynecologic Cancers Undergoing Brachytherapy
This randomized, pilot phase I trial studies whether phone or email reminders increases vaginal dilator use in patients with endometrial, cervical, or vaginal cancers after they undergo brachytherapy.
- Conditions
- Cervical Cancer, Endometrial Cancer, Radiation Toxicity, Vaginal Cancer
- Trial name
- NCT02058550
- Testing
- survey administration, computer-assisted intervention, telephone-based intervention
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Stanford University
Melanoma, Non Small Cell Lung Cancer
Safety, PK and Efficacy of AI-061 in Advanced Solid Tumors
AI-061 is a co-formulation drug product (DP) consisting of 1:1 ratio mix of AI-025, an anti-PD-1 antibody, and ONC-392, an anti-CTLA-4 antibody.
- Conditions
- Melanoma, Non Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma, High Grade Serous Adenocarcinoma of Ovary
- Trial name
- PRESERVE-009 (NCT05858736)
- Testing
- AI-061
- Where
- 5 sites in Australia
- Volunteers
- 18 people
- Sponsor
- OncoC4, Inc.
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