Clinical trials: Endometrial Disease
Intrauterine Adhesions
Treatment of Intrauterine Adhesions and Its Distribution of Genital Tract Flora
This study aims to investigate the treatment of intrauterine adhesion and the factors influencing its prognosis.
- Trial name
- NCT03731689
- Testing
- Intrauterine lavage therapy, Intrauterine gel-injection therapy
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Endometrial Hyperplasia, Endometrial Diseases
Topical Lidocaine vs. Traditional Management in Manual Vacuum Aspiration Pain Management.
The main objective of this study is to evaluate the effect of lidocaine versus placebo according to the visual analog pain scale, during manual uterine aspiration in patients with endometrial thickening, by means of a…
- Trial name
- ENDOLID (NCT06784024)
- Testing
- Lidocaine topical, Saline solution
- Where
- Honduras
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Ricardo A Gutierrez Ramirez, MD, MSc, FACOG
Advanced Malignancies, Metastatic Cancer
Phase 1/2 Study Exploring the Safety, Tolerability, and Efficacy of INCAGN01876 Combined With Immune Therapies in Advanced or Metastatic Malignancies
The purpose of this study is to determine the safety, tolerability, and efficacy of INCAGN01876 when given in combination with immune therapies in subjects with advanced or metastatic malignancies.
- Trial name
- NCT03126110
- Testing
- INCAGN01876, Nivolumab, Ipilimumab
- Where
- 38 sites in United States, Australia and 2 more
- Volunteers
- 145 people
- Sponsor
- Incyte Biosciences International Sàrl
Advance Solid Tumors
A Study of KIVU-107 in Participants With Locally Advanced or Metastatic Solid Tumors
This is a 2-part, first-in-human, open-label study to determine the safety and tolerability of KIVU-107, a PTK7-directed antibody-drug conjugate, in participants with locally advanced or metastatic solid tumors.
- Trial name
- NCT07229313
- Testing
- KIVU-107
- Where
- 7 sites in United States, Australia
- Volunteers
- 76 people
- Sponsor
- Kivu Bioscience Inc.
Endometrial Cancer, Cervical Cancer
An Enhanced Vaginal Dilator to Reduce Radiation-Induced Vaginal Stenosis
This is a randomized control trial aimed to decreased radiation-induced vaginal stenosis in patients with endometrial or cervical cancer treated with post-operative external beam radiation therapy with or without brachytherapy.
- Conditions
- Endometrial Cancer, Cervical Cancer, Vaginal Stricture, Radiation Toxicity
- Trial name
- NCT03876860
- Testing
- Silicone Dilator, Standard Dilator
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- Margaret Liotta
Solid Tumor, Breast Tumor
Niraparib in the Treatment of Patients With Advanced PALB2 Mutated Tumors
The purpose of this study is to further evaluate the efficacy and safety of niraparib in patients with locally advanced or metastatic solid tumors and a pathogenic or likely pathogenic tumor PALB2 (tPALB2) mutation.
- Conditions
- Solid Tumor, Breast Tumor, Colon Tumor, Malignant, Lung Tumor
- Trial name
- PAVO (NCT05169437)
- Testing
- Niraparib
- Where
- 80 sites in United States
- Volunteers
- 22 people
- Sponsor
- Tempus AI
Endometrial Cancer
DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer
DESTINY-Endometrial01 will investigate the efficacy of first-line T-DXd + rilvegostomig (Arm A) and/or T-DXd+ pembrolizumab (Arm B) when compared to chemotherapy (carboplatin + paclitaxel) + pembrolizumab (Arm C), by assessment…
- Trial name
- DE-01 (NCT06989112)
- Testing
- Trastuzumab deruxtecan, Rilvegostomig, Pembrolizumab
- Where
- 257 sites in United States, Australia and 21 more
- Volunteers
- 600 people
- Sponsor
- AstraZeneca
Dysfunctional Uterine Bleeding
Endometrial Ablation With Non-hysteroscopic Methods
Endometrial ablation in women with dysfunctional uterine bleeding using second generation ablation devices is a common widespread therapeutic approach.
- Trial name
- NCT01173965
- Testing
- MEA, Novasure
- Where
- 2 sites in Greece
- Volunteers
- 66 people
- Sponsor
- Aristotle University Of Thessaloniki
Fertility Disorders, Fertility Issues
Menstrual Phase Endometrial Scratch in IUI Cycles
Patients undergoing treatment with intrauterine insemination (IUI) will be randomized to receive an endometrial scratch or sham procedure during the menstrual phase of the treatment cycle.
- Trial name
- NCT04641598
- Testing
- Endometrial Scratch
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Carilion Clinic
Advanced Breast Cancer, Treatment-Refractory Solid Tumors
TAS-116 Plus Palbociclib in Breast and Rb-null Cancer
The purpose of this study is to evaluate the safety and efficacy of TAS-116 with palbociclib in two groups of patients: Patients with advanced breast cancer that has become worse after taking palbociclib alone Patients with…
- Conditions
- Advanced Breast Cancer, Treatment-Refractory Solid Tumors, Retinoblastoma Deficiency, SCLC
- Trial name
- NCT05655598
- Testing
- Palbociclib Oral Product, TAS-116
- Where
- United States
- Sponsor
- Brown University
Advanced or Metastatic Solid Tumors, Breast Cancer
A Study of PARG Inhibitor IDE161 in Participants With Advanced Solid Tumors
The purpose of this study is to characterize the safety, tolerability, and efficacy of IDE161 as a single agent and in combination with pembrolizumab.
- Conditions
- Advanced or Metastatic Solid Tumors, Breast Cancer, Ovarian Cancer, Prostate Cancer
- Trial name
- NCT05787587
- Testing
- IDE-161, Pembrolizumab
- Where
- 27 sites in United States
- Volunteers
- 216 people
- Sponsor
- IDEAYA Biosciences
Infertility, Polycystic Ovarian Syndrome
Endometrial Scratching During Laproscopic Ovarian Drilling in Subfertile PCOS Women
Laparoscopic Ovarian Drilling is a valid procedure for infertile anovulatory women with polycystic ovarian syndrome who failed to get pregnant or to ovulate with ovulation induction medications as clomiphene citrate or exogenous…
- Trial name
- ESLOD (NCT02140398)
- Testing
- Endometrial Currettage
- Where
- Egypt
- Volunteers
- 500 people
- Sponsor
- Mansoura University
Ovarian Carcinoma, Fallopian Tube Carcinoma
NM32-2668 in Adult Patients With Selected Advanced Solid Tumors
This is a first-in-human, open-label, multi-center, Phase 1, dose-escalation study with expansion cohorts to evaluate NM32-2668 for safety and immunogenicity, to determine the maximal tolerated dose and recommended Phase 2 dose…
- Conditions
- Ovarian Carcinoma, Fallopian Tube Carcinoma, Peritoneal Carcinoma, Endometrial Cancer
- Trial name
- NCT06299163
- Testing
- NM32-2668
- Where
- 11 sites in United States
- Volunteers
- 11 people
- Sponsor
- Numab Therapeutics AG
Endometrial Cancer
Atezolizumab Trial in Endometrial Cancer - AtTEnd
Atezolizumab is an engineered humanised monoclonal immunoglobulin G1 antibody that binds selectively to PD-L1 and prevents its interaction with PD-1 and B7-1.
- Trial name
- AtTEnd (NCT03603184)
- Testing
- Atezolizumab, Paclitaxel, Carboplatin
- Where
- 93 sites in Australia, Austria and 9 more
- Volunteers
- 549 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Endometrial Carcinoma
Preoperative Olaparib Endometrial Carcinoma Study (POLEN)
The primary objective of this study is to identify, in human tumour samples, biomarker changes associated to short exposure to AZD2281 as potential predictors of activity in Endometrial Carcinoma (EC).
- Trial name
- Polen (NCT02506816)
- Testing
- Olaparib
- Where
- 10 sites in Spain
- Volunteers
- 36 people
- Sponsor
- MedSIR
Surgically Staged Endometrial and Cervical Carcinoma, Cervical Cancer: Invasive Disease, FIGO Stage 1B1 or Higher
Diagnostic Accuracy of MRI, DWI MRI, FDG-PET/CT and FEC PET/CT in the Detection of Lymph Node Metastases in Surgically Staged Endometrial and Cervical Carcinoma
This is a prospective diagnostic performance study which compares three new imaging methods with the current standard imaging method for the diagnosis of metastatic lymph nodes.
- Conditions
- Surgically Staged Endometrial and Cervical Carcinoma, Cervical Cancer: Invasive Disease, FIGO Stage 1B1 or Higher, Endometrial Cancer, Stage 1A With Myometrial Invasion or Any Higher Stage and Grade 3
- Trial name
- MAPPING (NCT01836484)
- Testing
- Diffusion-weighted MRI, Fluorodeoxyglucose-18-PET/CT, Fluoro-ethyl-coline-PET/CT
- Where
- 7 sites in United Kingdom
- Volunteers
- 162 people
- Sponsor
- Barts & The London NHS Trust
Endometrium Cancer
Relationship of Endometrial Cancer and Serum Soluble L1CAM Level
The aim of this study is to evaluate the effect of serum soluble L1CAM (sL1CAM) on the diagnosis and prognosis of endometrial cancer.
- Trial name
- NCT04603599
- Testing
- serum soluble L1CAM (sL1CAM)
- Where
- Turkey (Türkiye)
- Volunteers
- 146 people
- Sponsor
- Kocaeli University
Endometrial Cancer
An Observational Study of Molecular profIling of Advanced and aggRessive ENdometrial Cancer and 1-st Line Treatment Approaches in Russian Federation
Multicenter, observational, prospective study of molecular profiling in advanced and aggressive endometrial cancer patients and 1-st line treatment approaches in Russian Federation
- Trial name
- IREN (NCT07041606)
- Where
- 19 sites in Russia
- Volunteers
- 500 people
- Sponsor
- AstraZeneca
Solid Tumors, Neoplasms (Cancer / Tumors)
Exploratory Study on the Efficacy and Safety of Trastuzumab Rezetecan in the Treatment of HER2-Expressiong Advanced Solid Tumor
The goal of this clinical trial is to learn if Trastuzumab Rezetecan can treat advanced solid tumors with HER-2 expression in adult participants.
- Conditions
- Solid Tumors, Neoplasms (Cancer / Tumors), Advanced Malignant Solid Neoplasm, Locally Advanced Malignant Solid Neoplasm
- Trial name
- NCT07631884
- Testing
- Trastuzumab Rezetecan
- Volunteers
- 15 people
- Sponsor
- Haihua Yuan
Atypical Endometrial Hyperplasia and Endometrial Cancer
Conservative Treatment for Atypical Endometrial Hyperplasia and Early Endometrial Cancer
Exploring the efficacy and pregnancy outcomes of conservative treatment for atypical endometrial hyperplasia and endometrial cancer. Study the factors related to predicting treatment efficacy.
- Trial name
- NCT06170684
- Volunteers
- 100 people
- Sponsor
- Beijing Obstetrics and Gynecology Hospital
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