Clinical trials: Endometrial Disease
Infertile
Prospective Study of an Human Endometrial Receptivity Test
Evaluation of endometrial receptivity is a crucial step in in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) programs.
- Trial name
- Win-Test (NCT04192396)
- Where
- France
- Volunteers
- 217 people
- Sponsor
- University Hospital, Montpellier
Endometrial Cancer, Ovarian Cancer
AZD2171 and Temsirolimus in Patients With Advanced Gynecological Malignancies
The purpose of this research study is to determine the safety of the combination of the two drugs cediranib and temsirolimus and the highest doses of these two drugs that can be given in combination to people safely.
- Conditions
- Endometrial Cancer, Ovarian Cancer, Cervical Cancer, Fallopian Tube Cancer
- Trial name
- NCT01065662
- Testing
- temsirolimus, cediranib
- Where
- 3 sites in United States
- Volunteers
- 11 people
- Sponsor
- Susana M. Campos, MD
Endometriosis
Progestin Treatment for Endometrial Stromal Cells in Adenomyosis
Long term treatment of progestin has been demonstrated to have an inhibitory effect on endometrial angiogenesis and the proliferation of endometrial stromal cells.
- Trial name
- NCT00155051
- Where
- Taiwan
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Endometrial Cancer
The Effects of the Endocrine System on Endometrial Cancer
Endometrial cancer usually begins in the endometrium, which is the tissue lining of the uterus. Endometrial cancer is the most commonly diagnosed gynaecological malignancy in Australia.
- Trial name
- Ghrelin (NCT01075386)
- Where
- Australia
- Volunteers
- 75 people
- Sponsor
- Queensland Centre for Gynaecological Cancer
IVF, Infertility Treatment
Biomarkers of Endometrial Receptivity
Analysis of proteins from cervical mucus will be done in patients undergoing infertility treatment (fresh or frozen embryo transfer). Cervical mucus will be analysed for potential new biomarkers of endometrium receptivity.
- Conditions
- IVF, Infertility Treatment, Fertility Disorders, Embryo Transfer
- Trial name
- BIOMER (NCT04619524)
- Testing
- Cervical mucus will be collected from patients undergoing IVF, Cervical mucus will be collected from patients undergoing transfer of cryopreserved embryos
- Where
- 3 sites in Czechia
- Volunteers
- 476 people
- Sponsor
- The Institute of Molecular and Translational Medicine, Czech Republic
Breast Carcinoma, Endometrial Carcinoma
Caloric Restriction Before Surgery in Treating Patients With Endometrial, Prostate, or Breast Cancer
The purpose of this trial is to determine that sort term calorie restriction will affect tumor biology in biopsy proven breast, endometrial or prostate cancers, which will positively impact biomarkers including miR-21, an…
- Conditions
- Breast Carcinoma, Endometrial Carcinoma, Prostate Carcinosarcoma
- Trial name
- NCT02983279
- Testing
- Dietary Intervention, Counseling, Therapeutic
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia, FIGO Grade 1 Endometrial Endometrioid Adenocarcinoma
A Study of Weight Loss Intervention With Tirzepatide and Progestin Intrauterine Device to Treat Endometrial Hyperplasia and Grade 1 Endometrial Cancer
This phase II trial studies whether adding tirzepatide injections to a levonorgestrel intrauterine device (LNG-IUD) improves pathologic response (absence of cancer cells in tissue samples after treatment) in women with…
- Trial name
- NCT07349641
- Testing
- Medical Device Usage and Evaluation, Tirzepatide
- Where
- 3 sites in United States
- Volunteers
- 55 people
- Sponsor
- National Cancer Institute (NCI)
Endometrial Cancer, Papillary Serous
Vaginal Cuff Brachytherapy Followed by Chemotherapy in Endometrial Cancer
The purpose of this study is to determine the feasibility of treatment in patients with high risk endometrial cancer treated by vaginal cuff brachytherapy followed by 3 cycles of dose dense paclitaxel and carboplatin chemotherapy.
- Conditions
- Endometrial Cancer, Papillary Serous, Clear Cell Endometrial Cancer
- Trial name
- NCT03189446
- Testing
- Vaginal Cuff Brachytherapy, Carboplatin, Paclitaxel
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Oklahoma
Endometrial Cancer
A Preliminary Exploratory Study of Cadonilimab Combined With Progestin for Fertility-Sparing Treatment in Early Endometrial Cancer
This is a single-center, prospective, open-label, single-arm exploratory phase II study evaluating the efficacy and safety of cadonilimab combined with megestrol acetate as fertility-sparing treatment for patients with…
- Trial name
- NCT07900256
- Testing
- Cadonilimab, Megestrol Acetate (MA), Levonorgestrel-releasing intrauterine system
- Volunteers
- 10 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Infertility of Uterine Origin, Implantation Failure
International Non-selection Study for ERA® Test in Patients With Previous Implantation Failures
Women´s period comprises different hormonal stages, being one of them the stage for maximum receptivity and proper embryo implantation.
- Trial name
- NCT06097559
- Testing
- Endometrial fluid and biopsy collection
- Where
- 8 sites in Argentina, Panama and 2 more
- Volunteers
- 738 people, healthy volunteers welcome
- Sponsor
- Igenomix
Head and Neck Squamous Cell Carcinoma (HNSCC) - Recurrent/Metastatic (R/M), Gastric/GEJ
CR-002 in Adult Participants With Locally Advanced or Metastatic Solid Tumors
The purpose of this study is to determine the safety and tolerability of monotherapy CR-002 and to identify the MTD and/or optimal biologic dose and RP2D(s) in participants with locally advanced or metastatic solid tumors.
- Conditions
- Head and Neck Squamous Cell Carcinoma (HNSCC) - Recurrent/Metastatic (R/M), Gastric/GEJ, Biliary Tract Cancer (BTC), Esophageal Squamous Cell Carcinoma (ESCC)
- Trial name
- APOLLO (NCT07909031)
- Testing
- CR-002
- Where
- 3 sites in United States
- Volunteers
- 219 people
- Sponsor
- Crescent Biopharma, Inc.
Infertility, Infertility (IVF Patients)
Endometrial Receptivity Prediction During in Vitro Fertilization Using Artificial Intelligence
The investigators plan to use artificial intelligence to analyse vaginal ultrasound images of the uterine lining (endometrium) taken during routine IVF treatment, which may predict implantation success during IVF treatment.
- Trial name
- NCT06717802
- Where
- Hungary
- Volunteers
- 1,500 people
- Sponsor
- Gottsegen National Cardiovascular Institute
Menorrhagia
A Study to Compare the Effectiveness of Two Different Outpatient Endometrial Ablation Techniques Used for Heavy Periods
STUDY HYPOTHESIS: Does outpatient NovaSureTM endometrial ablation alleviate excessive menstrual bleeding and improve life quality more effectively than outpatient ThermachoiceTM endometrial ablation?
- Trial name
- COAT (NCT01124357)
- Testing
- NovaSure, thermachoice
- Volunteers
- 81 people
- Sponsor
- Birmingham Women's NHS Foundation Trust
Endometrial Hyperplasia, Endometrial Cancer
Efficacy and Tolerability Study of Progesterone Vaginal Tablets (Endometrin®) in Menopausal Women Treated by Estrogen
The objective of the study is to confirm that the efficacy of vaginal progesterone is at least as good as oral progesterone in order to protect the endometrium of uncontrolled proliferation and prevent endometrial cancer.
- Trial name
- NCT00919919
- Testing
- progesterone, activella
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Rabin Medical Center
Endometrial Cancer, Fertility
Refining Fertility-sparing Treatment in Endometrial Carcinoma Based on Molecular Classification
Endometrial cancer (EC) stands among the most common gynecological malignancies in developed countries and regions, with a notable trend toward younger age at onset.
- Trial name
- FEMUS (NCT07319429)
- Testing
- PD1 antibody, Medroxyprogesterone Acetate 500 MG, Megestrol Acetate 160 MG
- Where
- 2 sites in China
- Volunteers
- 260 people
- Sponsor
- Fudan University
Metastatic Endometrial Cancer
Avelumab in Patients With MSS, MSI-H and POLE-mutated Recurrent or Persistent Endometrial Cancer and of Avelumab/Talazoparib and Avelumab/Axitinib in Patients With MSS Recurrent or Persistent Endometrial Cancer
This research study is evaluating a drug called Avelumab alone and in combination with Talazoparib or Axitinib as a possible treatment for recurrent or metastatic endometrial cancer.
- Trial name
- NCT02912572
- Testing
- Avelumab, Talazoparib, Axitinib
- Where
- 4 sites in United States
- Volunteers
- 106 people
- Sponsor
- Dana-Farber Cancer Institute
Thin Endometrium
Hysteroscopic Injections of Autologous Endometrial Cells and Platelet-rich Plasma in Patients With Thin Endometrium
The investigation is devoted to the study of the effect of the introduction of autologous platelet-rich plasma (PRP) on the thickness of the endometrium.
- Trial name
- NCT05455151
- Testing
- Conservative therapy, PRP injection, Injection of PRP after conservative therapy
- Where
- Russia
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Federal State Budget Institution Research Center for Obstetrics, Gynecology and Perinatology Ministry of Healthcare
Endometrial Cancer Stage I, Mmr Deficiency
SATELLITE Study (feaSibility sAfeTy Efficacy dostarLimab earLy-stage defIcient endomeTrial cancEr)
The main goal of this clinical trial is to evaluate dostarlimab, an immunotherapy drug, as a potential alternative to surgery for early-stage endometrial cancer with Mismatch Repair deficiency, a genetic cause for 20-30% of…
- Conditions
- Endometrial Cancer Stage I, Mmr Deficiency, Endometrioid Endometrial Adenocarcinoma, Immune-related Adverse Event
- Trial name
- SATELLITE (NCT06278857)
- Testing
- Dostarlimab-Gxly 50 MG/1 ML Intravenous Solution [JEMPERLI]
- Where
- 3 sites in Australia
- Volunteers
- 10 people
- Sponsor
- Queensland Centre for Gynaecological Cancer
Infertility
GnRH Antagonist to Prepare Recipients for Embryo Transfer
26% of all ART cycles performed in the USA in 2003 (CDC data) are frozen embryo transfers (FET) and transfer of embryos resulting from egg donation (ED) to recipients.
- Trial name
- NCT00460642
- Testing
- GnRH Antagonist (Cetrotide)
- Where
- 2 sites in United States
- Volunteers
- 130 people
- Sponsor
- Institute for Human Reproduction (IHR)
Endometrial Adenocarcinoma, Endometrial Carcinoma
Universal Endometrial Cancer DNA Sequencing for Detection of Lynch Syndrome and Personalized Care
This clinical trial studies universal screening for deoxyribonucleic acid (DNA) mismatch repair deficiency in patients with endometrial cancer, mutations in the genes responsible for Lynch syndrome (inherited forms of endometrial…
- Conditions
- Endometrial Adenocarcinoma, Endometrial Carcinoma, Lynch Syndrome, Relatives
- Trial name
- OPTEC (NCT03460483)
- Testing
- Genetic Counseling, Genetic Testing, Laboratory Biomarker Analysis
- Where
- 9 sites in United States
- Volunteers
- 1,001 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
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