Clinical trials: Endometrial Disease
Endometrial Cancer, Endometrial Hyperplasia
Cohort Study of Intrauterine Diseases
"This study employs a prospective cohort design by establishing a uterine cavity diseases research platform. The investigators will collect participants' current medical history, menstrual and obstetric history, past medical…
- Conditions
- Endometrial Cancer, Endometrial Hyperplasia, Endometrial Polyps
- Trial name
- TJ Intrauterin (NCT07048327)
- Testing
- No intervention (observational study)
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Wenwen Wang
Endometrial Carcinoma
Comparison of Letrozole With Lerociclib Versus Letrozole With Placebo Control in Patients With Advanced/Metastatic or Recurrent, Grade 1 or Grade 2 Endometrial Cancer
This is a randomized, double-blinded, placebo-controlled Phase 3 clinical trial to compare the combination of lerociclib (administered at 150 mg twice a day (BID) with letrozole (administered at 2.5 mg once a day (QD) to that of…
- Trial name
- NCT05712941
- Testing
- Lerociclib, Letrozole 2.5mg
- Sponsor
- EQRx International, Inc.
Endometrial Cancer
Signatera Assessment in Early-Stage Endometrial Cancer
The goal of this clinical trial is to assess if circulating tumor DNA can guide adjuvant selection in high-intermediate risk early-stage endometrial cancer.
- Trial name
- SIGNAL-EMC 101 (NCT07339384)
- Testing
- Signatera Genome ultra-sensitive ctDNA blood test
- Where
- 12 sites in United States
- Volunteers
- 1,010 people
- Sponsor
- Natera, Inc.
Infertility, Embryos Transfert
Plasma Relaxin Measurement Based on Endometrial Preparation for Embryo Transfer
Pregnancies achieved through assisted reproductive technology (ART) are associated with more obstetric complications than natural pregnancies.
- Trial name
- TEC-RELAX (NCT07477340)
- Testing
- Relaxine dosage
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Hospices Civils de Lyon
Breast Cancer, Gynecologic Cancer
Prasterone (Dehydroepiandrosterone) in Treating Postmenopausal Cancer Survivors With Vaginal Symptoms
RATIONALE: Dehydroepiandrosterone (DHEA) may help relieve vaginal symptoms in female cancer survivors. PURPOSE: This randomized phase III trial studies DHEA to see how well it works compared to placebo in treating postmenopausal…
- Trial name
- NCT01376349
- Testing
- prasterone
- Where
- 280 sites in United States
- Volunteers
- 464 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Endometrial Cancer
Retrospective Case Study Examining Patient Outcomes Compared to the ChemoFx Assay in Endometrial Cancer Patients
The purpose of this study is to assess the relationship of assay sensitive patients versus assay resistant patients with progression free survival.
- Trial name
- NCT01049126
- Testing
- ChemoFx
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Precision Therapeutics
Infertility
Endometrial Biopsy in Infertile Patients
When a woman becomes pregnant, the fertilized egg attaches itself to the lining of the uterus (endometrium). The endometrium is constantly changing throughout a woman's menstrual cycle in response to the female hormones estrogen…
- Trial name
- NCT00064935
- Testing
- Endometrial biopsy
- Where
- 8 sites in United States
- Volunteers
- 880 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Uterine Cervical Neoplasm, Endometrial Neoplasms
Optimal Margin Evaluation of Online Adaptive Radiotherapy for Postoperative Treatment of Endometrial and Cervical Cancer
Online adaptive radiotherapy has demonstrated to be feasible to reduce inter-fractional radiotherapy errors as it re-optimizes treatment plan every fraction.
- Trial name
- NCT05682950
- Testing
- online adaptive radiotherapy
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Peking Union Medical College Hospital
Ovarian Cancer, Breast Cancer
A Follow-up Study of Women Evaluated and Treated for Infertility
To assess the relations of infertility causes and treatment to cancer risk, we will conduct a retrospective cohort study of approximately 12,000 women evaluated for infertility between 1965-1988.
- Conditions
- Ovarian Cancer, Breast Cancer, Endometrial Cancer, Thyroid Cancer
- Trial name
- NCT00342446
- Where
- United States
- Volunteers
- 12,193 people
- Sponsor
- National Cancer Institute (NCI)
Endometrial Cancer
Papillary Serous Carcinoma of the Endometrium
Primary Objectives: To evaluate the results of Paclitaxel and pelvic radiation in pelvic confined papillary serous carcinoma of the endometrium for both local control and overall survival.
- Trial name
- NCT00515073
- Testing
- Paclitaxel, Pelvic Radiation, Dexamethasone
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- M.D. Anderson Cancer Center
Infertility, Female, Endometrial Diseases
Effect of Different Ovarian Stimulation Protocols on Endometrial Receptivity
This study will assess the change in endometrial gene expression signature on the day of embryo transfer according to the type of exogenous gonadotropins administered.
- Trial name
- NCT03755973
- Testing
- CFA, rFSH, Fixed daily rFSH dosing protocol of 200-300 IU
- Where
- Portugal
- Volunteers
- 24 people
- Sponsor
- Instituto Valenciano de Infertilidade de Lisboa
Lung Cancer Metastatic, Renal Cell Carcinoma
Study Comparing the Standard Administration of IO Versus the Same IO Administered Each 3 Months in Patients in Response After 6 Months of Standard IO
Immunotherapy (IO), such as treatment with anti-PD-1, PD-L1, or CTLA-4 inhibitors, is a rapidly expanding treatment for multiple metastatic cancers with improved survival for certain cancers.
- Conditions
- Lung Cancer Metastatic, Renal Cell Carcinoma, Head and Neck Cancer, Triple Negative Breast Cancer
- Trial name
- MOIO (NCT05078047)
- Testing
- Reduced dose intensity of IO
- Where
- 33 sites in France
- Volunteers
- 646 people
- Sponsor
- UNICANCER
Squamous Cell Carcinoma of the Head and Neck, Renal Cell Carcinoma
Study of PF-06940434 in Patients With Advanced or Metastatic Solid Tumors.
Open-label, multi-center, non-randomized, multiple dose, safety, tolerability, pharmacokinetic, and pharmacodynamics and clinical activity study of PF-06940434 (Integrin alpha-V/beta-8 Antagonist) in patients with SCCHN (Squamous…
- Conditions
- Squamous Cell Carcinoma of the Head and Neck, Renal Cell Carcinoma, Ovarian Cancer, Gastric Cancer
- Trial name
- NCT04152018
- Testing
- PF-06940434, PF-06801591
- Where
- 31 sites in United States, Australia and 3 more
- Volunteers
- 85 people
- Sponsor
- Pfizer
Physical Activity, Breast Cancer
Hula, a Physical Activity Intervention for Female-Cancer Survivors
A six-month interventional program to determine the biological and psychosocial effects of hula as a form of physical activity for female breast, cervical, endometrial or ovarian cancer survivors living on Oahu.
- Conditions
- Physical Activity, Breast Cancer, Cervical Cancer, Ovarian Cancer
- Trial name
- NCT02351479
- Testing
- Hula
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- University of Hawaii
Recurrent or Persistent Endometrial Carcinoma
Virexxa (Sodium Cridanimod) w/Progestin Therapy in Pts w/Progesterone Receptor Neg Recurrent/Persistent Endometrial CA
This is an open label, multi-center, single arm phase II study. The study will investigate the efficacy of sodium cridanimod in conjunction with progestin therapy in a population of patients with recurrent or persistent…
- Trial name
- NCT02064725
- Testing
- Sodium cridanimod
- Where
- 21 sites in United States, Belarus and 3 more
- Volunteers
- 8 people
- Sponsor
- Kevelt AS
Breast Cancer, Ovarian Cancer
Navigation Intervention for Adolescent and Young Adult Cancer Survivors
The investigators propose to: 1) Adapt an evidence-based cancer-focused patient navigation (PN) program for the Adolescent and Young Adult (AYA) cancer survivor population; and 2) Plan and conduct an effectiveness-implementation…
- Conditions
- Breast Cancer, Ovarian Cancer, Cervical Cancer, Testicular Cancer
- Trial name
- NCT07406087
- Testing
- Adapted patient navigation program targeting adolescent and young adult cancer survivors
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Kaiser Permanente
Endometrial Cancer
Usefulness of 18F-FDG PET/CT in the Initial Staging and Surveillance of Endometrial Cancer Patients
1. To assess the value of 18F-FDG PET/CT in the initial staging and detection of recurrent cases of endometrial cancer. 2. To determine correlation between PET/CT derived parameters including SUVmax, TLG and MTV and…
- Trial name
- PET/CT (NCT05056259)
- Testing
- 18F-FDG PET/CT
- Volunteers
- 42 people
- Sponsor
- Assiut University
Endometrial Cancer, Endometrial Neoplasms
Can 3D Ultrasound be Used as an Alternative to MRI to Assess Myometrial Invasion in Endometrial Cancer?
Aim: Assess the diagnostic accuracy of 3D Ultrasound, compared to MRI and final histology with respect to myometrial invasion of endometrial cancer.
- Conditions
- Endometrial Cancer, Endometrial Neoplasms, Endometrial Hyperplasia
- Trial name
- NCT03207061
- Testing
- 3D Ultrasound
- Where
- United Kingdom
- Volunteers
- 500 people
- Sponsor
- Imperial College London
Prostate Carcinoma, Rectum Carcinoma
Effect of Irradiation Doses < 10 Gy and of Irradiated Bone Volume on the Variation of Blood Elements of the Complete Blood Count During and After Pelvic Irradiation
Bone marrow is one of the organs at risk of complications during irradiation due to its radiosensitivity. Hematopoietic toxicity remains one of the main toxicities during irradiation of pelvic lymph node areas, especially when…
- Conditions
- Prostate Carcinoma, Rectum Carcinoma, Anal Canal Carcinoma, Endometrium Carcinoma
- Trial name
- MIFADORESOL (NCT04626466)
- Testing
- Biological investigations
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- Institut de cancérologie Strasbourg Europe
Infertility
Physical Endometrial Manipulation and Its Effect on ICSI
Unexplained infertility is clinically diagnosed when there are no apparent or clear factors causing infertility on regular infertility assessment tools .
- Trial name
- NCT03345251
- Testing
- Hydrotubation
- Where
- Egypt
- Volunteers
- 640 people, healthy volunteers welcome
- Sponsor
- Aljazeera Hospital
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