Clinical trials: Endometrial Disease
Infertility, Female
Transcriptomic Evaluation of Endometrial Receptivity
The purpose of this study is to comprehensively evaluate the transcriptomic signal of the endometrium before, during, and after the window of receptivity.
- Trial name
- NCT04141085
- Testing
- Endometrial biopsy
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Reproductive Medicine Associates of New Jersey
Infertility, Endometrial Peristalsis
Association Between Peri-Transfer Endometrial Peristalsis And Live Birth In Modified Natural Cycle Frozen Embryo Transfer: A Prospective Cohort Study
The uterus is a dynamic muscular organ that undergoes rhythmic, wave-like contractions known as endometrial peristalsis or endometrial waves.
- Conditions
- Infertility, Endometrial Peristalsis, Uterine Contraction, Endometrial Waves
- Trial name
- EPFE (NCT07358468)
- Testing
- Endometrial peristalsis and hormone measurements
- Where
- 2 sites in Vietnam
- Volunteers
- 384 people
- Sponsor
- Mỹ Đức Hospital
Endometrial Carcinoma
Targeting Inflammation for Endometrial Cancer Prevention
This study examines risk assessment and identifies prevention strategies for endometrial cancer. Collecting samples of blood and urine and risk assessments from patients with benign conditions or endometrial cancer may help…
- Trial name
- NCT05407025
- Testing
- Biospecimen Collection, Questionnaire Administration
- Where
- 2 sites in United States
- Volunteers
- 191 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Infertility
Efficacy of Endocell® vs Conventional Medium in the Treatment of Infertility
The aim of this study is to demonstrate the efficacy of a single embryo transfer at blastocyst stage (Day 5) after co-culture on Autologous Endometrial Cell Culture (AECC) versus transfer of a single embryo at Day 3 after culture…
- Trial name
- NCT01058603
- Testing
- - Conventional culture medium for IVF, - Endocell®
- Where
- France
- Volunteers
- 720 people
- Sponsor
- Laboratoires Genévrier
Gastroesophageal Cancer (GC), Hepatocellular Carcinoma (HCC)
A Phase 1 Study of the Safety and Tolerability of CTX-10726
This is a Phase 1, open-label, first-in-human study of CTX-10726 monotherapy in patients with metastatic or locally advanced malignancies.
- Conditions
- Gastroesophageal Cancer (GC), Hepatocellular Carcinoma (HCC), Endometrial Cancer, Renal Cell Carcinoma (RCC)
- Trial name
- NCT07419841
- Testing
- CTX-10726
- Where
- 8 sites in United States
- Volunteers
- 70 people
- Sponsor
- Compass Therapeutics
Endometrial Carcinoma Stage I
A Prospective Multi-center Study on Using Sonazoid Diagnose Early Stage Endometrial Cancer
Sonazoid as a new generation of ultrasound contrast agent.This study based on the features of Sonazoid specific angiography and higher mechanical index, the role of Sonazoid in the early diagnosis of Endometrial carcinoma was…
- Trial name
- NCT04961775
- Testing
- Perflubutane Microspheres for Injection
- Where
- China
- Volunteers
- 277 people
- Sponsor
- Chinese PLA General Hospital
HER2 Positive Solid Tumors
A Study of SBT6050 Alone and in Combination With PD-1 Inhibitors in Subjects With Advanced HER2 Expressing Solid Tumors
A first-in-human (FIH) study using SBT6050 and SBT6050 in combination with PD-1 inhibitors in HER2 expressing or amplified advanced malignancies
- Trial name
- NCT04460456
- Testing
- SBT6050, pembrolizumab, Cemiplimab
- Where
- 12 sites in United States, Australia and 1 more
- Volunteers
- 58 people
- Sponsor
- Silverback Therapeutics
Advanced Solid Tumor, Advanced Malignant Neoplasm
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
The Phase 2 monotherapy portion of this study is currently enrolling and will evaluate the efficacy and safety of PC14586 (INN rezatapopt) in participants with locally advanced or metastatic solid tumors harboring a TP53 Y220C…
- Conditions
- Advanced Solid Tumor, Advanced Malignant Neoplasm, Metastatic Cancer, Metastatic Solid Tumor
- Trial name
- NCT04585750
- Testing
- rezatapopt, pembrolizumab
- Where
- 76 sites in United States, Australia and 7 more
- Volunteers
- 300 people
- Sponsor
- PMV Pharmaceuticals, Inc
Endometrial Hyperplasia
Ultrasound and Endometrial Hyperplasia
The investigators hypothesize that endometrial thickness will be a significant predictor of endometrial hyperplasia in a postmenopausal female population with metabolic syndrome: diabetes and/or insulin resistance, hypertension…
- Trial name
- NCT00123188
- Testing
- Ultrasound and Biopsy
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Colorectal Cancer, Sarcoma
Lipid Mediators & Cancer: Montelukast, SPM, and Almonds
The purpose of this study is to create a prospective investigation to examine the effects of montelukast, almonds/almond oil, and specialized pro-resolving mediators (SPMs) on lipid profiles and tumor-associated macrophages…
- Conditions
- Colorectal Cancer, Sarcoma, Brain Tumors, Endometrial Cancer
- Trial name
- NCT06887673
- Testing
- No Interventions, Sports Pro Resolve 4 g, Double Wood SPM 4 g
- Where
- 2 sites in United States
- Volunteers
- 56 people
- Sponsor
- University of South Florida
Endometrial Cancer
Evaluation of Mirvetuximab Soravtansine (IMGN853) in Women With Folate Receptor-α Positive Endometrial Cancer
The purpose of this study is to evaluate the activity and safety profile of mirvetuximab soravtansine (IMGN853) in patients with type II endometrial cancers that overexpress folate receptor alpha (FRα).
- Trial name
- NCT03832361
- Testing
- IMGN853
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Alessandro Santin
Ovarian Cancer, Endometrial Cancer
Registry Platform Ovarian and Endometrial Cancer
The purpose of the project is to set up a national, prospective, longitudinal, multicenter cohort study, a tumor registry platform, to document uniform data on characteristics, molecular diagnostics, treatment and course of…
- Conditions
- Ovarian Cancer, Endometrial Cancer, Ovary Neoplasm, Endometrial Neoplasms
- Trial name
- SMARAGD (NCT05129969)
- Testing
- Physician's choice according to patient's needs.
- Where
- Germany
- Volunteers
- 1,975 people
- Sponsor
- iOMEDICO AG
Endometrial Receptivity Diagnosis
Quantitative Identification of Implantation Receptivity by Single Cell Transcriptome Analysis
This project aims to study the endometrial transcriptome at the single cell level in both endometrial native tissue (biopsies) and endometrial fluid.
- Trial name
- NCT03091023
- Testing
- Endometrial Biopsy and endometrial fluid collection
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Igenomix
Infertility, Female, IVF/ICSI
RCT to Assess the Clinical Benefit of the ERA Test in Infertile Women at Their First IVF/ICSI Cycle
Endometrial receptivity takes place in a self-limited period of time during the endometrial mid-secretory stage. This period, named as window of implantation (WOI), is modulated by molecular changes allowing embryo implantation…
- Trial name
- NCT04687670
- Testing
- ERA
- Where
- 3 sites in China
- Volunteers
- 714 people
- Sponsor
- Peking University Third Hospital
Endometrial Cancer, Cervical Cancer
Sexual Rehabilitation Programme After Radiotherapy for Gynaecological Cancer
The aim of this randomized controlled trial is to demonstrate that a nurse-led sexual rehabilitation intervention significantly improves sexual recovery and functioning among gynaecological cancer (GC) patients treated with…
- Conditions
- Endometrial Cancer, Cervical Cancer, Vaginal Cancer, Gynecologic Cancer
- Trial name
- SPARC (NCT03611517)
- Testing
- Sexual rehabilitation programme
- Where
- 8 sites in Netherlands
- Volunteers
- 220 people
- Sponsor
- Leiden University Medical Center
Advanced Breast Carcinoma, Advanced Endometrial Carcinoma
Phase I Study of Tumor Treating Fields (TTF) in Combination With Cabozantinib or With Pembrolizumab and Nab-Paclitaxel in Patients With Advanced Solid Tumors Involving the Abdomen or Thorax
This phase Ib trial tests the safety, side effects, and best dose of tumor treating fields therapy in combination with either cabozantinib or nab-paclitaxel and atezolizumab in treating patients with solid tumors involving the…
- Conditions
- Advanced Breast Carcinoma, Advanced Endometrial Carcinoma, Advanced Fallopian Tube Carcinoma, Advanced Hepatocellular Carcinoma
- Trial name
- NCT05092373
- Testing
- Atezolizumab, Cabozantinib S-malate, Nab-paclitaxel
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- M.D. Anderson Cancer Center
Endometrial Cancer, Fallopian Tube Cancer
Narrow Band Imaging (NBI): A Novel Imaging Modality in Minimally Invasive
The purpose of this study is to determine whether narrowband imaging (NBI) makes it easier for a surgeon to see cancer. NBI is a kind of light. Normally, white light is used during surgery.
- Conditions
- Endometrial Cancer, Fallopian Tube Cancer, Ovarian Cancer, Peritoneal Cancer
- Trial name
- NCT01262040
- Testing
- Narrow Band Imaging (NBI)
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Abnormal Uterine Bleeding (AUB), Endometrial Cancer
Endometrial Cancer Vaginal Fluid Specimen Collection Study
This is a multicenter, prospective, specimen collection study for development and evaluation of tests used to detect endometrial cancer, other cancers, or their causes.
- Conditions
- Abnormal Uterine Bleeding (AUB), Endometrial Cancer, Atypical Endometrial Hyperplasia, Endometrial Hyperplasia With Atypia
- Trial name
- ENVISION (NCT07544680)
- Where
- 5 sites in United States
- Volunteers
- 4,200 people
- Sponsor
- Exact Sciences Corporation
Endometrial Neoplasms
Sentinel Lymph Node Detection in Endometrial Cancer
In endometrial cancer (EC) pelvic and paraaortic lymphadenectomy is performed only in high risk groups (with approximately 20% of patients having lymph node metastases (LNM)) whereas no lymphadenectomy is recommended in low risk…
- Trial name
- NCT02690259
- Testing
- Sentinel node procedure
- Where
- Sweden
- Volunteers
- 257 people
- Sponsor
- Region Skane
Endometrial Carcinoma, Endometrial Carcinoma Stage III
GYNORYLAQ™-VLINIVAL™: Ψ-Guided Personalized Neoantigen Peptide Vaccine for High-Risk Endometrial Cancer
GYNORYLAQ-VLINIVAL is an Early Phase I, non-randomized, single-arm, open-label clinical trial enrolling 40 patients with high-risk or recurrent endometrial carcinoma.
- Trial name
- GYNORYLAQ™ (NCT07316361)
- Testing
- • Biological: GYNORYLAQ-TM Personalized Neoantigenic Peptide Vaccine
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Biogenea Pharmaceuticals Ltd.
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