Clinical trials: Endometrial Fluid
Cancer Screening, Endometrial Cancer
Host DNA Methylation for Endometrial Cancer Screening
Based on the previous study of NCT04651738, we performed this trial to further confirm the accuracy of host DNA CDO1 and CELF4 methylation for endometrial cancer screening in a multi-center cohort.
- Conditions
- Cancer Screening, Endometrial Cancer, DNA Methylation, Cervical Cytology
- Trial name
- NCT05290415
- Testing
- DNA methylation testing
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Lei Li
Endometrial Cancer, Liquid Biopsy
Cell-free DNA Methylation for Endometrial Cancer
Liquid biopsy is challenging for the diagnosis of endometrial cancer. In this study, investigators perform the methylation testing of host DNA, namely, BHLHE22, CELF4, HAND2, and ZNF177, in the peripheral serum to discover the…
- Conditions
- Endometrial Cancer, Liquid Biopsy, DNA Methylation, Cervical Cytology
- Trial name
- NCT04651738
- Testing
- DNA methylation testing
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Lei Li
Endometrial Cancer
Circulating Tumor DNA Study in Patients With Endometrial Cancer
The objective of this study is to identify a population at risk of early recurrence after oncologic resection surgery of a primary uterine tumor based on the detection of ctDNA
- Trial name
- ctDNA-endo (NCT05955079)
- Testing
- Whole blood
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Extracellular Vesicles
Isolation and Characterization of the Extracellular Vesicles Secreted by the Human Endometrium
The main aim of this study is to describe the morphology, size distributions and specific markers of the different vesicles populations present in the human endometrial fluid.
- Trial name
- NCT02797834
- Testing
- Endometrial fluid collection
- Where
- Spain
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Igenomix
Infertility, Female, IVF
The Study of the Implantation Window From Endometrial Biopsy With Gene Expression Methods
The objective of the study is to gain a better understanding of the gene expression changes in the endometrial biopsy especially whether the endometrium has reached a receptive status, i.e. the implantation window, or not.
- Trial name
- NCT04052464
- Testing
- endometrium biopsy, endometrium lavage, repeated endometrium lavage
- Volunteers
- 67 people
- Sponsor
- Prelife Kft
Gynecologic Neoplasms
Safety of Regular Diet as the First Meal in Patients Who Underwent Surgical Treatment for Gynecologic Cancer
The purpose of this study is to determine whether it is safe to give a regular diet as the first postoperative meal in patients who underwent surgical treatment for clinically early-stage gynecologic cancer.
- Trial name
- NCT00328757
- Testing
- Regular diet as the first postoperative meal
- Where
- Thailand
- Volunteers
- 240 people
- Sponsor
- Chiang Mai University
Infertility
Diagnostic Test for Endometrial Receptivity 24 Hours Before Embryo Transfer
This clinical validation study is being carried out to validate the efficacy of a test measuring the clinical application of prostaglandins present in the endometrial fluid in patients, 24 hours before the embryonic transfer.
- Trial name
- NCT02189369
- Testing
- Day 3 embryo transfer, Day 5 embryo transfer
- Where
- 2 sites in Spain
- Volunteers
- 120 people
- Sponsor
- Igenomix
Endometrial Cancer
Detection of Tumor DNA Through Cervical Smear and Liquid Biopsy in Endometrial Cancer Patients and Evaluation of Prognostic and Predictive Values of Tumor DNA Assay
Circulating tumor DNA (ctDNA) may help detect and prognosis-stratify patients with endometrial cancer. Both cervical swab-based genomic DNA (gDNA) and whole blood-based ctDNA can be utilized for this goal.
- Trial name
- NCT05504161
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Yonsei University
Bladder Carcinoma, Ureter Carcinoma
ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation
The purpose of ORACLE is to demonstrate the ability of a novel ctDNA assay developed by Guardant Health to detect recurrence in individuals treated for early-stage solid tumors.
- Conditions
- Bladder Carcinoma, Ureter Carcinoma, Renal Pelvis Carcinoma, Non-small Cell Lung Cancer
- Trial name
- ORACLE (NCT05059444)
- Testing
- Guardant Reveal
- Where
- 57 sites in United States, France and 3 more
- Volunteers
- 2,285 people
- Sponsor
- Guardant Health, Inc.
Cancer of Ovary
Identification and Characterization of Ovarian Cancer and Endometrial Cancer Specific Biomarkers in Vaginal Fluids
The purpose of this study is to: 1. Identification and characterization of ovarian carcinoma well-known biomarkers, carcinoma antigen 125 (CA125) and Human epididymis protein 4 (HE4) and other potential biomarkers in vaginal…
- Trial name
- NCT02704650
- Testing
- fluid sample
- Volunteers
- healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Lynch Syndrome, Lynch Syndrome I
Lynch Syndrome X-Talk of Enteral Mucosa With Immune System
Lynch syndrome (OMIM #120435) is the most common dominantly inherited colorectal cancer syndrome with an estimated prevalence of 1:270 individuals.
- Conditions
- Lynch Syndrome, Lynch Syndrome I, Lynch Syndrome II, Lynch Syndrome I (Site-specific Colonic Cancer)
- Trial name
- LYNX-EYE (NCT06708429)
- Testing
- LYNX EYE (Lynch syndrome X-Talk of Enteral mucosa with Immune System)
- Where
- 5 sites in United States, Italy
- Volunteers
- 300 people
- Sponsor
- San Raffaele University
Uterine Neoplasms, Cervical Cancer
Prospective Cohort Study of Minimal Residual Disease(MRD) Testing for Early Recurrence Detection in Endometrial and Cervical Cancer
This study aims to evaluate the clinical performance of blood-based Minimal Residual Disease (MRD) testing using circulating tumor DNA (ctDNA) in patients with endometrial and cervical cancer.
- Trial name
- NCT07382505
- Testing
- Serial blood collection for MRD testing
- Where
- South Korea
- Volunteers
- 600 people
- Sponsor
- Asan Medical Center
Endometriosis
Biomarkers in the Endometrial Fluid, Tissue, and Follicular Fluid of Moderate/Severe Endometriosis Patients
This study aims to explore biomarkers in the endometrial fluid and tissue of women with moderate to severe endometriosis, with a specific focus on those involved in pre-receptive endometrium and embryo implantation.
- Trial name
- NCT07182643
- Testing
- Endometrial fluid, Endometrial biopsy, Follicular fluid
- Where
- Sweden
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Region Stockholm
Infertility
Aspiration of Excessive Endometrial Fluid at the Day of Ovum Retrieval Plus Diosmin in (ICSI) Cycles
To notify the effect of aspiration of excessive endometrial fluid in addition to Diosmin in cases undergoing intracytoplasmic sperm injection (ICSI) cycles.
- Trial name
- NCT02158000
- Testing
- group A
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Benha University