Clinical trials: Endometrial Hyperplasia
Endometrial Hyperplasia and Endometrial Cancers
Role of Senescence in the Development of Endometrial Cancer
Several molecular studies showed chromosomal alterations in patients with endometrial cancer, with gains in 1q, 19p, 19q, 8q, 10q and 10p and loss of 4q, 16q and 18q.
- Trial name
- NCT03338985
- Testing
- Genetic analysis
- Where
- France
- Volunteers
- 140 people
- Sponsor
- CHU de Reims
Abnormal Uterine Bleeding
Transvaginal Ultrasound in Women With Abnormal Uterine Bleeding
The objective of this study is to investigate the role of transvaginal ultrasound in detecting endometrial hyperplasia and endometrial cancer in women aged more than 35 presenting with abnormal uterine bleeding.
- Trial name
- NCT01786798
- Testing
- Transvaginal sonography
- Where
- Thailand
- Volunteers
- 560 people
- Sponsor
- Chulalongkorn University
Endometrial Cancer
Risk Assessment of Endometrial Hyperplasia and Endometrial Cancer
Abnormal uterine bleeding (AUB) represents common diagnostic challenge in everyday gynecological practice. However, abnormal bleeding is a common symptom of many benign diseases and only indicates the presence of EC in 9% of…
- Trial name
- NCT04995731
- Testing
- Information about clinical risk factors for endometrial cancer and endometrial hyperplasia (EH), transvaginal ultrasound examination
- Where
- Egypt
- Volunteers
- 328 people
- Sponsor
- Assiut University
Complex Atypical Hyperplasia, Endometrial Cancer
18-fluorofuranylnorprogesterone (FFNP) PET/MRI as a Potential Biomarker of Response to Progesterone Therapy
Purpose: The purpose of this study is to evaluate FFNP PET/MRI's utility for predicting response to Levonorgestrel-releasing Intrauterine Device (LR-IUD) hormonal therapy for Complex Atypical hyperplasia (CAH) and Endometrial…
- Trial name
- NCT05483023
- Testing
- 18F-fluorofuranylnorprogesterone PET / MRI
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Endometrial Carcinoma
Non-Invasive Identification of Endometrial Cancer/Endometrial Atypical Hyperplasia With an AI-Based Classifier Applied to Transvaginal Ultrasound in Patients With Post-Menopausal Bleeding
This study evaluates if AI can be used with transvaginal ultrasound images for early detection of endometrial cancer or premalignant lesions.
- Trial name
- NCT06365905
- Testing
- Non-Interventional Study
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- Mayo Clinic
Endometrial Cancer, Endometrial Cancer Stage I
SHAPE-ENDO: Pilot Randomized Trial of Multimodal Pre-Surgical Optimization Versus Standard Surgery in Patients With Obesity and Early-Stage Endometrial Cancer
SHAPE-ENDO is a single-center, open-label, pilot randomized clinical trial conducted at Hospital Universitari de Bellvitge in Barcelona, Spain.
- Conditions
- Endometrial Cancer, Endometrial Cancer Stage I, Atypical Endometrial Hyperplasia and Endometrial Carcinoma Stage I, Atypical Endometrial Hyperplasia
- Trial name
- SHAPE-ENDO (NCT07462663)
- Testing
- GLP-1 Receptor Agonist, Levonorgestrel IUD (Lng-IUD), Oral Progestins
- Volunteers
- 80 people
- Sponsor
- Hospital Universitari de Bellvitge
Endometrial Hyperplasia, Endometrial Adenocarcinoma
Diagnostic and Prognostic Value of PTEN Expression in Functional and Pathological Endometrial Biopsies
endometrial hyperplasia may progress to endometrial adenocarcinoma. the exact possibility of such progression is not determined.
- Trial name
- NCT04873206
- Testing
- routine stain by H&E.
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sohag University
Abnormal Uterine Bleeding (AUB), Endometrial Cancer
Endometrial Cancer Vaginal Fluid Specimen Collection Study
This is a multicenter, prospective, specimen collection study for development and evaluation of tests used to detect endometrial cancer, other cancers, or their causes.
- Conditions
- Abnormal Uterine Bleeding (AUB), Endometrial Cancer, Atypical Endometrial Hyperplasia, Endometrial Hyperplasia With Atypia
- Trial name
- ENVISION (NCT07544680)
- Where
- 5 sites in United States
- Volunteers
- 4,200 people
- Sponsor
- Exact Sciences Corporation
Endometrial Cancer, Endometrial Hyperplasia With Atypia
Endometrial Changes in Breast Cancer Women.
This is a prospective observational multicentric study. The aim is to evaluate the incidence of endometrial cancer and endometrial atypical hyperplasia in patients with previous breast cancer, treated with different adjuvant…
- Conditions
- Endometrial Cancer, Endometrial Hyperplasia With Atypia, Breast Cancer, TAM
- Trial name
- NCT05717634
- Testing
- Hysteroscopy
- Where
- Italy
- Volunteers
- 829 people, healthy volunteers welcome
- Sponsor
- Regina Elena Cancer Institute
Endometrial Hyperplasia Without Atypia
Vaginal Micronized Progesterone Versus Levonorgestrel for Treatment of Non-atypical Endometrial Hyperplasia
The purpose of this study is to compare the efficacy of the vaginal micronized progesterone and Levonorgestrel-releasing Intrauterine System for treatment of non-atypical endometrial hyperplasia in premenopausal women.
- Trial name
- NCT03992937
- Testing
- Vaginal Micronized Progesterone, Levonorgestrel-Intrauterine System
- Where
- Turkey (Türkiye)
- Volunteers
- 132 people
- Sponsor
- Kocaeli University
Contraception, Menorrhagia
Mirena Observational Program
Mirena is used for long-term in Kazakhstan, and in our observational program we would like to study patients distribution per indications of Mirena, and also patient compliance within a year after Mirena insertion.
- Conditions
- Contraception, Menorrhagia, Endometrial Hyperplasia, Estrogen Replacement Therapy
- Trial name
- NCT00883662
- Testing
- Levonorgestrel (Mirena, BAY86-5028)
- Where
- Kazakhstan
- Volunteers
- 2,725 people
- Sponsor
- Bayer
Endometrial Hyperplasia, Endometrial Hyperplasia Without Atypia
Metformin for the Treatment of Endometrial Hyperplasia
The purpose of this study is to see if metformin will be effective in making endometrial hyperplasia without atypia better by returning the tissue to a normal state.
- Trial name
- NCT01685762
- Testing
- Metformin
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Cancer Risk, Cancer Predisposition Syndrome
InAdvance: Surveillance, Prevention, and Interception in a Population at Risk for Cancer
This research study is creating a way to collect and store specimens and information from participants who may be at an increased risk of developing cancer, or has been diagnosed with an early phase of a cancer or a family member…
- Conditions
- Cancer Risk, Cancer Predisposition Syndrome, Hereditary Cancer Prediction, Childhood Cancer Survivors
- Trial name
- NCT05463796
- Testing
- Samples
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Dana-Farber Cancer Institute
Endometrial Hyperplasia, Endometrial Diseases
Topical Lidocaine vs. Traditional Management in Manual Vacuum Aspiration Pain Management.
The main objective of this study is to evaluate the effect of lidocaine versus placebo according to the visual analog pain scale, during manual uterine aspiration in patients with endometrial thickening, by means of a…
- Trial name
- ENDOLID (NCT06784024)
- Testing
- Lidocaine topical, Saline solution
- Where
- Honduras
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Ricardo A Gutierrez Ramirez, MD, MSc, FACOG
Endometrial Hyperplasia, Osteoporosis
Study Evaluating Safety and Efficacy of Bazedoxifene/Conjugated Estrogens Combinations in Postmenopausal Women
The purpose of this study is to determine whether bazedoxifene/conjugated estrogens combinations are effective for the prevention of endometrial hyperplasia and for the prevention of osteoporosis in postmenopausal women.
- Trial name
- NCT00675688
- Testing
- Bazedoxifene/Conjugate Estrogens (CE), Raloxifene
- Volunteers
- 3,544 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Endometrial Atypical Hyperplasia/Endometrioid Intraepithelial Neoplasia, Endometrial Carcinoma
Megestrol Acetate Compared With Megestrol Acetate and Metformin to Prevent Endometrial Cancer
This phase II trial studies the effect of megestrol acetate alone or in combination with metformin in preventing the progression of uterine pre-cancer (endometrial intraepithelial neoplasia) to endometrial cancer.
- Trial name
- NCT04576104
- Testing
- Biopsy Procedure, Extended Release Metformin Hydrochloride, Megestrol Acetate
- Where
- 8 sites in United States
- Volunteers
- 51 people
- Sponsor
- Northwestern University
Infertility, Female, Endometrial Hyperplasia
Office Hysteroscopy in Infertility Work-out: the Role of Endometrial Hyperplasia in Southern Italian Women
To assess the prevalence of endometrial hyperplasia (EH), endometrial intraepithelial neoplasia (EIN) and endometrial carcinoma between obese and not obese women undergoing IVF techniques for primary or secondary infertility.
- Conditions
- Infertility, Female, Endometrial Hyperplasia, PCOS
- Trial name
- NCT03965585
- Testing
- in-office hysteroscopy
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Campania Luigi Vanvitelli
Endometrial Cancer, Atypical Endometrial Hyperplasia
Value of LNG-IUS as Fertility-preserving Treatment of EAH and EC
Primary end points: This clinical trial is aimed to analyze the effectiveness of Levonorgestrel-Releasing Intrauterine System (LNG-IUS, Mirena®) in the fertility-sparing treatment of atypical endometrial hyperplasia and early…
- Trial name
- NCT03463252
- Testing
- Progesterone, Mirena®, GnRH agonist
- Where
- China
- Volunteers
- 224 people
- Sponsor
- West China Second University Hospital
Postmenopausal Bleeding, Endometrial Cancer
Assessing the Benefit of Pipelle Biopsy in Patients With Postmenopausal Bleeding and an Atrophic-appearing Cavity
Postmenopausal bleeding (PMB) is the occurrence of vaginal bleeding 12 months following a woman's last menstrual cycle. PMB represents one of the most common reasons for referral to gynaecology services.
- Conditions
- Postmenopausal Bleeding, Endometrial Cancer, Endometrial Hyperplasia
- Trial name
- NCT05378152
- Testing
- Pipelle biopsy catheter
- Where
- Ireland
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Royal College of Surgeons, Ireland
Complex Endometrial Hyperplasia With Atypia, Grade 1 Endometrial Endometrioid Adenocarcinoma
Improving the Treatment for Women With Early Stage Cancer of the Uterus
Currently the standard treatment for early stage endometrial cancer or endometrial hyperplasia with atypia is a total hysterectomy (an operation to remove the uterus) and removal of both ovaries.
- Trial name
- feMMe (NCT01686126)
- Testing
- Levonorgestrel, Metformin
- Where
- 17 sites in Australia, New Zealand
- Volunteers
- 165 people
- Sponsor
- Queensland Centre for Gynaecological Cancer