Clinical trials: Endometrial Neoplasm Malignant Stage I
Endometrial Cancer Stage I, Mmr Deficiency
SATELLITE Study (feaSibility sAfeTy Efficacy dostarLimab earLy-stage defIcient endomeTrial cancEr)
The main goal of this clinical trial is to evaluate dostarlimab, an immunotherapy drug, as a potential alternative to surgery for early-stage endometrial cancer with Mismatch Repair deficiency, a genetic cause for 20-30% of…
- Conditions
- Endometrial Cancer Stage I, Mmr Deficiency, Endometrioid Endometrial Adenocarcinoma, Immune-related Adverse Event
- Trial name
- SATELLITE (NCT06278857)
- Testing
- Dostarlimab-Gxly 50 MG/1 ML Intravenous Solution [JEMPERLI]
- Where
- 3 sites in Australia
- Volunteers
- 10 people
- Sponsor
- Queensland Centre for Gynaecological Cancer
Endometrial Carcinoma Stage I, Atypical Endometrial Hyperplasia
Patient-derived Tumor-like Cell Clusters Predict Progesterone Sensitivity in Patients With Early Endometrial Cancer
To construct a prediction model of progesterone sensitivity in patients with endometrial cancer treated with fertility preservation
- Trial name
- NCT05647109
- Testing
- No intervention
- Where
- China
- Volunteers
- 244 people
- Sponsor
- Peking University People's Hospital
Cervical Carcinoma, Endometrioid Adenocarcinoma
Testing AZD1775 inC Combination With Radiotherapy and Chemotherapy in Cervical, Upper Vaginal and Uterine Cancers
This phase I trial studies the side effects and best dose of adavosertib when given together with external beam radiation therapy and cisplatin in treating patients with cervical, vaginal, or uterine cancer.
- Conditions
- Cervical Carcinoma, Endometrioid Adenocarcinoma, Malignant Female Reproductive System Neoplasm, Recurrent Cervical Carcinoma
- Trial name
- NCT03345784
- Testing
- Adavosertib, Cisplatin, External Beam Radiation Therapy
- Where
- 8 sites in United States, Canada
- Volunteers
- 10 people
- Sponsor
- National Cancer Institute (NCI)
Endometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma
Short Course Vaginal Cuff Brachytherapy in Treating Participants With Stage I-II Endometrial Cancer
This randomized phase III trial studies short course vaginal cuff brachytherapy to see how well it works compared with standard of care vaginal cuff brachytherapy in treating participants with stage I-II endometrial cancer.
- Conditions
- Endometrial Clear Cell Adenocarcinoma, Endometrial Endometrioid Adenocarcinoma, Endometrial Serous Adenocarcinoma, Stage I Uterine Corpus Cancer
- Trial name
- SAVE (NCT03422198)
- Testing
- Vaginal Cuff Brachytherapy, Short course vaginal cuff brachytherapy
- Where
- 5 sites in United States
- Volunteers
- 188 people
- Sponsor
- University of Utah
Endometrial Cancer
Radiation or Observation Only in Endometrial Cancer Who Have Undergone Surgery
RATIONALE: Radiation therapy uses high-energy x-rays to damage cancer cells. It is not yet known whether radiation therapy is more effective than observation only after sugery in treating endometrial cancer.
- Trial name
- NCT00002807
- Testing
- radiation therapy
- Where
- 25 sites in United States, Australia and 1 more
- Volunteers
- 116 people
- Sponsor
- NCIC Clinical Trials Group
Cervical Cancer, Endometrial Cancer
Pelvic Drains After Radical Hysterectomy in Treating Patients With Uterine, Cervical, or Vaginal Cancer
RATIONALE: The use of pelvic drains may help to prevent complications following radical hysterectomy and pelvic lymphadenectomy.
- Conditions
- Cervical Cancer, Endometrial Cancer, Infection, Perioperative/Postoperative Complications
- Trial name
- NCT00003267
- Testing
- infection prophylaxis and management, management of therapy complications, surgical procedure
- Where
- 18 sites in Austria, Belgium and 6 more
- Volunteers
- 214 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Endometrial Cancer
Exercise and Healthy Diet or Standard Care in Patients in Remission From Stage I or Stage II Endometrial Cancer
RATIONALE: Participating in a diet and exercise program may improve the quality of life of overweight and obese patients who are in remission from endometrial cancer.
- Trial name
- NCT00732173
- Testing
- behavioral dietary intervention, exercise intervention, counseling intervention
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Case Comprehensive Cancer Center
Cancer
A Phase I, Open-Label, First-Time-In-Human Study of the Oral AKT Inhibitor GSK2141795
This study is a first time in human, Phase I, open-label, dose-escalation study of the oral AKT inhibitor GSK2141795 in subjects with solid tumors or lymphomas.
- Trial name
- NCT00920257
- Testing
- GSK2141795
- Where
- 7 sites in United States, Canada
- Volunteers
- 77 people
- Sponsor
- GlaxoSmithKline
Stage I Endometrial Adenocarcinoma, Uterine Cancer
Assisted Exercise in Obese Endometrial Cancer Patients
This is an assisted exercise trial involving exercise on a stationary bike, brain imaging and DNA(genetics)sampling. The purpose of this study is to find out if performing a progressive, supervised assisted exercise program on a…
- Conditions
- Stage I Endometrial Adenocarcinoma, Uterine Cancer, Obesity
- Trial name
- NCT01870947
- Testing
- Exercise on stationary recumbent exercise cycle, Health Education, Questionnaires
- Where
- 2 sites in United States
- Volunteers
- 95 people
- Sponsor
- Case Comprehensive Cancer Center
Endometrial Cancer Stage I, Endometrial Cancer Stage II
PROfiling Based Endometrial Cancer Adjuvant Therapy
This is a prospective, multicenter, randomized phase III trial among women with endometrioid adenocarcinoma with high-intermediate and intermediate risk features to investigate the role of integrated genomic-pathologic…
- Trial name
- PROBEAT (NCT05179447)
- Testing
- Vaginal brachytherapy, External beam radiotherapy, Observation
- Where
- 10 sites in China
- Volunteers
- 590 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Endometrial Neoplasm Malignant Stage I
Megestrol Acetate Plus LNG-IUS in Young Women With Early Endometrial Cancer
To see if megestrol acetate plus Levonorgestrel-releasing intrauterine system (LNG-IUS) will not be inferior to returning the endometrial tissue to a normal state than megestrol acetate alone in patients with early endometrial…
- Trial name
- NCT03241914
- Testing
- Megestrol Acetate, Levonorgestrel-releasing Intrauterine System(LNG-IUS)
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Fudan University
Cancer
PV701 in Treating Patients With Advanced or Recurrent Peritoneal Cancer
RATIONALE: PV701 may be able to kill tumor cells while leaving normal cells undamaged. PURPOSE: Phase I trial to study the effectiveness of PV701 in treating patients who have advanced or recurrent ovarian epithelial, fallopian…
- Trial name
- NCT00055705
- Testing
- PV701
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Endometrial Cancer
Papillary Serous Carcinoma of the Endometrium
Primary Objectives: To evaluate the results of Paclitaxel and pelvic radiation in pelvic confined papillary serous carcinoma of the endometrium for both local control and overall survival.
- Trial name
- NCT00515073
- Testing
- Paclitaxel, Pelvic Radiation, Dexamethasone
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- M.D. Anderson Cancer Center
Endometrial Carcinoma, Endometrial Carcinoma Stage III
GYNORYLAQ™-VLINIVAL™: Ψ-Guided Personalized Neoantigen Peptide Vaccine for High-Risk Endometrial Cancer
GYNORYLAQ-VLINIVAL is an Early Phase I, non-randomized, single-arm, open-label clinical trial enrolling 40 patients with high-risk or recurrent endometrial carcinoma.
- Trial name
- GYNORYLAQ™ (NCT07316361)
- Testing
- • Biological: GYNORYLAQ-TM Personalized Neoantigenic Peptide Vaccine
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- Biogenea Pharmaceuticals Ltd.
Neoplasm Malignant
A Study of STRO-002 in Chinese Adults With Epithelial Ovarian Cancer and Other Advanced Malignant Solid Tumors
This is a multi-center, open-label, monotherapy dose escalation, PK bridging, and dose expansion Phase I/IIa study in Chinese adult subjects to evaluate the safety, tolerability, Pharmacokinetics (PK) profiles, immunogenicity…
- Trial name
- NCT06238687
- Testing
- STRO-002
- Where
- China
- Volunteers
- 19 people
- Sponsor
- Tasly Pharmaceutical Group Co., Ltd
Endometrial Cancer Stage I, Endometrial Cancer Stage II
PORTEC-4a: Molecular Profile-based Versus Standard Adjuvant Radiotherapy in Endometrial Cancer
This is prospective, multicenter, randomised phase III trial among women with endometrial cancer with high-intermediate risk features to investigate the role of an integrated clinicopathological and molecular risk profile to…
- Trial name
- PORTEC-4a (NCT03469674)
- Testing
- Vaginal brachytherapy, External beam radiotherapy, Observation
- Where
- 31 sites in Austria, Belgium and 6 more
- Volunteers
- 550 people
- Sponsor
- Leiden University Medical Center
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
Web-based Lifestyle Program, mHealth and EMA Intervention, to Improve Weight Loss in Rural Stage I-III Postmenopausal Breast and Endometrial Cancer Survivors, HERO-C Trial
This clinical trial identifies the needs and preferences of rural stage I-III postmenopausal breast and endometrial cancer survivors and evaluates the impact of an adaptive, online program, mobile (m)Health + ecological momentary…
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8, Endometrial Carcinoma
- Trial name
- NCT07723235
- Testing
- Aerobic Exercise, Biospecimen Collection, Dietary Intervention
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Cervical Cancer, Endometrial Cancer
Docetaxel in Treating Patients With Refractory or Recurrent Advanced Gynecologic Cancer
RATIONALE: Drugs used in chemotherapy, such as docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Cervical Cancer, Endometrial Cancer, Fallopian Tube Cancer, Ovarian Cancer
- Trial name
- NCT00287885
- Testing
- docetaxel
- Volunteers
- 18 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Leiomyosarcoma, Liposarcoma
MASCT-I Combined With Doxorubicin and Ifosfamide for First-line Treatment of Advanced Soft Tissue Sarcoma
This study will evaluate the safety and efficacy of MASCT-I combined with Doxorubicin and Ifosfamide for first-line treatment in patients with advanced soft tissue sarcoma.
- Conditions
- Leiomyosarcoma, Liposarcoma, Synovial Sarcoma, Angiosarcoma
- Trial name
- NCT06277154
- Testing
- MASCT-I, Doxorubicin, Ifosfamide
- Where
- China
- Volunteers
- 148 people
- Sponsor
- HRYZ Biotech Co.
Endometrial Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma
Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Stage III or Stage IV Endometrial Cancer
Phase I trial to study the effectiveness of combination chemotherapy plus radiation therapy in treating women who have stage III or stage IV endometrial cancer.
- Conditions
- Endometrial Adenocarcinoma, Endometrial Clear Cell Adenocarcinoma, Endometrial Serous Adenocarcinoma, Stage III Uterine Corpus Cancer
- Trial name
- NCT00005830
- Testing
- Doxorubicin Hydrochloride, Cisplatin, Radiation Therapy
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Gynecologic Oncology Group