Clinical trials: Endometrial Receptivity
Embryo Implantation
Assessment of Endometrial Receptivity in Recipients of Donated Oocytes
The purpose of this study is to determine whether endometrial receptivity markers obtained by endometrial sampling are effective in prediction of in vivo human embryo implantation.
- Trial name
- ERPOD (NCT00506480)
- Testing
- endometrial sampling
- Volunteers
- 100 people
- Sponsor
- Hadassah Medical Organization
Pregnancy Loss, Miscarriage
Implantation Test for Endometrial Receptivity
Background Miscarriage is the most frequent complication of pregnancy and represents the spontaneous loss of the embryo or foetus before it is able to survive independently (24 weeks of gestation).
- Trial name
- NCT03442335
- Testing
- Chromohysteroscopy, Endometrial biopsy (Pipelle)
- Where
- 6 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Birmingham
Embryo Implantation
Effect of Dilatation and Curettage on the Endometrial Receptivity
Effect of dilatation and curettage on the endometrial receptivity and pregnancy outcome in patients with recurrent implantation failure
- Trial name
- NCT03485235
- Testing
- D&C, ICSI
- Where
- Egypt
- Volunteers
- 160 people
- Sponsor
- Ain Shams University
Assisted Reproductive Technology, Ultrasonography
Evaluating the Endometrial Receptivity of FET Patient by Ultrasounicelastography
Prospective clinical study ：observing the correlation between endometrial elasticity score, endometrial blood flow index (PI, RI, S/D, endometrial thickness, morphology) and clinical pregnancy rate.
- Trial name
- NCT03881072
- Testing
- Ultrasounicelastography
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Jinling Hospital, China
Endometriosis, Uterine Diseases
SIRT-1 Antagonism for Endometrial Receptivity
Progesterone resistance is mediated through epigenetic modification through SirT1 activation and is thought to contribute to infertility and progression of endometriosis.
- Conditions
- Endometriosis, Uterine Diseases, Endometrial Diseases, Infertility Unexplained
- Trial name
- SAFER (NCT04184323)
- Testing
- EX-527 (Selisistat)
- Where
- United States
- Sponsor
- Wake Forest University Health Sciences
Infertility
Vitamin D and Endometrial Receptivity in Infertile Women
This is a prospective study comparing vaginal and endometrial biomarkers and the trophoblast spheroid attachment rate in women with fertility problems before and after taking Vitamin D for 8 weeks.
- Trial name
- NCT04721899
- Testing
- Vitamin D
- Where
- Hong Kong
- Volunteers
- 105 people
- Sponsor
- The University of Hong Kong
Embryo Implantation, ART
The Impact of Endometrial Compaction on Assisted Reproductive Technology Outcome
Absence of endometrial compaction on the day of ET has adverse effects on success of ART outcome.
- Trial name
- NCT04721522
- Testing
- blood sampling & ultrasound
- Where
- Egypt
- Volunteers
- 356 people
- Sponsor
- Zagazig University
Implantation Rate
Effect of Local Injury on Implantation
Local injury on two sights of endometrium are performed in 60 patients in their first IVF cycle and implantation rate are compared with fresh cycles without local injury.
- Trial name
- NCT00846183
- Testing
- local injury
- Where
- Iran
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Yazd Research & Clinical Center for Infertility
Infertility, Female, Infertility Unexplained
Pro-inflammatory Cytokines and Implantation Process in Women With Primary Idiopathic Infertility
Infertility is a common, worldwide problem. In about 20% of couples, the causative agent of infertility cannot be identified after routine diagnostic tests.
- Conditions
- Infertility, Female, Infertility Unexplained, Inflammatory Response
- Trial name
- NCT05190250
- Testing
- Pipelle biopsy
- Where
- Poland
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Jagiellonian University
Recurrent Implantation Failure (RIF)
Management of Recurrent Implantation Failure
This is the first study to investigate, whether pregnancy and implantation rates would improve in patients with recurrent implantation failure (RIF), if all embryos were to be frozen and transferred in a consecutive natural cycle.
- Trial name
- RIF (NCT02681367)
- Testing
- Freeze all policy
- Volunteers
- 200 people
- Sponsor
- TopLab Company for ART Laboratories Consultation and Training
Infertile Patients
the Effect of Hyaluronic Acid Intrauterine Wash on Endometrial Receptivity and Pregnancy Outcome
Hyaluronic acid intrauterine wash is done for infertile females undergoing intracytoplasmic sperm injection on the day of oocyte retrieval.
- Trial name
- NCT06937645
- Testing
- Hyaluronic Acid (HA), platlet rich plasma (PRP)
- Where
- Iraq
- Volunteers
- 120 people
- Sponsor
- Al-Nahrain University
RIF , Endometrial Receptivity
Endometrial Receptivity in Patients With Recurrent Implantation Failure as a Preparatory Step for PET
clinical trial to improve pregnancy outcome in patient with RLF , study done on 2 phases. phase 1 to study variations of endometrial receptivity genes in this group of patient, phase 2 repeat cycle or transfer frozen embryo in…
- Trial name
- NCT03361839
- Testing
- endometrial biopsy
- Volunteers
- 60 people
- Sponsor
- Cairo University
Infertility
Diagnostic Test for Endometrial Receptivity 24 Hours Before Embryo Transfer
This clinical validation study is being carried out to validate the efficacy of a test measuring the clinical application of prostaglandins present in the endometrial fluid in patients, 24 hours before the embryonic transfer.
- Trial name
- NCT02189369
- Testing
- Day 3 embryo transfer, Day 5 embryo transfer
- Where
- 2 sites in Spain
- Volunteers
- 120 people
- Sponsor
- Igenomix
Endometrial Receptivity
Modification of Endometrial Receptivity After Vaginal Seminal Plasma Application
The aim of the project is to investigate the effect of seminal plasma on the endometrium and to evaluate changes in the endometrial receptivity after exposure to seminal plasma.
- Trial name
- NCT04286425
- Testing
- seminal plasma, saline solution
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Infertility
Effect of Low Level Laser Therapy on Endometrial Cells: An In Vitro Study
The human endometrium is an extremely sensitive target. LLLT can enhance the proliferation rate of various cell lines, it produces higher rates of ATP, RNA, and DNA synthesis in stem cells and other cell lines.
- Trial name
- LLLT (NCT02764034)
- Testing
- Low level Laser diode machine
- Where
- Egypt
- Sponsor
- Cairo University
Progesterone Resistance
Step Down FSH Approach and Late Follicular Phase in Progesterone Level
Step-down approach and late follicular phase progesterone level
- Trial name
- FSH (NCT03356964)
- Testing
- follicle stimulating hormone
- Where
- United Arab Emirates
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Infertility
REFRESH: Receptivity Enhancement by Follicular-phase Renewal After Endometrial ScratcHing
A randomised controlled open-label clinical trial to assess the effect of artificially induced endometrial injury and repair during ovarian stimulation on the clinical pregnancy rate of an antagonist downregulated in-vitro…
- Trial name
- REFRESH (NCT02061228)
- Testing
- Pipelle de Cornier®
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- Universitair Ziekenhuis Brussel
Infertility of Uterine Origin
Clinical Study of PGT-A Versus PGT-A+ERA
Patients who have shown previous implantation failures, despite transferring good quality and chromosomally normal embryos (diagnosed by PGT-A), could have a displaced Window of Implantation (WOI) and consequently, alterations in…
- Trial name
- PGT-A&ERA (NCT03530254)
- Testing
- PGT-A, ERA Test
- Where
- 15 sites in United States, Argentina and 10 more
- Volunteers
- 368 people
- Sponsor
- Igenomix
Subfertility
BAP-EB as a Predictive Tool for Endometrial Receptivity and Pregnancy Outcome of IVF Treatment
To determine the predictive value of attachment rate of human embryonic stem cells (hESC)-derived trophoblast spheroids (BAP-EB, embryo surrogate) onto endometrial epithelial cells (EEC) on success of IVF treatment and to use the…
- Trial name
- NCT02713854
- Testing
- endometrial biopsy
- Where
- China
- Volunteers
- 240 people
- Sponsor
- The University of Hong Kong
Female Infertility
Effects of Intrauterine Flushing With Human Chorionic Gonadotropin on ICSI Outcome
a number of infertile women who were prepared for ICSI and immediately post ova pick up intrauterine flushing with human chorionic gonadotropin was done to study the effect of this drug on ICSI outcome and ultrasound parameter.
- Trial name
- NCT06684951
- Testing
- hCG
- Where
- Iraq
- Volunteers
- 90 people
- Sponsor
- Omayma Ismail Khalaf