Clinical trials: Endometrial Receptivity Diagnosis
Infertility
Comparison of Transfers of Fresh and Thawed Embryos in Normal Responder Patients
This study tests the hypothesis that controlled ovarian stimulation impairs endometrial receptivity in normal responders.
- Trial name
- NCT00963625
- Testing
- Embryo cryopreservation, Fresh blastocyst transfer
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fertility Center of Las Vegas
IVF, Infertility Treatment
Biomarkers of Endometrial Receptivity
Analysis of proteins from cervical mucus will be done in patients undergoing infertility treatment (fresh or frozen embryo transfer). Cervical mucus will be analysed for potential new biomarkers of endometrium receptivity.
- Conditions
- IVF, Infertility Treatment, Fertility Disorders, Embryo Transfer
- Trial name
- BIOMER (NCT04619524)
- Testing
- Cervical mucus will be collected from patients undergoing IVF, Cervical mucus will be collected from patients undergoing transfer of cryopreserved embryos
- Where
- 3 sites in Czechia
- Volunteers
- 476 people
- Sponsor
- The Institute of Molecular and Translational Medicine, Czech Republic
Recurrent Implantation Failure, Endometrial Receptivity Disorders
Experimental Study on the Use of Intrauterine Infusion of Autologous Platelet-rich Plasma (PRGF-IUI) in Patients With Recurrent Implantation Failure and/or Refractory Thin Endometrium
Endometrial receptivity is a key determinant of success in assisted reproductive technology (ART). A significant proportion of patients experience repeated implantation failure despite euploid embryos and adequate laboratory…
- Conditions
- Recurrent Implantation Failure, Endometrial Receptivity Disorders, Embryo Implantation, Platelet-Rich Plasma
- Trial name
- PMA_PREPAIRE (NCT07455773)
- Testing
- Intrauterine Platelet-Rich Plasma (PRP) Infusion, Hormone Replacement Therapy (HRT)
- Volunteers
- 80 people
- Sponsor
- Azienda Sanitaria Locale di Asti
Pregnancy Loss, Miscarriage
Implantation Test for Endometrial Receptivity
Background Miscarriage is the most frequent complication of pregnancy and represents the spontaneous loss of the embryo or foetus before it is able to survive independently (24 weeks of gestation).
- Trial name
- NCT03442335
- Testing
- Chromohysteroscopy, Endometrial biopsy (Pipelle)
- Where
- 6 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Birmingham
Repetitive Implantation Failure
ERA Test in Patients With Recurrent Implantation Failure
The purpose of this study is to demonstrate the clinical efficiency of the Endometrial Receptivity Array (ERA) diagnostic tool in patients with repetitive implantation failure (RIF), leading to the new concept of the personalized…
- Trial name
- ERA (NCT01668693)
- Testing
- ERA (Endometrial Receptivity Array), Personalized Embryo Transfer, Second ERA
- Where
- Spain
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Igenomix
Ovarian Hyperstimulation Syndrome
Endometrial Receptivity After GnRH Agonist Triggering
Conventional luteal phase support after human chorionic gonadotrophin (hCG) triggering in women undergoing in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) provides adequate pregnancy rates and live birth rates…
- Trial name
- ERAMAD (NCT01500863)
- Testing
- hCG, triptorelin, Triptorelin, estradiol valerate, micronized vaginal progesterone
- Where
- Spain
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- IVI Madrid
Infertility
Endometrial Curettage Before Embryo Transfer
Studies have shown that endometrial sampling in the month prior to embryo transfer may increase pregnancy rates. We wish to test this hypothesis by performing a hysteroscopy and curettage in the month proceeding embryo transfer…
- Trial name
- NCT00367367
- Testing
- Hysteroscopy and Curettage
- Where
- Israel
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Infertility
Effect of Low Level Laser Therapy on Endometrial Cells: An In Vitro Study
The human endometrium is an extremely sensitive target. LLLT can enhance the proliferation rate of various cell lines, it produces higher rates of ATP, RNA, and DNA synthesis in stem cells and other cell lines.
- Trial name
- LLLT (NCT02764034)
- Testing
- Low level Laser diode machine
- Where
- Egypt
- Sponsor
- Cairo University
Chronic Endometritis
Diagnosis of Chronic Endometritis in Endometrial Fluid Using Molecular Techniques to Improve the Outcomes of Assisted Reproductive Treatments
Chronic endometritis (CE) is a persistent inflammation of the endometrial lining caused by the infection of the uterine cavity mainly by bacterial pathogens.
- Trial name
- ChEndometritis (NCT03169621)
- Testing
- Endometrial Biopsy and endometrial fluid collection
- Where
- Spain
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Igenomix
Recurrent Implantation Failure, Infertility
Comparing FET Guided by ERA Vs Standard Timing in Patients with Recurrent Implantation Failure
The pregnancy rate of in vitro fertilisation (IVF) remains around 35% per transfer. Women who are not pregnant following several embryo transfers are regarded as having recurrent implantation failure (RIF), with one of the causes…
- Trial name
- NCT06762626
- Testing
- Frozen embryo transfer according to endometrial receptivity analysis result
- Where
- China
- Volunteers
- 734 people
- Sponsor
- The University of Hong Kong
Endometrial Receptivity Failure
Non Invasive Diagnostic of Endometrial Receptivity
The purpose of this study is to determine a lipidomic profile on the endometrial fluid, that can predict endometrial receptivity.
- Trial name
- NCT01588223
- Testing
- Lipid identification
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Igenomix
Infertility
Comparison of Transfers of Fresh and Thawed Embryos in High Responder Patients
This study tests the hypothesis that controlled ovarian stimulation impairs endometrial receptivity in high responders.
- Trial name
- NCT00963079
- Testing
- Embryo cryopreservation, Fresh blastocyst transfer
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fertility Center of Las Vegas
Infertility
Effect of Anticoagulant Therapy on Endometrial Receptivity and Pregnancy Outcomes in Infertility
The purpose of this prospective observational cohort study is to evaluate the effect of routine clinical anticoagulant therapy on endometrial receptivity and subsequent pregnancy outcomes in women with infertility.
- Trial name
- NCT07494877
- Testing
- Routine Anticoagulant Therapy (Aspirin or Heparin Sodium)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Tang-Du Hospital
Endometrial Hyperplasia Without Atypia, Endometrial Hyperplasia With Atypia
Endometrial Tissues and Mononuclear Cells Receptivity in Pathogenesis of Endometrial Proliferative Processes
A prospective observational study of endometrial tissue and peripheral blood mononuclear cells receptivity to sex steroid hormones in postmenopausal patients with endometrial proliferative processes
- Conditions
- Endometrial Hyperplasia Without Atypia, Endometrial Hyperplasia With Atypia, Endometrial Cancer, Peripheral Blood Mononuclear Cells
- Trial name
- NCT06115577
- Testing
- endometrial tissue and peripheral blood mononuclear cells receptivity
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Pirogov Russian National Research Medical University
Infertility, Female, ENDOMETRIAL RECEPTIVITY
Impact of Different Doses and Routes of Exogenous Progesterone Administration on Endometrial Receptivity Parameters
After so many years conducting artificial endometrial preparation cycles for embryo transfer, there is no clear indication about which is the optimal dose of exogenous progesterone in this scenario to optimize the outcome.
- Trial name
- PROGENDO (NCT04499131)
- Testing
- Progesterone, Artificial Cycle (no intervention)
- Where
- Spain
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Infertility, Implantation Failure
Does Local Injury of the Endometrium Improve Controlled Ovarian Hyperstimulation (COH) + Intrauterine Insemination (IUI) Outcome?
It was previously demonstrated in in vitro fertilization (IVF) patients that local injury of the endometrium during a spontaneous menstrual cycle that precedes IVF treatment doubled the rates of implantation and pregnancy.
- Trial name
- NCT01111799
- Testing
- endometrial biopsy, natural cycle + IUI + endometrial biopsy
- Where
- Israel
- Volunteers
- 600 people
- Sponsor
- Meir Medical Center
Infertility, Female, Infertility
Phase II Clinical Trial to Evaluate the Ongoing Pregnancy Rate With OXO-001 in IVF/ICSI With Donor Oocytes.
The main objective of this clinical research trial is to test the efficacy of OXO-001 in a daily oral administration increasing the pregnancy rate in IVF/ICSI by preparing the uterus to receive the embryo.
- Trial name
- OXOART2 (NCT05076032)
- Testing
- OXO-001
- Where
- 28 sites in Czechia, Poland and 1 more
- Volunteers
- 408 people
- Sponsor
- OXOLIFE
Endometrial Cancer Stage
Investigation Of Receptivity Markers For Endometrial Cancer Treatment Development
Hyaluronan is an extracellular matrix protein that is involved in cell-cell and cell-matrix interactions. Hyaluronan performs this activity through hyaladherins, which are intracellular and extracellular receptors.
- Trial name
- NCT05914844
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Manisa Celal Bayar University
Adenomyosis of Uterus, Implantation Failure
Linzagolix in Adenomyosis and Recurrent Implantation Failure
Adenomyosis is associated with impaired endometrial receptivity and reduced implantation rates in assisted reproduction, even when using high-quality embryos.
- Conditions
- Adenomyosis of Uterus, Implantation Failure, Infertility Female, Embryo Transfer
- Trial name
- LINZA-RIF (NCT07698561)
- Testing
- Linzagolix 200 mg (Yselty)
- Where
- 3 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Vida Fertility Institute
Infertility of Uterine Origin, Implantation Failure
International Non-selection Study for ERA® Test in Patients With Previous Implantation Failures
Women´s period comprises different hormonal stages, being one of them the stage for maximum receptivity and proper embryo implantation.
- Trial name
- NCT06097559
- Testing
- Endometrial fluid and biopsy collection
- Where
- 8 sites in Argentina, Panama and 2 more
- Volunteers
- 738 people, healthy volunteers welcome
- Sponsor
- Igenomix