Clinical trials: Endometriosis
Endometriosis
Effects of Aerobic Exercise and Core Muscle Strengthening on Pain, Menstrual Pattern and QOL in Endometriosis
Endometriosis is a complex and debilitating gynecological condition affecting millions of women worldwide. It is characterized by the abnormal growth of endometrial-like tissue outside the uterus, leading to chronic pelvic pain…
- Trial name
- NCT06241040
- Testing
- Aerobic Exercises with core Muscle strengthening, Aerobic Exercise without Core Muscle Strengthening
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Riphah International University
Endometriosis
Improving Access to Pelvic Health Physiotherapy for Endometriosis
This is a mixed-methods study aimed to generate new evidence to help optimize access to pelvic health physiotherapy (PHPT) for women living with endometriosis in the province of Quebec (Canada).
- Trial name
- ENDO-RM (NCT07731776)
- Where
- Canada
- Volunteers
- 264 people
- Sponsor
- Université de Sherbrooke
Endometriosis
Comparison Between the Effects of Implantable Gestrinone and Oral Dienogest in the Treatment of Endometriosis
This study aims to evaluate the effects of therapy with implantable Gestrinone compared to oral Dienogest in relieving complaints related to endometriosis.
- Trial name
- NCT06543550
- Testing
- Implantable gestrinone, Oral Dienogest
- Where
- 4 sites in Brazil
- Volunteers
- 70 people
- Sponsor
- Bio Meds Pharmaceutica Ltda
Prostate Cancer, Endometriosis
A Phase 1 Study to Evaluate the Effects of Fluconazole and Atorvastatin on the Pharmacokinetics of TAK-385 in Healthy Subjects
This is a nonrandomized, open-label, fixed-sequence, 2-arm study designed to assess the effect of multiple doses of fluconazole or atorvastatin on the single-dose pharmacokinetics of TAK-385 in healthy adult subjects.
- Trial name
- NCT02093390
- Testing
- TAK-385, Fluconazole, Atorvastatin
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Millennium Pharmaceuticals, Inc.
Endometriosis
Extension to Study on Efficacy and Safety of Linzagolix for the Treatment of Endometriosis-associated Pain (EDELWEISS 6)
The primary objective of this extension study is to assess the maintenance of efficacy of linzagolix administered orally once daily for up to an additional 6 months (for up to 12 months of treatment in total) in women who have…
- Trial name
- NCT04335591
- Testing
- 75 mg linzagolix tablet, 200 mg linzagolix tablet, Add-back capsule (E2 1 mg / NETA 0.5 mg)
- Where
- 47 sites in United States, Austria and 7 more
- Volunteers
- 356 people
- Sponsor
- Kissei Pharmaceutical Co., Ltd.
Endometriosis
Work Ability-Productivity Among Clinical Health Workers Endometriosis Study
A qualitative multicentre study protocol. The prospective research explores clinical health workers with a diagnosis of endometriosis, experiencing regular pain and their perceptions of work ability-productivity.
- Trial name
- Work ACHES (NCT05770843)
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Birkbeck, University of London
Endometriosis, Stem Cell Transplant
Bone Marrow Cell Engraftment of the Uterus and Genetic Studies of Reproductive Functioning
Background: Some transplant recipients have been found to have cells in their uterus that come from the donor. Researchers want to study uterine tissue from three different groups of women: (1) healthy volunteers, (2) people who…
- Conditions
- Endometriosis, Stem Cell Transplant, Healthy Volunteers
- Trial name
- NCT01468935
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Endometriosis, Bacterial Vaginosis
Effects of a Multi-strain Oral Probiotic on the Vaginal Microbiota Composition in Healthy Women and Women with Endometriosis
Endometriosis is a chronic inflammatory disease affecting approximately 10-15% of reproductive age women, and, in recent years, an association between this pathology and dysbiosis, either involving the gut or the genital…
- Conditions
- Endometriosis, Bacterial Vaginosis, Healthy Volunteer
- Trial name
- NCT06592976
- Testing
- Multi-strain Oral Probiotic (CDS22-formula)
- Where
- Italy
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Fibrin Blood Clot, Infertility, Female
Ovarian Hyperstimulation and Fibrin Clot Properties.
The impact evaluation of ovarian hyperstimulation on coagulation and fibrinolysis in infertile women. Comparative analysis between different ovarian stimulation protocols on thrombin formation and efficiency of fibrinolysis in…
- Conditions
- Fibrin Blood Clot, Infertility, Female, Endometriosis
- Trial name
- NCT04166825
- Testing
- fibrin clot properties
- Where
- Poland
- Volunteers
- 300 people
- Sponsor
- Jagiellonian University
Endometriosis, Hypofertility
Evaluation of Genetic Signature in Endometriosis Disease by Non Invasive Sampling
Endometriosis is a disease that affects 10-15% of the general population and 50% of infertile women. It is characterized by the presence of endometrial tissue outside the uterine cavity.
- Trial name
- niEndometriosi (NCT06100471)
- Testing
- Observational study
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Eurofins Genoma
Endometriosis Ovary
Impact on Ovarian Reserve According to the Type of Ovarian Endometrioma Excision: Laser Versus Conventional Cystectomy
Endometriosis is a disease characterized by the presence of endometrial tissue outside the uterus cavity, causing important chronic pain and sterility in those patients suffering from it.
- Trial name
- NCT03826355
- Testing
- CO2 (carbon dioxide) laser vaporisation, Stripping technique
- Volunteers
- 16 people
- Sponsor
- Hospital Clinic of Barcelona
Endometriosis
Clinical Trial the Use of Levonorgestrel-releasing Intrauterine System Versus Etonogestrel Implant in Endometriosis
Randomized clinical trial the use of levonorgestrel releasing intrauterine system. Objectives: To evaluate and compare the efficacy of- levonorgestrel releasing intrauterine system l(LNG-IUS) in relation to the subdermal implant…
- Trial name
- NCT02480647
- Testing
- Levonorgestrel, Etonogestrel
- Where
- Brazil
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Deep Endometriosis Stage III, Deep Endometriosis Stage IV
ENDmetriosis and Reserve Ovarienne
Endometriosis is the ectopic implantation of endometrial glands and stroma, and can be ovarian and peritoneal (superficial or deep).
- Trial name
- ENDRO (NCT02400684)
- Testing
- blood samples
- Where
- 2 sites in France
- Volunteers
- 118 people
- Sponsor
- University Hospital, Strasbourg, France
Ovarian Endometrioma
Randomized Study on Endometrioma Treatment
This is a randomised study comparing the effect of two laparoscopic techniques for treatment of ovarian endometriomas on recurrence rate and ovarian reserve.
- Trial name
- NCT00989118
- Testing
- Laser treatment of ovarian endometrioma
- Where
- Spain
- Sponsor
- Hospital Clinic of Barcelona
Endometriosis-related Pain
A Study to Evaluate the Efficacy and Safety of Gefapixant (MK-7264) in Women With Endometriosis-Related Pain (MK-7264-034)
The purpose of this study is to evaluate the efficacy, safety, and tolerability of gefapixant (MK-7264) in premenopausal female participants with moderate to severe endometriosis-related pain.
- Trial name
- NCT03654326
- Testing
- Gefapixant, Naproxen
- Where
- 78 sites in United States, Australia and 7 more
- Volunteers
- 187 people
- Sponsor
- Merck Sharp & Dohme LLC
Endometriosis
Flexofytol® for the Treatment of Endometriosis- Associated Pain
Endometriosis is a benign disease that affects 6-10% of women of reproductive age. The wide range of symptoms observed in patients with endometriosis is due to implantation of endometrial tissue outside the uterine cavity.
- Trial name
- ENDOFLEX (NCT04150406)
- Testing
- Flexofytol
- Where
- Austria
- Volunteers
- 54 people
- Sponsor
- Medical University of Vienna
Endometriosis
Study to Test the Safety of Increasing Multiple Doses of BAY2328065 Given by Mouth, How the Drug is Tolerated and Acts in the Human Body of Healthy Male Participants. Alteration of the Study Drug Effects by Another Drug and the Availability of the Drug Given in Different Formulations is Also Tested.
Study on the safety and tolerability of a new drug BAY2328065 when given increased doses as tablet or solution over 12 days to healthy male participants.
- Trial name
- NCT04027192
- Testing
- BAY2328065 LSF, BAY2328065 tablet, Midazolam
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Bayer
Breast Cancer, Colo-rectal Cancer
The French E3N Prospective Cohort Study
The French E3N cohort was initiated in 1990 to investigate the risk factors associated with cancer and other major non-communicable diseases in women.
- Conditions
- Breast Cancer, Colo-rectal Cancer, Parkinson Disease, Asthma
- Trial name
- E3N (NCT03285230)
- Where
- France
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Dysmenorrhea, Dyspareunia
Study Evaluating the Safety and Efficacy of ERB-041 on Reduction of Symptoms Associated With Endometriosis in Reproductive-Aged Women
The purpose of the study is to evaluate the efficacy and safety of two doses of ERB-041 (75 mg and 150 mg) relative to placebo on the relief of endometriosis-related symptoms (dysmenorrhea, pelvic pain, and deep dyspareunia) in…
- Conditions
- Dysmenorrhea, Dyspareunia, Endometriosis, Pelvic Pain
- Trial name
- NCT00318500
- Testing
- ERB-041
- Where
- 70 sites in United States, Australia and 5 more
- Volunteers
- 150 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Endometriosis, Endometrioma
Genomic Maps of Endometrial Tissues of Patients With Endometriosis and Healthy Controls
Endometriosis is a chronic inflammatory disease that affects 10-17% of women in childbearing age, 35-60% of women with chronic pelvic pain and can cause infertility, costing as much as 2.8 billion dollars per year.
- Trial name
- NCT03687398
- Testing
- genetic testing with nanoclonal technique
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Acibadem University