Clinical trials: Endometriosis Pelvic
Ehlers-Danlos Syndrome (EDS)
Impact of Ehlers-Danlos Syndrome on Gynaecological Health
Dysmenorrhea is a common problem in gynaecology, significantly impacting patients' quality of life. Ehlers-Danlos syndrome (EDS) is associated with joint hypermobility, tissue fragility and chronic pain.
- Trial name
- GYNESED (NCT07151274)
- Where
- France
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Endometriosis
Pelvic Endometriosis: Correlation of US and MRI With Laparoscopic Findings
Endometriosis is classically defined as the presence of endometrial glands and stroma outside the uterine cavity and its musculature. The definition of deep endometriosis is based on anatomic assumptions that may prove erroneous.
- Trial name
- NCT03860909
- Volunteers
- 30 people
- Sponsor
- Assiut University
Dysmenorrhea
Dysmenorrhea Exploration in Teenagers, Their Parents and Caregivers
Teenagers experimenting severe dysmenorrhea also face age-specific challenges, particularly impacting their self-confidence, self-esteem, and relations.
- Trial name
- DEMETER (NCT05414825)
- Testing
- focus group interview
- Where
- France
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Dysmenorrhea, Dyspareunia
Study Evaluating the Safety and Efficacy of ERB-041 on Reduction of Symptoms Associated With Endometriosis in Reproductive-Aged Women
The purpose of the study is to evaluate the efficacy and safety of two doses of ERB-041 (75 mg and 150 mg) relative to placebo on the relief of endometriosis-related symptoms (dysmenorrhea, pelvic pain, and deep dyspareunia) in…
- Conditions
- Dysmenorrhea, Dyspareunia, Endometriosis, Pelvic Pain
- Trial name
- NCT00318500
- Testing
- ERB-041
- Where
- 70 sites in United States, Australia and 5 more
- Volunteers
- 150 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Endometriosis
Study to Evaluate the Long-Term Safety and Efficacy of Elagolix in Adults With Moderate to Severe Endometriosis-Associated Pain
A randomized study evaluating the continued safety and efficacy of elagolix in the management of moderate to severe endometriosis-associated pain in pre-menopausal women.
- Trial name
- NCT01760954
- Testing
- Elagolix
- Volunteers
- 506 people
- Sponsor
- AbbVie
Endometriosis and Dysmenorrhea
Drug Use Investigation (DUI) of YazFlex for Endometriosis-associated Pelvic Pain and/or Dysmenorrhea
This study is a Japanese post-marketing surveillance (PMS) which is required by the regulatory authorities. General objective of PMS is to confirm the clinical usefulness, especially the safety profile of a drug under the routine…
- Trial name
- NCT03126747
- Testing
- BAY86-5300_YAZ-Flex
- Where
- Japan
- Volunteers
- 715 people
- Sponsor
- Bayer
Endometriosis, Endometriosis-related Pain
Conventional Laparoscopy Versus Robotic Surgery for Pain Relief in Patients With Deep Infiltrating Endometriosis
Background: Endometriosis is a common disease, affecting women in their reproductive age suffering from infertility, adnexal masses and chronic pelvic pain, obstruction of the bowel or urinary tract.
- Conditions
- Endometriosis, Endometriosis-related Pain, Endometriosis Pelvic
- Trial name
- NCT05362838
- Testing
- robotic-assisted laparoscopy, Conventional laparoscopy
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Medical University of Vienna
Endometriosis
The Role of a Mediterranean Diet in Patients With Endometriosis: a Feasibility Trial
This study aims to test if making changes to diet can affect the pelvic pain associated with endometriosis. One group will follow a Mediterranean diet for 12 weeks while the control group will continue with their current diet.
- Trial name
- MDIE (NCT05411549)
- Testing
- Diet Modification to Adopt Mediterranean Diet
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- McMaster University
Vestibulodynia, Temporomandibular Disorder
Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments
Vestibulodynia (VBD) is a complex chronic vulvar pain condition that impairs the psychological, physical, and sexual health of 1 in 6 reproductive aged women in the United States.
- Conditions
- Vestibulodynia, Temporomandibular Disorder, Fibromyalgia Syndrome, Irritable Bowel Syndrome
- Trial name
- NCT03844412
- Testing
- 5% lidocaine/5 mg/ml 0.02% estradiol compound cream, Nortriptyline
- Where
- 2 sites in United States
- Volunteers
- 209 people
- Sponsor
- Duke University
Endometriosis, Infertility Unexplained
Organic Pollutants in Pelvic Endometriosis
The health toxicity of polycyclic aromatic hydrocarbons (PAHs), present in air and food, generated during energy production and waste incineration, is well known.
- Trial name
- NCT05789407
- Testing
- Detection of PAHs in visceral fat with gas chromatography-isotope dilution mass spectrometry
- Where
- Poland
- Volunteers
- 46 people
- Sponsor
- Jagiellonian University
Endometriosis-related Pain, Endometriosis
Pelvic Neuro-Angiogenesis in Deep Endometriosis
Endometriosis is observed in one out of every ten women in society, causing endometrial cells to be found outside their normal location in the body and proliferate in other locations, leading to fibrosis in the tissue due to the…
- Conditions
- Endometriosis-related Pain, Endometriosis, Deep Endometriosis, Endometriosis; Peritoneum
- Trial name
- NCT06286371
- Testing
- Laparoscopic Endometriosis Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Uludag University
Endometriosis
Comparative Effects of Wurn Technique and Mercier Therapy in Women With Endometriosis
This project was a Randomized controlled trial conducted to check the comparative effects of wurn technique and mercier therapy on dyspareunia, dysmenorrhea, and quality of life in women with endometriosis.
- Trial name
- NCT06460376
- Testing
- Wurn Technique, Mercier Therapy
- Where
- 2 sites in Pakistan
- Volunteers
- 26 people
- Sponsor
- Riphah International University
Endometriosis Related Pain
SPIRIT 2: Efficacy and Safety Study of Relugolix in Women With Endometriosis-Associated Pain
The purpose of this study is to determine the benefit and safety of relugolix 40 milligrams (mg) once daily, co-administered with low-dose estradiol (E2) and norethindrone acetate (NETA) compared with placebo for 24 weeks, on…
- Trial name
- NCT03204331
- Testing
- Relugolix, Estradiol/norethindrone acetate
- Where
- 91 sites in United States, Australia and 9 more
- Volunteers
- 623 people
- Sponsor
- Myovant Sciences GmbH
Endometriosis, Endometriosis (Diagnosis)
Impact of the Antihistamine Desloratadine on the Quality of Life and Dysmenorrhea in Patients With Endometriosis
Endometriosis is a chronic inflammatory disease affecting approximately 10% of women in their reproductive years. It is characterized by the presence of endometrial-like tissue outside the uterine cavity.
- Conditions
- Endometriosis, Endometriosis (Diagnosis), Endometriosis and Dysmenorrhea, Endometriosis Associated Pelvic Pain
- Trial name
- NCT07821320
- Testing
- Desloratadine
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Medical University of Vienna
Cholecystitis, Endometriosis
Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery
This is a two period cross-over study randomizing patients undergoing laparoscopic surgery into 2 different groups: group 1 in which patients receive "deep neuromuscular blockade" in the beginning portion of their laparoscopic…
- Conditions
- Cholecystitis, Endometriosis, Bowel Obstruction, Fibroids
- Trial name
- NCT02812186
- Testing
- Deep to Moderate NMB, Moderate to Deep NMB, Rocuronium
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Stony Brook University
Endometriosis, Physical Inactivity
Chronic Pelvic Pain in Endometriosis
Endometriosis is a chronic, inflammatory disease affecting 10% (1 out of 10) of women of reproductive age. Pelvic pain is common among women with endometriosis.
- Conditions
- Endometriosis, Physical Inactivity, Chronic Pelvic Pain Syndrome, Quality of Life
- Trial name
- NCT05863663
- Testing
- questionnaire
- Where
- Hungary
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- University of Pecs
Endometriosis, Chronic Pain
Treatment With Radiofrequency in Patients With Chronic Pelvic Pain and History of Endometriosis
Managing chronic pelvic pain in patients with a past history of endometriosis might be a challenge for the gynaecologist. The objective of this study is to evaluate pelvic pain after treatment with radiofrequency in patients with…
- Conditions
- Endometriosis, Chronic Pain, Quality of Life
- Trial name
- NCT04012034
- Testing
- Radiofrequency A, Radiofrequency B
- Where
- 2 sites in Spain
- Volunteers
- 26 people
- Sponsor
- Hospital Clinic of Barcelona
Pelvic Pain, Endometriosis
Glycemic Regulation as Endometriosis Adjunct Treatment
The goal of this pilot trial is to learn if a novel non-hormonal treatment, metformin hydrochloride, works to treat pelvic pain in young women with endometriosis.
- Trial name
- GREAT (NCT06611501)
- Testing
- Metformin Hydrochloride
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Boston Children's Hospital
Endometriosis, Adhesion
Ovariopexy for Adhesion Prevention After Laparoscopic Removal of Endometriosis of the Pelvic Side Wall or the Ovary
prospective randomized Trial comparing ovariopexy over 2, 4 or 6 days vs Placebo after surgery because of endometriosis of the pelvic side wall or the ovary or both
- Conditions
- Endometriosis, Adhesion, Surgery
- Trial name
- NCT04669756
- Testing
- ovariopexy
- Where
- Germany
- Volunteers
- 409 people
- Sponsor
- University Hospital Muenster
Dysmenorrhea
Efficacy and Safety, Long-Term Study of NPC-01 to Treat Dysmenorrhea Associated With Endometriosis
The purpose of this long-term study is to determine whether NPC-01 is effective in the treatment of dysmenorrhea associated with endometriosis.
- Trial name
- NCT00902746
- Testing
- NPC-01
- Volunteers
- 149 people
- Sponsor
- Nobelpharma