Clinical trials: Endomicroscopy
Hepatocarcinoma, Hepatic Metastasis
Robotic Endomicroscopy to Better Define Resection Strategies Applied to Hepatic Surgery
This study aims at assessing the feasibility of Probe-based Confocal Laser Endomicroscopy (pCLE) during laparoscopic hepatic masses resection for intra-operative characterisation of hepatic masses and surgical margins assessment.
- Conditions
- Hepatocarcinoma, Hepatic Metastasis, Hepatic Tumor
- Trial name
- PERSEE (NCT03718078)
- Testing
- Confocal Laser Endomicroscopy
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Mauna Kea Technologies
Gastric Intestinal Metaplasia
Confocal Laser Endomicroscopy With Cresyl Violet for in Vivo Diagnosis of Gastric Intestinal Metaplasia
Confocal laser endomicroscopy (CLE) is a novel endoscopic system which can provide approximately 1000-fold magnification of the gastrointestinal mucosa.
- Trial name
- NCT03672708
- Testing
- Cresyl violet
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Shandong University
MALT-lymphoma
Endomicroscopy and Gastric MALT-lymphoma
Extranodal marginal zone B-cell lymphoma (MZBL) of the mucosa associated lymphoid tissue (MALT-lymphoma) represents a distinct clinical entity and is the most common form of extranodal lymphoma, with a predilection for the…
- Trial name
- NCT01583699
- Testing
- Confocal laser endomicroscopy, Confocal Laser Endomicroscope
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Medical University of Vienna
Barrett Syndrome, Barrett's Syndrome
CLE for Assessment of Neoplasia After Mucosal Ablation or Resection of Gastrointestinal Neoplasia
This study focuses on demonstrating the value of probe-based Confocal Laser Endomicroscopy (pCLE) in guiding endoscopic therapeutic procedures in Barrett's Esophagus (BE).
- Conditions
- Barrett Syndrome, Barrett's Syndrome, Barrett's Esophagus, Barrett Esophagus
- Trial name
- CLEAN-MARGIN (NCT01032044)
- Testing
- Standard endoscopic evaluation, pCLE guided evaluation
- Where
- 6 sites in United States, France and 1 more
- Volunteers
- 164 people
- Sponsor
- Mauna Kea Technologies
Fibrosis, Lung Cancer
Imaging FIB ONE in the Human Lung Using Endomicroscopy
While the process of fibrosis is essential for normal wound healing, an excessive and uncontrolled 'fibrotic' response can result in impaired tissue structure and function.
- Trial name
- FIB ONE (NCT02604862)
- Testing
- FIB ONE, AZD1236
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- University of Edinburgh
Undifferentiated Gastric Cancer
Role of Probe-based Confocal Laser Endomicroscopy Targeted Biopsy in the Molecular Study of Undifferentiated Gastric Cancer
The purpose of this study is to conduct a study on genetic pathology, obtaining of pure cancer tissues is mandatory. Although the endoscopy with biopsy has been a gold standard for diagnosing gastric cancer, percentage of cancer…
- Trial name
- NCT02799420
- Testing
- GastroFlex UHD, Cellvizio; Mauna Kea Technologies, Paris, France, white light endoscopy (WLE)
- Where
- South Korea
- Volunteers
- 74 people
- Sponsor
- Yonsei University
Gastric Cancer
A Pilot Study on Usefulness of Probe-based Confocal Laser Endomicroscopy Targeted Gastric Biopsy
The purpose of this study is to conduct a study on genetic pathology, obtaining of pure cancer tissues is mandatory. Although the endoscopy with biopsy has been a gold standard for diagnosing gastric cancer, percentage of cancer…
- Trial name
- NCT02089373
- Testing
- Probe-based confocal laser endomicroscopy, White light endoscopy
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Yonsei University
Irritable Bowel Syndrome
ConfocAl endomicroSCopy bAsed Diet Trial in IBS
After a thorough baseline evaluation, IBS patients will be exposed to nutrients while undergoing confocal laser endomicroscopy (CLE).
- Trial name
- CASCADE (NCT05097872)
- Testing
- Diet
- Where
- Belgium
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Liver Cirrhoses
Alterations in Intestinal Mucosal Barrier Visualized by Confocal Laser Endomicroscopy in Liver Cirrhosis: a Pilot Trial (AMBIC)
Clinical trial with medical devices. A diagnostic trial conducted to find a better (less invasive) procedure for predicting the onset of spontaneous bacterial peritonitis(SBP), which is a complication of liver cirrhosis with…
- Trial name
- AMBIC (NCT03878563)
- Testing
- Cellvisio 100 Series (fibered confocal microscopic system)
- Where
- 2 sites in Switzerland
- Volunteers
- 26 people
- Sponsor
- Dr.med. Monica Rusticeanu
Gastric Cancer
Confocal Laser Endomicroscopy for in Vivo Molecular Imaging of Gastric Cancer by Targeting MG7-Ag
The study aims to: 1. Achieve molecular imaging of MG7 antigen in patients with gastric cancer in vivo using confocal laser endomicroscopy. 2.
- Trial name
- NCT01366586
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Shandong University
Low Grade Glioma (LGG), High Grade Glioma (HGG)
Confocal Laser Endomicroscopy for Brain Tumors
Confocal Laser Endomicroscopy (CLE) could be a useful tool for real-time diagnosis of brain lesions (initial diagnosis or follow-up post resection to check for residual dysplasia) and real-time assessment of resections margins…
- Trial name
- GLIOFOCAL (NCT02240758)
- Testing
- confocal endomicroscopy with the CELLVIZIO® system (Mauna Kea technology)
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Hospices Civils de Lyon
Functional Dyspepsia
Confocal Laser Endomicroscopy Based Diet in Functional Dyspepsia
After a thorough baseline evaluation, functional dyspepsia (FD) patients will be exposed to nutrients while undergoing confocal laser endomicroscopy (CLE).
- Trial name
- CLEFD (NCT05666154)
- Testing
- Real diet, Wheat exclusion diet, Soy exclusion diet
- Where
- Belgium
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Pancreatic Cyst, Pancreatic Neoplasms
Clinical Registry of nCLE in Masses and Cystic Tumors of the Pancreas, Lymph Nodes, Submucosal Lesions of the GI Tract
This study focuses on four different lesions: pancreatic cysts, lymph nodes near the gastrointestinal tract, pancreatic masses and GIST tumors.
- Conditions
- Pancreatic Cyst, Pancreatic Neoplasms, Pancreatic Adenoma, Pancreatic Cancer
- Trial name
- US-nCLE (NCT01770405)
- Testing
- Endoscopic ultrasound fine needle aspiration
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- Mauna Kea Technologies
Ulcerative Colitis, Intraepithelial Neoplasia
Chromoscopic Guided Endomicroscpy to Diagnose Colitis Associated Dysplasia
Timely diagnosis of intraepithelial neoplasias (premalignant condition)is of crucial importance for clinical management of ulcerative colitis.
- Conditions
- Ulcerative Colitis, Intraepithelial Neoplasia, Cancer
- Trial name
- NCT00352404
- Testing
- Endomicroscope
- Where
- Germany
- Volunteers
- 114 people
- Sponsor
- Johannes Gutenberg University Mainz
Crohn Disease
AI-enabled Endoscopic Prediction of Post-operative Recurrence in Crohn's Disease
This is a multicentre prospective international observational study. This study aims to introduce a novel multidimensional approach to precision imaging, enabling the identification and stratification of high-risk patients who…
- Trial name
- PROSPER (NCT06505304)
- Testing
- Colonoscopy, Intestinal biopsies, Confocal laser endomicroscopy
- Where
- 15 sites in Belgium, Canada and 4 more
- Volunteers
- 225 people
- Sponsor
- University College Cork
Pleural Diseases, Pleural Effusion
Confocal Laser Endomicroscopy Guided Medical Thoracoscopy for the Diagnosis of Pleural Disease
A prospective multicenter randomized controlled trial was conducted to evaluate the efficacy and safety of thoracoscopic biopsy guided by confocal optical real-time microscopic imaging (nCLE) in the diagnosis of fibrinal pleurisy…
- Trial name
- NCT06741839
- Testing
- Confocal laser endomicroscopy guided pleural biopsy using medical thoracoscopy, Plerual biopsy using medical thoracoscopy
- Where
- China
- Volunteers
- 158 people
- Sponsor
- China-Japan Friendship Hospital
Colitis, Ulcerative
Confocal Laser Endomicroscopy Findings in Patients With Proctosigmoiditis Before and After Initiation of Treatment
Confocal laser endomicroscopy (CLE) is a novel method in evaluation of microscopic structures in vivo. The examination is carried out with a confocal laser endomicroscope, which is either part of the endoscope (manufactured by…
- Trial name
- NCT01684514
- Testing
- Confocal laser endomicroscopy
- Where
- 2 sites in Denmark
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
Digestive System Diseases
Confocal Laser Endomicroscopy
Confocal laser endomicroscopy (CLE) is a new diagnostic technique that allows microscopic examination of the digestive mucosa during ongoing endoscopy.
- Trial name
- NCT00561938
- Testing
- Colonoscopy, Endoscopy
- Where
- 5 sites in France
- Volunteers
- 61 people
- Sponsor
- Nantes University Hospital
Intestinal Metaplasia
Confocal Laser Endomicroscopy for the Detection of Gastric Intestinal Metaplasia: a Randomized Controlled Trial
The purpose of this study is to assess whether confocal laser endomicroscopy can reduce the biopsy number needed per patient for the detection of gastric intestinal metaplasia without the loss of corresponding diagnostic yield.
- Trial name
- NCT01024621
- Testing
- Endomicroscope, Standard endoscopy
- Where
- China
- Volunteers
- 168 people
- Sponsor
- Shandong University
COVID-19
Probe-based Confocal Laser Endomicroscopy in Critically Ill COVID-19 Patients
The study is devoted to the comparative analysis of the data received in patients with COVID-19 lung pathology using the method of probe-based confocal laser endomicroscopy of distal airways and two reference methods: high…
- Trial name
- NCT04451889
- Testing
- miniprobe Alveoflex
- Where
- Russia
- Volunteers
- 15 people
- Sponsor
- Federal Research Clinical Center of Federal Medical & Biological Agency, Russia