Clinical trials: Endomicroscopy
Pleural Malignant Mesothelioma, Thymoma
Confocal Laser Endomicroscopy in Pleural Malignancies
To date, the different biopsy methods, such as CT-guided pleural biopsy, mediastinal biopsy, endosonography and thoracoscopy have their limitations in diagnosing pleural malignancies, such as mesothelioma.
- Conditions
- Pleural Malignant Mesothelioma, Thymoma, Pleural Diseases
- Trial name
- NCT03290183
- Testing
- Confocal laser endomicroscopy
- Where
- 2 sites in Netherlands
- Volunteers
- 20 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
IBS, Food Intolerance
Confocal Laser Endomicroscopy in IBS Patients
This study will assess dynamic effects of two major antigens on the duodenal mucosa by confocal laser endomicroscopy (CLE). Patients will be blinded to the antigens used (wheat, yeast).
- Trial name
- NCT02313207
- Testing
- FODMAP
- Where
- Germany
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein
Gastric Subepithelial Tumors
Endoscopic Ultrasound-guided Needle-based Confocal Laser Endomicroscopy for Diagnosis of Gastric Subepithelial Tumors
The differential diagnosis of gastric subepithelial tumors by endoscopic ultrasound is currently suboptimal. Needle-based confocal laser endomicroscopy (nCLE) is a novel endoscopic technique, which is compatible with the 19-gauge…
- Trial name
- NCT02936986
- Where
- China
- Volunteers
- 94 people
- Sponsor
- Shandong University
Eosinophilic Esophagitis
Targeted Elimination Diet in EoE Patients Following Identification of Trigger Nutrients Using Confocal Laser Endomicroscopy
Using confocal laser endomicroscopy (CLE), gastrointestinal allergic reactions to certain foods in the duodenum will be evaluated on a cellular level.
- Trial name
- CLE-EoE (NCT05695456)
- Testing
- personalized exclusion diet based on CLE, empiric exclusion diet
- Where
- Belgium
- Volunteers
- 25 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Inflammation
Evaluation of Inflammation Activity in Ulcerative Colitis by pCLE
The aim:1) To test the correlation of pCLE-obtained features with histological findings in UC; comparing the real-time conventional colonoscopy Baron score with CLE assessment.
- Trial name
- NCT03788824
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Shandong University
Bilateral Laparoscopic Salpingectomy
Optical Biopsy and Fallopian Tube
High-grade serous ovarian cancer is the most threatening type of gynaecological cancer with an important mortality due to late diagnosis. However the prognosis is excellent in the early stages of the disease.
- Trial name
- FALLOPTIC (NCT02365779)
- Testing
- bilateral laparoscopic salpingectomy, endomicroscopy Cellvizio® system
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hospices Civils de Lyon
Frozen Sections, Indocyanine Green
Multi-center Study on CCeLL-In Vivo's Clinical Efficacy for Intraoperative Brain Tumor Diagnosis.
The primary objective of this study is to demonstrate the non-inferiority of cCeLL compared to frozen section analysis. The investigational device is intended for use with indocyanine green (ICG) for fluorescence imaging as an…
- Conditions
- Frozen Sections, Indocyanine Green, Brain Tumor
- Trial name
- PRECISION (NCT06867978)
- Testing
- cCeLL In vivo, Indocyanine Green
- Volunteers
- 100 people
- Sponsor
- VPIX Medical
Lung Cancer (Suspected or Confirmed), Cryoablation
One-stop Diagnosis and Treatment for Suspected Lung Cancer: Combined RBS, nClE, OBCT and Ablation
Using RBS as the navigation and treatment platform, precisely navigate to the target lesion. Utilize r-EUBS and nCLE to identify the lesion, and when the confocal AI model recognizes the lesion as malignant, perform a biopsy.
- Conditions
- Lung Cancer (Suspected or Confirmed), Cryoablation, Robotic Bronchoscopy System, Confocal Laser Endomicroscopy
- Trial name
- One-stop (NCT07521618)
- Testing
- Ablation
- Volunteers
- 30 people
- Sponsor
- Guangzhou Medical University
Eosinophilic Esophagitis, Barrett Esophagus
Imaging of the Esophagus Using a SECM Capsule
The goal of this validation study is to compare Spectrally Encoded Confocal Microscopy (SECM) Tethered Capsule Endoscopy (TCE) diagnosis of Eosinophilic Esophagitis to that of standard of care endoscopic biopsy.
- Trial name
- NCT03546660
- Testing
- SECM capsule
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Gastric Intestinal Metaplasia
The Value of Black Spots in Diagnosing Gastric Intestinal Metaplasia by Confocal Laser Endomicroscopy
The study aims to: 1. Explore the properties of mesenchymal black spots, and to determine the value of mesenchymal black spots in diagnosing gastric intestinal metaplasia by confocal laser endomicroscopy (CLE). 2.
- Trial name
- NCT01646528
- Testing
- CLE examination for upper gastrointestinal tract
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shandong University
Rectal Cancer
Optical Biopsy for Distal Margin in Low Rectal Cancer
This is a multi-center prospective randomized controlled study. In this study, the investigators will use confocal laser endomicroscopy to make real-time in vivo optical biopsy of distal margin in rectal cancer surgery and help…
- Trial name
- NCT04016948
- Testing
- Probe-based confocal laser endomicroscopy optical biopsy, Intra-operative frozen section
- Where
- China
- Volunteers
- 146 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Intestinal Metaplasia, Artificial Intelligence
Artificial Intelligence-assisted Confocal Laser Endomicroscopy Identification of Intestinal Metaplasia Severity
Currently, the Correa cascade is a widely accepted model of gastric carcinogenesis. Intestinal metaplasia is a high risk factor for gastric cancer.
- Conditions
- Intestinal Metaplasia, Artificial Intelligence, Confocal Laser Endomicroscopy
- Trial name
- NCT05462743
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Shandong University
Healthy
Feasibility, Safety and Utility of Endomicroscopy to Study the Intestines of Unsedated Infants at UVa
The purpose of this study is to demonstrate the feasibility of using the transnasal endomicroscopy (TNE) platform, using intestinal potential difference (IPD) and microbiome brush to evaluate the intestine of unsedated infants.
- Trial name
- NCT05857488
- Testing
- Transnasal introduction tube
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Probe-based Confocal Laser Endomicroscopy, Artificial Intelligence
Automatic Classification of Colorectal Polyps Using Probe-based Endomicroscopy With Artificial Intelligence
Probe-based confocal laser endomicroscopy (pCLE) is an endoscopic technique that enables real-time histological evaluation of gastrointestinal mucosa during ongoing endoscopy examination.
- Conditions
- Probe-based Confocal Laser Endomicroscopy, Artificial Intelligence, Colorectal Polyps
- Trial name
- NCT03787784
- Testing
- AI presentation
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shandong University
Graft Versus Host Disease
Early Detection of Mucosal Abnormalities in Graft-versus-host Disease
Gastro-intestinal graft versus host disease (GVHD) is a major source of morbidity and mortality amongst allogenic hematopoietic stem cell transplantation (Allo-HSCT).
- Trial name
- E-mage (NCT02707354)
- Testing
- Probe based confocal laser endomicroscopy (Cellvizio)
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Nantes University Hospital
Pancreas Neoplasms, Bile Duct Diseases
Intra-ductal Confocal Endomicroscopy for Characterization of Pancreas and Bile Duct Tumor
The endomicroscopy is an adaptation of traditional optical microscopy in the digestive endoscopy. Furthermore, with the integration of a miniaturized laser confocal microscope to a videoendoscope, it's possible to study the…
- Trial name
- EMID (NCT00930410)
- Testing
- Endoscopic Retrograde Cholangio-Pancreatography (ERCP)
- Where
- 2 sites in France, Monaco
- Volunteers
- 50 people
- Sponsor
- Institut Paoli-Calmettes
Lung Ground-Glass Opacity
GGO-dominant PPLs Diagnosis Using CLE and ssRAB-guided Cryobiopsy
The purpose of the study is to evaluate the diagnostic performance and safety of cryobiopsy for ground-glass opacity (GGO)-dominant peripheral pulmonary lesions (PPLs) under the guidance of shape-sensing robotic-assisted…
- Trial name
- NCT06910046
- Testing
- CLE and ssRAB-guided cryobiopsy
- Where
- China
- Volunteers
- 119 people
- Sponsor
- Shanghai Chest Hospital
Gastric Intestinal Metaplasia
The Learning Curve of Probe-based Confocal Laser Endomicroscopy (pCLE) Images Interpretation in Gastric Intestinal Metaplasia (GIM)
The Learning Curve of Probe-based Confocal Laser Endomicroscopy (pCLE) images interpretation in Gastric Intestinal Metaplasia (GIM) Objective: The aim of this study is to evaluate the learning curve of pCLE images interpretation…
- Trial name
- NCT01491724
- Where
- Thailand
- Volunteers
- 5 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Gastric Diseases, Artificial Intelligence
Automatic Real-time Diagnosis of Gastric Mucosal Disease Using pCLE With Artificial Intelligence
Probe-based confocal laser endomicroscopy (pCLE) is an endoscopic technique that enables real-time histological evaluation of gastric mucosal disease during ongoing endoscopy examination.
- Conditions
- Gastric Diseases, Artificial Intelligence, Confocal Laser Endomicroscopy
- Trial name
- NCT03784209
- Testing
- The diagnosis of Artificial Intelligence and endoscopist
- Where
- China
- Volunteers
- 951 people
- Sponsor
- Shandong University
Solid Pancreatic Masses
Endoscopic Ultrasound-guided Needle-based Confocal Laser Endomicroscopy in Solid Pancreatic Masses
The differential diagnosis of solid pancreatic masses by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is currently suboptimal.
- Trial name
- NCT02936960
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shandong University