Clinical trials: Endomicroscopy
Colitis, Ulcerative
Confocal Laser Endomicroscopy for Assessment of Mucosal Healing in Ulcerative Colitis
The aim of the study is to construct and validate an endomicroscopic score correlated with microscopic inflammation activity in patients with UC.
- Trial name
- ENHANCE (NCT02676817)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- European Georges Pompidou Hospital
Gastric Intestinal Metaplasia
Magnified Intelligence Chromoendoscopy Plus Probe-based Confocal Laser Endomicroscopy for Gastric Intestinal Metaplasia Diagnosis
Magnified intelligence chromoendoscopy (FICE) plus probe-based confocal laser endomicroscopy (pCLE) for Gastric Intestinal Metaplasia (GIM) diagnosis: a feasibility trial Research Question: Is confocal endomicroscope feasible to…
- Trial name
- NCT01489397
- Testing
- Confocol laser endomicroscopy
- Where
- Thailand
- Volunteers
- 45 people
- Sponsor
- King Chulalongkorn Memorial Hospital
Stomach Neoplasms, Precancerous Conditions
Detection of Early Gastric Cancers Using Confocal Laser Endomicroscopy
The purpose of this study is to determine whether endomicroscopy can improve the detection of Early Gastric Cancers (EGC).
- Trial name
- CLE (NCT00851305)
- Testing
- Endomicroscope (Pentax, Tokyo, Japan), Gastroscopes (Pentax, Tokyo, Japan)
- Where
- China
- Volunteers
- 1,786 people
- Sponsor
- Shandong University
Diagnosis of Peripheral Lung Nodules
nCLE For Diagnosis Of Peripheral Lung Nodules By Robotic Navigational Bronchoscopy
Needle based confocal laser endomicroscopy (nCLE) employs a small fiber which can be passed through a biopsy needle to enable real time microscopic imaging of cells.
- Trial name
- NCT04441749
- Testing
- Images acquired by needle-based Confocal Laser Endomicroscopy (nCLE)
- Where
- 2 sites in United States, Netherlands
- Volunteers
- 25 people
- Sponsor
- Fox Chase Cancer Center
Colorectal Polyps
Confocal Endomicroscopy for GI Neoplasia Study
The purpose of this study is to enhance probe stabilization using a 4mm clear cap attached to endoscope in comparison to standard "free-hand" image acquisition.
- Trial name
- NCT01515514
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Gastric Intestinal Metaplasia, Gastric Intraepithelial Neoplasia
Confocal Laser Endomicroscopy for the Diagnosis of Gastric Intestinal Metaplasia, Intraepithelial Neoplasia, and Carcinoma
i. To determine whether Confocal Laser Endomicroscopy (CLE) with optical biopsy and targeted mucosal biopsy improves the diagnostic yield of gastric IM/IN/CA in high risk populations compared to WLE with standard biopsy protocol.
- Conditions
- Gastric Intestinal Metaplasia, Gastric Intraepithelial Neoplasia, Gastric Carcinoma
- Trial name
- NCT01642797
- Testing
- Confocal laser endomicroscopy (Pentax, EG3870K), Standard White-light endoscopy (Pentax, 90i)
- Where
- 4 sites in Australia, China and 1 more
- Volunteers
- 242 people
- Sponsor
- Shandong University
Cerebral Tumors
Confocal Laser Endomicroscopy (CLE) During Medically Induced Neurosurgery in Craniobasal and Glioma Tumours
Purpose of the study is to answer the question whether confocal laser endomicroscopy (CLE, also named 'optical biopsy') might improve the results of medically necessary neurosurgery to prove practicability, safety and…
- Trial name
- Cleopatra (NCT02491827)
- Testing
- Cellvizio mini laser probe
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Charalampaki, Cleopatra, M.D.
Using Copolamine Butylbromide in Probe-based Confocal Laser Endomicroscopy for Gastroendoscopy Examination
The Application of Spasmolytic in PCLE Examination of Superior Gastrointestinal Endoscope
Scopolamine butylbromide might be helpful for the outcome of superior gastrointestinal endoscope examination.
- Trial name
- NCT02811341
- Testing
- Scopolamine Hydrobromide, normal saline
- Where
- China
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Shandong University
Irritable Bowel Syndrome, Inflammatory Bowel Disease
Assessment of Small Intestinal Bowel Epithelial Gaps in Irritable Bowel Syndrome
The study aims to: 1. Determine whether the density of epithelial gaps in terminal ileum of patients with irritable bowel syndrome (IBS) is different from that in inflammatory bowel disease (IBD) patients and normal controls by…
- Trial name
- NCT01632488
- Where
- China
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Shandong University
Parkinson Disease, Parkinson
Study of Gastrointestinal Dysfunction and Enteric Neural Pathology in Patients With Parkinson's Disease
The goal of this research is to determine (1) the feasibility of tethered capsule OCT esophageal imaging in the Parkinson's Disease population; (2) the morphologic changes in the enteric nervous system of the esophagus in…
- Trial name
- NCT04566341
- Testing
- OCT - TCE
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Gastric Cancer, Gastric High-grade Intraepithelial Neoplasia
Establishment and Effectiveness Evaluation of a Training System for Confocal Laser Endomicroscopy
Gastrointestinal endoscopy is a vital method for screening and diagnosing gastric cancer. It aids in identifying the tumor's location within the stomach and its macroscopic type, and allows biopsy for histological confirmation.
- Conditions
- Gastric Cancer, Gastric High-grade Intraepithelial Neoplasia, Gastric Low-grade Intraepithelial Neoplasia, Gastritis
- Trial name
- NCT06981819
- Testing
- Probe-based Confocal Laser Endomicroscopy by Experts, magnifying endoscopy with blue laser imaging, Probe-based Confocal Laser Endomicroscopy by trainees
- Where
- China
- Volunteers
- 147 people
- Sponsor
- Changhai Hospital
Barrett Esophagus
Pilot Study for OCT Guided In Vivo Laser Capture Microdissection for Assessing the Prognosis of Barrett's Esophagus
The investigators have developed a new technology, termed in-vivo laser capture microdissection (IVLCM), that addresses the limitations of endoscopic biopsy for screening for BE and provides targeted genomic profiling of aberrant…
- Trial name
- IVLCM (NCT03830801)
- Testing
- IVLCM tethered capsule
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Massachusetts General Hospital
Early Gastric Cancer
Comparison of the Sensitivity of pCLE and Pathological Biopsy for Gastric Mucosal Lesions
The pathological biopsy of gastric lesions, performed prior to endoscopic submucosal dissection (ESD), is crucial for differentiating the pathological nature of the lesions and guiding treatment decisions.
- Trial name
- pCLE (NCT07507071)
- Testing
- Probe-based Confocal Laser Endomicroscopy, Pathological biopsy
- Where
- China
- Volunteers
- 169 people
- Sponsor
- Changhai Hospital
Ulcerative Colitis, Artificial Intelligence
Automatic Evaluation of Inflammation Activity in Ulcerative Colitis Using pCLE With Artificial Intelligence
Probe-based confocal laser endomicroscopy (pCLE) is an endoscopic technique that enables to evaluate the inflammation activity of ulcerative colitis with excellent correlation with histopathology.
- Conditions
- Ulcerative Colitis, Artificial Intelligence, Confocal Laser Endomicroscopy
- Trial name
- NCT04131530
- Testing
- The diagnosis of Artificial Intelligence and endoscopist
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shandong University
Barrett Esophagus, Barrett's Esophagus Without Dysplasia
Evaluation of Tethered Capsule Endomicroscopy as a Screening Tool for Barrett's Esophagus in the Primary Care Setting
The investigators will conduct a large study in the primary care clinic to determine the feasibility of using tethered capsule endomicroscopy as a screening method for Barrett's esophagus (BE) in the primary care practice…
- Conditions
- Barrett Esophagus, Barrett's Esophagus Without Dysplasia, Barretts Esophagus With Dysplasia
- Trial name
- NCT04561791
- Testing
- Tethered Capsule Endomicroscopy
- Where
- United States
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Pleural Carcinomatosis
Probe Based Confocal Laser Endomicroscopy During Thoracoscopy for Pleural Malignancies Diagnosis.
Probe based confocal laser endomicroscopy (pCLE) is a new optical endoscopic technique, generating fluorescent light emission from the tissue of interest and allowing in vivo live imaging at a cellular level ("optical biopsies").
- Trial name
- NCT03805971
- Testing
- Study of the pleural cavity with a confocal laser endomicroscope.
- Where
- Belgium
- Volunteers
- 65 people
- Sponsor
- University of Liege
Lung Neoplasm, Peripheral Lung Parenchyma Tumor
nCLE-Cone-beam CT Navigation Bronchoscopy
The goal of this proof of principle observational study is to investigate in patients with suspected peripheral pulmonary nodules.
- Conditions
- Lung Neoplasm, Peripheral Lung Parenchyma Tumor, Lung Cancer
- Trial name
- NCT06505642
- Testing
- needle-based confocal laser endomicroscopy
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Inflammatory Bowel Disease
Association Between Inflammatory Activities and Gap Density
The study aims to: 1. To determine the relationship between inflammatory activities and epithelial gaps in IBD by CLE and evaluate epithelial gaps healing via dexamethasone treatment. 2.
- Trial name
- NCT01758926
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Shandong University
Frozen Sections, Indocyanine Green (ICG)
A PROSPECTIVE, SINGLE-CENTERED, ASSESSOR-BLINDED STUDY TO EVALUATE THE CLINICAL EFFICACY OF THE PROPOSED CELL/TISSUE HISTOPATHOLOGY PROCESSOR CCELL (CONFOCAL FLUORESCENCE ENDOMICROSCOPY) FOR INTRAOPERATIVE DIAGNOSIS IN BRAIN TUMORS
The primary objective of this single-center study is to demonstrate the performance of cCeLL, used in real time, compared to frozen section analysis.
- Conditions
- Frozen Sections, Indocyanine Green (ICG), Brain Tumor
- Trial name
- NCT07254845
- Testing
- cCeLL In vivo, Indocyanine Green
- Volunteers
- 30 people
- Sponsor
- VPIX Medical
Lung Neoplasms
Confocal Laser Endomicroscopy Nodule Localization by Robotic Bronchoscopy
This study is designed to evaluate the safety and feasibility of real-time needle-based confocal laser endomicroscopy (nCLE) in improving diagnostic accuracy of robotic-assisted bronchoscopy (RANB) biopsy performed with the…
- Trial name
- CLEAR (NCT05231278)
- Testing
- nCLE aided RANB biospy
- Where
- 4 sites in United States
- Volunteers
- 53 people
- Sponsor
- Johnson & Johnson Enterprise Innovation Inc.