Clinical trials: Endomicroscopy
Functional Dyspepsia
Mucosal Barrier Defects in Functional Dyspepsia by Confocal Laser Endomicroscopy
There has been recent interest into the potential role of mucosal barrier defects in the pathophysiology of functional gastrointestinal disorders (FGIDs).
- Trial name
- NCT01006642
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shandong University
Change of Image Quality of CLE
Evaluation of Image Quality Over Time After Injection of the fluorescein Sodium for Confocal Laser Endomicroscopy
Confocal laser endomicroscopy (CLE) is a newly developed endoscopic technique. The most commonly used fluorescent substance is Fluorescein sodium.The plasma half-life of fluorescein is 11 minutes.
- Trial name
- NCT01042171
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Shandong University
Barrett's Esophagus
A Trial Comparing Yield of Confocal Endomicroscopy Guided Biopsies
We wish to determine whether biopsies obtained with the technique of fluorescence-aided confocal endomicroscopy will detect more patients with specialized columnar epithelium than random biopsies among patients with Barrett's…
- Trial name
- NCT01030263
- Testing
- Fluorescence-aided confocal endomicroscopy guided biopsy., Random four-quadrant biopsies.
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Mayo Clinic
Peripheral Pulmonary Lesion
Diagnostic Value of Confocal Laser Endomicroscopy (CelTouch) for Peripheral Lung Lesions
This study uses CelTouch to explore patients with lung lesions scheduled for lung biopsy. By comparing with preclinical CLE images and pathological images, CLE diagnostic criteria for benign and malignant lung lesions under the…
- Trial name
- NCT07004946
- Where
- China
- Volunteers
- 286 people
- Sponsor
- Guangzhou Medical University
Bladder Cancer
The Accuracy of Optic Biopsies Versus Conventional Biopsies for the Diagnosis of Superficial Bladder Neoplasia
This study evaluates the accuracy of Confocal Laser Endomicroscopy (CLE) in the diagnostic of non-invasive flat and exophytic bladder neoplasia. CLE results are compared to histopathology results.
- Trial name
- NCT02841904
- Testing
- Confocal LASER Endomicroscopy
- Where
- Denmark
- Volunteers
- 189 people
- Sponsor
- Herlev Hospital
Barrett Esophagus, Barretts Esophagus With Dysplasia
Natural History of Barrett's Esophagus Using Tethered Capsule Endomicroscopy
The goal of this research is to determine the natural history of Barrett's esophagus (BE) using tethered capsule endomicroscopy (TCE) in participants undergoing surveillance endoscopy.
- Trial name
- NCT02994693
- Testing
- OFDI capsule imaging
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Lung Percutaneous Biopsy, Liver Percutaneous Biopsy
Needle-based Confocal Laser Endomicroscopy in Fluoroscopy-guided Procedures
This study is a prospective study in order to demonstrate the technical feasibility and safety of doing endomicroscopic imaging during interventional radiology procedure in two main indications: lung and liver.
- Trial name
- NCT02224885
- Testing
- CT-guided percutaneous biopsy or ablation
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Mauna Kea Technologies
Early Gastric Cancer
Usefulness of Probe-based Confocal Laser Endo-microscopy in Delineation of Margin of Early Gastric Cancer for Endoscopic Submucosal Dissection
The aim of this study is to evaluate the usefulness of pCLE (probe-based confocal laser endomicroscopy) compared with conventional chromoendoscopy (CE) for delineating the margin of early gastric cancer (EGC) with endoscopic…
- Trial name
- NCT02189226
- Testing
- Endoscopic submucosal dissection (ESD) with or without probe-based confocal laser endomicroscopy (pCLE)
- Where
- South Korea
- Volunteers
- 101 people
- Sponsor
- Yonsei University
Esophageal Cancer
Staging of Superficial EAC Using VLE
This study is being done to see if the NvisionVLE Imaging System can accurately determine the diagnostic performance of staging of T1 esophageal adenocarcinoma.
- Trial name
- NCT03385343
- Testing
- VLE imaging for staging EAC
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mayo Clinic
Endonasal Surgery, Endoscopic Sinus Surgery
In Vivo Imaging of the Olfactory Epithelium Using Confocal Laser Endomicroscopy
This research is being done to better characterize the part of the nose that helps people smell. Currently, the only ways to study smell loss mostly rely on how people report it, rather than being able to see the underlying…
- Conditions
- Endonasal Surgery, Endoscopic Sinus Surgery, Olfactory Dysfunction
- Trial name
- NCT07546617
- Testing
- CONVIVO system, Fluorescein injection, USP 10%
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Eosinophilic Esophagitis
Confocal Laser Endomicroscopy in Patients With Eosinophilic Esophagitis
Confocal laser endomicroscopy enables in vivo microscopic imaging within the mucosa layer of the gut at a subcellular resolution.
- Trial name
- NCT01234376
- Testing
- Confocal laser endomicroscopy
- Where
- Germany
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Brain Neoplasms
In Vivo Confocal Endomicroscopy of the Brain
The purpose of the study is to test the feasibility of obtaining interpretable in vivo endomicroscopy images which can be compared with traditional histopathology.
- Trial name
- NCT00949793
- Testing
- Endomicroscope
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Carl Zeiss Surgical GmbH
Pleural Diseases, Pleural Neoplasms
Mini Invasive Endomicroscopy of the Pleura for Malignancies Diagnosis
Recently, probe based confocal laser endomicroscopy showed to be able to distinguish malignant from benign pleura during medical thoracoscopy. However The clinical usefulness of this new tool remains to be determined.
- Trial name
- NCT04731129
- Testing
- Probe based confocal laser endomicroscopy of the pleura
- Where
- Belgium
- Volunteers
- 59 people
- Sponsor
- University of Liege
Gastro Esophageal Reflux, Barrett Esophagus
Confocal Endomicroscopy for Permeability of Esophageal Wall in Refractory Gastroesophageal Reflux Disease (GERD)
Confocal Endomicroscopy for Permeability of Esophageal Wall in Refractory Gastroesophageal Reflux Disease (GERD)
- Conditions
- Gastro Esophageal Reflux, Barrett Esophagus, Erosive Esophagitis
- Trial name
- NCT03228407
- Testing
- Confocal endomicroscopy, Endoscopic biopsies, Mucosal impedance (MI)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McGuire Research Institute
Colorectal Cancer
Optical Biopsy for Peritoneal Nodules in Colorectal Patients
During surgery, peritoneal metastasis is typically confirmed pathologically through resection sample. However, this process can be time-consuming when utilizing intro-operative frozen section pathology.
- Trial name
- NCT05879783
- Testing
- Confocal laser endomicroscopy
- Where
- China
- Volunteers
- 278 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Prostate Cancer
Feasibility of Timesaving When Using Histolog Confocal Laser Endomicroscopy for Margin Assessment in Prostatectomy Specimen
This study investigates a new, faster way to find cancer cells on the surface of the prostate during radical prostatectomy surgery.
- Trial name
- IMARHGIN (NCT07141121)
- Testing
- Histolog Scan
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Gastric Intestinal Metaplasia
Confocal Endomicroscopy Detection of Gastric Preneoplasia and Neoplasia
This is a prospective randomised study investigating the use of chromoendoscopy and confocal laser endomicroscopy for the detection of preneoplastic neoplasm in patients at high-risk of gastric cancer.
- Trial name
- R-CE-GCEP (NCT01384201)
- Where
- Singapore
- Volunteers
- 100 people
- Sponsor
- National University Hospital, Singapore
Colon Polyps, Adenomatous Polyps
Prospective Study for Evaluating Colon Polyp Histology With in Vivo Probe Based Confocal Laser Endomicroscopy
Chromoendoscopy (that involves spraying of dyes over the colonic mucosa) combined with magnification has been utilized for polyp histology identification.
- Conditions
- Colon Polyps, Adenomatous Polyps, Colon Cancer
- Trial name
- NCT01214031
- Testing
- Confocal laser endomicroscopy (CLE)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Midwest Biomedical Research
Endomicroscopy, Inflammatory Bowel Syndrome
Endomicroscopy, IBS and Food Intolerance
Background: The immediate endoscopic identification and diagnosis of intraepithelial structures and immediate and delayed reactions to allergens in the mucosal surface of the gut are unmet goals in the diagnosis and management of…
- Conditions
- Endomicroscopy, Inflammatory Bowel Syndrome, Food Intolerance
- Trial name
- NCT01692613
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein
Haematopoietic Stem Cell Transplantation
Endomicroscopy and Graft-versus-host Disease
Early diagnosis of acute Gastrointestinal Graft-versus-Host disease (aGI-GvHD) has a strong impact on morbidity and mortality of patients who underwent haematopoietic stem cell transplantation (HSCT).
- Trial name
- NCT01583712
- Testing
- Confocal laser endomicroscopy, Confocal Laser Endomicroscope
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Vienna