Clinical trials: Endomicroscopy
Non Small Cell Lung Cancer
Real-Time Imaging to Improve Lung Cancer Diagnosis : Comparing Confocal Laser Endomicroscopy (CLE) With Standard Biopsy for Quicker and Safer Detection of Non-Small Cell Lung Cancer
The goal of this observational study is to evaluate whether confocal laser endomicroscopy (CLE) can improve the real-time diagnosis of non-small cell lung cancer (NSCLC) in patients undergoing bronchoscopic biopsy for suspected…
- Trial name
- SCORACLE (NCT07538947)
- Testing
- bronchoscopic navigation with CLE
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Central Hospital, Nancy, France
Food Allergy
Endomicroscopy in Patients With Food Allergy: a New Diagnostic Option
The purpose of this study is to evaluate the endoscopic diagnostic options of the endomicroscopy in patients with food intolerance.
- Trial name
- NCT01072084
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Mediastinal Lymphadenopathies
Diagnostic Yield and Safety of Confocal Laser Endomicroscopy-Assisted Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration
Comparison of the Diagnostic Yield and Safety Between Confocal Laser Endomicroscopy-Assisted Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration and Endobronchial Ultrasound-Guided Transbronchial Mediastinal…
- Trial name
- COLLEBERATIONⅢ (NCT07040670)
- Testing
- Confocal laser endomicroscopy-assisted endobronchial ultrasound-guided transbronchial needle aspiration, Endobronchial ultrsound-guided Mediastinal cryobiopsy
- Volunteers
- 469 people
- Sponsor
- China-Japan Friendship Hospital
Crohn´s Disease, Ulcerative Colitis
Endomicroscopy for Assessment of Mucosal Healing
Inflammatory bowel disease (IBD) encompasses two major forms of chronic intestinal disorders, Crohn's disease and ulcerative colitis (UC).
- Trial name
- NCT01417715
- Testing
- Endomicroscopy
- Where
- Germany
- Volunteers
- 84 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
All Surgical Conditions Usually Necessitating Frozen Section, Malignant Tumor
Assessment of Intraoperative Probe-based Confocal Laser Endomicroscopy in Digestive and Endocrine Surgery: a Pilot Study
Intraoperative histological examination is a fundamental tool in surgery. Probe-based Confocal Laser Endomicroscopy (pCLE) is a new imaging technique which enables real-time, microscope-resolution imaging, currently used in…
- Conditions
- All Surgical Conditions Usually Necessitating Frozen Section, Malignant Tumor, Inflammatory Disease, Benign Tumor
- Trial name
- Pilot pCLE (NCT02552004)
- Testing
- pCLE, IV fluorescein administration
- Where
- France
- Volunteers
- 15 people
- Sponsor
- IHU Strasbourg
Esophageal Neoplasms, Artificial Intelligence
Automatic Diagnosis of Early Esophageal Squamous Neoplasia Using pCLE With AI
Detection and differentiation of esophageal squamous neoplasia (ESN) are of value in improving patient outcomes. Probe-based confocal laser endomicroscopy (pCLE) can diagnose ESN accurately.However this requires much experience…
- Conditions
- Esophageal Neoplasms, Artificial Intelligence, Confocal Laser Endomicroscopy
- Trial name
- NCT04136236
- Testing
- The diagnosis of Artificial Intelligence and endoscopist
- Where
- China
- Volunteers
- 57 people
- Sponsor
- Shandong University
Barrett's Esophagus
Pilot Study for TCE Imaging of the Esophagus Using an OFDI Capsule With a Compact Imaging System
The goal of this research is to test a distal scanning capsule and a compact redesigned version of the OFDI imaging system in healthy and BE participants to assess ease of use, safety and feasibility in preparation for its use in…
- Trial name
- NCT02947971
- Testing
- Experimental OFDI Imaging
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Barrett'S-associated Dysplasia, Intramucosal Adenocarcinoma
A Comparison of Volumetric Laser Endomicroscopy (VLE) and Endoscopic Mucosal Resection (EMR) in Patients With Barrett's Dysplasia or Intramucosal Adenocarcinoma
Barrett's esophagus (BE) is a pre-neoplastic condition formed by the metaplasia of the normal squamous mucosa of the distal esophagus into a specialized intestinal mucosa.
- Trial name
- NCT01862666
- Where
- Netherlands
- Volunteers
- 30 people
- Sponsor
- NinePoint Medical
Crohn Disease
Characterization of Crohn's Disease at Confocal Laser Endomicroscopy (CLE) and Related to Disease Activity
A blinded prospective observation and methodology study with Confocal Laser Endomicroscopy (CLE) together with standard white light colonoscopy including inter- and intra-observation of patients with Crohn's disease.
- Trial name
- NCT01738529
- Testing
- CLE ileocolonoscopy
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
Healthy
Pilot Study for Imaging of the Esophagus Using a Tethered Capsule OCT Endomicroscopy in the Primary Care Setting
The goal of this study is to test the feasibility and acceptability of tethered capsule Optical Coherence Tomography (OCT) endomicroscopy as a device for population-based screening in the primary care practice environment.
- Trial name
- NCT02445027
- Testing
- MGH OCT Imaging Capsule
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Pleural Effusion Disorder
Confocal Laser Endomicroscopy Assisted Ultrasound Guided Pleural Biopsy
This study aimed to evaluate the diagnostic yield and safety of confocal laser endomicroscopy and ultrasound-guided pleural biopsy in diagnosing patients with unknown pleural effusion.
- Trial name
- Confocal laser (NCT07040241)
- Testing
- Confocoal laser endomicroscopy-assisted ultrasound-guided pleural biopsy, Ultrasound-guided pleural biopsy
- Volunteers
- 260 people
- Sponsor
- China-Japan Friendship Hospital
Intestinal Metaplasia, Intestinal Dysplasia
Comparison Between Probe-based Confocal Laser Endomicroscopy, White-light Endoscopy and Virtual Chromoendoscopy
The investigators hypothesis that 1. clinical applicability and overall diagnostic sensitivity and specificity of pCLE for diagnosing gastric preneoplastic and neoplastic lesions is acceptable 2.
- Trial name
- pCLE-GCEP (NCT01398579)
- Testing
- Gastroscopy
- Where
- Singapore
- Volunteers
- 20 people
- Sponsor
- National University Hospital, Singapore
Barrett's Esophagus
pCLE in the Detection of Esophageal and Gastric Lesions and Intestinal Metaplasia or Dysplasia in Patients After Endoscopic Treatment of BORN
To assess diagnostic accuracy and clinical effectiveness including cost-effectiveness analysis of pCLE in patients after finishing the endoscopic treatment of BORN in detecting persistent/recurrent IM, recurrent neoplasia and…
- Trial name
- NCT02922049
- Testing
- Biopsies with histopathology
- Where
- Czechia
- Volunteers
- 67 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Dyspepsia
Gastric Barrier Dysfunction of Functional Dyspepsia and Therapeutic Response to Puyuanhewei Detected by Endomicroscopy
Functional dyspepsia might have impaired gastric mucosal dysfunction and Puyuanhewei may be helpful to improve the symptoms of FD.
- Trial name
- NCT02465996
- Testing
- pCLE examination, Puyuanhewei
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shandong University
Intrathoracic Lymphadenopathy
Optical Biopsy and Cytological Evaluation for Intrathoracic Lymphadenopathy
The purpose of this study is to describe and validate confocal laser endomicroscopy(CLE) and rapid on-site evaluation(ROSE) interpretation criteria for different types of intrathoracic lymphadenopathy.
- Trial name
- NCT07047417
- Testing
- CLE and ROSE
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Shanghai Chest Hospital
Pancreatic Cancer, Bile Duct Cancer
A Registry of Patients Undergoing Cellvizio Endomicroscopy and Endoscopic Retrograde Cholangiopancreatography(ERCP) Imaging Procedures for Diagnosing Pancreatic and Bile Duct Cancers
This registry will collect data from patients routinely undergoing an ERCP and Cellvizio endomicroscopy procedure (and optionally an additional cholangiopancreatoscopy procedure) due to suspected pancreatic or bile duct cancer.
- Trial name
- NCT00779688
- Testing
- Probe-based confocal laser endomicroscopy
- Where
- 6 sites in United States, France and 1 more
- Volunteers
- 130 people
- Sponsor
- Mauna Kea Technologies
Pancreatic Cyst, Serous Cystadenoma
A Phase II MULTICENTRE Trial of Needle Based Laser Confocal Endomicroscopy of Cystic and Solid Tumours of the Pancreas
A multicentre phase II study to determine the safety and efficacy of EUS-guided nCLE in patients with suspected cystic tumours of the pancreas in whom endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is clinically…
- Conditions
- Pancreatic Cyst, Serous Cystadenoma, Intraductal Papillary Mucinous Neoplasm, Cystadenoma, Mucinous
- Trial name
- CONCYST (NCT02523170)
- Testing
- AQ-Flex 19 probe (Mauna Kea Technologies, Paris)
- Where
- 4 sites in United Kingdom
- Volunteers
- 67 people
- Sponsor
- University College, London
Lung Cancer
Visualising c-MET and Activated Neutrophils in Lung Cancer
Lung cancer is currently a major health problem in the UK. Despite being one of the most common cancers, lung cancer has a poor prognosis compared to other types of cancer and is the leading cause of cancer death in the world.
- Trial name
- DUAL (NCT02676050)
- Testing
- Optical Imaging Agents (EMI-137, NAP), Delivery Device Cathetar and Miniaturised imaging fibre, Optical endomicroscopy system
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- University of Edinburgh
Barrett's Esophagus
High Resolution Optical Imaging of Barrett's Esophagus Using Nvision Volumetric Laser Endomicroscopy (VLE)
The primary objective of this clinical trial is to evaluate the performance of the Nvision Volumetric Laser Endomicroscopy (VLE) system to visualize subsurface tissue in subjects undergoing esophagogastroduodenoscopy (EGD) and to…
- Trial name
- NCT01503411
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- NinePoint Medical
Diagnostic Yield of Gastric Neoplasia
PCLE for the Diagnosis of Gastric Intestinal Metaplasia, Intraepithelial Neoplasia, and Carcinoma
Early detection of gastric intestinal metaplasia (GIM) intraepithelial neoplasia (IN), and gastric cancer are essential to improve patients' outcomes.
- Trial name
- PCLE (NCT02515721)
- Testing
- pCLE-TB, virtual chromoendoscopy-TB
- Where
- China
- Volunteers
- 242 people
- Sponsor
- Shandong University