Clinical trials: Endophthalmitis
Endophthalmitis
Clinical Features and Visual Prognosis of Infectious Endophthalmitis
The aim of this observational study was to retrospectively examine the clinical data of patients with infectious endophthalmitis and to analyse their clinical characteristics.
- Trial name
- NCT06755177
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhongnan Hospital
Endophthalmitis Following Cataract Surgery
Conjunctival Flora Before Cataract Surgery: a Microbiological Evaluation
The purpose of the present study is to elucidate the qualitative and quantitative variation of ocular flora after treatment with eyedrops containing 0.6% povidone-iodine in the eye of patients undergoing routine cataract surgery.
- Trial name
- NCT03958292
- Testing
- IODIM
- Where
- 6 sites in Italy
- Volunteers
- 140 people
- Sponsor
- Ospedale Sacra Famiglia - Fatebenefratelli Erba
Endophthalmitis
Study of Intraocular Concentrations (Aqueous Humor, Vitreous Humor) of Antibiotics After Local and/or Systemic Administration in Endophthalmitis
Endophthalmitis is an intraocular inflammation due to a serious infection of bacterial, fungal or parasitic origin, involving visual prognosis if it is not treated in time and correctly.
- Trial name
- CINEBIOPHTA (NCT03968341)
- Testing
- Pharmacokinetic and pharmacodynamic study of antibiotics used in severe endophthalmitis from samples taken from treated patients
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Endophthalmitis, Macula Edema
Evaluation of Macular Changes After Intracameral Moxifloxacin for Prevention of Endophthalmitis
The objective of this study is to evaluate the macular and choroidal thickness of patients submitted to intracameral moxifloxacin during the phacoemulsification surgery for endophthalmitis prophylaxis.
- Conditions
- Endophthalmitis, Macula Edema, Cataract
- Trial name
- NCT03363295
- Testing
- Moxifloxacin Injection
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Universidade Federal de Pernambuco
Endophthalmitis
Evaluation of Efficacy and Safety of Intracameral Moxifloxacin for Prevention of Postcataract Endophthalmitis.
There has thus far been only one randomized and masked clinical trial in the world to evaluate the efficacy of the intraoperative intracameral injection of antibiotics with the objective of preventing endophthalmitis following…
- Trial name
- NCT02770729
- Testing
- Moxifloxacin, No injection of moxifloxacin
- Where
- Brazil
- Volunteers
- 3,640 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Chlamydia Infections, Ophthalmia Neonatorum
Clinical Trial of Eye Prophylaxis in the Newborn
To compare the effectiveness of silver nitrate drops, erythromycin ointment, or no medication in preventing neonatal conjunctivitis caused by Chlamydia trachomatis and other eye infections.
- Trial name
- NCT00000120
- Testing
- Erythromycin Ointment, Silver Nitrate Drops
- Sponsor
- National Eye Institute (NEI)
Conjunctivitis, Iritis
Screening for NEI Clinical Studies
This screening protocol is designed to facilitate patient recruitment to National Eye Institute (NEI) clinical research studies.
- Conditions
- Conjunctivitis, Iritis, Keratitis, Retinitis
- Trial name
- NCT00001734
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- National Eye Institute (NEI)
Eye Infections
Comparative Efficacy of Different Regimens of PVPI 5% Eye Drops Instillation in Reducing Conjunctival Bacterial Flora
The present study intends to assess the efficacy of 3 drops of 5% povidone-iodine (PVPI) eyedrops in reducing the bacterial flora in a conjunctival sac fundus compared to the standard procedure consisting of the application of 1…
- Trial name
- NCT01739920
- Testing
- Povidone-iodine, Saline Solution
- Where
- Brazil
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Endophthalmitis
Endophthalmitis After Intravitreous Anti-VEGF Injections in Patients Receiving vs. Not Receiving Topical Antibiotics
This is a prospective case series which aims to determine the incidence of endophthalmitis following intravitreous anti-vascular endothelial growth factor (VEGF) injection comparing between eyes receiving post-injection…
- Trial name
- NCT02810587
- Testing
- Topical antibiotics following injection
- Where
- Thailand
- Volunteers
- 5,000 people
- Sponsor
- Chiang Mai University
Pharmacological Action
Intravitreal Triamcinolone and Moxifloxacin Injection After Cataract Surgery
This study aims to evaluate the short-term effects and safety of prophylactic intra-vitreal injection of triamcinolone-moxifloxacin combination after cataract surgery.
- Trial name
- NCT05428683
- Testing
- intra-vitreal triamcinolone-moxifloxacin injection after cataract surgery as a prophylactic measures against post-operative endophthalmitis
- Where
- Egypt
- Volunteers
- 84 people
- Sponsor
- Emad Abdel Aal Saliem
Ocular Inflammation, Crystalline Lens; Chalcosis
A Study of Ear Nerve Stimulation to Treat Eye Inflammation
The purpose of this study to find out whether a device that delivers mild electrical stimulation to the ear (transcutaneous auricular vagus nerve stimulation, or taVNS) can reduce inflammation in the eye in people with ocular…
- Conditions
- Ocular Inflammation, Crystalline Lens; Chalcosis, Intraocular Lens Complication
- Trial name
- NCT07831876
- Testing
- Cymbathera One System
- Where
- 7 sites in United States
- Volunteers
- 20 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Epiphora
Topical Cyclosporine vs. Placebo for Epiphora Associated With Docetaxel
Objective: To evaluate the safety and efficacy of topical cyclosporine eye drops (Restasis®) for the treatment of epiphora caused by canalicular stenosis secondary to Docetaxel (Taxotere®) treatment for various cancers.
- Trial name
- NCT00824811
- Testing
- Cyclosporine Eye Drops (Restasis), Lubricant Eye Drops (Refresh Endura™), Fluorometholone Eye Drops (FML Forte®)
- Sponsor
- M.D. Anderson Cancer Center
Endophthalmitis
Evaluation do Early Pars Plana Vitrectomy in Acute Endophthalmitis
Our study will evaluate the efficacy of early PPV in acute endophthalmitis and attempt to prove its greater effectiveness for combating infection when compared to eyes that received only intravitreal antibiotic therapy
- Trial name
- NCT04192994
- Testing
- Intravitreal Antibiotic Injection, Pars Plana Vitrectomy
- Where
- Brazil
- Volunteers
- 25 people
- Sponsor
- Federal University of São Paulo
Endophthalmitis
Preoperative Topical Gatifloxacin on Anterior Chamber Cultures After Cataract Surgery
Postoperative endophthalmitis, a possible severe complication of cataract surgery, is an infection of the anterior chamber of the eye caused by bacterial contamination and colonization through surgical incisions.
- Trial name
- NCT00335231
- Testing
- gatifloxacin ophthalmic (ZYMAR)
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Queen's University
Intracameral Antibiotics, Cataract Surgery
Intracameral Antibiotic Safety Study
The goal of this study is to determine the safety (but not efficacy in preventing infection) of sterile-packaged and pre-loaded injectable solutions of both vancomycin and moxifloxacin at certain dosages and concentrations as…
- Conditions
- Intracameral Antibiotics, Cataract Surgery, Phacoemulsification, Endophthalmitis
- Trial name
- NCT02590523
- Testing
- Vancomycin, Moxifloxacin
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Panhandle Eye Group, LLP
Endophthalmitis, Cataract
Early Vitrectomy for Endophthalmitis After Cataract Surgery
Post-operative infectious endophthalmitis is devastating condition that causes a diffuse intraocular inflammation and may lead to blindness.
- Conditions
- Endophthalmitis, Cataract, Vitreous Detachment, Retinal Detachment
- Trial name
- NCT05249413
- Testing
- Early 23-gauge pars-plana vitrectomy
- Where
- Egypt
- Volunteers
- 11 people
- Sponsor
- Benha University
Endophthalmitis, Trauma, Corneal
Use Of Intracameral Moxifloxacin For Prophylaxis Of Open Globe Endophthalmitis
Endophthalmitis is a severe inflammatory eye condition with profound impairment of vision, which can lead to irreversible visual loss and requires immediate treatment.
- Trial name
- NCT05079854
- Testing
- Intraocular Instillation Solution, Moxifloxacin Ophthalmic
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Federal University of São Paulo
Acute Endophthalmitis Post-operative
Targeted PCR and Acute Endophthalmitis
Endophthalmitis is a serious eye infection of exogenous origin (post-operational, post-traumatic) or endogenous origin (metastatic). This is a diagnostic and therapeutic emergency.
- Trial name
- Targeted PCR (NCT02850653)
- Testing
- PCR : 16S ribosomal DNA and real-time targeted PCR, Sampling of aqueous humour
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Cataracts
Modified Intraocular Lens to Reduce Eye Inflammation After Cataract Surgery in Uveitis Patients
This study will test the effectiveness of an intraocular lens treated with heparin in reducing or preventing inflammation after cataract surgery in patients with uveitis.
- Trial name
- NCT00001311
- Testing
- heparin-surface modified intraocular lens
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- National Eye Institute (NEI)
Intraocular Inflammation, Suspected Endophthalmitis
A Study of the Incidence of Intraocular Inflammation and Suspected Endophthalmitis Among Patients Treated With Aflibercept, Vial and Pre-filled Syringe, 2014-2022
Specific study objectives include: To describe patient and provider characteristics for aflibercept patients and aflibercept user injections by aflibercept dispensing device, overall, and stratified by time (quarterly, annually).
- Trial name
- NCT05791695
- Testing
- Non Applicable
- Where
- United States
- Volunteers
- 155,413 people
- Sponsor
- Regeneron Pharmaceuticals