Clinical trials: Endophthalmitis
Intraocular Inflammation
Intraocular Fluid Detection in Endophthalmitis
Endophthalmitis is also called vitreous inflammation. Broadly speaking, it refers to all kinds of serious intraocular inflammation, such as vitreitis, anterior chamber empyema and eye pain caused by intraocular infection…
- Trial name
- NCT04914884
- Testing
- intraocular fluid detection
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Endophthalmitis, Open Globe Injury
Safety and Efficacy of Topical Moxifloxacin for Prevention of Post-Traumatic Endophthalmitis: Randomized Controlled Clinical Trial
Open globe injuries (OGI) are among the main causes of blindness or irreversible severe reduction in visual acuity in the world.
- Conditions
- Endophthalmitis, Open Globe Injury, Moxifloxacin, Post-Traumatic Endophthalmitis
- Trial name
- NCT05162625
- Testing
- Moxifloxacin Ophthalmic 0.5% Ophthalmic Solution, Ciprofloxacin 400 MG/200 ML Intravenous Solution [CIPRO IV]
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- University of Campinas, Brazil
Endophthalmitis, Prophylaxy of Post Traumatic Endophthalmitis
Prophylaxis of Acute Post-Traumatic Bacterial Endophthalmitis
Purpose: To evaluate the efficacy of combined intraocular injection of gentamycin and clindamycin in prevention of acute posttraumatic bacterial endophthalmitis (APBE) following penetrating eye injuries.
- Conditions
- Endophthalmitis, Prophylaxy of Post Traumatic Endophthalmitis, Bacterial Endophthalmitis
- Trial name
- NCT00398658
- Testing
- gentamycin and clindamycin
- Where
- Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences
Endophthalmitis
Vascular Changes Associated With Endophthalmitis.
This study aims to describe and investigate vascular changes associated with exogenous endophthalmitis, as well as to create a photo library where they are evidenced
- Trial name
- NCT07175311
- Testing
- Multimodal imaging findings
- Where
- Mexico
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Asociación para Evitar la Ceguera en México
Intravitreal Injection Patients
Dosage Study for Vigamox Eye Drops Prior to Intravitreal Injections
Antibiotic eye drops are being used before and after intravitreal injections. Currently there is no study indicating the benefit of there usage or their dosage.
- Trial name
- NCT00690313
- Testing
- Vigamox
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Illinois Retina Associates
Post Operative Endophthalmitis
Effectiveness and Safety of 0.5% Moxifloxacin Hydrochloride Ophthalmic Solution in Perioperative Sterilization in Patients Undergoing Ophthalmic Surgery
This is a non-interventional, uncontrolled, prospective, multicenter, post marketing surveillance study.
- Trial name
- NCT05413980
- Testing
- Moxifloxacin hydrochloride ophthalmic solution
- Where
- 9 sites in India
- Volunteers
- 102 people
- Sponsor
- Novartis Pharmaceuticals
Intravitreal Injection
Endophthalmitis After Intravitreal Injection of Antiangiogenic Agents or Corticosteroids, a Cohort Study of the French Population of Patients Who Received Injections Over 9 Years
Intravitreal injections (IVI) of antiangiogenic agents (AA) have revolutionized the management of age-related macular degeneration (AMD) and diabetic macular edema (DME) in particular.
- Trial name
- ENIVAC (NCT03635268)
- Testing
- Data collection
- Volunteers
- 360,000 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Uveitis, Intermediate Uveitis
Safety Study of Suprachoroidal Triamcinolone Acetonide Via Microneedle to Treat Uveitis
This study is designed to determine the safety and tolerability of a single microinjection of triamcinolone acetonide (TRIESENCE®) into the suprachoroidal space (SCS) of patients who have non-infectious uveitis.
- Conditions
- Uveitis, Intermediate Uveitis, Posterior Uveitis, Panuveitis
- Trial name
- NCT01789320
- Testing
- triamcinolone acetonide (Triesence®)
- Where
- 3 sites in United States
- Volunteers
- 11 people
- Sponsor
- Clearside Biomedical, Inc.
Cataract
To Compare the Safety and Efficacy of Intracameral Levofloxacin and Intracameral Cefazolin in Reducing Rates of Endophthalmitis Following Cataract Surgery.
Patients with senile cataracts undergoing phacoemulsification were assigned to receive intracameral levofloxacin (0.1ml/0.5mg) or intracameral cefazolin (0.1ml/1mg).
- Trial name
- NCT06710977
- Testing
- Safety of intracameral levofloxacin in cataract surgery, Use of intracameral cefazolin in cataract surgery
- Where
- 2 sites in Singapore
- Volunteers
- 50 people
- Sponsor
- Tan Tock Seng Hospital
Juvenile Rheumatoid Arthritis, Uveitis
TNRF:Fc to Treat Eye Inflammation in Juvenile Rheumatoid Arthritis
This study will investigate the safety and effectiveness of the drug TNFR:Fc to treat uveitis (eye inflammation) in patients with juvenile rheumatoid arthritis.
- Trial name
- NCT00001862
- Testing
- Enbrel
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Eye Institute (NEI)
Endophthalmitis
The Pharmacokinetics of Topical Levofloxacin 1.5% vs Topical Moxifloxacin 0.5%
Endophthalmitis is defined as intraocular inflammatory disorder affecting the vitreous cavity that can result from exogenous or endogenous spread of infecting organisms into the eye.
- Trial name
- NCT04214821
- Testing
- Levofloxacin Ophthalmic Solution, Moxifloxacin Ophthalmic Solution
- Where
- 2 sites in Malaysia
- Volunteers
- 128 people
- Sponsor
- National University of Malaysia
Conjunctival Bacterial Flora
Effectiveness of Topical 0.5% Levofloxacin to Reduce the Conjunctival Bacterial Flora Before Intraocular Surgery
The purpose of this study is to determine whether additional topical application of 0.5% levofloxacin is more effective in reducing the load of the conjunctival bacterial flora in patients scheduled for intraocular surgery than…
- Trial name
- NCT00491049
- Testing
- 0.5% levofloxacin eye drops
- Where
- Germany
- Volunteers
- 140 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Cataract, Endophthalmitis
Hypochlorous Acid Disinfection Prior to Cataract Surgery
Antibiotics are commonly utilized to reduce the bacterial population of the eye prior to surgery with the assumption that this reduces the risk of endophthalmitis, although it is not clear if this actually occurs.
- Trial name
- NCT04568213
- Testing
- Hypochlorous Acid Gel 0.02%
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Loma Linda University
Inflammation Eye
A Clinical Study to Assess the Efficacy and Safety of Dexamethasone Suspension for Cataract Surgery
Patients at least 40 years of age who are undergoing cataract surgery will be randomized to receive treatment with one of two dose levels of dexamethasone ophthalmic suspension eye drops to determine if the drops decrease…
- Trial name
- NCT03687931
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- iDrop, Inc.
Endophthalmitis
Intracameral Moxifloxacin for Prevention of Postcataract Endophthalmitis
The aim of this study was to evaluate the efficacy and safety of the prophylactic effect of intracameral moxifloxacin for prevention of postcataract endophthalmitis.
- Trial name
- NCT02595359
- Testing
- Moxifloxacin
- Where
- Brazil
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Endophthalmitis
Study of Antibiotic Prophylaxis for Endophthalmitis Following Cataract Surgery
Cataract is the most important cause of visual impairment and decreased mobility in the elderly. While surgery is usually successful, it is also responsible for permanent loss of vision in up to 0.1% of patients due to severe…
- Trial name
- NCT00136344
- Testing
- Cefuroxime, Levofloxacin
- Where
- 24 sites in Austria, Belgium and 7 more
- Volunteers
- 35,000 people
- Sponsor
- City, University of London
Endophthalmitis Postoperative Acute
A Feasibility Randomised Controlled Trial of Early Vitrectomy for Post-operative Exogenous Endophthalmitis
This randomised clinical trial will explore the feasibility and acceptability of carrying out early vitrectomy surgical treatment compared to standard treatment in acute endophthalmitis.
- Trial name
- EVIAN (NCT04522661)
- Testing
- Vitrectomy, Intravitreal antibiotics
- Where
- United Kingdom
- Volunteers
- 63 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Endophthalmitis
Ozurdex Endophtamitis Cohort, Prognostic Assessment at 12 Months
OZURDEX endophthalmitis is a rare and potentially very serious pathology. Different treatments can be carried out early and change the functional prognosis of the patient.
- Trial name
- NCT06268561
- Testing
- Visual acuity analysis, Intraocular pressure analysis, Analysis of optical coherence tomography (OCT) images
- Where
- France
- Volunteers
- 8 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne