Clinical trials: Endoscopic Assessment
Primary Sclerosing Cholangitis
Endoscopic Ultrasound as an Early Diagnostic Tool for Primary Sclerosing Cholangitis
Primary sclerosing cholangitis (PSC) is a rare chronic cholestatic liver disease, typically affecting middle aged men and is frequently associated with inflammatory bowel disease.
- Trial name
- NCT01556412
- Where
- Germany
- Volunteers
- 32 people
- Sponsor
- Tischendorf, Jens, M.D.
Chronic Sinusitis, Ethmoidal
The PIO II Study: In-office Post-op Placement of a Steroid-eluting Sinus Implant
Randomized, controlled, blinded clinical trial with 40 patients randomized in a 1:1 ratio to either treatment (bilateral in-office placement of a drug-eluting implant in the ethmoid sinuses following ethmoidectomy) or control…
- Trial name
- NCT02668302
- Testing
- Steroid-eluting sinus implant, Post-op standard of care
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Collin County Ear Nose & Throat
Colorectal Adenoma, Colorectal Polyp
To Compare Artificial Intelligence Software Aided Adenoma Detection in Screening Colonoscopies Versus Standard Colonoscopy Without Artificial Intelligence Software Assistance in Participants Between 45 and 75 Years of Age
The aim of this study is to assess the efficacy of Ultivision Artificial Intelligence (AI) Software in detecting adenomas in screening colonoscopy procedures. The safety of Ultivision AI Software will also be assessed.
- Conditions
- Colorectal Adenoma, Colorectal Polyp, Colorectal Adenocarcinoma, Colorectal SSA
- Trial name
- AIDA (NCT04196088)
- Testing
- Ultivision Artificial Intelligence Software, No Artificial Intelligence Software enhancement
- Where
- 9 sites in United States
- Volunteers
- 978 people, healthy volunteers welcome
- Sponsor
- Docbot, Inc.
Pancreatic Neoplasms, Pancreatic Solid Lesions
EUS-DFI in Solid Pancreatic Lesions
This prospective, international, multicenter observational study aims to evaluate the role of Endoscopic Ultrasound-guided Detective Flow Imaging (EUS-DFI) in the characterization of solid pancreatic lesions.
- Trial name
- DFI (NCT07763561)
- Volunteers
- 48 people
- Sponsor
- Julio Iglesias García
Polyps
Experience and Enhancement: Improving Colonoscopic Polyp Detection
The study looks at 2 hypotheses in 2 patient groups: 1. Are more experienced endoscopists better at detecting subtle lesions (polyps) on the lining of the colon (large bowel) than less experienced endoscopists? 2.
- Trial name
- NCT00237276
- Testing
- colonoscopy
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- London North West Healthcare NHS Trust
Biliary Tract Disease
Clinical Utility of ERCP Guided Cholangiopancreatoscopy With the SpyGlass DS
This is a prospective evaluation of the clinical utility of the new cholangioscopy platform SpyGlass DS. The aims of this study are to prospectively document the clinical utility and technical aspects of ERCP with cholangioscopy…
- Trial name
- SPYDS (NCT02524418)
- Testing
- Cholangiopancreatoscopy
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Florida
Obscure Gastrointestinal Bleeding (Occult or Overt)
Trial of Wireless Capsule Endoscopy in the Evaluation of Obscure Gastrointestinal Bleeding
This study compares wireless capsule endoscopy (patients swallow a pill-size camera that sends pictures of the intestine to a recorder worn on their belt) to an x-ray study (called dedicated small bowel contrast radiography) in…
- Trial name
- NCT01006824
- Testing
- Capsule endoscopy, Dedicated small bowel contrast radiography
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- University of Southern California
Injury Due to Endoscopic Examination, Transnasal Endoscopy Induced Epistaxis
A Novel Anterior Rhinoscopic Scoring Scale to Predict Nasal Insertability Before Transnasal Endoscopy
A sniff test for nasal patency is a common method before ultrathin transnasal esophago-gastro-duodenoscopy (UT-EGD) to select the right or left nostril for insertion, yet there is no objective method to select an appropriate…
- Conditions
- Injury Due to Endoscopic Examination, Transnasal Endoscopy Induced Epistaxis, Transnasal Endoscopy Induced Nasal Pain
- Trial name
- NCT01784237
- Testing
- anterior meatoscopy, Nasal sniff test
- Where
- Taiwan
- Volunteers
- 233 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Pancreatic Tumors
Evaluation of Image-guided Brushing of Pancreatic Cyst Wall in Diagnosis of Cystic Pancreatic Tumors
The goal of this study is to compare a sample of the cyst taken by a standard method (fine needle aspiration) to the sample taken by a new method using a device called the EchoBrush to see which method is more accurate at…
- Trial name
- NCT01455311
- Testing
- EUS Guided Fine Needle Aspiration, EUS Guided EchoBrush Sampling
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Gastroenterology, Lesions
Evaluation of Diagnostic Yield of EUS-Guided Tissue Sampling
All patients will receive standard medical care and no experimental interventions will be performed. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is a well-established procedure commonly used for the…
- Trial name
- NCT02979509
- Testing
- Endoscopic ultrasound- (EUS) guided tissue sampling
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Florida
Esophageal Stricture, Caustic Esophageal Stricture
Evaluation of Topical Mitomycin C as Adjuvant Drug to Esophageal Dilation in Children
This study aims to evaluate mitomycin C as an adjunct to endoscopic treatment of esophageal strictures. This is a crossover, controlled, clinical trial in which children with esophageal stricture will be randomized in two groups…
- Conditions
- Esophageal Stricture, Caustic Esophageal Stricture, Peptic Esophageal Stricture, Post-Surgical Esophageal Stricture
- Trial name
- NCT00551824
- Testing
- Mitomycin C
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- Federal University of São Paulo
Colorectal Cancer
Point of Care Faecal Immunochemical Testing for Colorectal Cancer
Blood that can be detected in stool via faecal immunochemical testing is a recognised risk factor for the presence of colorectal cancer. There are a number of point of care faecal immunochemical testing devices available.
- Trial name
- POCFIT (NCT04402424)
- Testing
- Faecal Immunochemical Testing
- Where
- United Kingdom
- Volunteers
- 631 people
- Sponsor
- Royal Surrey County Hospital NHS Foundation Trust
Endoscopic Ultrasonography With Tissue Acquisition
Macroscopic on Site Evaluation (MOLSE) vs Standard Specimen Acquisition of Solid Lesions During EUS-FNB
Endoscopic ultrasonography (EUS) with tissue acquisition (TA) is nowadays a well-established technique for the sampling of solid lesions pancreatic and non-pancreatic lesions.
- Trial name
- MOSE (NCT04486274)
- Testing
- MOSE
- Where
- Italy
- Volunteers
- 370 people
- Sponsor
- Istituto Clinico Humanitas
Brain Tumor
Comparing Cosmetic Outcomes: Endoscopic vs. Conventional Craniotomy for Frontal Skull Base Lesions
This research study will compare the cosmetic outcomes, specifically scar assessment and complications, between two surgical approaches for treating frontal skull base lesions: the endoscopic supraorbital eyebrow craniotomy and…
- Trial name
- NCT06417658
- Testing
- Endoscopic Supraorbital Eyebrow Craniotomy, Conventional Frontal Craniotomy
- Volunteers
- 42 people
- Sponsor
- University of Health Sciences Lahore
Obesity
Preoperative and Postoperative Endoscopic Alterations in Patients Submitted to Gastric Bypass Without a Ring
Despite the high success rates of gastric bypass in the short and long terms, little is known about possible anatomopathological changes that can occur in these patients.
- Trial name
- NCT03106207
- Testing
- Upper gastric endoscopy (UGE)
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Kaiser Clinic and Hospital
Pancreatic Cancer, Pancreatic Neoplasms
Randomized Trial for Optimal Number of Passes Required for Molecular Profiling During EUS-FNB of Pancreatic Cancer
This is a randomized trial to evaluate the optimal number of passes required during endoscopic ultrasound-guided fine needle biopsy for molecular profiling in pancreatic cancer
- Conditions
- Pancreatic Cancer, Pancreatic Neoplasms, Adenocarcinoma of the Pancreas
- Trial name
- NCT05043532
- Testing
- 2 passes during EUS-guided fine needle biopsy, 3 passes during EUS-guided fine needle biopsy
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Orlando Health, Inc.
MASLD, MASH
Endoscopic Ultrasound Shear Wave Elastography Study
This study shall be a prospective, multicenter, single arm, consecutive, interventional study conducted in a post-market setting using commercially available devices.
- Conditions
- MASLD, MASH, Fibrosis, Liver, Chronic Liver Disease
- Trial name
- EUS-SWE (NCT06592820)
- Testing
- Endoscopic Ultrasound Shear Wave Elastography (EUS) and Attenuation Imaging, FibroScan, Liver biopsy
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Olympus Corporation of the Americas
Obesity, Weight Change Trajectory
Evaluation of the Safety and Efficacy of Revita® DMR on Body Weight Maintenance in Subjects With Obesity Who Have Achieved at Least 15% Weight Loss on Tirzepatide
Fractyl is evaluating Revita Duodenal Mucosal Resurfacing (DMR) in the REMAIN-1 pivotal study, which is designed to include two cohorts - an open label cohort referred to as REVEAL-1, and a randomized cohort, which includes both…
- Conditions
- Obesity, Weight Change Trajectory, Weight Change, Body
- Trial name
- REMAIN-1 (NCT06484114)
- Testing
- Revita Duodenal Mucosal Resurfacing (DMR)
- Where
- 32 sites in United States
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- Fractyl Health Inc.
Walled Off Necrosis
To Evaluate Early (2-Week) vs. Standard (4-Week) Metal Stent Removal Following Endoscopic Ultrasound Guided WON Drainage
In adults with walled-off pancreatic necrosis (WON) undergoing endoscopic ultrasound (EUS)-guided transluminal necrosectomy, does early removal of the lumen-apposing metal stent (LAMS) (at 2 weeks or immediately after the last…
- Trial name
- STEP1 (NCT07307248)
- Testing
- Standard LAMS Removal with Double-Pigtail Plastic Stent, Standard LAMS Removal without DPT
- Where
- India
- Volunteers
- 408 people
- Sponsor
- Asian Institute of Gastroenterology, India
Chronic Rhinosinusitis (CRS), Nasal Polyps
Triamcinolone Nanocapsules After Endoscopic Nasal Surgery
This randomised, single-masked, parallel-group clinical trial will evaluate the efficacy and safety of a topical triamcinolone acetonide-loaded polymeric nanocapsule formulation for postoperative care following endoscopic nasal…
- Conditions
- Chronic Rhinosinusitis (CRS), Nasal Polyps, Postoperative Healing After Endoscopic Nasal Surgery
- Trial name
- NCT07714525
- Testing
- Triamcinolone Acetonide-Loaded Polymeric Nanocapsules, Normal Saline Nasal Irrigation
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Deraya University