Clinical trials: Endoscopic Hemostasis
Endoscopic Hemostasis, Colonic Polyps
EndoClot for Preventing Rebleeding After Endoscopic Mucosal Resection (EMR)
Endoscopic mucosal resection (EMR) has been widely used as a diagnostic and treatment techniques of gastrointestinal small lesions. Postoperative rebleeding is one of the common complication following EMR.
- Trial name
- NCT01735786
- Testing
- EndoClot
- Where
- China
- Volunteers
- 164 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Ulcer Bleeding, Upper Gastrointestinal Tract Bleeding
The Use of Over-the-scope-clip for Prevention of Rebleeding in High Risk Peptic Ulcers
Non-variceal acute gastrointestinal bleeding is a common and potentially life-threatening problem. The conventional treatment of this condition is for esophagogastroduodenoscopy (OGD) for haemostasis.
- Trial name
- NCT03160911
- Testing
- Over-the-scope clip (OTSC), Conventional Endoscopic Haemostasis
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- Chinese University of Hong Kong
Gastrointestinal Bleeding
Efficacy of a Novel Hemostatic Powder in GI Bleeding
Hemospray™ is a new endoscopic hemostatic powder. Aims of this multicenter prospective study is to determine effectiveness of Hemospray™ on short and medium term in different clinical situations, predictive factors of rebleeding…
- Trial name
- GRAPHE (NCT02595853)
- Testing
- Non interventional study
- Where
- 19 sites in France, Monaco
- Volunteers
- 200 people
- Sponsor
- Nantes University Hospital
POEMS Syndrome, Hemostatic Disorder
To Evaluate Efficacy of Red Dichromatic Imaging (RDI) in Achieving Hemostasis During POEM Using GF 1500 UGI Scope
Peroral endoscopic myotomy (POEM) is a novel endoscopic technique for the treatment of achalasia and other esophageal motility disorders. Initially, it was introduced to the world by Inoue et al.
- Trial name
- RDIH-01 (NCT05476458)
- Testing
- White Light Imaging, Red Light Imaging
- Where
- 2 sites in India
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Cirrhosis, Coagulopathy
The Utility of Thromboelastography in Cirrhotic Patients Undergoing Endoscopic Procedures
Cirrhosis results in decreased synthesis of both procoagulants and anticoagulants resulting in "rebalanced homeostasis". However, conventional blood tests (platelets/ INR levels) that are performed prior to invasive procedures do…
- Trial name
- NCT02990273
- Testing
- Blood transfusion
- Volunteers
- 1 people
- Sponsor
- Johns Hopkins University
Bleeding Peptic Ulcer
High Dose Esomeprazole Na for Prevention of Rebleeding After Successful Endoscopic Therapy of a Bleeding Peptic Ulcer
To describe the rate of clinically significant rebleeding during 72 hours continuous i.v. infusion of high dose esomeprazole Na in patients in China with primary successful endoscopic haemostatic therapy of a bleeding peptic…
- Trial name
- NCT01757275
- Testing
- Esomeprazole Na, Cimetidine, Esomeprazole Mg
- Where
- 12 sites in China
- Volunteers
- 239 people
- Sponsor
- AstraZeneca
Peptic Ulcer Hemorrhage
Resolution Endoclips Vs Epinephrine Injection and Heater Probe
To compare the efficacy of a novel endoscopic clipping device(Resolution Clip™) and conventional epinephrine injection and heater probe thermocoagulation in control of peptic ulcer bleeding and prevention of recurrent bleeding
- Trial name
- NCT00165009
- Testing
- Resolution clip (endo-clipping device)
- Where
- China
- Volunteers
- 103 people
- Sponsor
- Chinese University of Hong Kong
Acute Upper Gastrointestinal Bleeding
To Compare a Hemostatic Powder TC-325 and Standard Treatment in the Control of Acute Upper Gastrointestinal Bleeding From Nonvariceal Causes
Acute upper gastrointestinal bleeding is a common medical emergency. Bleeding peptic ulcers and other non-variceal causes constitute to about 95% of all cases of bleeding.
- Trial name
- TC325 (NCT02534571)
- Testing
- Endoscopic Application of a Hemostatic Powder TC-325, Hemo-clipping, Epinephrine
- Where
- China
- Volunteers
- 224 people
- Sponsor
- Chinese University of Hong Kong
Acute Bleeding Esophageal Varices
RCT of Stent Versus Standard Therapy in Oesophageal Variceal Haemorrhage
The mortality rates from Acute Variceal Haemorrhage remain significant and first line therapy may fail in 15-25% of patients. The self-expandable metal stent has been described in case series as having a very high efficacy at…
- Trial name
- SOV (NCT01851564)
- Testing
- Self-expanding mesh-metal oesophageal stent (SEMS), Standard Therapy
- Where
- 3 sites in United Kingdom
- Volunteers
- 14 people
- Sponsor
- University College, London
Peptic Ulcer With Haemorrhage
Efficacy of Vonoprazan Versus Intravenous Proton Pump Inhibitors for Prevention of Rebleeding in High Risk Peptic Ulcers Bleeding After Successful Endoscopic Hemostasis
Upper gastrointestinal hemorrhage (UGIH) is common urgency condition.The estimate mortality rate about 7 percent from peptic ulcers disease(PUD).
- Trial name
- NCT05005910
- Testing
- Vonoprazan, PPIs IV infusion
- Where
- Thailand
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- Uayporn Kaosombatwattana
Bleeding Peptic Ulcers
Hemospray Versus the Combined Conventional Technique for Endoscopic Hemostasis of Bleeding Peptic Ulcers : A Pilot Study
Hemospray (TC-325, Cook Medical Inc, Winston-Salem, NC, USA), a new adsorptive nanopowder hemostatic agent for endoscopic treatment of high-risk bleeding peptic ulcers, provides significant ease of administration compared to the…
- Trial name
- NCT02088385
- Testing
- Hemospray, Combined Conventional Technique
- Where
- Singapore
- Volunteers
- 20 people
- Sponsor
- Changi General Hospital
Colorectal Cancer
Evaluation of Nexpowder Application to Prevent Delayed Bleeding After Colorectal Endoscopic Mucosal Resection
Delayed bleeding is the most frequent (5 to 15%) and challenging complication after large colorectal polypectomy. Different preventive treatments, such as the prophylactic use of clips, have been tried to prevent the occurrence…
- Trial name
- NEXBLEED (NCT05247515)
- Testing
- Endoscopic mucosal resection with nexpowder
- Where
- France
- Volunteers
- 304 people
- Sponsor
- Gabriel RAHMI
Sinusitis
Hemostatic Matrix in Endoscopic Sinus Surgery
Evaluating clinical performance of Hemostatic Matrix with bovine thrombin in achieving hemostasis in patients undergoing endoscopic sinus surgery.
- Trial name
- NCT00242437
- Testing
- Hemostatic matrix, bovine thrombin
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Ethicon, Inc.
Upper Gastrointestinal Bleeding
UI-EWD for Endoscopic Hemostasis of Bleeding Peptic Ulcers and Bleeding After EMR/ESD
UI-EWD (NextBiomedical Co, Incheon, South Korea), a new hemostatic powder for endoscopic treatment of high-risk bleeding peptic ulcers and bleeding after ESD/EMR.
- Trial name
- NCT02978391
- Testing
- UI-EWD Hemostatic system, epinephrine endoscopic injection (conventional therapy)
- Where
- 2 sites in South Korea
- Volunteers
- 76 people
- Sponsor
- Next Biomedical Co., Ltd.
Chronic Sinusitis
The Effect of Tranexamic Acid on Intraoperative and Post-Operative Bleeding in Functional Endoscopic Sinus Surgery
Sinus surgery is a common, day surgery procedure performed by general and subspecialty trained otolaryngologists. In most cases, this is a safe surgery with a low incidence of complications.
- Trial name
- NCT00671281
- Testing
- Tranexamic acid
- Where
- Canada
- Volunteers
- 74 people
- Sponsor
- University of Calgary
Bleeding, Peptic Ulcer
Early Selective TAE to Severely Bleeding Peptic Ulcers After Their Initial Endoscopic Hemostasis
The aim of this study is to determine if early angiographic embolization can forestall recurrent bleeding in selected high risk ulcers after their initial endoscopic control; to validate prospectively the investigators proposed…
- Conditions
- Bleeding, Peptic Ulcer, Arterial Embolization
- Trial name
- NCT01142180
- Testing
- TAE, No TAE
- Where
- China
- Volunteers
- 258 people
- Sponsor
- Chinese University of Hong Kong
Cirrhosis, Coagulopathy
Comparison of Blood Product Use and Bleeding Events During and After Endoscopic or Neurosurgical Procedures in Patients With Cirrhosis and Coagulopathy
A prospective, randomized clinical trial comparing blood product use and bleeding events during and after endoscopic or neurosurgical procedures in patients with cirrhosis and coagulopathy: Rotational Thromboelastometry (ROTEM)…
- Trial name
- SCARLET (NCT02457403)
- Testing
- ROTEM, Conventional Therapy
- Volunteers
- 68 people
- Sponsor
- Ohio State University
Hereditary Hemorrhagic Telangiectasia, Gastrointestinal Hemorrhage
Octreotide in Patients With GI Bleeding Due to Rendu-Osler-Weber
The purpose of this study is to determine whether long-acting octreotide is safe and effective in the treatment of patients with Rendu-Osler-Weber (e.g. HHT).
- Conditions
- Hereditary Hemorrhagic Telangiectasia, Gastrointestinal Hemorrhage, Anemia
- Trial name
- ROW (NCT02874326)
- Testing
- Octreotide LAR
- Where
- 2 sites in Netherlands
- Volunteers
- 15 people
- Sponsor
- Radboud University Medical Center
Acute Upper Gastrointestinal Non Variceal Hemorrhage
Endoscopic Diagnosis and Treatment of Acute Nonvariceal Upper Gastrointestinal Bleeding
Acute nonvariceal upper gastrointestinal bleeding (ANVUGIB) is a common critical disease in gastroenterology. Due to the development of modern medical technology, the incidence rate of ANVUGIB has been decreasing in recent years…
- Trial name
- NCT04895904
- Testing
- No intervention
- Volunteers
- 3,200 people
- Sponsor
- The First Affiliated Hospital of Nanchang University
Calcium Electroporation for Hemostasis in Gastric Neoplasms
Endoscopic Calcium Electroporation in Gastric Tumors
Brief Summary Background Gastric cancer (GC) remains a major global public health challenge, ranking as the fifth most common malignancy worldwide and the third leading cause of cancer-related mortality.
- Trial name
- GASTRIC-CaEP (NCT07647731)
- Testing
- Endoscopy Calcium Electroporation
- Volunteers
- 28 people
- Sponsor
- Hospital del Rio Hortega