Clinical trials: Endoscopic Sinus Surgery, active
Sphenoid Sinus, Endoscopic Sinus Surgery
Different Endoscopic Approaches for Sphenoid Sinus
Identification of the most effective approach for different lesion types Correlation between approach and complication rates
- Trial name
- NCT07702188
- Testing
- endoscopic sinus surgery
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Tumor, Solid
Phase II Study of Intensity Modulated Radiotherapy in Dose Painting for Sinus Carcinomas After Endoscopic Surgery
The patient is randomized to one of the following groups: Experimental group: Radiotherapy in painting dose on histoscannographic mapping Control group: standard pan-sinus radiotherapy
- Trial name
- SinocaRT (NCT05943119)
- Testing
- Radiotherapy in painting dose on histoscannographic mapping, Standard pan-sinusal Radiotherapy
- Where
- 3 sites in France
- Volunteers
- 52 people
- Sponsor
- Centre Francois Baclesse
Chronic Rhinosinusitis (CRS)
Intra-Sinus Povidone-Iodine and Budesonide After Endoscopic Sinus Surgery for Chronic Rhinosinusitis
Endoscopic sinus surgery (ESS) is commonly performed in patients with chronic rhinosinusitis (CRS) to improve sinus drainage and allow better delivery of topical therapies after surgery.
- Trial name
- PVP-I (NCT07383402)
- Testing
- Povidone-Iodine and Budesonide Gel-Forming Suspension
- Volunteers
- 180 people
- Sponsor
- Amin Javer
FESS Operation
Intratracheal Dexmedetomidine Versus Lidocaine for Smooth Tracheal Extubation
compare the efficacy of intratracheal dexmedetomidine versus intratracheal lidocaine in achieving smooth tracheal extubation in patients undergoing Functional Endoscopic Sinus surgery and reconstructive nasal surgeries under…
- Trial name
- NCT07504497
- Testing
- dexmedetomidine Lidocaine Saline
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Younes Ahmed Younes
Chronic Rhinosinusitis (Diagnosis)
The Effect of Intra-sinus Application of Betamethasone Dipropionate Nasal Cream on Patients with Chronic Rhinosinusitis Post Functional Endoscopic Sinus Surgery (FESS)
To assess the safety and efficacy of one (single) application of Betamethasone Dipropionate Nasal Cream (BMDP CREAM) onto the sinus mucosa.
- Trial name
- NCT05882903
- Testing
- Betamethasone Dipropionate Nasal Cream 0.0644%, Pre-filled syringe and applicator device
- Where
- 4 sites in Australia
- Volunteers
- 24 people
- Sponsor
- Oticara Australia PTY LTD
Chronic Rhinosinusitis (CRS) With and Without Nasal Polyps
Paclitaxel-Coated Balloon Treatment of Chronic Rhinosinusitis
This is a prospective, multicenter, randomized, controlled, double-blind clinical trial enrolling 300 adult subjects with chronic rhinosinusitis (CRS) with and without nasal polyps (CRSwNP and CRSsNP) indicated for endoscopic…
- Trial name
- RESTORE-2 RCT (NCT07290140)
- Testing
- Airiver ESSpand DCB, ESS
- Where
- 16 sites in United States
- Volunteers
- 300 people
- Sponsor
- Airiver Medical, Inc.
Comparison of Airway Management Techniques in Functional Endoscopic Sinus Surgery, Rhinosinusitis With Polyps
Comparison of Laryngeal Mask and Tracheal Intubation With and Without Topical Lidocaine Application
The study aims to identify the advantages and disadvantages of each of the three methods of airway management during FESS.
- Conditions
- Comparison of Airway Management Techniques in Functional Endoscopic Sinus Surgery, Rhinosinusitis With Polyps, Deviated Nasal Septum, Osteoma of the Paranasal Sinuses
- Trial name
- NCT07548866
- Testing
- anesthesia of the respiratory tract with lidocaine, tracheal intubation, laryngeal mask placement
- Where
- Russia
- Volunteers
- 150 people
- Sponsor
- St. Petersburg State Pavlov Medical University
Olfactory Dysfunction, Chronic Rhinosinusitis
The Effect of Modified Olfactory Training on Postoperative Olfactory Dysfunction in Patients With CRS
The goal of this clinical trial is to validate the effectiveness of the modified olfactory training device, the main questions it aims to answer are: Is it possible that the device can treat postoperative olfactory dysfunction in…
- Trial name
- NCT06837051
- Testing
- Conventional olfactory training device, Modified olfactory training device, Budesonide irrigation
- Where
- China
- Volunteers
- 213 people
- Sponsor
- Peking University Third Hospital
Chronic Rhinosinusitis, Enhanced Recovery After Surgery
Effects of Esketamine Versus Magnesium Sulfate on Emotional State and Postoperative Pain in Patients Undergoing Nasal Endoscopic Surgery
Functional endoscopic sinus surgery (FESS) is one of the effective modalities for the treatment of Functional endoscopic sinus surgery (FESS) is one of the effective ways to treat chronic sinusitis, which has the advantages of…
- Trial name
- NCT06920576
- Testing
- Esketamine, Magnesium sulfate, Saline
- Where
- China
- Volunteers
- 144 people
- Sponsor
- The Second People's Hospital of Huai'an
Chronic Rhinosinusitis (CRS)
Effectiveness of Penthrox vs Placebo in Sinus Procedures, a Clinical Trial
The goal of this randomized controlled trial is to evaluate the effectiveness of inhaled methoxyflurane (Penthrox) as an analgesic for patients undergoing minor rhinology and sinus procedures, specifically comparing it to a…
- Trial name
- NCT06750302
- Testing
- Methoxyflurane - Penthrox
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- St. Paul's Hospital, Canada
Controlled Hypotension for Nasal Surgeries
Comparison of Two Sedative Agents in Terms of Controlled Hypotension
Propofol and Isoflurane are commonly used sedative agents in general anaesthesia.Both these drugs have a side effect of decreasing blood pressure which when used optimally can be used to acheive controlled hypotention.
- Trial name
- NCT07460050
- Testing
- Propofol, Isoflurane
- Where
- Pakistan
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Hayatabad Medical Complex
Chronic Rhinosinusitis (Diagnosis), Cystic Fibrosis
Impact of Sinus Surgery on Individuals With Cystic Fibrosis
This study will be a prospective, observational study of patients who undergo endoscopic sinus surgery for cystic fibrosis-related chronic rhinosinusitis (CRS).
- Trial name
- NCT04469439
- Where
- 9 sites in United States
- Volunteers
- 170 people
- Sponsor
- University of California, Los Angeles
Cough Suppression
Magnesium Sulfate Versus Lidocaine as Additives to Dexmedetomidine for Cough Suppression After Functional Endoscopic Sinus Surgery
Functional Endoscopic Sinus Surgery (FESS) is a widely performed procedure for the management of chronic rhinosinusitis and nasal polyposis.
- Trial name
- NCT07213037
- Testing
- Dexmedetomidine, Magnesium sulfate, lidocaine
- Volunteers
- 102 people
- Sponsor
- Assiut University
Functional Endoscopic Sinus Surgery (FESS)
Nasal Dexmedetomidine Versus Systemic Infusion Dexmedetomidine in Reducing Intraoperative Opioid Consumption in Nasal Endoscopic Surgeries
Background: Optimizing intraoperative hemodynamics and minimizing opioid use are crucial in nasal endoscopic surgeries. Objective: To compare the efficacy of intranasal dexmedetomidine spray and intravenous dexmedetomidine…
- Trial name
- NCT07012213
- Testing
- Patients in group A received .5 g/kg/h dexmedetomidine infusion after general anesthesia, in group B received 1 ml (100 mic) dexmedetomidine intranasal spray before induction.
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Maxillary Sinusitis
Single-step Functional Sinus Endoscopy and Transoral Surgery
Dento- alveolar or dental structural diseases that affect the floor of the maxillary sinus can cause maxillary sinusitis which is known as odontogenic maxillary sinusitis (OMS).
- Trial name
- NCT06130176
- Testing
- Single-step Functional Sinus Endoscopy and Transoral Surgery, Functional sinus endoscopy, Trans oral Surgery
- Where
- Saudi Arabia
- Volunteers
- 36 people
- Sponsor
- Qassim University
Magnesium Sulfate, Remifentanil
Anesthesia Techniques, Neuroprotection and Surgical Field in FESS Under Controlled Hypotension
This prospective, randomized controlled trial investigates the effect of four different anesthetic maintenance techniques on surgical field conditions, hemodynamic stability, and neuroprotection during functional endoscopic sinus…
- Conditions
- Magnesium Sulfate, Remifentanil, S 100beta, S100 Beta Protein, Human
- Trial name
- NCT07181564
- Testing
- Propofol / Remifentanil, Ketamine + Magnesium sulfate (drug combination), Sevoflurane and Remifentanil
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- University General Hospital of Patras
Chronic Rhinosinusitis (CRS), Frontal Sinusitis
Endoscopic Direct "Draf IIa" (Carolyn's Window Approach) Versus Endoscopic Angled "Draf IIa"Approach in Chronic Rhinosinusitis With Frontal Sinus Affection ( A Comparative Study ).
Patients with chronic rhinosinusitis with frontal sinus affection indicated for sinuscopy will be randomly categorized in 2 groups: group A will have endoscopic directDraf IIa frontal sinusotomy and group B will have endoscopic…
- Conditions
- Chronic Rhinosinusitis (CRS), Frontal Sinusitis, Draf I or IIa, Functional Endoscopic Sinus Surgery (FESS)
- Trial name
- NCT06668844
- Testing
- Endoscopic direct Draf IIa, Endoscopic angled Draf IIa
- Volunteers
- 68 people
- Sponsor
- Assiut University
Emergence Agitation
The Effect of Dexmedetomidine Versus Lidocaine on Emergence Agitation.
The effect of intravenous dexmedetomidine versus intravenous lidocaine on the emergence agitation after endoscopic sinus surgery.
- Trial name
- NCT07355049
- Testing
- Dexmedetomidine, Lidocaine
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Fayoum University
Endonasal Surgery, Endoscopic Sinus Surgery
In Vivo Imaging of the Olfactory Epithelium Using Confocal Laser Endomicroscopy
This research is being done to better characterize the part of the nose that helps people smell. Currently, the only ways to study smell loss mostly rely on how people report it, rather than being able to see the underlying…
- Conditions
- Endonasal Surgery, Endoscopic Sinus Surgery, Olfactory Dysfunction
- Trial name
- NCT07546617
- Testing
- CONVIVO system, Fluorescein injection, USP 10%
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Preoperative Stapokibart for Endoscopic Sinus Surgery in Chronic Rhinosinusitis With Nasal Polyps
This is a single-center, randomized, double-blinded, placebo-controlled clinical trial in adults with moderate-to-severe chronic rhinosinusitis with nasal polyps (CRSwNP) who have no previous nasal surgery.
- Trial name
- NCT07616609
- Testing
- Stapokibart
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Beijing Tongren Hospital