Clinical trials: Endoscopic Sleeve Gastroplasty, open to volunteers
Obesity and Obesity-related Medical Conditions
ESG With Fundal Mucosal Ablation
Endoscopic sleeve gastroplasty (ESG) have emerged as an effective primary endoscopic therapy for weight loss. While ESG recapitulates the configuration of a gastric sleeve, it has not yet been shown to achieve as robust weight…
- Trial name
- ESG-FUMA (NCT06790329)
- Testing
- Endoscopic sleeve gastroplasty with fundal mucosal ablation
- Where
- Hong Kong
- Volunteers
- 10 people
- Sponsor
- Chinese University of Hong Kong
Endoscopic Sleeve Gastroplasty, Obesity
Endoscopic Sleeve Gastroplasty (ESG) for the Treatment of Obesity
The purpose of this study is to evaluate endoscopic sleeve gastroplasty (ESG) for the treatment of obesity. The ESG procedure is an U.S.
- Trial name
- NCT06339320
- Testing
- Endoscopic Sleeve Gastroplasty (ESG), Apollo OverStitch endoscopic suturing device
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- The Methodist Hospital Research Institute
Obesity
Endoscopic Sleeve Gastroplasty (ESG) Prospective Trial for Obesity (EGO-Trial)
EGO-Trial is the first multicenter study in France which aims to evaluate the efficacy of Endoscopic Sleeve Gastroplasty (ESG) in patients with obesity.
- Trial name
- NCT07449520
- Testing
- Endoscopic sleeve gastroplasty
- Where
- 12 sites in France, Guadeloupe
- Volunteers
- 300 people
- Sponsor
- IHU Strasbourg
Obesity (Disorder), Metabolic Disorders
Hormonal and Microbiota Modulation After Endoscopic Sleeve Gastroplasty
Obesity is a chronic disease with a rapidly increasing prevalence, expected to affect up to 25% of the French population by 2030, and is associated with significant morbidity, mortality, and healthcare burden.
- Trial name
- HOVIGAMI-ESG (NCT07576777)
- Testing
- Laparoscopic sleeve gastrectomy, Endoscopic sleeve gastroplasty
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Obesity, Morbid, End Stage Renal Disease
Endoscopic Sleeve Gastroplasty With Endomina® for the Treatment of Obesity in Kidney Transplant Candidates
The aim of this pilot prospective interventional study is to evaluate the efficacy of endoscopic sleeve gastroplasty (ESG) in allowing obese subjects (≥35 kg/m2) with end stage renal disease who need of kidney transplantation to…
- Conditions
- Obesity, Morbid, End Stage Renal Disease, Kidney Transplantation, Endoscopic Sleeve Gastroplasty
- Trial name
- ESGiTXKidney (NCT05917795)
- Testing
- Endoscopic Sleeve Gastroplasty (ESG)
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Obesity, Overweight
Comparing the Efficacy and Safety of the EndoZip System and Apollo ESG in Obese Patients
evaluation of the EndoZip system procedure compared to the Apollo ESG procedure in obese patients.
- Trial name
- ESG (NCT07090005)
- Testing
- EndoZip System, OverStitch Endoscopic Suturing System (ESG)
- Where
- 5 sites in United States, Italy
- Volunteers
- 184 people
- Sponsor
- Nitinotes Surgical Ltd.
Obesity
Identification of Factors Predictive of the Efficacy of Endoscopic Endoscopic Sleeve Gastroplasty
Endoscopic sleeve gastroplasty and bypass are currently available for weight loss in obese patients who have failed nutritional management. Despite very low risks, these techniques remain invasive.
- Trial name
- PREDISLEGE (NCT06153056)
- Testing
- Bloed-, ontlasting- en speekselmonsters
- Where
- France
- Volunteers
- 205 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Type 2 Diabetes Mellitus (T2D), Obesity (BMI>30)
Impact of Endoscopic Sleeve Gastroplasty (ESG) in Obese Adults With Type 2 Diabetes (T2D)
The goal of this clinical trial is to determine whether Endoscopic Sleeve Gastroplasty (ESG)-induced weight loss can improve glycemic outcomes and alter the trajectory toward insulin dependence in adults with obesity and…
- Trial name
- MEASURE (NCT07639684)
- Testing
- ESG with OverStitch
- Volunteers
- 50 people
- Sponsor
- Boston Scientific Corporation
Obesity, Obesity, Morbid
Efficacy and Safety of Endoscopic Antral Myotomy as a Novel Weight Loss Procedure
Gastric myotomy has been performed for several years as a means of addressing chronic stenosis after sleeve gastrectomy and treating gastroparesis.
- Conditions
- Obesity, Obesity, Morbid, Obesity, Primary, Metabolic Disease
- Trial name
- PSAM (NCT05711758)
- Testing
- PSAM Treatment Patients
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Christopher C. Thompson, MD, MSc
Obese Adolescents, Obesity, Morbid
ESG in Obese Adolescents
The primary goal of this pilot study is to learn if the use of the Apollo Endosurgery ESG System is a safe, well tolerated intervention for weight loss in adolescents with obesity.
- Conditions
- Obese Adolescents, Obesity, Morbid, Obesity/Therapy
- Trial name
- NCT06914765
- Testing
- Endoscopic Sleeve Gastroplasty (ESG) Procedure
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's Hospital of Philadelphia
Obesity
Bariatric Endoscopy for Treatment of Obesity
A single-center, randomized trial will be conducted in order to compare three Endoscopic Gastroplasty (EG) techniques in obese patients (BMI 30-44.99 kg/m2) at Gastroenterology and Gastrointestinal Endoscopy Unit, Mater Olbia…
- Trial name
- NCT04854317
- Testing
- Endoscopic gastroplasty
- Where
- Italy
- Volunteers
- 189 people
- Sponsor
- Mater Olbia Hospital
Inflammatory Bowel Diseases, Obesity
Faesiblity and Safety of Endoscopic sLeeve gastrOplasty in Patients With obEsity and nflammatoRy Bowel Disease
Obesity is classified as a body mass index (BMI) above 30 kg/m2 by the World Health Organization. Both overweight (BMI > 25 kg/m2) and obesity (BMI >30 kg/m2) have increased worldwide during the last decades: 1.46 billion of the…
- Trial name
- FLOWER (NCT06616714)
- Testing
- Observtional Study
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Laterza Lucrezia
Obesity, Liver Diseases
Effect of Endoscopic Sleeve Gastroplasty in Patients With Obesity and MASH: A Randomized Controlled Trial
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease globally. While weight loss through lifestyle modification is the standard treatment, most patients regain weight limiting…
- Conditions
- Obesity, Liver Diseases, Liver Fibrosis, Liver Fat
- Trial name
- NCT06138821
- Testing
- ESG + lifestyle modification, Lifestyle modification
- Where
- 2 sites in United States
- Volunteers
- 132 people
- Sponsor
- Pichamol Jirapinyo, MD, MPH
Obesity, Obesity (Body Mass Index >30 kg/m2)
ENLIGHT Trial: ESG With Fundal Mucosal Ablation
The ENLIGHT Trial is a single-center, randomized controlled trial evaluating whether adding fundal mucosal ablation (FMA) to endoscopic sleeve gastroplasty (ESG) improves weight loss and metabolic outcomes in adults with obesity.
- Trial name
- NCT07792226
- Testing
- Endoscopic Sleeve Gastroplasty (ESG), Fundal Mucosal Ablation
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- West Virginia University
Obesity, Obesity, Morbid
Endoscopic Metabolic and Bariatric Therapies
This is a prospective collection of data from adult patients who have had an endoscopic metabolic and bariatric endoscopy procedure (EMBT) for primary or revision surgical procedures for obesity.
- Conditions
- Obesity, Obesity, Morbid, Obesity Associated Disorder, Bariatric Surgery Candidate
- Trial name
- EMBTs (NCT05725967)
- Testing
- Primary Obesity Endoscopic Procedures, Endoscopic Revision of Bariatric Surgical Procedures, Bariatric Surgery Procedures
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Christopher C. Thompson, MD, MSc
Obesity (BMI>30), Heart Failure With Preserved Ejection Fraction (HFPEF)
Pilot Study of Endoscopic Sleeve Gastroplasty for Obese Patients With Heart Failure and Preserved Ejection Fraction
This is a small research study to see whether losing weight with a minimally invasive weight-loss procedure called endoscopic sleeve gastroplasty (ESG) can help improve symptoms of a type of heart failure called HFpEF in adults…
- Trial name
- NCT07798219
- Testing
- Endoscopic sleeve gastroplasty (ESG)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Cedars-Sinai Medical Center
Endoscopic Tissue Apposition, Endoscopic Suturing
Prospective Evaluation of the Efficacy and Safety of Endoscopic Tissue Apposition
This study is a prospective registry of patients undergoing endoscopic suturing and/or clip placement at our institution to assess the efficacy and safety of endoscopic tissue apposition.
- Conditions
- Endoscopic Tissue Apposition, Endoscopic Suturing, Endoscopic Clipping, Bariatric Endoscopy
- Trial name
- NCT03626194
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- University of Colorado, Denver
Obesity
Ablation Registry (Combined Gastric Mucosal Ablation With Endoscopic Sleeve Gastroplasty for Weight Loss)
The purpose of this study is to construct a multi-site, prospective registry to evaluate the clinical outcomes of patients who have undergone combined gastric mucosal ablation with endoscopic sleeve gastroplasty at True You…
- Trial name
- NCT06420700
- Testing
- Combined gastric mucosal ablation with endoscopic sleeve gastroplasty
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- True You Weight Loss
Obesity & Overweight
ENDOBARIHEART STUDY
The primary outcome of this study is to evaluate changes in cardiovascular risk after endoscopic sleeve gastroplasty (ESG) in patients at high cardiovascular risk, using the SCORE2 ( Systematic COronary Risk Evaluation 2) and…
- Trial name
- NCT07847307
- Testing
- echocardiography, Coronary CT angiography, blood analysis
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Maria Cecilia Hospital
Obesity Type 2 Diabetes Mellitus
Endoscopic Sleeve Gastroplasty Plus Duodenal pulsENDO for Obese T2DM
This study is designed to evaluate the efficacy, safety, and mechanisms of combining ESG and pulsENDO procedure in obese patients with T2DM
- Trial name
- DRAGON (NCT07660445)
- Testing
- Endoscopic sleeve gastroplasty plus duodenal recellularization via electroporation therapy (pulsENDO)
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- Chinese University of Hong Kong