Clinical trials: Endoscopic Ultrasound (EUS)
Autoimmune Pancreatitis, Pancreatic Cancer
To Differentiate Focal Autoimmune Pancreatitis From Pancreatic Cancer by Endoscopic Ultrasound
Autoimmune pancreatitis (AIP) is a special type of chronic pancreatitis mediated by autoimmunity. The classic manifestation of AIP is diffuse pancreatic enlargement, some of which are characterized by focal enlargement.
- Trial name
- NCT04834505
- Testing
- Diagnostic imaging modalities for validation sample, EUS for derivation sample
- Where
- China
- Volunteers
- 286 people
- Sponsor
- Peking Union Medical College Hospital
Endoscopic Ultrasonography, Liver Biopsy
19G FNB Needle vs 22G FNB Needle for EUS-Guided Liver Biopsy
EUS-guided liver biopsy (EUS-LB) is increasingly used to diagnose patients with liver disease, especially in anxious patients who need sedation. There is an ongoing debate about the optimal needle size for EUS-LB.
- Trial name
- NCT06643520
- Testing
- 19-gauge, 22-gauge
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Duzce University
Neuroendocrine Tumors
Nonfunctioning Small (≤2 cm) Neuroendocrine Pancreatic Incidentaloma
Neuroendocrine tumors (NETs) and carcinomas account for 10-15 % of all pancreatic incidentalomas. The management of pancreatic NETs depends on tumor stage and on presence or not of hormonal syndrome.
- Trial name
- NCT03022188
- Where
- 22 sites in Belgium, France
- Volunteers
- 100 people
- Sponsor
- Société Française d'Endoscopie Digestive
Liver Diseases, Liver Fibrosis
Prospective Single Centre Observational Study to Compare the Diagnostic Yield of Different Modalities of Liver Biopsy
The goal of this study is to learn about endoscopic ultrasound(EUS) guided liver biopsy and how this compares to traditional methods of obtaining liver biopsy samples, in patients with liver disease.
- Trial name
- NCT05912179
- Testing
- Liver biopsy - percutaneous, Liver biopsy - transjugular, liver biopsy - EUS guided
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Nottingham University Hospitals NHS Trust
Pancreatic Disease, Pancreatic Cancer
EUS Examination Using EndoSound Vision System vs. Standard Echoendoscope
This is a randomized trial to compare the standard echoendoscope with the newly developed EndoSound Visual System in the evaluation of lesions in the gastrointestinal tract.
- Conditions
- Pancreatic Disease, Pancreatic Cancer, Pancreatic Cyst, Gastrointestinal Tumor
- Trial name
- NCT06340620
- Testing
- Endoscopic ultrasound examination
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Orlando Health, Inc.
Abdominal Pain
EUS vs EGD in Emergency Room Patients Referred for EGD
Emergency room patients referred for esophago-gastro-duodenoscopy (EGD) often have many possible causes for their symptoms. These patients inevitably undergo further testing if EGD is inconclusive, which adds costs and prolongs…
- Trial name
- EUSvsEGD (NCT04408872)
- Testing
- Esophago-gastro-duodenoscopy (EGD), Endoscopic ultrasound (EUS)
- Where
- 2 sites in Canada
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Non-alcoholic Steatohepatitis (NASH), Endoscopic Sleeve Gastroplasty
A Physiologic Analysis of Endoscopic Sleeve Gastroplasty (ESG)
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Affecting approximately one-third of the United States (U.S.) population, the prevalence of NAFLD increases to 90% in patients with…
- Conditions
- Non-alcoholic Steatohepatitis (NASH), Endoscopic Sleeve Gastroplasty, Non-alcoholic Fatty Liver Disease (NAFLD), Endoscopic Ultrasound
- Trial name
- NCT04820036
- Testing
- Insulin Resistance, Quality of Life Assessment, Liver Function Test
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Brigham and Women's Hospital
Mediastinal or Intra-abdominal Lymphadenopathy,, Pancreatic Masses,
A Randomized Controlled Trial Of Endoscopic Ultrasound-Guided Fine-Needle Aspiration With And Without A Stylet
Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) has become an important tool in the diagnostic evaluation of gastrointestinal tract lesions and other organ sites such as mediastinal and intra-abdominal…
- Conditions
- Mediastinal or Intra-abdominal Lymphadenopathy,, Pancreatic Masses,, Left Adrenal Masses,, Gastrointestinal Submucosal Lesions, and
- Trial name
- NCT01213290
- Testing
- EUS - FNA with stylet, Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA)
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- American Society for Gastrointestinal Endoscopy
Cancer of Pancreas, Pancreatic Neoplasms
EUS-Coeliac Plexus Block Versus Radiofrequency Ablation in Pain Relief of Patients With Malignancy
Many cancer patients suffer from intractable pain and which is often suboptimally controlled by even strong opioid analgesics. Coeliac plexus neurolysis (CPN) is procedure which intended to permanently destroy the nociceptive…
- Conditions
- Cancer of Pancreas, Pancreatic Neoplasms, Pain, Cancer-Associated Pain
- Trial name
- NCT04809935
- Testing
- 98% dehydrated alcohol, 19G EUSRA needle, Taewoong Medical, Korea
- Where
- Hong Kong
- Volunteers
- 54 people
- Sponsor
- The University of Hong Kong
Acute Cholecystitis
A Randomized Controlled Trial on EGBD vs PC for Acute Cholecystitis.
Acute cholecystitis commonly occurs in elderly patients that are high-risk candidates for surgery. Percutaneous cholecystostomy (PC) is frequently employed for gallbladder drainage in these patients.
- Trial name
- DRAC (NCT02212717)
- Testing
- EUS-guided gallbladder drainage (EGBD), Percutaneous cholecystostomy (PC)
- Where
- 4 sites in China, Japan and 1 more
- Volunteers
- 60 people
- Sponsor
- Chinese University of Hong Kong
Gall Stones, Gall Stones (& [Calculus - Gall Bladder])
A Study on the Efficacy and Safety of Endoscopic Ultrasound-guided Gastro-/Duodeno-cholecystostomy for the Treatment of Gallstones.
Gallstones, as a common benign gallbladder disease worldwide, have a prevalence of approximately 6.1%. Although laparoscopic cholecystectomy (LC) is currently the mainstream treatment, its associated complications cannot be…
- Trial name
- NCT07522385
- Testing
- cholecystolithotomy
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Cholecystitis, Acute, Pancreas Cancer, Duct Cell Adenocarcinoma
Safety and Efficacy of EUS-guided Gallbladder Drainage Under Endoscopist-directed Conscious Sedation
This prospective single-center study was designed by the investigators to evaluate the feasibility, safety, and efficacy of endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) performed under endoscopist-directed…
- Conditions
- Cholecystitis, Acute, Pancreas Cancer, Duct Cell Adenocarcinoma, Cholangiocarcinoma
- Trial name
- NCT07704021
- Testing
- Sedation
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- Azienda Unita Sanitaria Locale di Piacenza
Gastric Varix
Endoscopic Ultrasound-guided Coil With Cyanoacrylate Injection Versus Balloon-Occluded Retrograde Transvenous Obliteration in Managing Patients With Gastric Varices
Gastrointestinal bleeding is a common complication of liver cirrhosis which caused by esophageal and gastric varices. The risk of bleeding from gastric varices is relatively low.
- Trial name
- NCT05500625
- Testing
- Endoscopic ultrasound-guided coil embolization combined with endoscopic cyanoacrylate injection, Ballon-occluded retrograde transvenous obliteration
- Volunteers
- 70 people
- Sponsor
- Assiut University
Crohn Disease (CD), Cryptoglandular Perianal Fistula
A Study Comparing Transperineal Ultrasound, Magnetic Resonance Imaging, Endoscopic Ultrasound, and Examination Under Anesthesia to Detect and Classify Perianal Fistulas in Patients With Crohn's Disease or Fistulas of Unknown Cause
The goal of this study is to learn how well different imaging tests detect and describe perianal fistulas in adults with Crohn's disease or fistulas with no known cause (cryptogenic).
- Trial name
- TRANSIT CD (NCT07794410)
- Testing
- Transperineal Ultrasound (TPUS), Magnetic Resonance Imaging (MRI), Endoscopic Ultrasound (EUS)
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Asian Institute of Gastroenterology, India
Endoscopic Ultrasonography, EUS-FNA
Heparin-based Wet Suction Method in EUS Fine Needle Biopsy of Solid Pancreatic Mass
The objective of this randomized cross-over trial is to evaluate whether Heparin based wet suction technique, compared with dry suction technique, shall present a higher quality tissue core by using quantitative macroscopic and…
- Conditions
- Endoscopic Ultrasonography, EUS-FNA, Pancreatic Neoplasms
- Trial name
- NCT04707560
- Testing
- EUS fine needle biopsy with heparin wet suction
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Cheng-Kung University Hospital
Walled Off Necrosis, Pancreatitis
Encapsulation-oriented vs. Timing-oriented Strategies for Necrotizing Pancreatitis
This multicenter, randomized controlled trial (WONDER-03 study) investigates the optimal timing for endoscopic ultrasound (EUS)-guided drainage in patients with necrotizing pancreatitis.
- Conditions
- Walled Off Necrosis, Pancreatitis, Acute Necrotic Collection, Necrotizing Pancreatitis
- Trial name
- WONDER-03 (NCT07106346)
- Testing
- The timing of endoscopic intervention for necrotizing pancreatitis is determined based on the degree of encapsulation, EUS-guided drainage based on the interval from the onset of acute pancreatitis
- Where
- 36 sites in Japan
- Volunteers
- 224 people
- Sponsor
- Tokyo University
Cancer of Pancreas, Cancer of Stomach
Wet Heparinized Suction for Abdominal Cancer
The purpose of this research is to compare the amount and quality of tissue obtained by EUS-FNB when the device is flushed with an anticoagulant or "blood thinner" vs.
- Conditions
- Cancer of Pancreas, Cancer of Stomach, Cancer of Esophagus, Cancer of Liver
- Trial name
- EUS Heparin (NCT05041335)
- Testing
- wet heparinzed suction, Microsieve, No heparin flush
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Diagnoses Diseases, Ultrasound Therapy; Complications
19 Versus 22-Gauge Needle for EUS-LB
Chronic liver disorders (CLD) are a major cause of morbidity and mortality for individuals in the US. Though serologic analysis will often lead to a conclusive diagnosis, liver biopsy remains an important method for helping to…
- Conditions
- Diagnoses Diseases, Ultrasound Therapy; Complications, Liver Diseases
- Trial name
- EUSLB1922 (NCT02967991)
- Testing
- EUS-guided liver biopsy
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Geisinger Clinic
Pancreatic Adenocarcinoma, Chronic Pancreatitis
Endoscopic Ultrasound Elastography in Pancreatic Masses
The aim of the study is to assess elastography during EUS examinations of focal pancreatic masses, and to consequently differentiate benign versus malignant pancreatic masses in a prospective multi-center design.
- Trial name
- EUS-EG (NCT00909103)
- Where
- 18 sites in Belgium, Denmark and 8 more
- Volunteers
- 285 people
- Sponsor
- University of Medicine and Pharmacy Craiova
Biopsy, Fine-Needle, Endosonography
Impact of Suction in the EUS-guided Fine Needle Biopsy of Solid Pancreatic Lesions
Tissue acquisition by Endoscopic Ultrasound (EUS) has become a modality of diagnosis and clinical orientation for several diseases.
- Conditions
- Biopsy, Fine-Needle, Endosonography, Pancreatic Neoplasm
- Trial name
- NCT04164017
- Testing
- EUS-guided FNB with Syringe Suction, EUS-guided FNB without Syringe Suction
- Where
- Portugal
- Volunteers
- 100 people
- Sponsor
- Centro Hospitalar De São João, E.P.E.