Clinical trials: Endothelial Cell Loss, Corneal
Endothelial Cell Loss, Corneal, Cataract and Intraocular Lens (IOL) Surgery
Effect of Vitamin C Supplementation in Corneal Endothelial Damage in Phacoemulsification of Patients with Hard Cataracts
The goal of this clinical trial is to analyze the protective effects of oral ascorbic acid on the corneal endothelial layer undergoing oxidative stress due to phacoemulsification in patients with hard cataracts.
- Trial name
- NCT06781970
- Testing
- Oral Vitamin C
- Where
- 2 sites in Indonesia
- Volunteers
- 120 people
- Sponsor
- Universitas Indonesia
Fuch's Endothelial Dystrophy, Bullous Keratopathy, Unspecified Eye
Comparing Endoglide to Endoserter for DSAEK Graft Insertion
The purpose of this study is to compare the Tan EndoGlide with the new Endoserter injector in terms of damage to the donor corneal endothelium by comparing the endothelial cell loss at 1 month, 3 months, 6 months, and 1 year post…
- Trial name
- NCT01791075
- Testing
- Tan Endoglide, Endosaver
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- University Health Network, Toronto
Cataract
Influencing Factors of the Corneal Endothelial Cell Loss
This is a multi-center cohort study with prognostic aims to identify factors associated with endothelial cell loss during cataract surgery.
- Trial name
- PREDICS (NCT05265832)
- Testing
- Phacoemulsification
- Where
- 2 sites in France
- Volunteers
- 154 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Corneal Endothelial Cell Loss, Fuchs' Endothelial Dystrophy
Technique And Results In Endothelial Keratoplasty
To assess and compare the complications and results of different lamellar endothelial keratoplasty techniques and its variations.
- Trial name
- TREK (NCT02470793)
- Testing
- Descemet Stripping Automated Endothelial Keratoplasty, Descemet Membrane Endothelial Keratoplasty
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- EDUARD PEDEMONTE-SARRIAS
Corneal Endothelial Cell Loss, Mydriasis
Effect of Intracameral Injection of Mydriatic Plus Anaesthetic Combination on Corneal Endothelial Count in Phaco
Study evaluates safety of intracameral injection of Fydrane (tropicamide 0.02%, phenylephrine 0.31% and lidocaine 1%) on corneal endothelium, and efficiency in maintaining pupillary dilatation during phacoemulsification surgery.
- Conditions
- Corneal Endothelial Cell Loss, Mydriasis, Cataract
- Trial name
- NCT04396301
- Testing
- Fydrane®: (Manufacturer DELPHARM TOURS, FRANCE).
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Cataract
The Effect of Hydrodynamic Parameters on Corneal Endothelial Cell Loss After Phacoemulsification
The purpose of this study is to compare two surgical techniques (high vacuum and low vacuum) on corneal endothelium after phacoemulsification.
- Trial name
- NCT00370955
- Testing
- phacoemulsification using either high vacuum or low vacuum techniques
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Corneal Endothelial Cell Loss
Comparative Study of Specular Microscopes for Measurements of Cell Density, Coefficient of Variation and Hexagonality
The primary objective of this clinical study is to collect clinical data to support an FDA 510(k) submission for the Nidek CEM-530 Center point method and Corner point method.
- Trial name
- NCT02276638
- Testing
- Specular Microscope Nidek CEM-530, Specular Microscope Konan CELLCHEK XL
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Nidek Co. LTD.
Corneal Endothelial Cell Loss, Cataract
Comparison of Phacoemulsification and Corneal Damage Between FLACS and Standard Phaco With Two Handpieces
The main goal of this study is to compare traditional cataract surgery with two new technologies: the femtosecond laser and the new Active Sentry handpiece.
- Conditions
- Corneal Endothelial Cell Loss, Cataract, Astigmatism
- Trial name
- NCT05119270
- Testing
- Femtosecond laser assisted cataract surgery with Active Sentry handpiece, Standard phacoemulsification with the Active Sentry handpiece, Standard phacoemulsification with the OZil handpiece
- Where
- Canada
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Fuchs Endothelial Corneal Dystrophy, Corneal Endothelial Decompensation
Effect of Donor Diabetes and Other Factors on Corneal Transplant Endothelial Cell Loss and Success at 5 Years
This multi-center clinical trial is designed to assess the association of diabetes in a cornea donor with transplant success and loss of endothelial cells 5 years following Descemet membrane endothelial keratoplasty (DMEK).
- Trial name
- DEKS (NCT07217249)
- Testing
- Descemet membrane endothelial keratoplasty
- Where
- 14 sites in United States
- Volunteers
- 570 people
- Sponsor
- Case Western Reserve University
Corneal Endothelial Cell Loss, Glaucoma
Corneal Endothelial Cell Loss After Trabeculectomy Versus Phakotrabeculectomy
Corneal endothelial cells health and pumping function is crucial to permit corneal optical clarity by keeping cornea in relatively dehydrated state.
- Trial name
- NCT03107000
- Testing
- Trabeculectomy, Phako-trabeculectomy
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Sunnybrook Health Sciences Centre
Hard Nuclear Cataract, Phacoemulsification Cataract Surgery
Study on the Surgical Strategy of Corneal Endothelial Protection for Hard Nuclear Cataract Patients
In this study, we compared two types of phacoemulsification commonly used in cataract surgery to evaluate their effect on the prognosis of patients with hard nuclei.
- Conditions
- Hard Nuclear Cataract, Phacoemulsification Cataract Surgery, Endothelial Cell Density Loss, Central Corneal Thickness
- Trial name
- NCT06991374
- Testing
- combined burst mode, torsional mode
- Where
- China
- Volunteers
- 207 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Cataract
Outcomes of Phacoemulsification With Torsional Ultrasound
To determine the differences in intra-operative complications, surgical duration, fluid usage, corneal thickness and endothelium cell density in eyes undergoing microcoaxial phacoemulsification (MCP) either with Torsional or…
- Trial name
- NCT01010490
- Testing
- Torsional ultrasound (INFINITI, Alcon, USA), Longitudinal U/S (Infiniti system, Alcon, USA), Longitudinal U/S (LEGACY 20000, Alcon, USA)
- Where
- India
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Iladevi Cataract and IOL Research Center
Corneal Endothelial Cell Loss, Ocular Pain
RTA 408 Ophthalmic Suspension for the Prevention of Corneal Endothelial Cell Loss Following Cataract Surgery - GUARD
This study assesses the efficacy and safety of two concentrations of omaveloxolone (RTA 408) ophthalmic suspension for the prevention of corneal endothelial cell loss following cataract surgery.
- Conditions
- Corneal Endothelial Cell Loss, Ocular Pain, Ocular Inflammation, Cataract Surgery
- Trial name
- NCT02128113
- Testing
- Vehicle Ophthalmic Solution, Omaveloxolone Ophthalmic Suspension 0.5%, Omaveloxolone Ophthalmic Suspension 1%
- Where
- 15 sites in United States
- Volunteers
- 307 people
- Sponsor
- Biogen
Senile Cataract
Corneal Endothelial Cell Loss After Phacoemulsification Compared With Extracapsular Cataract Extraction
the investigators will compare between the endothelial cell loss after phacoemulsification and extracapsular cataract extraction in management of senile cataract
- Trial name
- NCT03262285
- Testing
- phacoemulsification, extracapsular cataract extraction
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Assiut University
Diabetes, Cataract
Corneal Endothelial Changes Associated With Phacoemulsification in Diabetes Mellitus Type II
Some studies indicated that the diabetic corneal endothelium is morphologically abnormal and may be at risk in any intraocular surgical procedure, while others showed no significant differences between diabetic and non-diabetic…
- Trial name
- NCT01078103
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Frederiksberg University Hospital
Cataract
Comparison of Femtosecond Laser Assisted Cataract Surgery to Conventional Phacoemulsification Cataract Surgery
In this project, the investigators aim to compare the safety, efficacy, and predictability outcomes of conventional CEIOL surgery to Femtosecond-laser-assisted CEIOL (FLACS) in an effort to improve cataract surgery outcomes.
- Trial name
- NCT02096627
- Where
- United States
- Volunteers
- 154 people
- Sponsor
- Johns Hopkins University
Corneal Endothelial Cell Loss
Effect of Intravitreal Bevacizumab on Corneal Endothelium
To evaluate corneal endothelium cell change after intravitreal Bevacizumab injection
- Trial name
- NCT01726790
- Where
- Thailand
- Volunteers
- 37 people
- Sponsor
- Khon Kaen University
Endothelial Cell Loss, Corneal
Protecting the Corneal Endothelium During Cataract Surgery Using the Anterior Capsule
Cataract surgery is one of the most frequently performed surgical procedures worldwide. Since the introduction of phacoemulsification to remove the cataractous lens, risk and complication rates of cataract surgery decreased…
- Trial name
- NCT03855293
- Testing
- Rhexis protection shield
- Volunteers
- 70 people
- Sponsor
- Prim. Prof. Dr. Oliver Findl, MBA
Diabetes Mellitus, Corneal Endothelial Cell Loss
Effect of Intracameral Dexamethasone After Phacoemulsification in Diabetics on Corneal Endothelial Cell Density
The prevalence of diabetes mellitus (DM) is rapidly growing worldwide. One major concern with diabetes mellitus is how it may affect vision in different ways; including the increased risk of developing cataract.
- Conditions
- Diabetes Mellitus, Corneal Endothelial Cell Loss, Dexamethasone Adverse Reaction, Corneal Endothelial Decompensation
- Trial name
- DIABEDEX (NCT03361709)
- Testing
- Dexamethasone, Saline Solutions, Intraocular
- Sponsor
- Cairo University
Corneal Edema, Fuchs
Study of EO2002 in Subjects With Corneal Edema Secondary to Corneal Endothelial Dysfunction
This study will evaluate the safety and effectiveness of a single injection of EO2002 at one of two dose levels (150,000 or 500,000 magnetic human corneal endothelial cells [mHCECs]), compared with a placebo injection, in…
- Conditions
- Corneal Edema, Fuchs, Fuchs Dystrophy, Fuchs' Endothelial Dystrophy
- Trial name
- EMERALD (NCT07729137)
- Testing
- 150K cells, 500K cells
- Where
- 10 sites in United States
- Volunteers
- 121 people
- Sponsor
- Emmecell