Clinical trials: Endothelial Corneal Dystrophy
Corneal Endothelial Decompensation, Fuchs' Endothelial Dystrophy
Impact of Donor Diabetes on DMEK Success and Endothelial Cell Loss
This double-masked multi-center trial will evaluate the association of diabetes in the cornea donor with transplant success and loss of endothelial cells through 1 year following Descemet membrane endothelial keratoplasty (DMEK).
- Trial name
- DEKS (NCT05134480)
- Testing
- Descemet membrane endothelial keratoplasty
- Where
- 2 sites in United States
- Volunteers
- 1,097 people
- Sponsor
- Case Western Reserve University
Corneal Transplantation, Descemet Stripping Automated Endothelial Keratoplasty
DSAEK- Postoperative Positioning and Transplant Dislocation
Corneal transplant is a surgical procedure where a damaged or diseased cornea is replaced by donated corneal tissue (the graft) in its entirety (penetrating keratoplasty) or in part (lamellar keratoplasty).
- Conditions
- Corneal Transplantation, Descemet Stripping Automated Endothelial Keratoplasty, Fuchs' Endothelial Dystrophy, Corneal Dystrophies, Hereditary
- Trial name
- NCT01206127
- Testing
- Postoperative positioning: Bed rest, Postoperative positioning: Sitting up
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- Oslo University Hospital
Fuchs' Endothelial Corneal Dystrophy, Pseudophakic Bullous Keratopathy
Prognosis of Posterior Lamellar Keratoplasty
Over the past decade, the management of Fuchs' endothelial corneal dystrophy (FECD) and pseudophakic bullous keratopathy (PBK) has been revolutionized by the development of posterior lamellar keratoplasty techniques: DSAEK and…
- Trial name
- CORNEACOHORT (NCT06859411)
- Testing
- visual acuity comparaison
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Fuchs Endothelial Corneal Dystrophy
Prevalence of Fuchs Endothelial Corneal Dystrophy in a Population of Dermatology Patients.
The prevalence of Fuchs Endothelial Corneal Dystrophy (FECD) varies from 3.7 to 21.6% of adults depending on the population studied (country and age class), the method of diagnosis and the definition adopted.
- Trial name
- NCT07117071
- Testing
- collection of medical data
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Fuchs Endothelial Corneal Dystrophy
SUCCESS Score Validation in Fuchs Dystrophy
This prospective multicenter diagnostic study aims to externally validate and extend the SUCCESS Score for predicting the need for endothelial keratoplasty after cataract surgery in patients with Fuchs endothelial corneal…
- Trial name
- SUCCESS (NCT07265388)
- Testing
- Phacoemulsification Cataract Surgery
- Where
- Spain
- Volunteers
- 250 people
- Sponsor
- Instituto Ramón y Cajal de Investigación Sanitaria
Corneal Disease, Fuch's Dystrophy
Cornea Donor Study
The Cornea Donor Study (CDS) was designed as a prospective cohort study with the following objectives: To determine whether the graft-failure rate over a 5-year follow-up period following corneal transplantation is the same when…
- Conditions
- Corneal Disease, Fuch's Dystrophy, Pseudophakic Corneal Edema
- Trial name
- CDS (NCT00006411)
- Testing
- corneas assigned by donor age group
- Where
- United States
- Volunteers
- 1,090 people
- Sponsor
- National Eye Institute (NEI)
Fuchs Endothelial Corneal Dystrophy
A Study to Investigate the Safety and Efficacy of K-321 Eye Drops After Simultaneous Cataract Surgery and Descemetorhexis in Participants With Fuchs Endothelial Corneal Dystrophy (FECD)
A study to assess the safety and efficacy of K-321 in participants with FECD after simultaneous cataract surgery and descemetorhexis.
- Trial name
- NCT05826353
- Testing
- Ripasudil
- Where
- 43 sites in United States, Canada and 4 more
- Volunteers
- 110 people
- Sponsor
- Kowa Research Institute, Inc.
Fuchs' Endothelial Dystrophy, Fuchs Dystrophy
TTHX1114(NM141) in Combination With DWEK/DSO
Open label, single-treatment, with a concurrent non-treatment control
- Conditions
- Fuchs' Endothelial Dystrophy, Fuchs Dystrophy, Fuchs
- Trial name
- NCT04676737
- Testing
- TTHX1114(NM141)
- Where
- 11 sites in United States
- Volunteers
- 49 people
- Sponsor
- Trefoil Therapeutics, Inc.
Fuchs' Endothelial Corneal Dystrophy
Fuchs' Endothelial Dystrophy: Clinical Characteristics, Treatment Outcome, and Pathology
Background Fuchs' Endothelial Dystrophy Fuchs' Endothelial Dystrophy (Fuchs' ED) is characterized by changes on the inside of the cornea, which leads to a substantial decline in visual acuity.
- Trial name
- NCT01979250
- Testing
- DSAEK surgery
- Where
- Denmark
- Volunteers
- 81 people
- Sponsor
- Aarhus University Hospital
Retinal Detachment, Epiretinal Membrane
PIONEER: Intraoperative and Perioperative OCT Study
OCT provides high-resolution information regarding the anatomic structure of the tissues of the eye in a 2-dimensional and 3-dimensional view. Much of this information is not able to be recognized by a clinician.
- Conditions
- Retinal Detachment, Epiretinal Membrane, Macular Hole, Fuchs Endothelial Dystrophy
- Trial name
- PIONEER (NCT02423161)
- Where
- United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Fuchs Endothelial Corneal Dystrophy, Cataract
The Effect of Topical Rho-kinase Inhibitors on Corneas of Patients With Fuchs Endothelial Corneal Dystrophy
The goal of this study is to learn if topical ROCK inhibitors protect endothelial corneal cells in patients with glaucoma and Fuchs endothelial corneal dystrophy after cataract surgery.
- Conditions
- Fuchs Endothelial Corneal Dystrophy, Cataract, Glaucoma
- Trial name
- NCT06969586
- Testing
- Netarsudil 0.02% Ophthalmic Solution, artificial tear substitute
- Where
- Croatia
- Volunteers
- 50 people
- Sponsor
- University Hospital Dubrava
Fuchs' Endothelial Dystrophy
Evaluation of Amphotericin B in Optisol-GS for Prevention of Post-Keratoplasty Fungal Infections.
With the increasing popularity of endothelial keratoplasty, a coincident increase in the rate of fungal infections post-keratoplasty has been seen in the United States.
- Trial name
- NCT04018417
- Testing
- Amphotericin B
- Where
- United States
- Sponsor
- Cornea Research Foundation of America
Fuchs' Endothelial Dystrophy, Corneal Edema
Plasma Rich in Growth Factors in Corneal Endothelial Transplantation
The purpose of the study is to determine the safety and efficacy of brief intraoperative corneal endothelial graft incubation in plasma rich in growth factors (PRGF) for reducing postoperative endothelial cell loss.
- Trial name
- NCT06261346
- Testing
- Endothelial keratoplasty, PRGF
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Miami
Fuchs' Dystrophy, Bullous Keratopathy
Comparison of Two Steroid Regimens to Prevent Transplant Rejection After Corneal Transplant (DMEK)
The purpose of this study is to compare two different commonly used steroid dosing regimens after Descemet's membrane endothelial keratoplasty (DMEK) transplant surgery.
- Trial name
- NCT01448213
- Testing
- Prednisolone acetate, Fluorometholone
- Where
- 2 sites in United States, Germany
- Volunteers
- 264 people
- Sponsor
- Price Vision Group
Fuchs' Corneal Dystrophy, Cataract
Combined Cataract Surgery and Planned Descemetorhexis
A pilot study designed to assess the feasibility of planned descemetorhexis for the treatment of Fuchs' corneal dystrophy.
- Trial name
- NCT02206594
- Testing
- Descemetorhexis
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Medical College of Wisconsin
Fuch's Endothelial Dystrophy
Comparison of Two Techniques in Achieving Corneal Graft
The cornea is a transparent membrane, half a millimeter thick, embedded as a window in front of the eye. When the eye becomes opaque, the eye is not seeing and the only way to restore the visual acuity is to replace the cornea by…
- Trial name
- NCT01610973
- Testing
- Endothelial descemet membrane graft
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Rouen
Mild to Moderate Corneal Endothelial Decompensation, Bullous Keratopathy
Safety and Efficacy of Tissue Engineered Endothelial Keratoplasty
Assessment of safety and efficacy of tissue-engineered corneal endothelial graft material generated using cultured human corneal endothelial cells for tissue-engineered endothelial keratoplasty (TE-EK).
- Conditions
- Mild to Moderate Corneal Endothelial Decompensation, Bullous Keratopathy, Fuchs' Endothelial Dystrophy, Post-surgical Corneal Decompensation (Irreversible)
- Trial name
- TE-EK (NCT04319848)
- Testing
- TE-EK treatment group
- Where
- Singapore
- Volunteers
- 30 people
- Sponsor
- Singapore Eye Research Institute
Fuchs Endothelial Dystrophy
Ripasudil for Enhanced Corneal Clearing Following Descemet Membrane Endothelial Keratoplasty in Fuchs' Dystrophy
Recently, published literature has reported that performing a descemetorhexis in combination with topical Rho kinase (ROCK) inhibitor therapy was successful in clearing edematous corneas in patients with Fuchs Endothelial Corneal…
- Trial name
- NCT03813056
- Testing
- Glanatec, Optive, Ophthalmic Solution, Descemet Membrane Endothelial Keratoplasty
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Michael D. Straiko, MD
Corneal Endothelial Dystrophy, Corneal Edema
Loteprednol Etabonate 0.25% for Prevention of Cornea Transplant Rejection
The purpose of this study is to assess off-label use of loteprednol etabonate 0.25% ophthalmic suspension (Eysuvis) for prevention of immunologic rejection in the first year after Descemet membrane endothelial keratoplasty…
- Trial name
- NCT05136443
- Testing
- loteprednol etabonate 0.25% ophthalmic suspension
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Price Vision Group
Fuchs Dystrophy
Association Between Fuchs' Endothelial Corneal Dystrophy Severity and Estrogen Exposure
This study is being done to discover if there is a link between estrogen exposure and the severity of Fuchs Endothelial Corneal Disease.
- Trial name
- NCT04564378
- Testing
- This is an observational study. There is no therapeutic intervention.
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- State University of New York at Buffalo