Clinical trials: Endothelial Function
Type 2 Diabetes Mellitus
Free Fatty Acids and Vascular Function in Subjects With Diabetes
This study will test the hypothesis that reduction in release of free fatty acids from adipocytes will restore insulin-mediated endothelium-dependent vasodilation and skeletal muscle glucose metabolism in subject with type 2…
- Trial name
- NCT00153179
- Testing
- acipimox
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Cystic Fibrosis
Blood Flow and Vascular Function in Cystic Fibrosis
Cystic fibrosis (CF) has many health consequences. A reduction in the ability to perform exercise in patients with CF is related to greater death rates, steeper decline in lung function, and more frequent lung infections.
- Trial name
- CF-FLOW (NCT02057458)
- Testing
- Sildenafil (Acute-1 hour), Sildenafil (Subchronic-4 weeks)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Augusta University
Prediabetes, Obese
Inflammation Inhibition in Prediabetic Humans
Prediabetes, characterized by elevated fasting blood sugar or exaggerated blood sugar response to sugar ingestion, effects over 79 million adult Americans and is a precursor to the development of Type 2 diabetes.
- Trial name
- INCITE (NCT01977417)
- Testing
- Salsalate
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Gary L. Pierce
Healthy
Arginine Supplementation to Improve Cardiovascular and Endothelial Function After NSAID Treatment
A single centre, placebo controlled, blinded (participant, investigator, outcome assessor) trial to evaluate the effects of COX-2 inhibition with celecoxib on endothelial function in healthy male volunteers.
- Trial name
- ASCENT (NCT04765644)
- Testing
- Celecoxib, L-arginine + celecoxib
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Diabetes Mellitus, Insulin-Dependent, Hypercholesterolemia
Statins in Children With Type 1 Diabetes and Hypercholesterolemia
Children with type1 diabetes (T1DM) have increased risk for cardiovascular disease (CVD) due to chronic increase in the blood sugars and inflammation.
- Trial name
- NCT01236365
- Testing
- Atorvastatin
- Where
- 5 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Hypertension
Melatonin and Nighttime Blood Pressure in African Americans--24 mg Study
The purpose of this study is to test the effect of oral melatonin supplementation (24 mg per night for 4 weeks) on nighttime blood pressure in African Americans with a history of elevated nighttime blood pressure.
- Trial name
- NCT01114373
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Emory University
Endothelial Dysfunction
The Effects of Resveratrol and Acute Exercise on Endothelial Function in Postmenopausal Women
This pilot study plans to learn more about the aging of blood vessels and arteries in women. As women age and go through menopause, their risk for cardiovascular disease increases.
- Trial name
- NCT02256540
- Testing
- Climara, Resveratrol
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Diseases, Metabolic, Insulin Sensitivity
Comparing Soybean Oil-Based (Intralipid) With an Olive Oil-Based (ClinOleic) Lipid Emulsion on Healthy Volunteers
Many patients in the hospital who are malnourished or not eating received intravenous feeding or total parenteral nutrition (TPN). Despite improving nutrition, TPN may increase the risk of infections and hospital complications.
- Trial name
- TPN1 (NCT02185729)
- Testing
- Intralipid, ClinOleic, Dextrose
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Emory University
Aging, Inflammation
Effect of Age and Fitness on Vascular Function and Oxidative Stress During Acute Inflammation
This study focuses on whether high cardiorespiratory fitness in older adults has a protective effect on the vascular response to acute inflammation in comparison to low-fit older and young adults.
- Trial name
- NCT03889158
- Testing
- Typhoid Vaccine, Ascorbic Acid
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Endothelial Function, Lipids
Effects of Etravirine on Endothelial Function in HIV-uninfected Adults: A Pilot Study
The purpose of this study is to determine the safety and effects of etravirine, an HIV antiretroviral medication, on vascular function.
- Conditions
- Endothelial Function, Lipids, Insulin Resistance, Inflammation
- Trial name
- NCT00871234
- Testing
- Etravirine
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Indiana University
Endothelial Dysfunction
The Effects of Watermelon Juice Supplementation on Postprandial Vascular Endothelial Function
The purpose of this study is to test if watermelon juice supplementation improves vascular dysfunction experience during hyperglycemia.
- Trial name
- WMJ (NCT04092439)
- Testing
- Watermelon Juice
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Endothelial Dysfunction, Aging
Passive Mobilization and Vascular Function
With aging, vascular function (VF) declines. Inactivity and sedentary life style have been shown to contribute to the worsening of VF.
- Conditions
- Endothelial Dysfunction, Aging, Bed Rest
- Trial name
- NCT03087643
- Testing
- Passive mobilization - PM
- Where
- 3 sites in Italy
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Universita di Verona
Postural Tachycardia Syndrome (POTS)
Effect of Dietary Sodium Intake on Vascular Endothelium
The investigators will test the hypothesis that markers of vascular endothelial dysfunction will be exaggerated acutely with an extreme high sodium diet compared to an extreme low-sodium diet.
- Trial name
- NCT01550315
- Testing
- Pulsitile Arterial Tonometry (PAT) Protocol, Calf Blood Flow in Reactive Hyperemia (CBF-RH), Evaluation of Forearm-Mediated Dilation
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Cardiovascular Diseases
Effect of Estradiol+Drospirenone Versus Estradiol+MPA on Endothelial Function
This study compares the effects of two common hormone medications on the heart and blood vessels of healthy post-menopausal women over the age of 45. The study will take place over the course of about 5 months.
- Trial name
- NCT01109979
- Testing
- Estradiol+MPA, Estradiol+Drospirenone
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Insulin Resistance
The Effects of Altering Physical Activity on Cardiometabolic Health
The effects of physical inactivity on variations in blood glucose and vascular health are not fully understood. The purpose of this study is to determine if an acute transition from physical activity to inactivity alters vascular…
- Trial name
- PIA (NCT01879059)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Cardiovascular Diseases, Atherosclerosis
Aspirin Dose and Atherosclerosis in Patients With Heart Disease
The purpose of the study is to test higher versus lower doses of aspirin on markers of atherosclerosis in patients who have had a heart attack.
- Conditions
- Cardiovascular Diseases, Atherosclerosis, Myocardial Infarction
- Trial name
- TAD (NCT00272337)
- Testing
- Aspirin
- Where
- 2 sites in United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Florida Atlantic University
Cardiovascular Disease
Efavirenz Versus Rilpivirine on Vascular Function, Inflammation, and Oxidative Stress
The purpose of this study is to compare the cardiovascular profiles of efavirenz and rilpivirine, which are two drugs used to treat HIV infection.
- Trial name
- NCT01585038
- Testing
- Efavirenz, Rilpivirine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Indiana University
Obstructive Sleep Apnea
Study to Assess the Changes in Blood Clotting Factors and Blood Vessel Wall Function in Obstructive Sleep Apnea
Obstructive sleep apnea is a condition in which people have decreased breathing during their sleep. Untreated sleep apnea has been linked to increased risk for cardiovascular diseases.
- Trial name
- NCT00936481
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Endothelial Dysfunction
Impact of Smoking Cessation and γ-Tocopherol to Restore Vascular Endothelial Function
Cigarette smoking is a significant risk factor for cardiovascular disease (CVD) and is the leading cause of premature mortality in the US.
- Trial name
- NCT01314443
- Testing
- Nicotine Replacement Therapy (NRT), Gamma-Tocopherol, Smoking cessation
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
HIV Infection
Comparing Blood Vessel Endothelial Function in HIV-Infected People and Matched HIV-Uninfected People
The blood vessels that carry blood from the heart to the rest of the body are normally capable of relaxing and constricting when needed to provide more or less blood to the body.
- Trial name
- NCT00919724
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Indiana University