Clinical trials: Endothelial Function
HIV Infections, Dyslipidemia
Study of Niacin on Endothelial Function in HIV-infected Subjects With Low High Density Lipoprotein Cholesterol Levels
This study is a pilot study examining the effect of extended-release niacin (Niaspan ®) on flow-mediated vasodilation (FMD) of the brachial artery, among human immunodeficiency virus (HIV)-1 infected individuals with low high…
- Conditions
- HIV Infections, Dyslipidemia, Endothelial Dysfunction
- Trial name
- NCT00986986
- Testing
- extended release niacin
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Hawaii
Vascular Endothelium
Health Effects of Biodiesel Exhaust Exposure
Urban air pollution is a major contributor to greenhouse gases and has been shown to increase cardiovascular mortality and morbidity.
- Trial name
- BD100 (NCT01883466)
- Testing
- Forearm venous occlusion plethysmography study
- Where
- Sweden
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Umeå University
Arteriosclerosis, Stress, Psychological
The Effect of Beta-Blockers and Aspirin on Hemostasis and Endothelial Function After Acute Mental Stress
This randomized double-blinded controlled trial uses a factorial design to investigate whether application of beta-blockers (inderal 80 mg) or aspirin (100 mg) or a combination thereof has an effect on the activation of the…
- Trial name
- NCT00174902
- Testing
- inderal (drug), acetylsalicylic acid (drug)
- Where
- Switzerland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Cardiovascular Diseases, Heart Diseases
Endothelial Vasomotor Function in the Framingham Study
To determine whether the presence of endothelial dysfunction is an independent risk factor for cardiovascular disease events.
- Trial name
- NCT00005751
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hyperuricemia, Chronic Kidney Disease
The Effect of Uric Acid Decrement on Endothelial Function in Patients With Chronic Renal Failure
In this prospective study, the investigators aimed to evaluate the effects of improved hyperuricemia, a minor cardiovascular risk factor, on endothelial dysfunction in patients with chronic kidney disease.
- Trial name
- NCT00978653
- Testing
- allopurinol
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Istanbul University
Sarcopenia
Effects of L-ARGinine and Liposomal Vitamin C Supplementation On Physical Performance
In older age, reduced mobility is associated with an increased risk of reduced quality of life, disability, institutionalisation, and death, as well as increased healthcare expenditures.
- Trial name
- ARGO (NCT06865261)
- Testing
- Bioarginina C
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Cardiovascular Disease, Diabetes
Yerba Mate (Ilex Paraguariensis A.St.-Hil.): Assessment of Cardiovascular Health
Mate or yerba-mate (Ilex paraguariensis A.St.-Hil.) is a native plant from South America highly consumed in this region. Different traditional products (mate, mate tea, chimarrao, tereré) are obtained from the yerba-mate leaves…
- Trial name
- YMCH-2015 (NCT02789722)
- Testing
- Yerba Mate Extract
- Where
- Brazil
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Karimi Sater Gebara
Non-obstructive Coronary Artery Disease
Endothelial Function Guided Therapy in Patients With Non-obstructive Coronary Artery Disease
The purpose of this study is to systematically evaluate the clinical application value of vascular endothelial function examination in patients with non-obstructive coronary artery disease.
- Trial name
- EndoFIND (NCT04013204)
- Testing
- Endothelial function guided therapy
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Peking University
Vascular Function, Atherothrombosis
Effect of Real-fire Training on Vascular Function
Fire-fighters are at increased risk of death from heart attacks when compared to other emergency service professionals whose jobs involve similar components such as emergency call-outs and shift work.
- Trial name
- FIREPROOF (NCT01812317)
- Testing
- Forearm Vascular Study, Badimon Chamber Study
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
HIV Infections
Safety and Effectiveness of Low-Dose Methotrexate for Reducing Inflammation in HIV-Infected Adults on ARV Medications
People with HIV infection who are taking antiretroviral therapy (ART) could be at risk for cardiovascular disease (CVD), which can be caused by inflammation.
- Trial name
- NCT01949116
- Testing
- LDMTX, Folic acid
- Where
- 22 sites in United States
- Volunteers
- 176 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Coronary Artery Bypass Grafting, Coronary Artery Disease
Cardiac and Endothelial Function Response to Early Exercise Training After Coronary Artery Bypass Surgery
Background: Coronary artery bypass grafting (CABG) due to coronary artery disease (CAD) is one of the main surgical procedures performed in the area of cardiology.
- Conditions
- Coronary Artery Bypass Grafting, Coronary Artery Disease, Cardiac Rehabilitation
- Trial name
- CEFREET (NCT03096158)
- Testing
- Ventilatory Muscle Training (TREMVEN), Aerobic Training (AERO), Isometric Handgrip Training (ISO)
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Healthy
Acute Strawberry Intake on Endothelial Function
The primary objectives of the study are (1) to evaluate the effects of acute dietary strawberry intake on measures of vascular function in healthy adults following a meal challenge, (2) to evaluate the effects of acute dietary…
- Trial name
- SFMD (NCT03596008)
- Testing
- Active drink
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Healthy, Ageing
Can Cocoa Flavanols Protect Endothelial Function During Prolonged Sitting in Healthy Older Adults?
Sitting time is high in older adults and has been shown to temporarily impair endothelial function and blood pressure. Flavanols, plant-derived compounds, acutely enhance endothelial function and reduce Blood pressure in older…
- Trial name
- NCT07265869
- Testing
- High-flavanol cocoa powder, Low-flavanol cocoa powder
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
HIV-1 Infection
Effect of HAART Vs. Statin Treatment on Endothelial Function and Inflammation/Coagulation
Since people started taking HIV medications, illnesses related to AIDS have decreased, but other serious illnesses like heart disease (heart attacks) and certain kinds of cancer have increased.
- Trial name
- NCT01515813
- Testing
- Pravastatin sodium, Efavirenz/Emtricitabine/Tenofovir Disoproxil Fumarate
- Where
- 9 sites in United States
- Sponsor
- Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections
HIV Infections, HIV Metabolic Cardiovascular Syndrome
Yoga for the Management of HIV-Metabolic Syndromes
We are testing the safety and efficacy of a 16-wk yoga lifestyle intervention on oral glucose tolerance, fasting lipid/lipoprotein levels, body composition, cardiovascular function, quality of life, CD4+ T-cell counts and viral…
- Conditions
- HIV Infections, HIV Metabolic Cardiovascular Syndrome, HIV Lipodystrophy, HIV Metabolic Syndromes
- Trial name
- NCT00627380
- Testing
- Yoga lifestyle intervention, Standard of care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Washington University School of Medicine
Bradycardia
Endothelial Function and Cardiac Output in RV Pacing
Pacing from the right ventricle (as is current practice in patients implanted with permanent pacemakers for bradycardia), has been associated with worse outcomes particularly in heart failure patients.
- Trial name
- NCT00508196
- Testing
- RVP-min, RVP-max
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- University of Dundee
Diabetes Type 2
The Effect of Aliskiren on Endothelial Function in Pre-Diabetes and Diabetes
The purpose of this research is to study and determine the effects of Aliskiren on blood vessels and blood flow. The primary hypothesis is that Aliskiren will increase endothelial function by 30% or more in comparison to the…
- Trial name
- NCT01165983
- Testing
- Aliskiren
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Diabetes, Hyperglycemia
Hyperglycemia and Mitochondrial Function in The Endothelium of Humans
In this study, the investigators will test the hypothesis that acute in vivo exposure to hyperglycemia increases mitochondrial network fragmentation and mitochondrial reactive oxygen species production (ROS) production in human…
- Trial name
- NCT02682342
- Testing
- 75 g glucose solution
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Diabetes Mellitus, Type 2, Hypertension
A Phase 2 Trial of IW-1973, A Stimulator of Soluble Guanylate Cyclase (sGC), in Patients With Stable Type 2 Diabetes and Hypertension
To evaluate the impact of escalating doses of IW-1973 on endothelial function [using EndoPAT to measure fingertip small vessel pulse volume], blood pressure (BP), and heart rate.
- Trial name
- NCT02906579
- Testing
- IW-1973
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Cyclerion Therapeutics
Endothelial Dysfunction, Bone Disease
Influence of Nitrates on Bone Remodeling and Endothelial Function in Patients With Type 2 Diabetes Mellitus
Type 2 diabetes mellitus (DM) is becoming a leading global epidemic. DM affects several systems in the body. Most of the complications encountered in DM are attributed to uncontrolled hyperglycemia or poor glycemic control.
- Trial name
- NCT02011620
- Testing
- Isosorbide-5-mononitrate
- Where
- United Kingdom
- Sponsor
- Tameside Hospital NHS Foundation Trust