Clinical trials: Endothelial Function and Arterial Stiffness
Heart Failure
Arterial Stiffness and Endothelial Function in Heart Failure
Heart Failure (HF) is a global condition affecting at least 26 million people worldwide. Despite advances in treatment, HF patients continue to experience poor health outcomes.
- Trial name
- ASEF-HF (NCT07713719)
- Testing
- Study Assessment
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Coventry University
Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Female
Wild Blueberries for Gut, Brain, and Cardiometabolic Health in Prediabetes
The goal of this clinical trial is to determine the effectiveness of using a freeze-dried wild blueberry powder on cardiometabolic health, cognitive function, and gut microbiota composition in adult women with prediabetes.
- Conditions
- Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Female, Adult, Endothelial Function (Reactive Hyperemia)
- Trial name
- NCT06735651
- Testing
- Wild Blueberry
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Georgia State University
Type 1 Diabetes Mellitus
The Effect of Uric Acid Lowering in Type 1 Diabetes
Patients with type 1 diabetes mellitus (T1DM) are at high risk of developing kidney complications potentially leading to end stage renal disease.
- Trial name
- NCT02344602
- Testing
- Febuxostat
- Where
- Canada
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Periodontal Disease (PD), Cardio Vascular Disease
PMPR and Chlorhexidine on Periodontal Disease and Vascular Function
Gum inflammation is called gingivitis. Gum disease, known as periodontal disease, is a long-term inflammation of the gums and bone around teeth, leading to tooth loss.
- Conditions
- Periodontal Disease (PD), Cardio Vascular Disease, Oral-Systemic Link, Vascular Dysfunction
- Trial name
- CHX-PMPR-PERIV (NCT07311512)
- Testing
- Chlorhexidine (0.2%) mouthwash
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Mahdi Mutahar
Impaired Glucose Tolerance
ACute and Chronic Effects of Saxagliptin
Glucose ACCES study will explore the acute and long term (12-week treatment) effects of saxagliptin in patients with impaired glucose tolerance during fasting and after a standardised breakfast.
- Trial name
- ACCES (NCT01521312)
- Testing
- saxagliptin
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypertension, Cardiovascular Diseases
The Effects of Strawberries on Blood Pressure in Postmenopausal Women
Cardiovascular disease (CVD) is the leading cause of death in the US. Statistics show that approximately 91% of individuals with CVD have vascular dysfunction.
- Conditions
- Hypertension, Cardiovascular Diseases, Vascular Diseases
- Trial name
- NCT02099578
- Testing
- 25 g of Freeze-dried Strawberry Powder, 50 g of Freeze-dried Strawberry Powder
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Florida State University
Aging
Passive Heat Therapy for Lowering Systolic Blood Pressure and Improving Vascular Function in Mid-life and Older Adults
This study aims to determine the effects of ~12 weeks of repeated hot water immersion ("heat therapy") vs. thermoneutral water immersion on blood pressure and vascular function in late middle-life to older (≥40 years) adults.
- Trial name
- NCT05300971
- Testing
- Heat therapy, Thermoneutral water immersion
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Aging
Safety & Efficacy of Nicotinamide Riboside Supplementation for Improving Physiological Function in Middle-Aged and Older Adults
The purpose of this study is to assess the efficacy of supplementation with the Nicotinamide Adenine Dinucleotide (NAD+) precursor compound, Nicotinamide Riboside (NR), for improving physiological function (vascular, motor, and…
- Trial name
- NCT02921659
- Testing
- Niagen™
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Cardiovascular Disease
STRETCH Study: Effect of Distensibility on Endothelial-Dependent Vasoreactivity in Patients With ISH
Determine whether increasing arterial distensibility by decreasing advanced glycation end-product (AGE) cross-link components of vascular stiffness improves (a) endothelial-mediated vasoreactivity at rest, as assessed by…
- Trial name
- NCT00277875
- Testing
- ALT-711 (alagebrium chloride)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Synvista Therapeutics, Inc
Cardiovascular Diseases, Vitamin D Deficiency
The Effect of Vitamin D Statues on Endothelial Function
In the United States, cardiovascular disease causes over one-third of all deaths and vitamin D deficiency is an epidemic. An increasing body of data suggests that low vitamin D status adversely impacts the cardiovascular system.
- Trial name
- CVD Cookie (NCT01049048)
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Cardiovascular Diseases, Chronic Kidney Disease Stage 3
Vitamin K to Slow Progression of Cardiovascular Disease Risk in Hemodialysis Patients
The life span of adults with end-stage renal disease is reduced, and cardiovascular disease (CVD) accounts for approximately half the deaths among those undergoing hemodialysis (HD).
- Conditions
- Cardiovascular Diseases, Chronic Kidney Disease Stage 3, Chronic Kidney Disease Stage 4, Chronic Kidney Disease Stage 5
- Trial name
- NCT03311321
- Testing
- Vitamin K2 (menaquinone-7; 360-mcg/d)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Augusta University
Smoking, Cardiovascular Disease Risk
Effect of Resistance Training on Tobacco-Related Cardiovascular Disease Risk
This project is prompted by the urgent public health need to identify novel strategies to prevent and treat tobacco-related cardiovascular disease (CVD) and by compelling pilot data that suggests cessation of smoking results in…
- Trial name
- START (NCT01705951)
- Testing
- Resistance Training (RT), Nicotine Replacement Therapy (NRT)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Arterial Disease, Frail Elderly Syndrome
Relationship Between Digital Vascular Function Measured by EndoPAT® in elderlY Patients and Arterial Stiffness
Due to the aging of populations worldwide, we observe an increase of age-related diseases and loss of autonomy with consequent personal, social, medical and economic implications.
- Conditions
- Arterial Disease, Frail Elderly Syndrome, Stiffness, Vascular, Endothelial Degeneration
- Trial name
- ENDY (NCT04651894)
- Testing
- reactive hyperaemia index measurement
- Where
- France
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Insulin Sensitivity, Endothelial Dysfunction
Resistance Training and Cardiometabolic Health
This study will investigate the relationship between resistance training load and repetitions on cardiometabolic outcomes. The primary objective of this clinical trial is to determine whether high load or low load resistance…
- Conditions
- Insulin Sensitivity, Endothelial Dysfunction, Blood Pressure
- Trial name
- NCT03325933
- Testing
- High Load/Low Rep Resistance Training, Low Load/High Rep Resistance Training
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Vascular Health, Autonomic Function
Vascular and Neuro-inflammatory Effects of Endurance Exercise Training in African Americans
The purpose of this study is to test the effects of endurance exercise training on arterial structure and function, and to examine potential mechanisms producing changes in arterial structure and function in young (18-35 years of…
- Trial name
- VINE (NCT01024634)
- Testing
- Endurance Exercise
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Hypertension
Effect of Regular Sildenafil on Blood Pressure and Arterial Function in Hypertension
The purpose of the study is to investigate if regular treatment with sildenafil reduces blood pressure and improves blood vessel function in patients with hypertension (high blood pressure).
- Trial name
- NCT00317421
- Testing
- Sildenafil citrate
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Edinburgh
Acute Myocardial Infarction
The Acute and Chronic Effects of Remote Ischemic Conditioning on Cardiovascular Function
The investigators are going to examine 270 patients within 48h of STEMI with primary percutaneuous intervention. The investigators utilise either a double -with a 15- min intervening interval-, or a single ischemic stimulus by…
- Trial name
- NCT03984123
- Testing
- Brachial cuff, in order to achieve ischemic stimuli
- Where
- Greece
- Volunteers
- 270 people
- Sponsor
- University of Athens
Rheumatoid Arthritis, Stiffness, Aortic
Methotrexate, Blood Pressure and Arterial Function in Rheumatoid Arthritis
The investigators will study the effects of methotrexate on blood pressure, arterial stiffness and endothelial function in patients with rheumatoid arthritis.
- Conditions
- Rheumatoid Arthritis, Stiffness, Aortic, Endothelial Dysfunction, Cardiovascular Risk Factor
- Trial name
- NCT03254589
- Testing
- Methotrexate, Sulfasalazine, Other DMARDs
- Where
- Australia
- Volunteers
- 124 people
- Sponsor
- Flinders University
Endothelial Dysfunction
Effect of Local Heat Stress Via Leg Bath on Artery Function
Arteries are flexible in their structure and function and change in response to a variety of factors. Endothelial cells, are the skin type cells that form a layer inside arteries, and they are very important for arterial health.
- Trial name
- HEAT (NCT03618524)
- Testing
- Lower limb hot water immersion
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- McMaster University
Hypertension
Blood Pressure Lowering Effects of Grape Juice
Recent studies suggest that a diet rich in fruit and vegetables can lower blood pressure, and a number of lines of evidence suggest that grape products may have such an effect.
- Trial name
- NCT00302809
- Testing
- Concord Grape Juice
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boston University