Clinical trials: Endothelium, Vascular
Type 2 Diabetes
INSUlin Regimens and VASCular Functions
Vago-sympathetic activity, arterial stiffness and endothelial function are integrators of cardiovascular risk. The aim of this pilot study is, in type 2 diabetic patients now requiring insulin, to compare the effects of improving…
- Trial name
- INSUVASC (NCT01022658)
- Testing
- Insulin
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Renal Transplantation
Influence of Sirolimus and MMF on Vascular Function and Markers of Cellular Function in Renal Transplant Recipients
Chronic transplant nephropathy and cardiovascular death are the main reasons for loss of transplanted organs after kidney transplantation.
- Trial name
- NCT00204321
- Testing
- sirolimus (drug), mmf (drug)
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- University Hospital Muenster
Change in Flow Mediated Dilation
Effects of FSH on Endothelial Function (FEND)
Purpose of the study will be to evaluate the effects of the s.c. administration of 300 IU of FSH in 16 healthy males. The endothelial function will be evaluated by the measurement with ecographic approach of the flow mediated…
- Trial name
- FEND (NCT04430621)
- Testing
- Follicle Stimulating Hormone
- Where
- Italy
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Federico II University
Sepsis Related Acute Lung Injury/Acute Respiratory Distress Syndrome
EVLWI Exhibits Pulmonary and Systemic Permeability in Sepsis Related ALI/ARDS
To investigate the possible mechanisms of pulmonary and systemic permeability change including cytokine, extravascular lung water index (EVLWI), and oxygenation parameters in patients with sepsis related acute lung injury…
- Trial name
- NCT01694147
- Testing
- PiCCO monitoring system
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Chang Gung Memorial Hospital
Metastatic Colorectal Cancer
Soluble Vascular Endothelial Growth Factor Receptor 2 as Predictor of Benefit From Bevacizumab Beyond Progression in Metastatic Colorectal Cancer
A growing amount of reports has consistently evidenced that a sustained inhibition of the angiogenesis is an effective therapeutic strategy, able to improve the outcome of metastatic colorectal cancer (mCRC) patients.
- Trial name
- CIRCUS (NCT02623621)
- Testing
- chemotherapy plus bevacizumab
- Where
- Italy
- Volunteers
- 103 people
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana
Hypertension
Investigation of Dietary Nitrate Effects in Hypertension-induced Target Organ Damage
This study aims to determine whether dietary inorganic nitrate (in beetroot juice) is able to reduce overall thickening of the heart (left ventricular hypertrophy or LVH) and stiffness of the arteries when given to patients with…
- Trial name
- NITRATE-TOD (NCT03088514)
- Testing
- Beetroot juice
- Where
- United Kingdom
- Volunteers
- 149 people
- Sponsor
- Queen Mary University of London
Cerebral Infarction, Chinese Herbal Medicine
Th Tl Xb Prescription on Reprogramming of Lipid Metabolism and Endothelial Injury for Cerebral Infarction Patients
This study is a prospective, open-label, randomized control trial. It is planning to include 160 cerebral infarction patients which will be randomized in a 1﹕1 fashion to receive Chinese herbal medicines combined basic medicine…
- Conditions
- Cerebral Infarction, Chinese Herbal Medicine, Clinical Trial, Lipid Metabolism Disorder
- Trial name
- NCT06549582
- Testing
- Taohong Tongluo Xiaoban Prescription, Fundamental medical treatment
- Volunteers
- 160 people
- Sponsor
- Yan Zhu
Hypertension, Abdominal Obesity
Treatment of Adiposity Related hypErTension (TARGET)
High blood pressure (hypertension) is an important cause of myocardial infarction and stroke. High blood pressure often occurs in people who are overweight. These people frequently also have abnormal fat and sugar metabolism.
- Conditions
- Hypertension, Abdominal Obesity, Metabolic Syndrome
- Trial name
- TARGET (NCT01138423)
- Testing
- Aliskiren, Moxonidine, Hydrochlorothiazide
- Where
- Netherlands
- Volunteers
- 32 people
- Sponsor
- UMC Utrecht
Hypertension, Proteinuria
Pharmacodynamic Effects of Anti-Vascular Endothelial Growth Factor Therapy in Patients With Advanced Malignancies
1. To determine the effect of anti-vascular endothelial growth factor (VEGF) on endothelial function and on retinal microvasculature 2.
- Trial name
- NCT00698659
- Where
- Singapore
- Sponsor
- National University Hospital, Singapore
Major Depressive Disorder
Linking Affective Dynamics in Response to Daily Stress to Peripheral Vascular Function in Working Age Adults
The objective of this proposal is to determine whether heightened negative affective responsivity (NA-R) to daily stressors is related to blunted nitric oxide (NO)-mediated endothelium-dependent dilation (EDD) in working age…
- Trial name
- NCT06860724
- Testing
- NG-nitro-L-arginine methyl ester (L-NAME)
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Type 1 Diabetes, Diabetic Kidney Disease
MANATEE-T1D: Metformin ANd AutomaTEd Insulin Delivery System Effects on Renal Vascular Resistance, Insulin Sensitivity, and Cardiometabolic Function in Youth With Type 1 Diabetes
Diabetic kidney disease and cardiovascular disease remain the leading causes of morbidity and mortality in people with type 1 diabetes and are exacerbated with longer duration of diabetes and time outside goal glycemic range.
- Conditions
- Type 1 Diabetes, Diabetic Kidney Disease, Cardiovascular Diseases, Endothelial Dysfunction
- Trial name
- MANATEE-T1D (NCT05065372)
- Testing
- Metformin Hcl 1000Mg Tab, Aminohippurate Sodium 20 % Injection, Iohexol 300 Mg/mL Injectable Solution
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Kalie Tommerdahl
Type 2 Diabetes Mellitus Related Endothelial Dysfunction
Effects of Atazanavir Treatment on Type 2 Diabetes Mellitus Related Endothelial Dysfunction
The purpose of this study is to determine whether atazanavir use is of influence on the endothelial dysfunction associated with type 2 diabetes mellitus.
- Trial name
- DM2ATV (NCT00696722)
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Radboud University Medical Center
Benign Prostatic Hyperplasia
Effect of Dutasteride on HIF-1alpha and VEGF in the Prostate
The purpose of this study is to determine whether dutasteride may influence the expression of angiogenesis factors such as hypoxia inducible factor (HIF)-1alpha and vascular endothelial growth factor (VEGF) in patients with lower…
- Trial name
- NCT00880672
- Testing
- dutasteride
- Volunteers
- 40 people
- Sponsor
- Seoul National University Hospital
Choroidal NeoVascularization, Age-Related Macular Degeneration
Does Vascular Endothelial Growth Factor (VEGF) or Complement Factor H Gene Polymorphism Play a Role in the Treatment Success With VEGF Inhibitors in Patients With Choroidal NeoVascularization (CNV)?
Age related macular degeneration (AMD) is a multifactorial disease with a strong genetic component. Most importantly a genetic polymorphism in the gene encoding for the complement factor H (CFH) has been recently identified which…
- Trial name
- NCT00813514
- Testing
- VEGF genotyping
- Where
- Austria
- Sponsor
- Medical University of Vienna
Cardiovascular Diseases, Hypertension
Impact of a Plant-Based Diet on Indices of Cardiovascular Health in African Americans
The role of diet in preventing hypertension and cardiovascular diseases in African Americans, who have a much higher risk of developing these diseases, is not well understood.
- Conditions
- Cardiovascular Diseases, Hypertension, Diet, Healthy
- Trial name
- NCT05344287
- Testing
- Typical American Diet, Plant-Based Diet
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Ischemic Stroke, Acute Coronary Syndrome
Comparative Study of Arterial Properties After an Ischaemic Stroke or an Acute Coronary Syndrome
A pilot, prospective, comparative study. To include both male and female patients who have presented an ischaemic stroke (full stroke or TIA) or an ACS, 5 to 30 days prior to inclusion.
- Conditions
- Ischemic Stroke, Acute Coronary Syndrome, Obstructive Sleep Apnea Syndrome
- Trial name
- AVC/SCA (NCT00926874)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Grenoble
Spondylitis, Ankylosing
Growth Factor Concentration to Predict an Ankylosing Spondylitis Patient's Response to Infliximab (Study P04041)(COMPLETED)
This is a Phase 4, multi-center, open-label, one-arm, pilot study in patients with active ankylosing spondylitis refractory to conventional treatment.
- Trial name
- NCT00779935
- Testing
- Remicade
- Volunteers
- 44 people
- Sponsor
- Merck Sharp & Dohme LLC
Dietary Supplements
Muscadine Grape Seed Supplementation and Vascular Function
The investigators sought to evaluate the effect of muscadine grape seed supplementation on brachial diameter and flow-mediated vasodilator responses in subjects with, or at risk for cardiovascular disease.
- Trial name
- NCT01011517
- Testing
- Muscadine grape seed supplement
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Hypertension
Effects of Cocoa on Ambulatory Blood Pressure and Vascular Function in Patients With Stage I Hypertension
The proposed study Dose And Response to Cocoa (DARC), will examine variation in dose of cocoa-containing product consumption over an 8-week period and assess effects on blood pressure, endothelial function and arterial stiffness.
- Trial name
- DARC (NCT01672840)
- Testing
- 5g Cocoa Consumption, 10g Cocoa Consumption
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Griffin Hospital
Coronary Artery Disease
Effect of Cocoa Flavanols on Vascular Function
Endothelial dysfunction is associated with a higher incidence of adverse cardiovascular events in patients with coronary artery disease (CAD).
- Trial name
- Cocoa (NCT00553774)
- Testing
- Cocoa Flavanols
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of California, San Francisco
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