Clinical trials: Endothelium, Vascular
Diabetes Mellitus, Non-Insulin-Dependent, Hypertensive Disease
To Evaluate the Effect of Liraglutide on Ambulatory Blood Pressure-A Pilot Study
The investigators are conducting this research to study the effect of Liraglutide on blood pressure. Several studies have shown increased cardiovascular complications and deaths in diabetics with hypertension.
- Trial name
- NCT02299388
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Tulane University School of Medicine
Macular Disease
Effect of Vascular Endothelial Growth Factor Blockers on Aqueous Humor Dynamics
The objective of this research is to determine the effects of anti-VEGF drugs (bevacizumab, ranibizumab or aflibercept) on aqueous humor dynamics (AHD) in patients with retinal vascular disease.
- Trial name
- NCT01994174
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- University of Nebraska
Cystic Fibrosis
Blood Flow and Vascular Function in Cystic Fibrosis
Cystic fibrosis (CF) has many health consequences. A reduction in the ability to perform exercise in patients with CF is related to greater death rates, steeper decline in lung function, and more frequent lung infections.
- Trial name
- CF-FLOW (NCT02057458)
- Testing
- Sildenafil (Acute-1 hour), Sildenafil (Subchronic-4 weeks)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Augusta University
Obstructive Sleep Apnea, Hypoxemia
Mechanisms of Endothelial Cell Dysfunction in Sleep Apnea
Sleep apnea is a common sleep disorder characterized by temporary stops in breathing during sleep and has been associated with the development of cardiovascular disease.
- Trial name
- NCT00859950
- Testing
- Continuous Positive Airway Pressure (CPAP)
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Healthy
Effects of Miconazole on Blood Flow
This study will investigate the effect of the drug miconazole on blood vessel dilation. Miconazole stops production of EDHF, a substance that causes arteries to dilate. EDHF is produced by the cells that line blood vessels.
- Trial name
- NCT00004575
- Testing
- Miconazole, L-NMMA, Bradykinin
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Obesity, Prehypertension
Vascular Dysfunction in Human Obesity Hypertension
The purpose of the study is to test the effects of blocking sympathetic nerve activity with a drug called clonidine on blood vessel function and muscle nerve activity in adults who are obese and have high blood pressure.
- Conditions
- Obesity, Prehypertension, Hypertension
- Trial name
- VANISH (NCT01983462)
- Testing
- Clonidine, Hydrochlorothiazide
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Gary L. Pierce
Lung Neoplasms
Impact of Endostar Combined With Chemotherapy on the Angiogenesis of Advanced Non-small Cell Lung Cancer (NSCLC)
To study the impact of endostar combined with docetaxel and cisplatin on the angiogenesis of non-small cell lung cancer, patients will be randomly assigned to the group one (endostar combined with docetaxel and cisplatin) and…
- Trial name
- NCT00657423
- Testing
- Treated by endostar combined with docetaxel and cisplatin, Treated by docetaxel and cisplatin
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Atherosclerosis, Systemic Lupus Erythematosus
Vitamin D to Improve Endothelial Function in SLE
Determine the effect of vitamin D repletion on flow mediated dilation (FMD, a measure of endothelial function) in vitamin D deficient systemic lupus erythematosus (SLE) patients.
- Trial name
- NCT01911169
- Testing
- Cholecalciferol
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Medical University of South Carolina
Intraocular Pressure, Neovascular Glaucoma
Aflibercept as Adjunctive Treatment for Filtration Surgery in Neovascular Glaucoma
Purpose: To investigate intravitreal aflibercept (IVA) injection as an adjunctive treatment to trabeculectomy with mitomycin C (TMC) and panretinal photocoagulation (PRP) for neovascular glaucoma (NVG).
- Conditions
- Intraocular Pressure, Neovascular Glaucoma, Vascular Endothelial Growth Factor Overexpression, Glaucoma Secondary to Eye Inflammation
- Trial name
- NCT04970251
- Testing
- Aflibercept Ophthalmic
- Where
- Thailand
- Volunteers
- 5 people
- Sponsor
- Siriraj Hospital
Pancreatic Cancer, Pancreas Neoplasms
Human Leukocyte Antigen-A*02:01-restricted Tumor Vessel Specific Peptide Vaccination for Advanced Pancreatic Cancer
Pancreatic cancer is the fourth leading cause of cancer death in the United States, and no combination therapy is far superior to gemcitabine alone.
- Trial name
- NCT00683085
- Testing
- HLA-A*02:01-restricted VEGFR1-derived peptide vaccination
- Where
- Japan
- Volunteers
- 2 people
- Sponsor
- Tokyo University
Postural Tachycardia Syndrome (POTS)
Effect of Dietary Sodium Intake on Vascular Endothelium
The investigators will test the hypothesis that markers of vascular endothelial dysfunction will be exaggerated acutely with an extreme high sodium diet compared to an extreme low-sodium diet.
- Trial name
- NCT01550315
- Testing
- Pulsitile Arterial Tonometry (PAT) Protocol, Calf Blood Flow in Reactive Hyperemia (CBF-RH), Evaluation of Forearm-Mediated Dilation
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Hypertension
Melatonin and Nighttime Blood Pressure in African Americans-8 mg Study
This purpose of this study is to test the effect of oral melatonin supplementation (8 mg per night for 4 weeks) on nighttime blood pressure in African Americans with a history of elevated nighttime blood pressure.
- Trial name
- NCT01114360
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Emory University
Retinopathy of Prematurity
Bevacizumab Eliminates the Angiogenic Threat for Retinopathy of Prematurity
The purpose of this study was to determine the efficacy and additional advantages of intravitreal bevacizumab in the treatment of ROP for both Zone I and Zone II Posterior.
- Trial name
- BEAT-ROP (NCT00622726)
- Testing
- Bevacizumab, Conventional Laser for ROP
- Where
- 15 sites in United States
- Volunteers
- 150 people
- Sponsor
- The University of Texas Health Science Center, Houston
Atherosclerosis
Impact of Sarpogrelate in the Function of Endothelial Progenitor Cells
The purpose of this study is to evaluate the effects of Sarpogrelate in endothelial progenitor cells of patients with atherosclerosis.
- Trial name
- NCT01548274
- Testing
- Sarpogrelate
- Where
- Japan
- Volunteers
- 20 people
- Sponsor
- Aichi Gakuin University
Coronary Artery Disease
Inflammation and Coronary Endothelial Function
The investigators are studying whether anti-inflammatory agents can improve abnormal coronary artery function in patients with coronary artery disease (CAD) and abnormal coronary artery endothelial function.
- Trial name
- NCT02366091
- Testing
- Methotrexate, Colchicine
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Johns Hopkins University
Covid19
Accelerating COVID-19 Therapeutic Interventions and Vaccines 4 ACUTE
This is a randomized, open label, adaptive platform trial to compare the effectiveness of antithrombotic and additional strategies for prevention of adverse outcomes in COVID-19 positive inpatients
- Trial name
- ACTIV-4A (NCT04505774)
- Testing
- theraputic heparin, prophylactic heparin, P2Y12
- Where
- 101 sites in United States, Brazil and 2 more
- Volunteers
- 3,591 people
- Sponsor
- Matthew Neal MD
Coronary Artery Ectasia
Endothelial NO Synthase Polymorphic Gene in Coronary Artery Dilation Disease
Introduction: The coronary artery dilatations disease (Coronary artery aneurysm/coronary artery ectasia) characterized by inappropriate coronary artery dilations.
- Trial name
- NCT06220682
- Testing
- The specific genetic PCR laboratory test were performed for all selected patients for eNOS SNPs
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University
Diabetes, Hypertension
Effects of Intralipid Versus Olive Oil Infusions on Endothelial Function, Immune Function, Inflammatory Markers
Recent evidence suggests that increased levels of a circulation fat (free fatty acids or FFAs) can cause high blood pressure and cardiac complications. Intralipid is the only type of fat approved by the FDA for clinical use.
- Conditions
- Diabetes, Hypertension, Obesity
- Trial name
- NCT00989339
- Testing
- Twenty-four Hour TPN and Saline Infusion
- Volunteers
- healthy volunteers welcome
- Sponsor
- Emory University
Spinal Cord Injuries, Cardiovascular Diseases
Role of Endothelial Function in SCI CVD Risk
Individuals with spinal cord injury have heart attacks and strokes more frequently, and much earlier in life. People with spinal cord injuries develop plaque in vessels much faster, and the reasons why are unclear.
- Conditions
- Spinal Cord Injuries, Cardiovascular Diseases, Endothelial Dysfunction
- Trial name
- NCT06443151
- Testing
- Brachial intra-arterial infusion of vasoactive and antioxidant drugs (acetylcholine, nitroprusside, ascorbic acid), venous occlusion plethysmography, Acetylcholine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Craig Hospital
Blood Transfusion, Endothelial Physiopathology
Pilot Study About the Harmful Effects of Blood Storage on Overweight People and the Role of iNO in This Setting
The purpose of this study is to determine whether storage time affects how human body responds to autologous blood transfusion. An autologous blood transfusion is when a person donates blood and then receives that same blood back…
- Conditions
- Blood Transfusion, Endothelial Physiopathology, Nitric Oxide, Pulmonary Hypertension
- Trial name
- NCT01529502
- Testing
- Red blood Cells auto-transfusion, Inhaled Nitric Oxide (iNO) administration
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Massachusetts General Hospital
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