Clinical trials: Endothelium, Vascular
Peripheral Artery Disease, Endothelial Dysfunction
Effect of Transcutaneous Vagal Stimulation (TVS) on Endothelial Function in PAD
Peripheral arterial disease (PAD) constitutes a major public health burden. The incidence of PAD increases with age and is associated with other comorbid cardiovascular disorders.
- Conditions
- Peripheral Artery Disease, Endothelial Dysfunction, Autonomic Imbalance
- Trial name
- TVS-PAD (NCT03445754)
- Testing
- TVS
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Oklahoma
Ophthalmology, Macular Edema
Evaluation of Changes in Visual Acuity in Patients With Diabetic Macular Edema (DME) Starting Treatment With an Approved Anti-VEGF Therapy
POLARIS : A non-interventional study in patients with diabetic macular edema (DME) with central involvement to assess the effectiveness of existing anti-vascular endothelial growth factor (anti-VEGF) treatment regimens.
- Conditions
- Ophthalmology, Macular Edema, Macular Degeneration
- Trial name
- POLARIS (NCT01771081)
- Testing
- Ranibizumab (or other DME treatment)
- Where
- 8 sites in France, Germany and 6 more
- Volunteers
- 911 people
- Sponsor
- Bayer
Acute Coronary Syndrome, Premature Coronary Heart Disease
Markers of Cardiovascular Risk in Patients With Premature Coronary Artery Disease and Treatment
The aim of study is to examine the relationship between lipid subfractions, inflammation and structural-functional properties of the arterial wall in patients with premature coronary heart disease, to study genetic polymorphisms…
- Conditions
- Acute Coronary Syndrome, Premature Coronary Heart Disease, Lipoproteinemia, Inflammation
- Trial name
- GEBI (NCT04613167)
- Testing
- Alirocumab, Evolocumab, Control group
- Where
- Slovenia
- Volunteers
- 70 people
- Sponsor
- University Medical Centre Ljubljana
Endophthalmitis
Endophthalmitis After Intravitreous Anti-VEGF Injections in Patients Receiving vs. Not Receiving Topical Antibiotics
This is a prospective case series which aims to determine the incidence of endophthalmitis following intravitreous anti-vascular endothelial growth factor (VEGF) injection comparing between eyes receiving post-injection…
- Trial name
- NCT02810587
- Testing
- Topical antibiotics following injection
- Where
- Thailand
- Volunteers
- 5,000 people
- Sponsor
- Chiang Mai University
Lung Protective Ventilation, Cardiopulmonary Bypass
Unilateral Ventilation on Cardiopulmonary Bypass During Cardiac Surgery
This study investigates if single lung ventilation on cardiopulmonary bypass can mitigate postoperative lung water accumulation determined by lung ultrasound in the ventilated lung as compared to the non-ventilated lung in…
- Conditions
- Lung Protective Ventilation, Cardiopulmonary Bypass, High-risk Cardiac Patients, Lung Ultrasound
- Trial name
- NCT07612709
- Testing
- Ventilated lung, Non-ventilated lung.
- Where
- Austria
- Volunteers
- 45 people
- Sponsor
- Medical University of Vienna
Exudative Age-related Macular Degeneration
Plasma Levels of Vascular Endothelial Growth Factor Before and After Intravitreal Injection of Aflibercept
The purpose of this study is to examine the plasma concentration of vascular endothelial growth factor (VEGF) after standard treatment with one of the newest growth factor inhibitors, aflibercept (Eylea).
- Trial name
- Eylea-2014 (NCT02125864)
- Testing
- intravitreal injection
- Volunteers
- 16 people
- Sponsor
- Oslo University Hospital
Hypertension, Coronary Arteriosclerosis
SAFE-CRP: Structural Alterations and Function of Endothelium in Cardiovascular Risk Patients
The aim of this trial is to evaluate the efficacy and safety of telmisartan 80 mg administered once daily in patients with documented coronary artery disease (CAD) and a probably cardiovascular risk profile concerning the…
- Trial name
- NCT00274105
- Testing
- telmisartan
- Where
- 2 sites in Germany
- Volunteers
- 22 people
- Sponsor
- Boehringer Ingelheim
Hypertension
A Study of the Effects of 6R-BH4 on Blood Pressure in Subjects With Poorly Controlled Systemic Hypertension
The purpose of this study is to determine whether 6R-BH4 (sapropterin dihydrochloride) is safe and effective in the treatment of poorly controlled hypertension in the presence or absence of type 2 diabetes.
- Trial name
- NCT00325962
- Testing
- 6R-BH4 (sapropterin dihydrochloride)
- Where
- 24 sites in United States
- Volunteers
- 84 people
- Sponsor
- BioMarin Pharmaceutical
Hypertension, Endothelial Dysfunction
Effects of Magnesium Supplementation on Vascular Structure and Function in Hypertensive Patients
Introduction: Magnesium has been the target for many experimental and clinical studies due to the negative correlation between its serum and intracellular levels and the prevalence of hypertension and other cardiovascular…
- Trial name
- MG600 (NCT01151683)
- Testing
- magnesium
- Where
- Brazil
- Volunteers
- 52 people
- Sponsor
- Rio de Janeiro State University
MELAS Syndrome
L-arginine Therapy on Endothelium-dependent Vasodilation & Mitochondrial Metabolism in MELAS Syndrome
MELAS patients suffer from exercise intolerance, weakness, poor vision or blindness, poor growth, developmental delay, and deafness.
- Trial name
- NCT01603446
- Testing
- L-Arginine
- Where
- Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Vascular Aging
Oral Trehalose Therapy to Reverse Arterial Aging in Middle-Aged and Older Adults
The proposed study will assess the ability of a naturally occurring sugar to improve the function of arteries with age. Overall, the proposed research project has the long-term potential to influence clinical practice guidelines…
- Trial name
- NCT01575288
- Testing
- High-dose trehalose
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Stress, Psychological
Stress Management in Patients With Coronary Artery Disease
Introduction: Stress can cause hemodynamic and metabolic changes that contribute to endothelial dysfunction and there is a significant association between high stress and cardiovascular events.
- Trial name
- NCT04223882
- Testing
- Management of Stress, Usual care
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Intraocular Pressure, Neovascular Glaucoma
Aflibercept as Adjunctive Treatment for Filtration Surgery in Neovascular Glaucoma
Purpose: To investigate intravitreal aflibercept (IVA) injection as an adjunctive treatment to trabeculectomy with mitomycin C (TMC) and panretinal photocoagulation (PRP) for neovascular glaucoma (NVG).
- Conditions
- Intraocular Pressure, Neovascular Glaucoma, Vascular Endothelial Growth Factor Overexpression, Glaucoma Secondary to Eye Inflammation
- Trial name
- NCT04970251
- Testing
- Aflibercept Ophthalmic
- Where
- Thailand
- Volunteers
- 5 people
- Sponsor
- Siriraj Hospital
Endothelial Dysfunction, Oxidative Stress
Creatine Monohydrate Supplementation and Vascular Endothelial Health
To determine the effects of 4 weeks of creatine monohydrate supplementation on markers of macrovascular and microvascular function, cognitive performance, and physical performance.
- Trial name
- NCT05014659
- Testing
- Creatine monohydrate
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Florida State University
AML, Acute Myeloid Leukemia
Phase I-II Study of Idarubicin, Cytarabine, and Sorafenib (BAY43-9006)
A primary goal of this clinical research study is to find the highest safe dose of sorafenib that can be given in combination with idarubicin and Ara-C for the treatment of acute myelogenous leukemia (AML) and high-risk…
- Conditions
- AML, Acute Myeloid Leukemia, Myelodysplastic Disorders
- Trial name
- NCT00542971
- Testing
- Idarubicin, Sorafenib, Ara-C
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- M.D. Anderson Cancer Center
Vein Injury
Vascular Graft Storage Solution Preserves Endothelial Function
Since Saline is still the most widely used storage and flushing solution in cardiovascular procedures despite knowing evidence of its influence on the human endothelial cell function the main aim of this study was to assess the…
- Trial name
- VGE (NCT04614077)
- Testing
- ex vivo organ bath testing, preservation of vein sections without contact to patient
- Where
- Austria
- Volunteers
- 12 people
- Sponsor
- Klinikum Floridsdorf
Extensive-stage Small-cell Lung Cancer
Safety and Efficacy of BNT327, an Investigational Therapy in Combination With Chemotherapy for Patients With Untreated Small-cell Lung Cancer
This is a Phase III, multisite, randomized, double-blinded study to investigate pumitamig (BNT327) combined with chemotherapy (etoposide/carboplatin) compared to atezolizumab combined with chemotherapy (etoposide/carboplatin) for…
- Trial name
- NCT06712355
- Testing
- Pumitamig, Atezolizumab, Etoposide
- Where
- 225 sites in United States, Australia and 12 more
- Volunteers
- 621 people
- Sponsor
- BioNTech SE
Uterine Leiomyomas
The Effect of Anesthetic Technique on VEGF-C and PGE2
The purpose of this study is to verify the effect of anesthetic technique on the change of postoperative serum vascular endothelial growth factor C and prostaglandin E2, and to explore the potential impact of the anesthetic…
- Trial name
- NCT02829333
- Testing
- general anesthesia and patient controlled intravenous analgesia, spinal anesthesia and continuous postoperative epidural analgesia
- Volunteers
- 44 people
- Sponsor
- General Hospital of Ningxia Medical University
Cystic Fibrosis, Endothelial Dysfunction
Vascular Health and Function in Cystic Fibrosis
The goal of this observational study is to learn whether blood vessel health and function differ between adults aged 40 years or older with cystic fibrosis (CF) who are taking CFTR modulator therapy and healthy adults of the same…
- Conditions
- Cystic Fibrosis, Endothelial Dysfunction, Cardiovascular Risk Factor
- Trial name
- CF-VHF (NCT07904325)
- Testing
- Non-invasive vascular, cerebrovascular and autonomic assessment
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust
Wet Macular Degeneration
OZURDEX in Age Related Macular Degeneration as Adjunct to Ranibizumab
In the Western World, Age Related Macular Degeneration (ARMD) is a leading cause of blindness. This disease was once thought to be a natural part of aging, but recent research has introduced effective treatments.
- Trial name
- STAR (NCT01243086)
- Testing
- Ranibizumab, OZURDEX
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- McMaster University
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