Clinical trials: Endothelium, Vascular
Coronary Artery Disease
Sort Out XI - Combo Stent Versus BioMatrix Alpha Stent
SORT OUT XI Comparison of Combo™ stent and BioMatrix Alpha™ stent in the treatment of unselected patients with ischemic heart disease.
- Trial name
- SORTOUTXI (NCT03952273)
- Testing
- PCI with BioMatrix Alpha™ stent, PCI with Combo™ stent
- Where
- 2 sites in Denmark
- Volunteers
- 3,141 people
- Sponsor
- Phillip Freeman
ARDS, Acute Respiratory Distress Syndrome
Intravenous Imatinib in Mechanically Ventilated COVID-19 Patients
The SARS-CoV2 pandemic and resulting COVID-19 infection has led to a large increase in the number of patients with acute respiratory distress syndrome (ARDS).
- Conditions
- ARDS, Acute Respiratory Distress Syndrome, Covid19, Endothelial Dysfunction
- Trial name
- INVENT COVID (NCT04794088)
- Testing
- Imatinib Mesylate intravenous solution
- Where
- 2 sites in Netherlands
- Volunteers
- 67 people
- Sponsor
- Dr. Jurjan Aman
Venous Insufficiency of Leg, Venous Insufficiency (Chronic)(Peripheral)
Management of Endothelial Dysfunction in Patients With Chronic Venous Insufficiency After Endovenous Surgical Procedure
Endothelial dysfunction is assessed in patients with chronic venous insufficiency of lower limbs (grade C4 according to C - clinical manifestations, E - etiologic factors, A - anatomic distribution of disease, and P - underlying…
- Conditions
- Venous Insufficiency of Leg, Venous Insufficiency (Chronic)(Peripheral), Endothelial Dysfunction
- Trial name
- NCT04180137
- Testing
- Endovenous laser ablation of great saphenous vein (GSV) and microphlebectomy of varicose veins, Pharmacotherapy
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- State Budgetary Healthcare Institution, National Medical Surgical Center N.A. N.I. Pirogov, Ministry of Health of Russia
Human Immunodeficiency Virus, Ischemic Heart Disease
Omacor and Cardiovascular Risk Factors in HIV Patients on HAART Treatment
The purpose of this study is to evaluate the effect of Omacor 4g/day on blood lipid parameters and on the function and stiffness of blood vessels in HIV infected patients on Antiretroviral Therapy (HAART)
- Trial name
- NCT00296153
- Testing
- Omega-3-acid ethyl esters 90
- Where
- Denmark
- Volunteers
- 51 people
- Sponsor
- Pronova BioPharma
Non-Small Cell Lung Cancer, Chronic Obstructive Pulmonary Disease
Detection of Circulating Endothelial Progenitors Cells (EPCs) in Non-small Cell Lung Cancer (NSCLC)
Bone-marrow-derived progenitor cells (EPCS) play an important role in neovascularization and tumor growth. In lung cancer, angiogenesis is an important event in mechanisms of tumor proliferation and metastasis.
- Trial name
- CBNPC:PCE (NCT00826683)
- Testing
- Enumeration of endothelial cell progenitor in peripheral blood by flow cytometry, Endothelial cell progenitor characterization by primary cell cultures
- Where
- France
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University Hospital, Limoges
Stable Angina, Acute Coronary Syndrome
Relationship Between Fractional Flow Reserve/ Instantaneous Wave Free Ratio and Endothelial Wall Shear Stress
This study, designed as a retrospective registry, aims to investigate the relationship and potential interplay between fractional flow reserve (FFR) or instantaneous waves free ratio (iFR) with wall shear stress (WSS) in the…
- Conditions
- Stable Angina, Acute Coronary Syndrome, Coronary Artery Disease
- Trial name
- RELATE (NCT04048005)
- Testing
- Fractional flow reserve
- Where
- 3 sites in Italy
- Volunteers
- 200 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Coronary Arteriosclerosis
Safety and Efficacy of the Combo Bio-engineered Sirolimus-eluting Stent Versus the Nano Polymer-free Sirolimus-eluting Stent in the Treatment of Patients With de Novo Stenotic Lesions
To evaluate the safety, efficacy and deliverability of the Combo bio-engineered sirolimus-eluting stent versus the Nano polymer-free sirolimus- eluting stents in the treatment of patients with de novo stenotic lesions of native…
- Trial name
- RECOVERY (NCT02542007)
- Testing
- OrbusNeich Combo stent™, sirolimus-eluting stent system
- Where
- 15 sites in China
- Volunteers
- 440 people
- Sponsor
- OrbusNeich
Lymphedema
A Study of Vascular Endothelial Growth Factor (VEGF) Inhibition in Patients With Unilateral Upper Extremity Lymphedema Following Treatment for Cancer
The major purpose of this study is to determine if a new drug called pazopanib decreases lymphedema in subjects previously treated for cancer.
- Trial name
- NCT00827372
- Testing
- Pazopanib
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Kathy Miller
Adverse Childhood Experiences, Vascular Dilatation
The Iowa ACEs and Sleep Cohort and Manipulating Sleep in Young Adults With ACEs Studies
The overall purpose of this study is to understand the role of disrupted sleep in the association of exposure to early life adversity (adverse childhood experiences (ACEs)) with vascular endothelial (dys)function.
- Conditions
- Adverse Childhood Experiences, Vascular Dilatation, Sleep, Sleep Disturbance
- Trial name
- NCT06454344
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBT-i)
- Where
- 2 sites in United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Coronary Artery Disease
CD133+ Cell Therapy for Refractory Coronary Heart Disease
The aim of this study is to evaluate if the intracoronary infusion of autologous bone-marrow derived CD133+ endothelial precursor cells is able to promote neovascularization and to improve myocardial perfusion and contractility…
- Trial name
- NCT01049867
- Testing
- Intracoronary Infusion of CD133+ Cells
- Where
- Mexico
- Volunteers
- 10 people
- Sponsor
- Hospital y Clinica OCA, S.A. de C.V.
Nitric Oxide, Endothelium-Derived Relaxing Factor
Effects of Nitrite on Blood Vessel Dilation in Normal Volunteers
Nitric oxide gas is important in regulating blood vessel dilation, and consequently, blood flow. This gas is continuously produced by endothelial cells, which line the blood vessels.
- Conditions
- Nitric Oxide, Endothelium-Derived Relaxing Factor, Healthy
- Trial name
- NCT00048477
- Testing
- L-NMMA and Sodium Nitrite
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronary Artery Disease
Inflammation and Coronary Endothelial Function
The investigators are studying whether anti-inflammatory agents can improve abnormal coronary artery function in patients with coronary artery disease (CAD) and abnormal coronary artery endothelial function.
- Trial name
- NCT02366091
- Testing
- Methotrexate, Colchicine
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Johns Hopkins University
Retinopathy of Prematurity
Incidence of Hypoxia During Intravitreal Anti-VEGF (Vascular Endothelial Growth Factor) Injections for Retinopathy of Prematurity (ROP) Under Topical Anesthesia
Purpose: To evaluate the incidence and severity of hypoxia and address a genuine evidence gap focusing on intraprocedural hypoxia during bedside intravitreal ranibizumab injection for retinopathy of prematurity (ROP), an area…
- Trial name
- NCT07701759
- Testing
- ranibizumab
- Where
- Saudi Arabia
- Volunteers
- 74 people
- Sponsor
- Minia University
Large Vessel Vasculitis, Giant Cell Arteritis (GCA)
Dapagliflozin and Endothelin Receptor Antagonism in Large Vessel Vasculitis (DERAIL-LVV)
Large vessel vasculitis (LVV) is a disease that causes damage to blood vessels. This damage to blood vessels can increase the risk of patients with LVV developing cardiovascular disease, including heart attacks and strokes.
- Conditions
- Large Vessel Vasculitis, Giant Cell Arteritis (GCA), Takayasu Arteritis
- Trial name
- DERAIL-LVV (NCT06887062)
- Testing
- Bosentan and dapagliflozin
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Hypercholesterolemia, Hypertension
Nutritional Intervention With Black Garlic
A controlled clinical intervention study is proposed to determine the effect of black garlic consumption on biomarkers of cardiovascular function and associated pathologies in a healthy population at risk for cardiovascular…
- Conditions
- Hypercholesterolemia, Hypertension, Hyperlipidemias, Inflammation
- Trial name
- NCT05082350
- Testing
- black garlic
- Where
- Spain
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Maria Pilar Zafrilla Rentero
Hypertension
Effects of Cocoa on Ambulatory Blood Pressure and Vascular Function in Patients With Stage I Hypertension
The proposed study Dose And Response to Cocoa (DARC), will examine variation in dose of cocoa-containing product consumption over an 8-week period and assess effects on blood pressure, endothelial function and arterial stiffness.
- Trial name
- DARC (NCT01672840)
- Testing
- 5g Cocoa Consumption, 10g Cocoa Consumption
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Griffin Hospital
Aging, Oxidative Stress
Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction During Disuse
Prolonged periods of reduced activity are associated with decreased vascular function and muscle atrophy. Physical inactivity due to acute hospitalization is also associated with impaired recovery, hospital readmission, and…
- Conditions
- Aging, Oxidative Stress, Vascular Endothelium, Skeletal Muscle
- Trial name
- NCT04351113
- Testing
- MITO-AO, PB-125, Passive Leg Movement (PLM)
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Joel Trinity
Atherosclerosis
Impact of Sarpogrelate in the Function of Endothelial Progenitor Cells
The purpose of this study is to evaluate the effects of Sarpogrelate in endothelial progenitor cells of patients with atherosclerosis.
- Trial name
- NCT01548274
- Testing
- Sarpogrelate
- Where
- Japan
- Volunteers
- 20 people
- Sponsor
- Aichi Gakuin University
Hypertension
Effects of Acute Ingestion of Dark Chocolate on Endothelial Function in Hypertensive Patients
We aimed to identify clinical and vascular parameters of treated hypertensive patients who present beneficial effects of dark chocolate for one-week period on vascular function.
- Trial name
- NCT01314924
- Testing
- Dark chocolate
- Where
- Brazil
- Volunteers
- 21 people
- Sponsor
- Hospital Universitario Pedro Ernesto
Preeclampsia, Hypertension
Effects of Nitrate-rich Beetroot Juice in Pregnant Women With High Blood Pressure
BACKGROUND: Preeclampsia (PE) is a serious syndrome that affects 3-7% of all pregnant women. PE is characterized by hypertension and kidney problems after the 20th week of pregnancy and is associated with an increased risk of…
- Conditions
- Preeclampsia, Hypertension, Endothelial Dysfunction, Nitric Oxide
- Trial name
- NITBEETPE (NCT05241327)
- Testing
- Beetroot Juice
- Where
- Sweden
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
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