Clinical trials: Endothelium, Vascular
Sepsis
Midkine and ACE-Ang II Induced Endothelial Injury in Sepsis
Plasma midkine has reported to be elevated in infection and a regulator of angiotensin-converting enzyme (ACE). We aimed to investigate the plasma midkine in septic patients and its association with 28-day mortality and organ…
- Trial name
- NCT02605681
- Where
- China
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Southeast University, China
Oxidative Stress, Cardiovascular Diseases
Effect of a Specific Aquaporin-1 Inhibitor on Vascular Oxidative Stress in Healthy Volunteers
Bacoxy_II study aims to evaluate the efficacy of a standardized Bacopa monnieri extract, KeenMind®, on vascular oxidative stress.
- Conditions
- Oxidative Stress, Cardiovascular Diseases, Bacopaside II, Bacopa Monnieri
- Trial name
- Bacoxy_II (NCT06059131)
- Testing
- KeenMind
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Diabetic Foot Ulcers
A Prospective Study of Endothelial Dysfunction and Diabetic Foot Ulcer Risk
This project will identify risk factors for diabetic foot ulcer by studying the relationship between endothelial dysfunction and foot ulcer risk.
- Trial name
- NCT00013286
- Testing
- Prevention Diabetic Foot Ulcer
- Where
- United States
- Volunteers
- 750 people
- Sponsor
- US Department of Veterans Affairs
Diabetic Retinopathy, Dyslipidemias
Effects of Oral Fenofibrate on Retinal Thickness and Macular Volume
Lipid levels in the blood are proposed to play a role in the progression of diabetic retinopathy. Lipid levels can be controlled with dyslipidemic drugs, such as fenofibrate.
- Conditions
- Diabetic Retinopathy, Dyslipidemias, Diabetes Mellitus
- Trial name
- NCT04885153
- Testing
- Fenofibrate
- Volunteers
- 36 people
- Sponsor
- Universitas Indonesia
Acute Coronary Syndrome
Plaque Regression and Progenitor Cell Mobilization With Intensive Lipid Elimination Regimen (PREMIER), Phase I
The purpose of this randomized, multi-site, clinical trial is to determine whether intensive therapy consisting of cholesterol-lowering statin drugs plus apheresis to cleanse the blood of low-density lipoprotein (LDL) cholesterol…
- Trial name
- PREMIER (NCT01004406)
- Testing
- intensive LDL-lowering therapy, standard statin monotherapy
- Where
- 2 sites in United States
- Volunteers
- 59 people
- Sponsor
- VA Office of Research and Development
Hypertension,Essential
Endothelial Function in Prehypertension
In the frame of this proposal investigators will test the hypothesis that high normal blood pressure (prehypertension; PreHT) induces systemic endothelial dysfunction and endothelial activation in both micro- and…
- Trial name
- NCT06316271
- Where
- Croatia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Chronic Kidney Disease
Advanced Glycation End-products, Inflammation and Vascular Health in Chronic Kidney Disease
The purpose of the study is to learn more about how advanced glycation end-products can affect insulin resistance, inflammation and blood vessel health in people with kidney disease.
- Trial name
- NCT01769963
- Testing
- Research diet
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Alabama at Birmingham
Metastatic Renal Cell Carcinoma
Vascular Endothelial Growth Factor (VEGF) Imaging Before and During Everolimus Treatment for Renal Cell Carcinoma
Everolimus indirectly inhibits angiogenesis by reducing VEGF production. VEGF can be non-invasively visualized and quantified with serial 89Zr-bevacizumab PET imaging in patients.
- Trial name
- Everolimage (NCT01028638)
- Testing
- 89Zr-bevacizumab PET scan
- Where
- Netherlands
- Volunteers
- 13 people
- Sponsor
- University Medical Center Groningen
Cystic Fibrosis
Cystic Fibrosis and Endothelial Function: At Rest and During Exercise
Perhaps one of the most disturbing aspects of Cystic Fibrosis (CF) is the associated premature death. Oxidative stress has been observed in patients with CF and exercise intolerance has been shown to predict mortality in patients…
- Trial name
- NCT01772758
- Testing
- BH4 5mg, BH4 20mg, Antioxidant Cocktail
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Augusta University
Glaucoma
Bevacizumab Versus Mitomycin C as Trabeculectomy Adjuvant in Uncontrolled Glaucoma
Refractory glaucoma often requires vision-sparing trabeculectomy. To increase surgical success, adjunctive pharmacotherapy is utilized albeit the risk of adverse events.
- Trial name
- AvastinvsMMC (NCT02901236)
- Testing
- Standard Guarded Trabeculectomy, Mitomycin C, Bevacizumab
- Volunteers
- 40 people
- Sponsor
- Athens Vision Eye Institute
Wet Macular Degeneration
Mechanisms of Retinal Revascularization and Clinical Indicators of Neovascular AMD Relapse
Age-related macular degeneration (AMD) is a chronic and progressive eye disease and is one of the leading causes of vision impairment globally.
- Trial name
- NCT05211804
- Testing
- Ophthalmic Drugs
- Where
- Norway
- Volunteers
- 31 people
- Sponsor
- Sorlandet Hospital HF
Proliferative Diabetic Retinopathy, Angiogenesis
Fractalkine, a CX3C Chemokine, Act as a Mediator of Ocular Angiogenesis
Fractalkine (FKN) is a chemoattractant and adhesion molecule for leukocytes. Angiogenic effect of FKN also has been reported. We investigate FKN-mediated angiogenesis in ocular angiogenic disorders.
- Trial name
- NCT00728598
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- National Taiwan University Hospital
Bladder Cancer
Antiangiogenic Effects of BCG on Urinary Concentration of Angiogenic Factors
To determine if there is an association between basic fibroblast growth factor,vascular endothelial growth factor, and interleukin levels and a patients response to BCG treatment ( as standard treatment)in the urine of patients…
- Trial name
- NCT00216814
- Where
- Canada
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Coronary Artery Disease
Endothelial Modulation for Angiogenic Therapy
Coronary artery disease is the single most important killer of Canadians. Despite major advances in therapy, there is still a significant proportion of patients identified with the disease who die of it because current treatment…
- Trial name
- NCT00134433
- Testing
- intramyocardial VEGF angiogenesis (at a dose of 2 mg), oral L-arginine supplementation (at a dose of 6 g/day)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Hepatocellular Carcinoma (HCC)
Immune Checkpoint Inhibitors and Anti-vascular Endothelial Growth Factor Antibody/Tyrosine Kinase Inhibitors With or Without HAIC for Unresectable HCC With Portal Vein Tumor Thrombosis
Anti-vascular endothelial growth factor antibody/tyrosine kinase inhibitors (VEGF/TKI-ICI) plus Immune checkpoint inhibitors (ICIs) are recommended for patients with unresectable hepatocellular carcinoma (HCC) with PVTT in China.
- Trial name
- NCT06881433
- Where
- China
- Volunteers
- 1,649 people
- Sponsor
- Zhongda Hospital
Asthma, Inflammation
Vascular Implications of a Naturally Occurring Asthma Exacerbation
Although asthma is a disease of the airways, research is now showing that asthmatics are more likely to develop cardiovascular disease (CVD) compared to non-asthmatics.
- Conditions
- Asthma, Inflammation, Cardiovascular Risk Factor
- Trial name
- NCT03679299
- Testing
- Observational - No intervention
- Where
- 2 sites in Canada
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Age Related Macular Degeneration
A Study to Compare LY09004 and Eylea in the Treatment of Wet Age-related Macular Degeneration（wAMD）
A randomized, double-blind, parallel controlled, multicenter clinical trial to compare the efficacy and safety of LY09004 and EYLEA in the Treatment of Wet Age-related Macular Degeneration（wAMD)
- Trial name
- NCT04572698
- Testing
- LY09004, Eylea
- Volunteers
- 416 people
- Sponsor
- Luye Pharma Group Ltd.
Healthy
Vascular Effects of Dietary Salt in Humans With Salt-Resistant Blood Pressure
The purpose of this study is to determine the effects of dietary salt restriction on central hemodynamics and vascular function in men and women with salt resistant blood pressure.
- Trial name
- NCT03424993
- Testing
- Dietary Sodium Restriction, Control
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Metastatic Renal Cell Carcinoma
A Study of E7080 Alone, and in Combination With Everolimus in Subjects With Unresectable Advanced or Metastatic Renal Cell Carcinoma Following One Prior Vascular Endothelial Growth Factor (VEGF)-Targeted Treatment
This is an open-label, multicenter, Phase 1b/2 study of lenvatinib alone and in combination with everolimus in subjects with unresectable advanced or metastatic renal cell carcinoma following one prior VEGF-targeted treatment.
- Trial name
- NCT01136733
- Testing
- Lenvatinib, Everolimus
- Where
- 37 sites in United States, Czechia and 3 more
- Volunteers
- 173 people
- Sponsor
- Eisai Inc.
Colorectal Cancer
A Study to Evaluate Avastin in Combination With Chemotherapy in Patients With Metastatic Colorectal Cancer
This Phase II, multicenter, double-blind, randomized, active-controlled trial is designed to evaluate the efficacy and safety of rhuMAb VEGF (Avastin) when administered at a dose of 5 mg/kg every 2 weeks in combination with 5 FU…
- Trial name
- NCT00109226
- Testing
- Avastin (Bevacizumab)
- Sponsor
- Genentech, Inc.
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