Clinical trials: Endothelium, Vascular
Coronary Artery Disease
Endothelium, Stenting, and Antiplatelet Therapy (EST) - Clopidogrel, Prasugrel, Ticagrelor Study
Endothelial dysfunction is an important predictor - and a determinant - of adverse clinical outcome. Endothelial function is impaired by coronary artery stenting, a stud from our group has shown that it can be improved by…
- Trial name
- EST (NCT01700322)
- Testing
- Coronary stenting, Ticagrelor, Clopidogrel
- Where
- Germany
- Volunteers
- 126 people
- Sponsor
- Johannes Gutenberg University Mainz
Intradialytic Hypertension
Mechanisms and Treatment of Intradialytic Hypertension
1. To determine in a cross sectional case-controlled cohort study of 50 hemodialysis patients if blood pressure elevations with hemodialysis are associated with decreased endothelial cell function (measured by brachial artery…
- Trial name
- MATCH (NCT00827775)
- Testing
- Carvedilol
- Where
- 3 sites in United States
- Volunteers
- 55 people
- Sponsor
- University of Texas Southwestern Medical Center
Autonomic Nervous System, Hypertension
Influence of the Autonomic Nervous System in Response to Exercise in Hypertensive Individuals
Systemic arterial hypertension (SAH) has a direct association with endothelial dysfunction and major cardiovascular events. Evidence points to possible benefits of aerobic training in the endothelial function analyzed by the flow…
- Trial name
- NCT04371757
- Testing
- α1-adrenergic block
- Where
- Brazil
- Volunteers
- 39 people
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Hyperuricemia, Chronic Kidney Disease
The Effect of Uric Acid Decrement on Endothelial Function in Patients With Chronic Renal Failure
In this prospective study, the investigators aimed to evaluate the effects of improved hyperuricemia, a minor cardiovascular risk factor, on endothelial dysfunction in patients with chronic kidney disease.
- Trial name
- NCT00978653
- Testing
- allopurinol
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Istanbul University
Atherosclerotic Disease
Telomeres and Arterial Aging
The prevailing view in telomere epidemiology is that leukocyte telomere length (LTL) is associated with atherosclerosis and accelerated aging since it serves as a biomarker of the cumulative burden of inflammation and oxidative…
- Trial name
- TELARTA (NCT02176941)
- Where
- 2 sites in France
- Volunteers
- 340 people
- Sponsor
- Central Hospital, Nancy, France
Vascular Aging
Sodium Nitrite to Treat Arterial Aging
The proposed research will determine the effectiveness of nitrite, a naturally occurring compound in the body, for improving the health and function of arteries in middle-aged and older adults.
- Trial name
- NCT02022670
- Testing
- Sodium Nitrite
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
PCOS, Hyperinsulinism
Cardiovascular and Endothelial Markers During OGTT Before and at Six and Twelve Months Post-treatment in Women With PCOS
The aim of the present study is to investigate a) the presence of subclinical markers of vascular, myocardial and endothelial function in women with PCOS b) the acute alterations in these markers during the oral glucose tolerance…
- Conditions
- PCOS, Hyperinsulinism, Hyperandrogenism, Metabolic Syndrome
- Trial name
- NCT06889454
- Testing
- GLP-1 receptor agonist, Oral contraceptive, Metformin
- Where
- Greece
- Volunteers
- 120 people
- Sponsor
- Attikon Hospital
Essential Hypertension, Endothelial Dysfunction
Evaluation of Black Chokeberry Bio Juice on Blood Pressure Levels and Endothelial Damage
In Romania, the diseases of the circulatory system account for 59.3% of deaths, representing the main cause of morbidity and mortality.
- Conditions
- Essential Hypertension, Endothelial Dysfunction, Inflammation
- Trial name
- AROBLENDO (NCT05912322)
- Testing
- Black chokeberry juice
- Where
- Romania
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy "Victor Babes" Timisoara
Type 1 Diabetes, Type 2 Diabetes
Arginase Inhibition in Type 1 and Type 2 Diabetes Mellitus
To evaluate the efficacy of arginase inhibition on endothelial function in patients with type 1 diabetes and type 2 diabetes.
- Trial name
- NCT05806502
- Testing
- Nω-hydroxy-nor-arginine
- Where
- Sweden
- Volunteers
- 12 people
- Sponsor
- Karolinska Institutet
Healthy
Effects of Cocoa Procyanidins on Vascular Function
There is a question regarding the role of higher flavanol oligomers (procyanidins) and of intestinal flavanol metabolites i.e. valerolactones, in the context of flavanol intake-related vascular effects.
- Trial name
- NCT02728466
- Testing
- Flavanol and procyanidin supplement, Procyanidin-containing supplement, control supplement deprived of flavanols and procyanidins
- Where
- Germany
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Type 1 Diabetes
EFFECT OF HYBRID CLOSED-LOOP SYSTEMS ON CARDIOVASCULAR MARKERS IN TYPE 1 DIABETES.
This is a prospective, non-randomized, observational cohort study conducted in adult patients with type 1 diabetes.Participants with poorly controlled T1D under multiple daily injection (MDI) treatment will be assigned to one of…
- Trial name
- NCT07241702
- Testing
- HCLS, SGLT2 inhibitor, MDI
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Attikon Hospital
Chest Pain
Women With Chest Pain and Normal Coronary Arteries Study
The purpose of this study is to compare the effectiveness of standard medical therapy versus usual care in women with chest pain, coronary endothelial dysfunction and unblocked coronary arteries.
- Trial name
- NCT00743197
- Testing
- Aspirin, Lisinopril, Simvastatin
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Northwestern University
Obstructive Sleep Apnea, Cardiac Syndrome X
A Prevalence Study of Obstructive Sleep Apnea in Subjects With Chest Pain, Positive Exercise Treadmill Test and Normal Coronary Angiogram
Cardiac syndrome X consists of a triad of chest pain, abnormal exercise stress testing and normal coronary angiogram, and is hypothesized to be related to endothelial dysfunction.
- Conditions
- Obstructive Sleep Apnea, Cardiac Syndrome X, Endothelial Dysfunction
- Trial name
- NCT01217346
- Testing
- no intervention is involved in this study
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- The University of Hong Kong
Peripheral Arterial Disease, Cardiovascular Disease
Endothelial Function and Vein Graft Remodeling
The purpose of this study is to better understand why some vein bypass grafts develop narrowing. Evidence suggests that there is a relationship between inflammatory markers in the blood and the narrowing that occurs in blood…
- Trial name
- EFVGR (NCT00831090)
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- University of California, San Francisco
Hypertension
Role of Enhanced External Counterpulsation (EECP) Therapy in Patients With Resistant Hypertension
High Blood Pressure or Hypertension is one of the main causes of stroke, heart disease, heart attack and kidney disease. Traditionally physicians use diet and lifestyles change and medications to control patient's blood pressure.
- Trial name
- EECP (NCT00953797)
- Testing
- Enhanced External Counterpulsation
- Where
- United States
- Sponsor
- Albert Einstein Healthcare Network
CKD, Dialysis
Long Term Cardio-Vascular Risk Assessment in CKD and Kidney Transplanted Patients Following SARS-COV-2
The occurrence of novel coronavirus disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2), has offered an unmatched global challenge for the healthcare research community.
- Conditions
- CKD, Dialysis, Kidney Transplant, COVID-19
- Trial name
- CARDIO SCARS (NCT05125913)
- Testing
- FMD, Arterial stiffness, Assessment of IMT
- Where
- Romania
- Volunteers
- 250 people
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Burns, Coagulation Disorder
Factor XIII in Major Burns Coagulation
Prospective observational study in which FXIII levels and coagulation tests and cicatrization are measured during the 30 days after the thermal trauma.
- Conditions
- Burns, Coagulation Disorder, Factor XIII Deficiency, Cicatrization
- Trial name
- NCT03188913
- Testing
- Coagulation tests
- Volunteers
- 20 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Coronary Artery Disease, Endothelial Function
Differential Effect of Ticagrelor Versus Prasugrel Maintenance Dose on Endothelial Function of Peripheral Vessels in Patients With Coronary Artery Disease
Ticagrelor administration, whose molecule resembles to adenosine, led to reduction in overall mortality and thrombotic cardiovascular (CV) events when directly compared to clopidogrel in the PLATO trial, implicating possible…
- Trial name
- NCT01957540
- Testing
- Ticagrelor, Prasugrel
- Where
- Greece
- Volunteers
- 22 people
- Sponsor
- University of Patras
Cardiovascular Diseases
Hunting for the Off-Target Properties of Ticagrelor on Endothelial Function in Humans (HI-TECH)
The purpose of this randomized, cross-over study, is to ascertain if ticagrelor, but not prasugrel or clopidogrel, is associated to an improved endothelial function as assessed with peripheral arterial tonometry and markers of…
- Trial name
- HI-TECH (NCT02587260)
- Testing
- Ticagrelor, Prasugrel, Clopidogrel
- Where
- 5 sites in Italy, Netherlands and 2 more
- Volunteers
- 54 people
- Sponsor
- Erasmus Medical Center
Atherosclerosis
Effects of Chronic Smoking on Circulating Endothelial and Platelet-derived Microparticle
The investigators hypothesized that circulating EMP is a useful surrogate marker of early stage of endothelial damage. To determine the effects of chronic smoking on circulating EMP, from healthy volunteers who have habit of…
- Trial name
- NCT00795249
- Testing
- smoking cessation
- Where
- Japan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kurume University
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