Clinical trials: Endothelium, Vascular
Cardiovascular Diseases, Vascular Diseases
Influence of Age, Weight and Ethnic Background on Blood Pressure
Hypertension, also known as high blood pressure, is a chronic medical condition, in which the blood pressure is elevated. This is a common condition, which can lead to severe complications such as cardiovascular disease, heart…
- Conditions
- Cardiovascular Diseases, Vascular Diseases, Hypertension
- Trial name
- AWE (NCT03014791)
- Testing
- Brief lifestyle/medical history questionnaire, Anthropometric measures, Blood pressure and arterial stiffness
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Chronic Total Occlusion of Coronary Artery, Coronary Occlusion
ABSORB FIRST is a Registry Designed to Evaluate the Safety and Performance of Absorb Bioresorbable Vascular Scaffold (Absorb BVS) Used in Real-world Patients.
ABSORB FIRST is a prospective, multi-center registry. The objectives of the study are to: Provide ongoing post-market surveillance for documentation of safety, performance and clinical outcomes of the Absorb BVS (Bioresorbable…
- Conditions
- Chronic Total Occlusion of Coronary Artery, Coronary Occlusion, Coronary Artery Disease, Coronary Artery Restenosis
- Trial name
- NCT01759290
- Testing
- Absorb Bioresorbable Vascular Scaffold
- Where
- Belgium
- Volunteers
- 1,800 people
- Sponsor
- Abbott Medical Devices
Breast Cancer, Breast Neoplasm Female
Targeting Stress-Driven Inflammatory and Angiogenic Pathways With Brief ACT to Enhance Neoadjuvant Chemotherapy Response in Locally Advanced Breast Cancer
This clinical trial aims to learn whether a brief psychological therapy called Brief Acceptance and Commitment Therapy (Brief-ACT) can improve the effectiveness of neoadjuvant chemotherapy in patients with locally advanced breast…
- Conditions
- Breast Cancer, Breast Neoplasm Female, Locally Advanced Breast Cancer (LABC), Locally Advanced Breast Cancer
- Trial name
- NCT07570368
- Testing
- Brief Acceptance and Commitment Therapy, Standard Counseling, Neoadjuvant Chemotherapy
- Volunteers
- 54 people
- Sponsor
- Universitas Airlangga
HIV-1
HIV-1, Insufficient Sleep and Vascular Endothelial Dysfunction
The investigators hypothesize that chronic insufficient sleep is associated with diminished endothelium-dependent nitric oxide-mediated vasodilation and tissue-type plasminogen activator release in anti-retroviral (ART)-treated…
- Trial name
- NCT04956861
- Testing
- Individualized Targeted Sleep
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Colorado, Boulder
Preeclampsia, Preeclampsia Postpartum
Vascular Effects of High-Salt After Preeclampsia
Women who develop preeclampsia during pregnancy are more likely to develop and die of cardiovascular disease later in life, even if they are otherwise healthy.
- Trial name
- NCT06749418
- Testing
- Eplerenone
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Anna Stanhewicz, PhD
Coronary Artery Disease, Atherosclerosis
MASCOT - Post Marketing Registry
To collect post marketing surveillance data on patients receiving at least one Combo Bio-Engineered Sirolimus Eluting Stent when used according to the Instructions for Use.
- Trial name
- MASCOT (NCT02183454)
- Testing
- OrbusNeich COMBO stent
- Where
- Netherlands
- Volunteers
- 2,500 people
- Sponsor
- OrbusNeich
Sickle Cell Disease
Evaluation of Non-invasive Endothelial Function in Children Sickle by Vascular Ultrasound
Sickle cell disease (SCD) is an inherited disorder characterized by recurrent painful crises with ischemia resulting from vascular occlusion.
- Trial name
- NCT02829580
- Testing
- Echocardiography
- Where
- France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Toulouse
Von Hippel-Lindau Disease, Hemangioblastoma
Visualizing Vascular Endothelial Growth Factor (VEGF) Producing Lesions in Von Hippel-Lindau Disease
Von Hippel Lindau disease (VHLD) is an inherited syndrome characterized by vascular malformations, kidney cancer, adrenal gland and pancreas tumors.
- Conditions
- Von Hippel-Lindau Disease, Hemangioblastoma, Renal Cell Carcinoma, Pheochromocytoma
- Trial name
- VHLimage (NCT00970970)
- Testing
- 89Zr bevacizumab PET scan
- Where
- Netherlands
- Volunteers
- 22 people
- Sponsor
- University Medical Center Groningen
Cystic Fibrosis
Investigation of Relationship Between Vascular Functions, Exercise Capacity, and Respiratory Functions in CF
In the literature, there is no study that evaluates the endothelial function and arterial stiffness together and investigates its relationship with exercise capacity and respiratory functions in children with CF of different…
- Trial name
- NCT04259983
- Testing
- Maximal exercise test, Endothelial dysfunction assessment, Arterial stiffness assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Hacettepe University
Erectile Dysfunction Due to Arterial Disease, Atheroscleroses
TRIal of STatin Therapy Effect on Androgen Status and Erectile functioN in Men
Aim. To study the effect of different intensities of statin therapy on androgen status and erectile function in men aged 40-65 years with high and very high cardiovascular risk.
- Conditions
- Erectile Dysfunction Due to Arterial Disease, Atheroscleroses, Erectile Disfunction, Endothelial Dysfunction
- Trial name
- NCT07460960
- Testing
- Pitavastatin 1-4 mg daily, Rosuvastatin 20-40 mg daily
- Where
- Russia
- Volunteers
- 150 people
- Sponsor
- Lomonosov Moscow State University Medical Research and Educational Center
Hereditary Haemorrhagic Telangiectasia
Genotype Expression and Phenotype of Endothelial Cells, Carrying an ACVRL1, ENG or SMAD4 Mutation, in Response to BMP9 for the Identification of New Therapeutic Targets in Hereditary Haemorrhagic Telangiectasia
Hereditary hemorrhagic telangiectasia (HHT) or Osler-Weber-Rendu syndrome patients are carriers of a heterozygous mutation of the activin receptor-like kinase 1 (ACVRL1), Endoglin (ENG) or Mothers against decapentaplegic homolog…
- Trial name
- CAERO (NCT05632484)
- Testing
- Cord blood sampling, Cord sampling
- Where
- 3 sites in France
- Volunteers
- 16 people
- Sponsor
- Hospices Civils de Lyon
Diabetic Retinopathy, Diabetic Macular Edema
Anti-VEGF Treatment for Prevention of PDR/DME
Multiple studies have implicated vascular endothelial growth factor VEGF as a major causative factor in human eye diseases characterized by neovascularization including proliferative diabetic retinopathy (PDR) and vascular…
- Trial name
- NCT02634333
- Testing
- Prompt aflibercept, Deferred laser, Deferred aflibercept
- Where
- 85 sites in United States, Canada
- Volunteers
- 399 people
- Sponsor
- Jaeb Center for Health Research
Obesity, Adolescent
The Effects of a Combined Exercise Training Program on Vascular Health and Metabolic Profile in Obese Adolescent Girls.
The purpose of this study was to examine the impact of 12 weeks of combined exercise training (CET) on arterial stiffness, endothelial function, inflammatory markers, insulin resistance, and body composition in obese adolescent…
- Trial name
- NCT03146026
- Testing
- Combined Exercise Training
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pusan National University
Acute Coronary Syndrome
Endothelial Dysfunction and Plaque Vulnerability
Thinning of fibrous cap in atherosclerotic plaques is associated with plaque vulnerability. The high resolution of optical coherence tomography (OCT) provides an accurate measurement of fibrous cap thickness.
- Trial name
- NCT01578616
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Yokohama City University Medical Center
End Stage Renal Disease, Hemodialysis Vascular Access Failure
Reduction of Plasma Free VEGF-A Using Low-dose Bevacizumab in Hemodialysis Patients
The primary purpose of this pilot study is to assess the pharmacokinetic profile of low-dose bevacizumab and its effectiveness in reducing plasma free VEGF-A levels safely in hemodialysis patients.
- Trial name
- NCT02695641
- Testing
- 1.25mg bevacizumab, 2.50mg bevacizumab
- Sponsor
- Mayo Clinic
Healthy People
Establishment of Vascular Permeability Model for Research Purpose by Human Umbilical Vascular Endothelial Cells
HUVEC primary cells for researches about the relation between plasma leakage and infections.
- Trial name
- NCT01261195
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Endothelial Dysfunction
The Effects of Watermelon Juice Supplementation on Postprandial Vascular Endothelial Function
The purpose of this study is to test if watermelon juice supplementation improves vascular dysfunction experience during hyperglycemia.
- Trial name
- WMJ (NCT04092439)
- Testing
- Watermelon Juice
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Reperfusion Injury, Vascular Complications
Trial to Investigate the Effect of Dapagliflozin on Ischemia Reperfusion Induced Endothelial Dysfunction
The aim of the study is to investigate the effect of dapagliflozin or placebo on acetylcholine (Ach)- or nitroglycerin (GTN)-induced vasodilation of the forearm resistance vasculature, as determined by FBF measurement before and…
- Trial name
- NCT05217654
- Testing
- Dapagliflozin 10mg
- Where
- Austria
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Coronary Artery Disease
Uric Acid Levels and Endothelial Functions
Uric acid is a risk factor for coronary artery disease (CED) in postmenopausal women but the association with inflammation and coronary microvascular endothelial dysfunction is not well-defined.
- Trial name
- NCT02862522
- Testing
- Questionnaire of overall health
- Where
- United States
- Volunteers
- 229 people
- Sponsor
- Mayo Clinic
Endothelial Dysfunction, Coronary Microvascular Disease
Functional Assessment of the Infart-related Artery With Bioactive and Polymer-free Coronary Stents (The FUNCOMBO Trial)
A total of 50 patients with ST-elevation myocardial infarction (STEMI) undergoing primary-percutaneous coronary intervention (PPCI) will be randomized to two different coronary stents: BIOFREEDOM vs. COMBO stent.
- Conditions
- Endothelial Dysfunction, Coronary Microvascular Disease, Myocardial Infarction
- Trial name
- FUNCOMBO (NCT04202172)
- Testing
- Stent implantation in the infart-related artery in patients with ST elevation myocardial infarction
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Institut d'Investigació Biomèdica de Bellvitge
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