Clinical trials: Endothelium, Vascular
Leukemia
A Multi-Center Phase 2 Study of VEGF Trap as a Single Agent in Acute Myeloid Leukemia
RATIONALE: Aflibercept may stop the growth of cancer cells by blocking blood flow to the cancer. PURPOSE: This phase II trial is studying how well aflibercept works in treating patients with advanced refractory, relapsed, or…
- Trial name
- NCT00601991
- Testing
- VEGF Trap, Bone marrow biopsy, bone marrow aspiration
- Sponsor
- Vanderbilt-Ingram Cancer Center
Cardiovascular Diseases, Endothelial Dysfunction
Investigation of the Effects of Dietary Nitrate and Sex on COVID-19 Vaccine Induced Vascular Dysfunction in Healthy Men and Women (DiNOVasc-COVID-19)
Inorganic nitrate can protect blood vessels from the damage that occurs during cardiovascular disease. Early experimental work suggests that nitrate-induced improvements in vascular function relate to the suppression of…
- Trial name
- NCT04889274
- Testing
- COVID-19 vaccine, Concentrate beetroot Juice, Nitrate-deplete beetroot juice
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Covid19
Accelerating COVID-19 Therapeutic Interventions and Vaccines 4 ACUTE
This is a randomized, open label, adaptive platform trial to compare the effectiveness of antithrombotic and additional strategies for prevention of adverse outcomes in COVID-19 positive inpatients
- Trial name
- ACTIV-4A (NCT04505774)
- Testing
- theraputic heparin, prophylactic heparin, P2Y12
- Where
- 101 sites in United States, Brazil and 2 more
- Volunteers
- 3,591 people
- Sponsor
- Matthew Neal MD
Vascular Disease, Heart Disease
Gap Junction Potentiation of Endothelial Function With Rotigaptide
Hypothesis - Rotigaptide will improve endothelial function in the context of endothelial dysfunction. The lining of blood vessels (endothelium) can react to hormones in the blood stream causing the blood vessel muscle to relax…
- Trial name
- NCT00901563
- Testing
- Rotigaptide, Forearm vascular study
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Coronary Disease
EGO-COMBO Angiographic Extension Study
Evaluation of Endothelial ProGenitor Cell Capture Sirolimus-Eluting Stent by Optical Coherence Tomography: the COMBO Stent angiographic extension Study (EGO-COMBO angiographic extension Study)
- Trial name
- NCT01756807
- Testing
- The COMBO Stent
- Where
- China
- Volunteers
- 41 people
- Sponsor
- Prof. Stephen Lee
Healthy
Leptin and Endothelial Function
The purpose of this trial was to determine if injections of leptin would improve vascular function in normal-weight, healthy volunteers.
- Trial name
- NCT00121433
- Testing
- leptin
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Metastatic Renal Cell Cancer
Expanded Access Study of RAD001 in Metastatic Renal Cell Cancer Patients Who Are Intolerant of or Who Have Failed Despite Prior Vascular Endothelial Growth Factor Therapy
This expanded access study is designed to provide RAD001 to patients with MRCC who are without satisfactory treatment alternatives, until RAD001 becomes commercially available.
- Trial name
- NCT00655252
- Testing
- Everolimus
- Where
- 84 sites in United States, Australia and 11 more
- Sponsor
- Novartis Pharmaceuticals
Complication Following Ectopic Pregnancy
Vascular Endothelial Growth Factor Levels in Ectopic Pregnancy
The aim of this study is to determine plasma Vascular Endothelial Growth Factor level and change in patient with ectopic pregnancy who needs to surgical treatment.
- Trial name
- VEGF (NCT01601964)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Bagcilar Training and Research Hospital
Choroidal NeoVascularization, Age-Related Macular Degeneration
Does Vascular Endothelial Growth Factor (VEGF) or Complement Factor H Gene Polymorphism Play a Role in the Treatment Success With VEGF Inhibitors in Patients With Choroidal NeoVascularization (CNV)?
Age related macular degeneration (AMD) is a multifactorial disease with a strong genetic component. Most importantly a genetic polymorphism in the gene encoding for the complement factor H (CFH) has been recently identified which…
- Trial name
- NCT00813514
- Testing
- VEGF genotyping
- Where
- Austria
- Sponsor
- Medical University of Vienna
French PNNS Guidelines in Vascular Function
Impact of Dietary Status on Vascular Function Before and After a Standardized Breakfast. An "Exposed/Unexposed" Study Embedded in the SUVIMAX2 Cohort
In France, primary cardiovascular and metabolic prevention is supported by the French National Program for Nutrition and Health (PNNS: Programme National Nutrition Santé).
- Trial name
- Nutri-MicroVas (NCT01579409)
- Testing
- PNNS guidelines
- Where
- France
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Coronary Artery Disease
Evaluation of CTCA in Assessing Plaque Pathology and Physiology
Computed tomographic coronary angiography (CTCA) has been recently introduced to non-invasively evaluate coronary artery pathology.
- Trial name
- NCT03556644
- Testing
- CTCA imaging
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University College, London
Intradialytic Hypertension
Mechanisms of Increased Ambulatory Blood Pressure in Patients With Intradialytic Hypertension
The purpose of this study is 1) to determine what physiologic factors (extracellular fluid overload or vasoconstriction) contribute more to increased blood pressure levels between dialysis treatments in hemodialysis patients…
- Trial name
- NCT01862497
- Testing
- Carvedilol vs. Prazosin
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- University of Texas Southwestern Medical Center
Acute Kidney Injury, Hemodialysis
Role of Vascular Endothelial Markers in Predicting Renal Prognosis and Mortality in Patients Undergoing HD-AKI
The aim of this study was to evaluate the role of Activin A, Nostrin, and Angiopoetin-2 levels in predicting the prognosis of renal function and in-hospital and 6-month mortality in patients undergoing emergency hemodialysis…
- Trial name
- VEMhemodiAKI (NCT07637435)
- Testing
- Serum samples before hemodialysis.
- Where
- Turkey (Türkiye)
- Volunteers
- 170 people
- Sponsor
- Muğla Sıtkı Koçman University
Critical Limb Ischemia, Peripheral Arterial Disease
Revascularization of Stenosed Vessels Using Optimized Treatment of Rejuveinix for Reversing Endothelial Dysfunction
A Phase I/IIa Dose-Escalation Study Evaluating the Safety, Tolerability and Efficacy of Rejuveinix in Combination With Standard Interventional Therapy for Critical Limb Ischemia Patients with Rutherford Class 4, 5 and 6 Disease
- Trial name
- RESTORE (NCT03041259)
- Testing
- Rejuveinix Low Dose, Rejuveinix High Dose
- Volunteers
- 320 people
- Sponsor
- Reven Pharmaceuticals, Inc.
Severe Traumatic Brain Injury, Trauma
Impact of Severe Brain Injury on Neuro-vascular and Endothelial Regulation of Peripheral Microcirculation.
Severe brain injury (SBI) is one of the world's leading causes of death and disability in young adults, but its peripheral vascular consequences in humans are poorly understood.
- Trial name
- MicroTC (NCT04597879)
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Diabete Type 2, Cardio Vascular Disease
Role of Endothelial Progenitor Cells Dysregulation and Inflammation in the Pathophysiology of Cardiovascular Complications of Type 2 Diabetes
This study aims to isolate endothelial progenitor cells (EPCs) from participants with type 2 diabetes (T2D) and cardiovascular complications and to comprehensively characterize EPC dysfunction.
- Trial name
- NCT07556497
- Where
- Qatar
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Weill Cornell Medical College in Qatar
Endothelial Function, Hyperglycemia
Hyperglycemia, Exercise, and Endothelial Function
The main purpose of this study is to determine if exercise preserves vascular function during hyperglycemia. All subjects will consume a sugary beverage three times daily for seven days.
- Trial name
- NCT03651713
- Testing
- GLU+EX, GLU
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Macular Degeneration, Age-related Macular Degeneration
A Study To Evaluate The Safety, Tolerability And Pk Of Pazopanib Eye Drops In Healthy Adult And Elderly Subjects.
This is a two-part study to evaluate the safety, tolerability and pharmacokinetics of single (Part A) and repeat (Part B) eye drop doses of pazopanib in healthy adult and elderly subjects.
- Trial name
- NCT00463320
- Testing
- Pazopanib eye drops and Allergen Refresh Plus eye drops
- Where
- 2 sites in United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Sickle Cell Disease
Study of Biological Markers in Children With Sickle Cell Disease
Sickle cell disease is associated with significant morbi-mortality hence the interest in an early and targeted care. At present, there is no plasmatic marker able to identify infants at higher risk of developping severe…
- Trial name
- NCT04839159
- Testing
- Blood sampling
- Where
- 3 sites in Belgium
- Volunteers
- 41 people
- Sponsor
- Queen Fabiola Children's University Hospital
Rheumatoid Arthritis, Coronary Heart Disease
Endothelial Dysfunction Evaluation for Coronary Heart Disease Risk Estimation in Rheumatoid Arthritis (EDRA Study)
To evaluate the contribution of the assessment of endothelial dysfunction (ED) in improving coronary hearth disease (CHD) risk stratification obtained by the Framingham risk score (FRS) in rheumatoid arthritis population (RA).
- Trial name
- EDRA (NCT02341066)
- Testing
- Endothelial Dysfunction evaluation by EndoPAT
- Where
- 3 sites in Italy
- Volunteers
- 3,000 people
- Sponsor
- Azienda Ospedaliero Universitaria di Sassari
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