Clinical trials: Endothelium, Vascular
Atherosclerosis
Vascular Effects of Ezetimibe/Simvastatin and Simvastatin on Atherosclerosis
Multiple clinical trials, using 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors (statins), have shown benefit in the primary and secondary prevention of atherosclerotic complications.
- Trial name
- NCT00560170
- Testing
- Simvastatin (Zocor), 10mg/10mg of Ezetimibe/Simvastatin (Vytorin)
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Cheng-Kung University Hospital
Healthy
Spices, Inflammation and Vascular Response in Humans
The objectives of this study are: 1. To characterize the time course of herbs/spice action on endothelial function as measured by FMD over 24 h using a challenge meal paradigm. 2.
- Trial name
- SPC (NCT03926442)
- Testing
- Italian Herb meal, Cinnamon Meal, Pumpkin Spice meal
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Diabetic Retinopathy
Lucentis (Ranibizumab) in Diabetic Macular Oedema: a Treatment Evaluation
This exploratory study will compare the effects of ranibizumab treatment with conventional macular laser therapy for patients with diabetic macular oedema.
- Trial name
- LUCIDATE (NCT01223612)
- Testing
- Ranibizumab, Modified ETDRS laser
- Where
- United Kingdom
- Volunteers
- 37 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Major Depressive Disorder, Depression
Anti-INFLammatory to Address Mood and Endothelial Dysfunction (INFLAMED)
The objective of this clinical trial is to evaluate whether an anti-inflammatory medication, pentoxifylline, reduces depressive symptoms and improves artery function.
- Conditions
- Major Depressive Disorder, Depression, Depressive Symptoms, Cardiovascular Disease (CVD)
- Trial name
- INFLAMED (NCT01625845)
- Testing
- Pentoxifylline, Standard Treatment
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Indiana University
Peripheral Artery Disease
DUAL Pathway Inhibition to Improve Endothelial Function in Peripheral Artery Disease
Peripheral artery disease (PAD) is a manifestation of systemic atherosclerosis, causing patients to be at high risk of major adverse cardiovascular and limb events.
- Trial name
- DUAL-PAD (NCT04218656)
- Testing
- Rivaroxaban 2.5 Mg Oral Tablet
- Where
- 2 sites in Netherlands
- Volunteers
- 159 people
- Sponsor
- Radboud University Medical Center
Cerebrovascular Accident, Fabry Disease
Vasodilation in Patients With Fabry's Disease
Fabry's disease a genetic disorder (X-linked recessive) due to the absence of the enzyme alpha-galactosidase A. The disease is characterized by abnormal collections of glycolipids in cells (histiocytes) within blood vessel walls…
- Conditions
- Cerebrovascular Accident, Fabry Disease, Healthy
- Trial name
- NCT00001774
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Polypoidal Choroidal Vasculopathy
Initial Versus Delayed PDT Combination With Conbercept in PCV
To compare the initial versus delayed verteporfin photodynamic therapy (PDT) in combination with conbercept in patients with symptomatic polypoidal choroidal vasculopathy (PCV).
- Trial name
- NCT02821520
- Testing
- conbercept, Initial PDT, Delayed PDT
- Where
- 3 sites in China
- Volunteers
- 80 people
- Sponsor
- The Eye Hospital of Wenzhou Medical University
Coronary Disease
The Impact of Caffeine on Brachial Endothelial Function in Healthy Subjects and in Patients With Ischemic Heart Disease
Prior work (Chris, M. et al, Clinical Science 2005; 109, 55-60) has demonstrated that drinking a cup of coffee (80-100 mg of caffeine) an hour before endothelium-dependent FMD (flow-mediated dilatation) of the brachial artery…
- Trial name
- NCT00564824
- Testing
- Caffeine
- Where
- Israel
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Blood Sugar, Endothelial Function
Comparing Blood Sugar Levels and Endothelial Function of PEAK ATP® With GlycoCarn®, PEAK ATP® and GlycoCarn® Supplements
To purpose of this study is to assess the effectiveness, safety and tolerability of PEAK ATP® with GlycoCarn®, PEAK ATP® and GlycoCarn® on levels of blood sugar and endothelial function improvement which may lead to improved…
- Trial name
- NCT01855373
- Testing
- PEAK ATP® with GlycoCarn®, PEAK ATP®, GlycoCarn®
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Supplement Formulators, Inc.
Preeclampsia
Vascular Endothelial Factor Gene Polymorphism in Preeclampsia
In this study, the investigators assessed one of the released protein factors during the pathophysiology of preeclampsia. They evaluated vascular endothelial growth factor gene mutation which affects the angiogenesis in case of…
- Trial name
- NCT03500588
- Testing
- PCR, Doppler ultrasound
- Where
- Egypt
- Volunteers
- 290 people
- Sponsor
- Beni-Suef University
Cardiovascular Diseases, Hypertension
The Impact of Goode Health Beverage on Markers of Physiological and Neurocognitive Health
The overall research objective of this proposal is to determine the acute and chronic impact of daily supplementation of a Good Health beverage on indices of physiological and neurocognitive health.
- Conditions
- Cardiovascular Diseases, Hypertension, Cognitive Decline, Diet, Healthy
- Trial name
- NCT06245382
- Testing
- Goode Health Beverage, Vanilla Base Beverage Blend
- Where
- 2 sites in United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Von Hippel-Lindau Syndrome, Renal Cell Carcinoma
Evaluation of Sunitinib Malate in Patients With Von Hippel-Lindau Syndrome (VHL) Who Have VHL Lesions to Follow
The goal of this clinical research study is to learn if sunitinib malate (SU011248) can help to control VHL. The safety of this drug will also be studied.
- Conditions
- Von Hippel-Lindau Syndrome, Renal Cell Carcinoma, Hemangioblastoma
- Trial name
- NCT00330564
- Testing
- SU011248
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- M.D. Anderson Cancer Center
Autosomal Dominant Polycystic Kidney, Hypertension
Effect of Beetroot Juice on Reducing Hypertension in Autosomal Dominant Polycystic Kidney Disease
People with autosomal dominant polycystic kidney disease (ADPKD) develop high blood pressure and kidney disease. Previous studies have shown that a commonly occurring chemical, nitric oxide (NO), is reduced in ADPKD, and may…
- Conditions
- Autosomal Dominant Polycystic Kidney, Hypertension, Endothelial Dysfunction
- Trial name
- BEET-PKD (NCT05401409)
- Testing
- Beetroot juice, Nitrate-depleted beetroot juice
- Where
- 2 sites in Australia
- Volunteers
- 60 people
- Sponsor
- Western Sydney Local Health District
Stroke
Autologous Endothelial Progenitor Cells Transplantation for Chronic Ischemic Stroke
Stroke is a frequently occurring and common diseases in nervous system,and most of the survivors will remain disorders of motor,sensory and cognition function.Stem cell transplantation provides a promising approach for…
- Trial name
- NCT02605707
- Testing
- Intravenous stem cell transplantation
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Southern Medical University, China
Endothelial Dysfunction
Effects of Dietary Nitrate on Age-related Vascular Function
Purpose of the study is to characterize the chronic effect of dietary nitrate on vascular function in healthy volunteers with particular emphasis on age-related alterations.
- Trial name
- NCT01729234
- Testing
- Nitrate
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Cardiovascular Disease
Impact of Meal Fatty Acids on Postprandial Vascular Reactivity
Cardiovascular disease (CVD) is the leading cause of death in women. Premenopausal women have a lower risk of CVD compared with men of a similar age. However, the incidence of CVD increases greatly after the menopause.
- Trial name
- DIVAS-2 (NCT02144454)
- Testing
- Saturated fat, Monounsaturated fat, n-6 polyunsaturated fat
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Reading
Pulmonary Hypertension
Anticoagulation For Pulmonary Hypertension in Sickle Cell Disease
Sickle cell disease (SCD) is often referred to as a hypercoagulable state. However, the contribution of coagulation activation to the pathogenesis of SCD remains uncertain.
- Trial name
- NCT01036802
- Testing
- Warfarin
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of North Carolina, Chapel Hill
Renal Function, Endothelial Function
Study of Vitamin D and Uric Acid Lowering on Kidney and Blood Vessel Function
The investigators hypothesize that, among non-hypertensive overweight and obese individuals, treatment of vitamin D deficiency and lowering uric acid concentrations (by either xanthine oxidase inhibition or increased renal…
- Conditions
- Renal Function, Endothelial Function, Blood Pressure, Overweight
- Trial name
- MODERATE (NCT01320722)
- Testing
- Vitamin D ergocalciferol, Probenecid, Allopurinol
- Where
- United States
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Coronary Artery Disease, Graft Failure
Clinical Effect of No-touch Harvesting Technique in OPCABG
This study aims to investigate the clinical effect of the new saphenous vein harvesting technique "No-touch" in off-pump coronary artery bypass grafting(OPCABG), comparing to the conventional technique.
- Trial name
- NCT03729531
- Testing
- Conventional vein harvesting technique, no-touch vein harvesting technique
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Beijing Anzhen Hospital
Obstructive Sleep Apnea
Obstructive Sleep Apnea (OSA), Hypertension , β1 Subunit of Maxi-k+ Channel and Cardiovascular Risk
To describe the relationship between OSA and clinical Hypertension (performing ABPM), endothelial dysfunction (performing flowmetry), and its relation at the basic research (determining the β1 subunit in Peripheral Leukocytes in…
- Trial name
- OSAS (NCT01791270)
- Testing
- Continuous positive airway pressure (CPAP) therapy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Angeles Sanchez Armengol