Clinical trials: Endothelium, Vascular
Coronary Heart Disease
Global Vascular Effects of Intermittent Pneumatic Compression-Pilot Study
Intermittent pneumatic compression (IPC) of the lower extremities is a well-established technique for preventing deep vein thrombosis (DVT) and for treating venous stasis.
- Trial name
- NCT01064323
- Testing
- Intermittent pneumatic compression of the lower extremities
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Acute Ischemic Stroke
CERebrolysine Effect on Blood-brain Barrier in acUte Ischemic Stroke
The study investigates whether Cerebrolysin stabilizes blood-brain barrier integrity in a manner that can be monitored using serum levels of the principal tight junction proteins, e.g., occludin (OCL), claudin-5 (CLN), and zonula…
- Trial name
- CERBERUS (NCT06078215)
- Testing
- Cerebrolysin
- Where
- Poland
- Volunteers
- 350 people
- Sponsor
- Poznan University of Medical Sciences
Wet Age-related Macular Degeneration
A Study to Evaluate the Efficacy and Safety of Intravitreal KSI-301 Compared With Intravitreal Aflibercept in Participants With Neovascular (Wet) Age-related Macular Degeneration (wAMD)
This Phase 3 study will evaluate the efficacy and safety of KSI-301 compared to aflibercept, in participants with neovascular (wet) age-related macular degeneration (wAMD)
- Trial name
- DAYLIGHT (NCT04964089)
- Testing
- KSI-301, Aflibercept
- Where
- 66 sites in United States, Puerto Rico
- Volunteers
- 557 people
- Sponsor
- Kodiak Sciences Inc
Neovascular (Wet) Age-related Macular Degeneration
A Study to Learn How Well Aflibercept Injected Into the Eye Works and How Safe it is When Given in Customized Treatment Intervals in Patients With an Eye Disease Called Neovascular Age-related Macular Degeneration After Start of Treatment
Researchers are looking for a better way to treat people who have neovascular (wet) age-related macular degeneration (nAMD or wet AMD).
- Trial name
- XPAND (NCT05473715)
- Testing
- Aflibercept(BAY86-5321, Eylea)
- Where
- 3 sites in Canada, United Kingdom
- Volunteers
- 3 people
- Sponsor
- Bayer
Hemodialysis Patients, Peripheral Vascular Disease
Effects of Cilostazol on VEGF and Oxidative Stress Biomarkers in Hemodialysis Patients With Peripheral Vascular Disease
Peripheral arterial disease (PAD) is the most common manifestation of systemic atherosclerosis and accounts for significant morbidity and mortality among end-stage renal disease (ESRD) patients.
- Trial name
- NCT00431249
- Testing
- Cilostazol
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tungs' Taichung Metroharbour Hospital
Salt; Excess, Pregnancy Related
Dietary Salt During Pregnancy and Maternal Vascular Function
The main goal of this study is to investigate the association of dietary salt intake during pregnancy with systemic micro- and macrovascular reactivity and uteroplacental vascular function of the mother, and to examine the…
- Trial name
- NCT05048225
- Where
- Croatia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
HIV Infections, HIV Metabolic Cardiovascular Syndrome
Yoga for the Management of HIV-Metabolic Syndromes
We are testing the safety and efficacy of a 16-wk yoga lifestyle intervention on oral glucose tolerance, fasting lipid/lipoprotein levels, body composition, cardiovascular function, quality of life, CD4+ T-cell counts and viral…
- Conditions
- HIV Infections, HIV Metabolic Cardiovascular Syndrome, HIV Lipodystrophy, HIV Metabolic Syndromes
- Trial name
- NCT00627380
- Testing
- Yoga lifestyle intervention, Standard of care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Washington University School of Medicine
Male Breast Carcinoma, Recurrent Breast Carcinoma
Pazopanib in Treating Patients With Newly Diagnosed or Locally and/or Regionally Recurrent Breast Cancer That Can Be Removed By Surgery
This pilot clinical trial studies how well pazopanib hydrochloride works in treating patients with breast cancer that is newly diagnosed or has come back at or near the same place as the original tumor and can be removed by…
- Conditions
- Male Breast Carcinoma, Recurrent Breast Carcinoma, Stage IA Breast Cancer, Stage IB Breast Cancer
- Trial name
- NCT00450879
- Testing
- Pazopanib Hydrochloride, Dynamic Contrast-Enhanced Magnetic Resonance Imaging, Pharmacological Study
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- National Cancer Institute (NCI)
Endothelial Dysfunction, Biochemical Markers
Acute Effects of E-Cigarette Aerosol Inhalation
This study comprises a portion of a larger study designed to compare results of vascular function in non-smokers to vascular function in healthy smokers chronically exposed to nicotinized electronic cigarette aerosol versus…
- Trial name
- NCT03479203
- Testing
- Electronic Cigarette Aerosol
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Renal Cell Carcinoma Metastatic, Renal Cell Carcinoma
Pharmaco-Economic Study of Treatment Options in Patients With Advanced RCC
This is a retrospective cohort study aiming to collect data on patients' characteristics, resource utilization, adverse events management and calculate costs attributed to current treatments of advance RCC patients who have…
- Trial name
- NCT03699579
- Where
- 2 sites in Taiwan
- Volunteers
- 28 people
- Sponsor
- Ipsen
Endothelial Dysfunction, Inflammation in Cardiopulmonary and Vascular Disease States
Samples From Human Subjects to Facilitate Basic, Translational and Clinical Research
Background: This study is designed to provide samples to help us study the genes your blood cells are making as well as the proteins, sugars, fats, vitamins and other metabolites found in your blood or urine.
- Conditions
- Endothelial Dysfunction, Inflammation in Cardiopulmonary and Vascular Disease States, Healthy Volunteers
- Trial name
- NCT03253705
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Pulmonary Embolism, Hematopoiesis
Is Clonal Hematopoiesis of Indeterminate Potential Associated With Unprovoked Pulmonary Embolism?
The clonal hematopoiesis of indetermined prognosis (CHIP) has been described as risk factor for juvenile atherosclerosis. Moreover, some of CHIP genes are responsible of myeloproliferative disorders.
- Trial name
- HEMEP (NCT04711746)
- Testing
- blood sample
- Where
- France
- Volunteers
- 544 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Pulmonary Hypertension
Effect of Endothelin-1 Receptor Blockade on Circulating Endothelial Microparticles Levels in Patients With Pulmonary Hypertension
Pulmonary hypertension is a progressive and life threatening condition. It is characterized by severe remodeling of the pulmonary vessel wall, obstructive plexiform lesions, multi-focal thrombosis, and enhanced vasoconstriction.
- Trial name
- NCT00675051
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
HIV Infection
Comparing Blood Vessel Endothelial Function in HIV-Infected People and Matched HIV-Uninfected People
The blood vessels that carry blood from the heart to the rest of the body are normally capable of relaxing and constricting when needed to provide more or less blood to the body.
- Trial name
- NCT00919724
- Where
- United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Indiana University
High Blood Pressure, Metabolic Syndrome
Comparison of Aliskiren and Amlodipine on Insulin Resistance and Endothelial Dysfunction in Patients With Hypertension and Metabolic Syndrome
The purpose of this study was to determine the effects of Aliskiren on insulin resistance (IR) and endothelial dysfunction (ED) in patients with high blood pressure and metabolic syndrome.
- Conditions
- High Blood Pressure, Metabolic Syndrome, Insulin Resistance, Endothelial Dysfunction
- Trial name
- NCT00417170
- Testing
- Aliskiren, Amlodipine
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Novartis Pharmaceuticals
Diabetic Macular Edema (DME)
Comparison of Bevacizumab and Aflibercept in Treatment of Diabetic Macular Edema
Diabetic macular edema is a frequent complication of long-standing diabetes mellitus in which fluid leaks into the central part of the retina (macula), leading to reduced vision.
- Trial name
- NCT07338097
- Testing
- Aflibercept (2.0 mg), Bevacizumab
- Where
- Pakistan
- Volunteers
- 116 people
- Sponsor
- CMH Multan Institute of Medical Sciences
n-3 Polyunsaturated Fatty Acids
N-3 Polyunsaturated Fatty Acids Enriched Chicken Meet and Cardiovascular Function
Evidence from multiple experimental, epidemiological, and clinical studies indicate that n-3 polyunsaturated fatty acids (n-3 PUFAs) may exert their cardiovascular (CV) protective effect, at least in part, by improving vascular…
- Trial name
- NCT05725486
- Testing
- N-3 PUFAs Chicken Meet, Regular Chicken Meet
- Where
- Croatia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Depressive Disorder, Depression
Exploring Effects of Electroconvulsive Therapy on the Human Brain in Depression - The Danish ECT/MRI Study
The main purpose of this study is to determine whether electroconvulsive therapy (ECT) causes any structural or functional brain changes and thus indicating its mechanism of action.
- Conditions
- Depressive Disorder, Depression, Depressive Disorder, Major
- Trial name
- NCT03040388
- Where
- Denmark
- Volunteers
- 26 people
- Sponsor
- University of Copenhagen
Leukemia, Myelodysplastic Syndromes
Bevacizumab, Cytarabine, and Mitoxantrone on Treating Patients With Hematologic Cancers
RATIONALE: Monoclonal antibodies such as bevacizumab can locate cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells.
- Trial name
- NCT00015951
- Testing
- bevacizumab, cytarabine, mitoxantrone hydrochloride
- Where
- 3 sites in United States
- Sponsor
- University of Maryland, Baltimore
Diabetic Angiopathies, Bone Diseases, Metabolic
Microcirculation and Bone Metabolism in Patients With Type 2 Diabetes Mellitus and Charcot Foot - A Pilot Study
This study is part of a research project for a University MD Program. This is an observational study aimed at comparing the differences in bone metabolism and microcirculation in patients with type 2 diabetes mellitus (with and…
- Trial name
- NCT02435329
- Testing
- Baseline comparison of microcirculation and bone metabolism
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Tameside General Hospital
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